Assays oecd toxicity tests acute. Medical search. Frequent questions

The Eye Irritation Test (EIT) is an OECD-approved in vitro non-animal test method for identifying chemicals and mixtures that may be irritating to the corneal epithelium. (iivs.org)
Whether evaluating ultra-mild cosmetics and personal care products, or rank ordering the irritation potential of candidate formulations and ingredients, we can provide custom Ocular Screening protocols to best meet your testing goals. (iivs.org)
The BCOP (Bovine Corneal Opacity and Permeability) assay is an in vitro eye irritation test method developed by Gautheron et al. (iivs.org)
The Short Time Exposure (STE) assay, developed by Kao Corporation (Japan), is an in vitro assay used to assess acute eye irritation potential as an alternative to the traditional in vivo Draize test. (iivs.org)
The Ocular Irritection Assay is an in chemico eye irritation assay that detects, ranks, and predicts the corneal irritation potential of a test material. (iivs.org)
However, no current validated non-animal ocular irritation test methods or prediction tools are able to predict corneal recovery in a manner consistent with the animal tests historically employed. (iivs.org)
Acute dermal and eye irritation tests in New Zealand white rabbits indicate that the test item is nonirritant to the skin and eyes. (hindawi.com)
In a notice issued on March 22, the NMPA drafted acceptance of nine test methods including: Direct Peptide Reaction Assay (DPRA) for Skin Sensitization (OECD TG 442C) Short Time Exposure Assay (STE) for eye irritation (OECD TG 491) These new regulations will go into effect January. (iivs.org)
Among these are two in vitro methods: DPRA for skin sensitization and the Short Time Exposure (STE) assay for eye irritation. (iivs.org)
Acute Dermal Irritation and Acute Dermal Toxicity with 1,1-2-trifluoro- 2-(perfluoroethoxy)ethane sulfonate, potassium salt. (epa.gov)
Since the in vitro skin irritation test is based on the application of an excess amount of the test substance, and since the skin surface was completely covered with Sugar Factory Lime in the present study, it was concluded that the skin membranes were sufficiently exposed to the test substance. (europa.eu)
The toxicity information for some of the health effects listed above may be categorical in nature (presence/absence of genotoxicity or skin irritation, for example) while other outcomes are expressed through quantitative information and/or potency data. (cdc.gov)

Toward that end, a new assay for the determination of skin sensitisation in the mouse, the Local Lymph Node Assay (LLNA) has been sufficiently validated and accepted to justify its adoption as a new Test Guideline (1)(2)(3). (cdc.gov)
The other Guideline (406) utilises guinea pig tests, notably the guinea pig maximisation test and the Buehler test (4). (cdc.gov)
Following the methodology described in OECD Test Guideline 497, KeratinoSens is an alternative to animal testing methods necessary for the purpose of hazard identification. (iivs.org)
It is described in the OECD 236 Guideline as a test required for ecotoxicological regulatory purposes, and it is also useful to assess the safety of compounds in preclinical research. (zeclinics.com)
Following the OECD 236 Guideline, a convenient, rapid and inexpensive acute toxicity test has been set up. (zeclinics.com)
One example is the Risk Assessment process for chemicals for concern of skin sensitization where the OECD has elaborated a detailed guideline on how to proceed during risk assessment. (douglasconnect.com)

Please note that for other Annexes of REACH, covering chemicals used at higher tonnage bands, there are currently no regulatory in vitro tests available for some of the required endpoints such as repeat dose / chronic exposure and reproductive toxicity. (x-cellr8.com)

The main objectives of the project included the compilation, evaluation and generation of high quality in vitro and in vivo data on a set of reference chemicals for comparative analyses, and the identification of factors that influence the correlation between in vitro (concentration) and in vivo (dose) toxicity, particularly taking into consideration biokinetics, metabolism and organ toxicity (liver, central nervous system, kidney). (enhesa.com)

In a study with female mice, Iso E Super was positive in the local lymph node assay (LLNA) and irritancy assay (IRR), but negative in the mouse ear swelling test (MEST). (wikipedia.org)
OTNE is classified as a skin irritant (R38 EU DSD, H315 EU CLP) and is positive in the Local Lymph Node Assay (LLNA - OECD 429) and therefore classified as a skin sensitiser (R43 EU DSD, H317 EU CLP), though OTNE lacks any structural alerts for sensitisation in in silico prediction models (DEREK) and is not identified as an allergen in in vivo Human Repeated Patch Tests. (wikipedia.org)
Draft Results on an OECD 429 Skin Sensitization: Local Lymph Node Assay with 1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate. (epa.gov)

