Aspergillus fumigatus. Medical search. Frequent questions

Additionally, A. fumigatus can cause chronic pulmonary infections, allergic bronchopulmonary aspergillosis, or allergic disease in immunocompetent hosts. (wikipedia.org)
The fungus and its polysaccharides have ability to regulate the functions of dendritic cells by Wnt-β-Catenin signaling pathway to induce PD-L1 and to promote regulatory T cell responses Immunosuppressed individuals are susceptible to invasive A. fumigatus infection, which most commonly manifests as invasive pulmonary aspergillosis. (wikipedia.org)
Deficiency in HapX, but not SreA, attenuates virulence of A. fumigatus in a murine model of aspergillosis, which underlines the crucial role of adaptation to iron limitation in virulence. (frontiersin.org)
Ecology of aspergillosis: insights into the pathogenic potency of Aspergillus fumigatus and some other Aspergillus species. (jcvi.org)
For all the phosphomutants, there is an increase in the sensitivity to cell wall-damaging agents and a reduction in the MpkA phosphorylation upon CR stress, suggesting these phosphosites could be important for the MpkA modulation and CWI pathway regulation.IMPORTANCEAspergillus fumigatus is an opportunistic human pathogen causing allergic reactions or systemic infections, such as invasive pulmonary aspergillosis in immunocompromised patients. (bath.ac.uk)
Aspergillus fumigatus is an opportunistic human pathogen, which causes the life-threatening disease, invasive pulmonary aspergillosis. (fapesp.br)
In the present study, 52 clinical isolates of A. fumigatus from 12 airway specimens from patients with invasive aspergillosis (hospitalized in three different centres) were characterized by short tandem repeat (STR) typing and multilocus sequence typing (MLST). (elsevierpure.com)
Aspergillus fumigatus is a human fungal pathogen that causes aspergillosis in immunocompromised hosts. (biomedcentral.com)
Filamentous fungus Aspergillus fumigatus is a ubiquitous fungus commonly found in soil, but is also reported as a major cause of invasive fungal aspergillosis infections in humans, especially in patients with compromised or suppressed host immunity [ 2 , 3 , 4 ]. (biomedcentral.com)

Aspergillus fumigatus is the most frequent cause of invasive fungal infection in immunosuppressed individuals, which include patients receiving immunosuppressive therapy for autoimmune or neoplastic disease, organ transplant recipients, and AIDS patients. (wikipedia.org)
A. fumigatus primarily causes invasive infection in the lung and represents a major cause of morbidity and mortality in these individuals. (wikipedia.org)
However, in healthy individuals, the innate immune system is an efficacious barrier to A. fumigatus infection. (wikipedia.org)
3. Mellado E, De La Camara R, Buendia B, Rodriguez-Tudela JL, Cuenca-Estrella M. Breakthrough pulmonary Aspergillus fumigatus infection with multiple triazole resistance in a Spanish patient with chronic myeloid leukemia. (cdc.gov)
abstract = "Aspergillus fumigatus is the most pathogenic species among the Aspergilli, and the major fungal agent of human pulmonary infection. (manchester.ac.uk)
Given the dependency of A. fumigatus upon stress adaptation for colonization and infection of mammalian hosts, and the merits of targeting receptor-mediated signaling as an antifungal strategy, a closer scrutiny of sensory perception and signal transduction in this organism is warranted. (manchester.ac.uk)
These results highlight the importance of PkcA to the CWI pathway but also indicated that additional regulatory circuits may be involved in the biosynthesis and/or reinforcement of the A. fumigatus cell wall during infection. (fapesp.br)
In contrast to the majority of other Aspergillus species, which are in most cases nonpathogenic, A. fumigatus features an armory of virulence determinants to establish an infection. (leibniz-hki.de)
We also discuss the potential impact of recent advances in immunoproteomics to improve diagnosis and therapy of an A. fumigatus infection. (leibniz-hki.de)
One patient, the index case, had a laboratory-confirmed Aspergillus fumigatus image icon infection. (cdc.gov)
When A. fumigatus establishes an infection in the human lung, the mycelia must respond to highly variable conditions, which might impose stress on the fungal pathogen [ 4 , 5 ]. (biomedcentral.com)
Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs. (leibniz-hki.de)
Pollmächer J, Timme S, Schuster S, Brakhage AA, Zipfel PF, Figge MT (2016) Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs. (leibniz-hki.de)
To investigate the counterplay of infection and inflammation, we simulated the invasion of the human-pathogenic fungus Aspergillus fumigatus in lung alveoli by evolutionary games on graphs. (leibniz-hki.de)
Fatal Fungicide-Associated Triazole-Resistant A fumigatus An older, immunocompromised patient presented with a case of triazole-resistant Aspergillus fumigatus infection that was linked to agricultural fungicide use. (medscape.com)