The kinetic direct peptide reactivity assay (kDPRA) is a modification of the DPRA (OECD TG 442C) wherein the reaction kinetics of a test substance towards a synthetic cysteine-containing peptide is evaluated. (iivs.org)
Also, don't miss our posters: The kinetic Direct Peptide Reactivity Assay (kDPRA): An in chemico method to characterize the skin sensitization potency of chemicals (Poster Viewing 1) Increased Throughput and Cryopreservation of Precision-Cut Lung. (iivs.org)

reported that repeated oral supplementation of an ethanol extract of G. mangostana fruit rind for twenty-eight days did not show systemic toxicity in Sprague Dawley rats, which concluded its safety for human consumption [ 9 ]. (hindawi.com)
These findings suggest quantitative considerations for building scientific confidence in NAM-based systemic toxicity predictions. (nih.gov)
For this reason, the skin is often exposed to potentially hazardous agents, including chemicals, which may contribute to the onset of a spectrum of adverse health effects ranging from localized damage (e.g., irritant contact dermatitis and corrosion) to induction of immune-mediated responses (e.g., allergic contact dermatitis and pulmonary responses), or systemic toxicity (e.g., neurotoxicity and hepatoxicity). (cdc.gov)

The EPA waived the test for formulations in 2016, saying that information from acute oral tests was sufficient. (acs.org)
An acute oral toxicity test was done based on the Organization for Economic Cooperation and Development (OECD 425) guidelines using Swiss albino mice. (bvsalud.org)
The present communication describes a battery of toxicity studies that include an acute oral toxicity, a subacute twenty-eight-day repeated oral dose toxicity, and genotoxicity studies on a herbal formulation CinDura® (GMCT). (hindawi.com)
The acute oral toxicity study in Wistar rats suggests that the median lethal dose of CinDura® is at least 2000 mg/kg body weight. (hindawi.com)
A twenty-eight-day repeated dose oral toxicity study was conducted in male and female Wistar rats using daily doses of 250, 500, and 1000 mg/kg body weight, followed by a fourteen-day reversal period for two satellite groups. (hindawi.com)
For the acute study, the extract was administered to the animals at single oral graded doses of 1000, 2000 and 5000 mg/kg body weight (b.w.) and subsequently observed for 14 days, while it was given at 250, 500, and 1000 mg/kg b.w. once daily for 28 days in the sub-acute testing. (ijpsr.com)
Acute Oral Toxicity of P-tert-butylbenzaldehyde in Rats with Cover Letter dated 092386 (company Sanitized). (epa.gov)
Acute Oral Toxicity Study (Up and Down Method) in Rats with N,N-dimethyl-1, 1,2,2-tetrafluoroethylamine. (epa.gov)
Draft Report of a Combined 28-Day Repeated Dose Oral (Gavage) Toxicity Study with Reproduction/Developmental Toxicity Screening Test in Rats. (epa.gov)
Safety of both strains was confirmed by acute oral toxicity in rats. (frontiersin.org)
The potential of acute toxicity of Ethoxylated Bisphenol A diacrylate was evaluated in two studies, one by oral route and one by dermal route. (europa.eu)
Details on the available acute oral and dermal toxicity studies are provided in Tables 7 and 8 . (canada.ca)

Iso E Super may cause allergic reactions detectable by patch tests in humans and chronic exposure to Iso E Super from perfumes may result in permanent hypersensitivity. (wikipedia.org)
Chlorothene Vg: a Chronic Inhalation Toxicity and Oncogenicity Study in Rats and Mice (part 1 & 2) with Cover Letter dated 08/21/1984. (epa.gov)
Diarrhoea can be categorized based on duration, namely acute diarrhoea, persistent diarrhoea and chronic diarrhoea (Mekonnen et al. (springeropen.com)

Acute Inhalation Study of Five Male Rats/Group using Propane, 1,2-dibromo-1-1-2-3-3-hexafluoro. (epa.gov)
Acute Inhalation Toxicity Study in Rats with 1,2,2,2- Tetrafluoroethane (HFC-134). (epa.gov)
Acute Inhalation Toxicity Study of MTDID 18132 in Male and Female Rats: 09-123. (epa.gov)
Acute Inhalation Toxicity Study of MTDID 19763 in Female Rats: 09-173. (epa.gov)
Acute Inhalation Toxicity Study with 1,1-Difluoroethane (HFC-152a) and Denatonium Benzoate (DB). (epa.gov)
Acute Vapor Inhalation Study in Fischer 344 Rats Using Aerothene Tt with Cover Letter Dated 03/22/1988. (epa.gov)
Data on Acute Inhalation Toxicity Study Conducted in Sprague-Dawley Rats with Ethane, 1,1,2,2-tetrafluoro- 1-methoxy. (epa.gov)

When toxicity data are present for a given endpoint, a weighted score based on that health endpoint is assigned. (cdc.gov)

The toxicological evaluations were performed following the Organization for Economic Cooperation and Development (OECD) guidelines. (hindawi.com)
However, to the best of our knowledge, no report is available so far on preclinical toxicological evaluations, including genetic toxicity studies on C tamala leaves. (hindawi.com)
This study evaluated the toxicological effects of the acute and sub-acute dosing treatments of the aqueous root extract of Ha in male and female wistar rats using OECD guidelines 423 and 407. (ijpsr.com)
Acute toxicological investigations have shown that both E. indicum extracts have a high L.D. 50 value of 1533 mg/kg b.w for AE and 1567 mg/kg b.w for ME making them safe and non-toxic. (springeropen.com)

The test method utilizes an in vitro reconstructed human corneal epithelium (RhCE) model (EpiOcular™, MatTek Corp. or HCE, SkinEthic™), in an acute exposure assay to support international regulatory labeling requirements, according to the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). (iivs.org)
The EPA is evaluating whether an equation that sums the hazards of individual chemicals can replace the animal test for formulations and mixtures. (acs.org)
Fish Embryo Acute Test is designed to determine the acute toxicity of chemicals in vivo in just a few days. (zeclinics.com)
These include testing that may be considered essential to protect the safety of manufacturing workers, who need to handle chemicals in a neat or highly concentrated form. (x-cellr8.com)
ACuteTox set the very ambitious overall objective of developing an in vitro test strategy sufficiently robust and powerful to completely replace in vivo testing of acute toxicity of chemicals. (enhesa.com)

The LLNA assesses this proliferation as a dose- response in which the proliferation in test groups is compared to that in vehicle treated controls. (cdc.gov)
Overall, the no-observed-adverse-effect level (NOAEL) of the herbal blend is 1000 mg/kg body weight, the highest tested dose. (hindawi.com)
As such, we assessed potential differences in exposure/toxicity and pharmacologic effect of a model ASO (RTR5001) in the juvenile Göttingen Minipig in an 8-week repeat-dose toxicity study (weekly subcutaneous dosing starting at postnatal day 1). (uantwerpen.be)
Dose-response curves for mortality at 96 hpf after exposure of embryos to a vehicle (negative control), a toxic compound (positive control) and a study molecule that shows some toxicity. (zeclinics.com)
The result revealed that, at a limit dose of 5000 mg/kg b.w., the extract neither had treatment - mediated symptoms of toxicity nor mortality over the 14 days observation period. (ijpsr.com)
In the sub-acute study and particularly for the male rats, the extract significantly increased the serum levels of the erythrocytes and haemoglobin, while the platelet counts increased dose-dependently in both male and female treated animals. (ijpsr.com)
Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test in the Han Wistar Rat. (epa.gov)
The starting dose-level was selected in agreement with the Sponsor, based on the following rationale: since no relevant toxicity data are available for the estimation of a lethal dose-level and any existing data were taken into account by the Sponsor, the starting dose-level was 300 mg/kg for animal welfare reasons. (europa.eu)
None of the protocol variables such as test type, skin patch size, sample size, or dose applied were associated with high or low variability. (nih.gov)
Also, female rat kidney revealed acute tubular necrosis at highest dose used in this study. (biomedcentral.com)
No reliable data on the repeated dose toxicity of L-Carvone is available. (europa.eu)
L-Carvone is predicted to have a comparable level of repeated dose toxicity to D-Carvone, so using a read-across approach, a NOAEL of 375 mg/kg bw/day is predicted for L-carvone. (europa.eu)
Data matrix), the information from the source chemical is reliable and read across from D-carvone to L-Carvone for repeated dose toxicity is proposed. (europa.eu)
In the latter case, clearly specified quantitative benchmarks, such as median lethal doses (LD50s) for acute toxicity and no- observed-adverse-effect levels (NOAELs), or equivalent point of departure such as benchmark dose lower confidence limit (BMDL), for STOT-RE, are used. (cdc.gov)