Fungi of the genus Aspergillus are widespread in the environment. (jcvi.org)
The antibacterial and antifungal activities of hexane, dichloromethane, acetone and methanol extracts of the leaves were determined using a two-fold serial microdilution method against a range of commonly encountered animal pathogenic fungi (A. fumigatus, Candida albicans, C. neoformans, Microsporum canis and Sporothrix schenckii) and four nosocomial bacteria (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa). (up.ac.za)
The interaction of A. fumigatus and other airborne fungi with the immune system is increasingly linked to severe asthma and sinusitis. (doe.gov)
Filamentous fungi were cultured at baseline in 49% (63 out of 128) of COPD subjects, of which 75% (47 out of 63) were A. fumigatus. (ox.ac.uk)
Aspergillus fumigatus is just one of the 1,700 strains of fungi from the ARS Fungal Culture Collection, which survived Hurricane Katrina as freeze dried specimens. (usda.gov)
In contrast to black DHN-melanin fungi such as Magnaporthe grisea, the polyketide synthase Alb1p in A. fumigatus produces naphthopyrone YWA1 instead of 1,3,6,8-THN (T4HN) and YWA1 is converted to T4HN by Ayg1p. (olmdiagnostics.com)

Aspergillus fumigatus is a species of fungus in the genus Aspergillus, and is one of the most common Aspergillus species to cause disease in individuals with an immunodeficiency. (wikipedia.org)
Aspergillus fumigatus is a ubiquitous saprophytic fungus, which has become the most common air-borne fungal pathogen of humans ( Tekaia and Latge, 2005 ). (frontiersin.org)
In the model fungus Aspergillus nidulans, a MAPK pathway known as the pheromone module is utilized to regulate both development and SM production. (ku.edu)
The filamentous fungus Aspergillus fumigatus can cause a distinct set of clinical disorders in humans. (bath.ac.uk)
Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus. (doe.gov)
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. (doe.gov)
Aspergillus fumigatus is a saprotrophic filamentous fungus and also the most prevalent airborne fungal pathogen of humans. (leibniz-hki.de)
Fungus was cultured in three out of 22 controls (two were A. fumigatus). (ox.ac.uk)
However, their spread in the environment can lead to the selection of triazole resistance not only in crop pathogens, but also in non-target organisms, such as a non-phytopathogenic fungus Aspergillus fumigatus. (fortunejournals.com)
During this period, these fungicides may have unintended effects on Aspergillus fumigatus , a non-phytopathogenic fungus naturally present in soils, through the exertion of selection pressure [10]. (fortunejournals.com)
Aspergillus fumigatus is a ubiquitous airborne fungus and opportunistic human pathogen. (ilrs.de)

The genome sequences of three Aspergillus species-Aspergillus fumigatus, Aspergillus nidulans, and Aspergillus oryzae-were published in Nature in December 2005. (wikipedia.org)
Aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on Aspergillus fumigatus azole resistance. (cdc.gov)
Some Aspergillus species, most commonly Aspergillus fumigatus, may lead to a variety of allergic reactions and life-threatening systemic infections in humans. (jcvi.org)
Here, we synthesize these findings in relation to the way in which some Aspergillus species have become successful opportunistic pathogens of human- and other animal hosts. (jcvi.org)
We focus on the biophysical capabilities of Aspergillus pathogens, key aspects of their ecophysiology and the flexibility to undergo a sexual cycle or form cryptic species. (jcvi.org)
Overall, these data provide evidence of the existence of a conserved MAP kinase signaling pathway in Aspergillus species and suggest that this pathway is critical for the regulation of fungal development and secondary metabolism. (ku.edu)
Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability. (doe.gov)
Aspergillus species are the most common fungal infections in these patients. (ac.ir)
Erosion of a major pulmonary artery caused by angiotropism of the Aspergillus species may lead to severe hemorrhage. (medscape.com)

Conidial pigment is an important virulence factor in Aspergillus fumigatus, a human fungal pathogen. (olmdiagnostics.com)

In this study, homologs of each of these proteins have been identified in the opportunistic human pathogen A. fumigatus. (ku.edu)
Aspergillus fumigatus is exceptional among microorganisms in being both a primary and opportunistic pathogen as well as a major allergen. (doe.gov)

The identification and functional characterization of 24 genes that are involved in iron homeostasis in A. fumigatus and/or Aspergillus nidulans , respectively, revealed significant insights into iron metabolism and its regulation (Table 1 ). (frontiersin.org)
A. nidulans is a less virulent A. fumigatus relative and longstanding genetic model organism. (frontiersin.org)
The genome mining of secondary metabolites produced by A. fumigatus , A. nidulans , A. niger , and A. terreus revealed unique biosynthetic gene clusters and biosynthetic pathways 9 . (nature.com)