2-Nitrotoluene was genotoxic in a range of in vitro and in vivo assays, was notably clastogenic in human peripheral lymphocytes and formed DNA adducts in exposed rodents. (gc.ca)

90-day Dermal Toxicity Study in Rats of Simulated Cutting Fluid Containing Para-tert-butyl Benzoic Acid with Cover Letter dated 071186. (epa.gov)
Acute Dermal Toxicity Study of P-tert-butylbenzoic Acid on Rats with Attacments and Cover Letter Dated 07/23/1987. (epa.gov)

3Rs-aligned method for fast and high throughput acute toxicity assessment in vivo . (zeclinics.com)
Evaluation tree of developmental toxicity effects during risk assessment. (douglasconnect.com)
To ensure integrity of the experimental outcomes, authorities, such as the OECD, EFSA, EPA, FDA and others, have elaborated specific guidelines on procedures which have to be followed during risk assessment. (douglasconnect.com)
No specific studies are available however based on physicochemical data, toxicity data and theoretical assessment, the basic toxicokinetics of Fatty acids C18 unsat, reaction products with pentaethylenehexamine, acetate salts can be adequately characterised. (europa.eu)

The use of fish embryos allows high throughput screening while providing similar predictivity to adult fish and reducing animal testing. (zeclinics.com)

The mean fifty percent inhibition concentration (IC50) was determined for each assay. (bvsalud.org)
The test material was tested up to a maximum concentration of 4000 µg/mL, representing the solubility limit of the test material. (europa.eu)
Without metabolic activation treatment with test material led to a moderate and concentration-dependent growth inhibiting down to the concentration of 500 µg/mL. (europa.eu)
In the absence of recommendation from the Sponsor, the solubility assay first started at the concentration of 200 mg/mL, and the first choice vehicle was drinking water treated by reverse osmosis. (europa.eu)
As unsatisfactory solubility of the test item was obtained in this vehicle (i.e. heterogeneous emulsion or suspension at the concentration of 200 mg/mL was obtained), another vehicle was chosen from the following organic solvents (in order of preference): 0.5% methylcellulose aqueous solution and corn oil. (europa.eu)

We present a novel approach for assessing pesticide toxicity on mammalian cells, by measuring the response patterns of four cell lines (two neuroblastoma and two fibroblast) to three different pesticide groups (carbamates, organophosphates, pyrethroids) at a broad range of concentrations. (siftdesk.org)

Moreover, the LLNA offers a substantial refinement of the way in which animals are used for contact sensitisation testing. (cdc.gov)

KeratinoSensTM is a cell-based reporter gene assay that models the second key event in the Adverse Outcome Pathway for Dermal Sensitization (keratinocyte activation). (iivs.org)
The assay measures the induction of a stably transfected luciferase gene under the control of the antioxidant response element (ARE) derived from the human AKR1C2 gene. (iivs.org)
While broad coverage of MDI Category substances is availalbe for bacterial gene mutation, additional OECD 471 studies will be conducted on all remaining data-gaps to complete the data set. (europa.eu)
The potential of the test material to cause gene mutation in bacterial strains was determined in accordance with standardised guidelines OECD 471, EU Method B.14 and EPA OPPTS 798.5265. (europa.eu)
The potential of the test material to cause gene mutation or clastogenic effects in mammalian cells was determined in accordance with standardised guidelines OECD 476and EPA OPPTS 798.5300. (europa.eu)

Combined with in vivo mutagenicity testing on the worst-case substance (4,4'-MDI) and hypothesized MoA, this complete data-set will confirm the lack of mutagenic potential for the entire MDI Substance category. (europa.eu)
Numerous other category substances have been tested in high quality bacterial mutagenicity studies are negative and includes (often multiple) representatives from all MDI subgroups. (europa.eu)
Accordingly, 4000 µg/mL with and without metabolic activation were chosen as highest concentrations for the first mutagenicity assay. (europa.eu)
The original mutagenicity assay was therefore performed at 148.15, 444.44, 1333.33 and 4000.00 µg/mL. (europa.eu)

WHO is not responsible, and does not accept any liability, for the testing of pesticides for compliance with the specifications, nor for any methods recommended and/or used for testing compliance. (who.int)
The US Environmental Protection Agency is working to reduce the number of animals used in testing the acute toxicity of pesticides. (acs.org)
In early 2016, the US Environmental Protection Agency set an immediate goal to reduce the number of animals used to test the toxicity of pesticides. (acs.org)
The US Environmental Protection Agency is working to replace these in vivo animal tests with nonanimal alternatives to categorize the toxicity of pesticides. (acs.org)
This is why we want to record their effects (e. g. genotoxicity, mutagenity, and bacteria toxicity).At present we are focusing on pesticides, pharmaceuticals, textile auxiliary agents and nanoparticles. (leuphana.de)

We don't currently provide the regulatory in vitro genotoxicity tests (Ames Test, Micronucleus Test, Chromosome Aberration Test) because all 3 require the use of animal-derived components and would contravene our commitment to a fully animal product-free testing strategy. (x-cellr8.com)

The test method evaluates the cytotoxicity induced by a series of test chemical dilutions in a monolayer of rabbit corneal fibroblasts (Statens Seruminstitut Rabbit Cornea - SIRC) after a single five-minute exposure. (iivs.org)
A preliminary range finding test was run assessing cytotoxicity. (europa.eu)

Glyphosate showed significantly lesser lethality and toxicity while Trifluralin and 2,4-D showed the highest toxicity in A. franciscana among the examined herbicides. (ac.ir)

From the data presented in this study, it could be logically inferred that aqueous root extract of H. africana is non-toxic at the tested doses and within the period of exposure. (ijpsr.com)

1993) found there is a chemical conversion of MDI to MDA in the solvent which could explain a number of positive responses recorded in some genotoxicity assays in vitro . (europa.eu)
Because humans are the primary subject of interest for regulatory safety testing, it is advantageous to have human reference data available for evaluation of NAMs for assessing chemical safety. (nih.gov)
The Tier 2 process for occupational exposure banding also assesses the sufficiency of toxicity data to ensure that adequate information is available to reliably band a chemical. (cdc.gov)

Final Results on an OECD 202 Acute Toxicity to Daphnia magna and an OECD 211 21-Day Reproduction Test, Conducted with 1,1,3,3-Tetramethylbutyl Hydroperoxide. (epa.gov)

The biodegradation of OTNE in fresh water (T1/2) is at most 40 days, and at most 120 days in sediment (OECD 314 test), though the biodegradation within the 28day window was around 11% (OECD 301-C). Given the outcome of the OECD 314 test OTNE does not meet the criteria for "Persistent" (P) or "very Persistent" (vP). (wikipedia.org)

Acute toxicity (48 h LC50) of five herbicides were determined via OECD standard method. (ac.ir)

Following the 3R principles (Replace, Reduce, Refine) new approach method scientists seek ways to generate high quality research evidence in toxicology without unneeded animal testing. (douglasconnect.com)

The data collection identified 2,255 tests that were deemed to be sufficiently reliable for the analysis, including reports for 232 substances with at least two test results. (nih.gov)

A preclinical study demonstrated that CinDura®-supplemented Swiss albino mice had improved grip strength and swimming performance in a forced swim test. (hindawi.com)
However, the adult Göttingen Minipig has been recognized as a suitable alternative to NHPs in the safety testing of ASOs, as it showed similar pharmacokinetic, pharmacodynamic, and safety profiles in a previous study. (uantwerpen.be)
In this study the toxicity of five widely used herbicides formulations including: Paraquat, 2,4-dichlorophenoxy acetic acid (2,4-D), Trifluralin, Glyphosite and Atrazin were compared using ecotoxicity bioindicator, Artemia franciscana. (ac.ir)
Then for sustainable agricultural activity, especially in areas that runoff water flow to aquatic ecosystems, it is highly recommended to use environmental friendly herbicides like glyphosate as an alternative to highly toxic herbicides like trifluralin, Paraquat and 2,4-D. To the best of our knowledge, this work is the ﬁrst study comparing the toxicity of highly used herbicides using ecotoxicity bioindicator, Artemia franciscana. (ac.ir)
The results of the study demonstrate the potential of bioelectric profiling as a tool for developing novel toxicity assays and associated biosensors with superior analytical capacity, speed of assay and the ability to respond to a broad spectrum of toxicants, at the same time satisfying the demand for increased cost-efficiency and ease of operation. (siftdesk.org)
The potential of the test material to induce structural chromosomal aberrations was determined in a study performed in accordance with standardised guidelines OECD 473, EU Method B.10 and EPA OPPTS 798.5375. (europa.eu)
Justification for choice of vehicle: The vehicle used in this study was selected from the results of solubility assays performed by the CiToxLAB France Pharmacy. (europa.eu)
The aim of this study was to compare the acute toxicity of acetylsalicylic acid to embryonic and juvenile stages of aquarium fish - zebrafish (Danio rerio), oxidative stress parameters and detoxifying enzyme. (nel.edu)
The aim of the present study is to investigate the relationship between loneliness and sex steroid hormones, test osterone (T) and 17β-estradiol (E2). (nel.edu)
During the main study it was not possible to transfer the complete mixture to the skin surface and some test substance remained in the vial. (europa.eu)
This study aims to identify active phytocompounds found in the extracts of Eranthemum indicum ( E. indicum ) and to determine its antioxidative activities and toxicity. (springeropen.com)