Consistently, production of both extra and intracellular siderophores is crucial for virulence of A. fumigatus . (frontiersin.org)
Inactivation of 10 of the 19 A. fumigatus genes caused defects in virulence. (frontiersin.org)
This review summarizes the current knowledge on iron homeostasis and its role in virulence in Aspergillus spp. (frontiersin.org)

Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major cause of morbidity and mortality globally. (manchester.ac.uk)

It had cytotoxicity against human lung carcinoma A549 cell line and was stable up to 100 °C. Thus, the study revealed that the strain A. fumigatus nHF-01 produces a potent broad-spectrum AMC 5-butyl-2-pyridine carboxylic acid that could be used against human food and topical pathogenic bacteria. (nature.com)

Conidia: phialoconidia of Aspergillus fumigatus. (doe.gov)
Since the incidence of fungal systemic infections drastically increased over the last years, it is a major goal to investigate the pathobiology of A. fumigatus and in particular the interactions of A. fumigatus conidia with immune cells. (ilrs.de)
The analysis reported here, reveals that different mutants of A. fumigatus have a major influence on the ability of macrophages to adhere and to phagocytose the respective conidia. (ilrs.de)
Because Aspergillus conidia are usually acquired from the environment, measures to reduce exposure to conidia are essential to prevent disease transmission. (medscape.com)

Clonal expansion and Emergence of eEnvironmental multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR(34)/L98H mutations in the cyp51A gene in India. (cdc.gov)
We describe here the impact of linear (maltodextrin) or cyclic (cyclodextrins, CDs) dextrins and their interaction with two fungicides (difenoconazole and tebuconazole), through measurements of growth in 20 A. fumigatus strains. (fortunejournals.com)
Here, we report the development of an automated analysis of confocal laser scanning microscopy images from macrophages coincubated with different A. fumigatus strains. (ilrs.de)

Aspergillus fumigatus has a stable haploid genome of 29.4 million base pairs. (wikipedia.org)
The genome sequence and gene predictions of Aspergillus fumigatus A1163 were not determined by the JGI, but were downloaded from ENSEMBL and have been published ( Natalie D. Fedorova (2008) , William C. Nierman (2005) , Catherine M. Ronning (2005) ). (doe.gov)
Completion of the sequence of the Aspergillus fumigatus partitivirus 1 genome. (herts.ac.uk)
A Portuguese isolate of Aspergillus fumigatus was found to contain three double-stranded (ds) RNA elements ranging in size from 1.1 to 1.8 kbp and comprising the genome of a strain of Aspergillus fumigatus partitivirus 1 (AfuPV-1) previously thought to contain only the two largest dsRNA elements. (herts.ac.uk)
Dive into the research topics of 'Completion of the sequence of the Aspergillus fumigatus partitivirus 1 genome. (herts.ac.uk)

High prevalence of azole-resistant Aspergillus fumigatus in adults with cystic fibrosis exposed to itraconazole. (cdc.gov)
High prevalence of triazole resistance in Aspergillus fumigatus , especially mediated by TR/L98H, in a French cohort of patients with cystic fibrosis. (cdc.gov)
The relation between antibody titres of aspergillus in patients with cystic fibrosis and the population density of their place of residence was investigated. (nih.gov)

We investigated the frequency of filamentous fungal culture and IgE sensitisation to Aspergillus fumigatus and the relationship to clinical outcomes in COPD subjects. (ox.ac.uk)

Minimum spanning tree comparing genotypic relatedness of clinical azole- resistant Aspergillus fumigatus isolates carrying TR34/L98H alteration in the CYP 51A gene from Iran with those reported from European countries. (cdc.gov)
Triazole resistance among clinical Aspergillus fumigatus isolates. (cdc.gov)
Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene. (cdc.gov)
Screening of cellulolytic activity by ten fungal isolates recovered from soil and agricultural wastes indicated that Aspergillus fumigatus showed the highest cellulolytic activity, under solid-state fermentation (SSF) using rice straw as substrate. (scialert.net)

L. alata was selected for further work to isolate compounds active against A. fumigatus and other fungal pathogens. (up.ac.za)
a much smaller number of infections may be attributed Malassezia, Zygomycetes, or Aspergillus pathogens. (medscape.com)

Please confirm that you want to SAVE all your changes for 'Aspergillus fumigatus A1163' . (doe.gov)

In this review we highlight the progress made in characterizing receptor-mediated environmental adaptation in A. fumigatus and its relevance for pathogenicity in mammals. (manchester.ac.uk)
Thus, the adaptation mechanism in mycelia plays an important role in terms of pathogenicity of A. fumigatus . (biomedcentral.com)

Genomics of Aspergillus fumigatus. (doe.gov)

Patients with high titres of antibodies to Aspergillus fumigatus were significantly more likely to live in an area of low population density. (nih.gov)