Furthermore, it is highly versatile and suitable for applications in the preclinical drug research and in vitro assays. (bvsalud.org)

Highly predictive for acute toxicity effects in humans. (zeclinics.com)
Scientists with CPSC , FDA , and NIEHS and collaborators compiled such a data set for human skin sensitization potential by collecting data from the scientific literature for human predictive patch tests that used the human maximization or human repeated insult patch test protocols. (nih.gov)

The few macroscopic findings noted (red discoloration in the thymus in two females from group 3) at the end of the observation period were of those commonly recorded in the Sprague-Dawley rat and none were considered to be related to the test item administration. (europa.eu)

Based on such evaluation it was concluded that the results of in vitro genotoxicity studies undertaken using solvents such as DMSO must be treated with caution as any positive response may very well be an artefact of the testing conditions caused by the breakdown of the isocyanate into the mutagenic amine. (europa.eu)

Mammalian cells are a unique tool for in vitro toxicity assays, since they represent, with a fairly high degree of accuracy, the actual biological targets of many environmental pollutants or other compounds with proven or suspected toxicity. (siftdesk.org)
With this progress, new assays and methods can be developed to assess the risk of compounds and materials and to make the world a safer and greener place. (douglasconnect.com)
With the development of new tissue and organoid models, it is nowadays possible to test compounds with high predictability for effects in different organisms including humans. (douglasconnect.com)
Based on those guidelines it is not only possible to develop assays anchored to specific key events but to also evaluate already existing data by in silico approaches and to characterize existing and new compounds with concern for their potential risks for organisms. (douglasconnect.com)
The traditional use of organic solvents in various branches of industry is being rethought as these compounds very often display high volatility, toxicity and lipophilicity (related to the ability to interact with biological membranes). (easychair.org)

Also, the results of the bacterial reverse mutation test and the erythrocyte micronucleus assay in mouse bone marrow suggest that CinDura® (GMCT) is neither mutagenic nor clastogenic. (hindawi.com)

The assay assesses changes to the reagent solution (containing proteins, glycoproteins, lipids), which mimics the denaturation and disruption that occurs in corneal proteins in vivo . (iivs.org)

METHODOLOGY: The roots, stem bark and leaves of Caesalpinia decapetala (Roth) Alston (Caesalpiniaceae) were collected and air-dried under a shade then extracted consecutively with dichloromethane and methanol (1:1 (v/v) (4 × 0.8 L). The extracts were tested for antiplasmodial activities against four strains of Plasmodium falciparum (W2, DD2, 3D7, and D6) and fresh P. falciparum field isolates using the SYBR green I assay. (bvsalud.org)
Test s were performed according to OECD No. 203 (Fish, acute toxicity test ) and OECD No. 212 (Fish, short-term toxicity test on embryo and sac-fry stages) methodology. (nel.edu)

Additional in vitro micronucleus studies (OECD 487) will be conducted on ALL category substance to assess potential effects on cytogenetics. (europa.eu)

Artemia is one of the most important test organisms available for ecotoxicity test. (ac.ir)
The substance met the ecological categorization criteria for persistence, but did not meet the ecological categorization criteria for bioaccumulation potential or inherent toxicity to aquatic organisms. (gc.ca)
There is little information on the toxicity of the fire-fighting substances in connection with aquatic and terrestrial organisms. (ncsu.edu)
A preliminary test was carried out on all the samples to evaluate the (positive / negative) effects of the fire water on the test organisms. (ncsu.edu)

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