Nucleotide sequence of a genomic and a cDNA clone encoding an extracellular alkaline protease of Aspergillus fumigatus. (unil.ch)

Aspergillus fumigatus grown on certain building materials can produce genotoxic and cytotoxic mycotoxins, such as gliotoxin. (wikipedia.org)

The time series transcriptome analysis revealed the stress-responsive genes underlying the adaptation mechanisms in A. fumigatus mycelia. (biomedcentral.com)

Depending on the host's immune status, the variety of diseases caused by A. fumigatus ranges from allergies in immunocompetent hosts to life-threatening invasive infections in patients with impaired immunity. (leibniz-hki.de)
Title : Pulmonary immune responses to Aspergillus fumigatus in an immunocompetent mouse model of repeated exposures Personal Author(s) : Buskirk, Amanda D.;Templeton, Steven P.;Nayak, Ajay P.;Hettick, Justin M.;Law, Brandon F.;Green, Brett J.;Beezhold, Donald H. (cdc.gov)

Reducing the Unintentional Impact of Triazole Fungicides on Aspergillus fumigatus: Are Cyclodextrins a Solution? (fortunejournals.com)

Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus . (ilrs.de)
Mech F, Thywissen A, Guthke R, Brakhage AA, Figge MT (2011) Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus . (ilrs.de)

Interference of Aspergillus fumigatus with the immune response. (leibniz-hki.de)
This chapter summarizes the different strategies of A. fumigatus to manipulate the immune response. (leibniz-hki.de)

Although the burden of invasive disease caused by A. fumigatus is substantial, the basic biology of the organism is mostly obscure. (doe.gov)

fumigatus and high-osmolarity glycerol (HOG) pathway MAPK mutants upon cell wall damage. (bath.ac.uk)

In A. fumigatus this signaling cascade is partially characterized, but the mechanisms by which it is activated are not fully elucidated. (fapesp.br)

Patients at risk should be counseled to avoid exposure to Aspergillus organisms. (medscape.com)

As part of studies on the spread of infections, risk factors and prevention, several typing methods were developed to investigate the epidemiology of Aspergillus fumigatus. (elsevierpure.com)

Aspergillus infections. (medscape.com)

Aspergillus fumigatus, a saprotroph widespread in nature, is typically found in soil and decaying organic matter, such as compost heaps, where it plays an essential role in carbon and nitrogen recycling. (wikipedia.org)

Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient', Current Medical Mycology , 2(3), pp. 37-41. (ac.ir)

200). Although bioaerosols can be generated through a range of operational procedures it has also been suggested that large numbers of Aspergillus fumigatus spores can be emitted from static compost piles through the action of natural air movements across the surface of the biodegrading material. (whiterose.ac.uk)
The aim of this work was to use controlled laboratory experiments using compost samples and Aspergillus fumigatus spores to determine the sporulation rate of Aspergillus fumigatus. (whiterose.ac.uk)
A series of experiments were carried out using Aspergillus fumigatus spores on agar plates and small samples of green waste compost to determine the number of spores that could be generated by each existing spore over a seven day period. (whiterose.ac.uk)
Despite the limitations the original intention of the work was to attempt to establish the long term applicability of the fugitive release rates for Aspergillus fumigatus from green waste compost quoted in the literature and it has achieved this objective. (whiterose.ac.uk)
A. fumigatus is isolated from human habitats and vegetable compost heaps. (doe.gov)

Subsequently, we constructed and analyzed a non-essential A. fumigatus pkcAG579R mutant, carrying a Gly579Arg substitution in the PkcA C1B regulatory domain. (fapesp.br)

With the aid of RNA-seq, we explored the global gene expression profiles of mycelia in A. fumigatus upon exposure to diverse environmental changes, including heat, superoxide, and osmotic stresses. (biomedcentral.com)

When the fermentation broth of A. fumigatus was screened, a number of indolic alkaloids with antimitotic properties were discovered. (wikipedia.org)

A. fumigatus sensitisation is related to poor lung function. (ox.ac.uk)

Factors contributing to sex differences in mice inhaling Aspergillus fumigatus. (cdc.gov)

Aspergillus fumigatus during stable state and exacerbations of COPD. (ox.ac.uk)

For example, A. fumigatus is able to evade the human complement system by binding or degrading complement regulators. (leibniz-hki.de)

Aspergillus fumigatus causes severe problems in poultry production systems. (up.ac.za)

Here, an evaluation of the global A. fumigatus phosphoproteome under cell wall stress caused by the cell wall-damaging agent Congo red (CR) revealed 485 proteins potentially involved in the cell wall damage response. (bath.ac.uk)

To gain insights into the adaptation to environmental stresses in A. fumigatus mycelia, we conducted time series transcriptome analyses. (biomedcentral.com)

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