• apoptosis
  • Treatment with ascorbate in conjunction with extracts prepared from several medicinal herbs stimulated apoptosis and disrupted the cell cycle. (hindawi.com)
  • metabolites
  • Here we show that MGd is endocytosed by the clathrin-dependent pathway with ensuing lysosomal membrane permeabilization, most likely via formation of reactive oxygen species involving redox-active metabolites, such as ascorbate. (diva-portal.org)
  • Stress-induced ROS accumulation is counteracted by enzymatic antioxidant systems and non-enzymatic low molecular weight metabolites, such as ascorbate, glutathione and α-tocopherol. (mdpi.com)
  • The cycle involves the antioxidant metabolites: ascorbate, glutathione and NADPH and the enzymes linking these metabolites. (wikipedia.org)
  • vitro
  • The present studies demonstrate that a combined use of ascorbate and herbal extracts results in ROS production and a significant decrease in the number of cancer cells after a single in vitro treatment. (hindawi.com)
  • In in vitro studies, sodium ascorbate has been found to produce cytotoxic effects in various malignant cell lines, which include melanoma cells that are particularly susceptible. (wikipedia.org)
  • rapidly
  • In the absence of a reductase, two monodehydroascorbate radicals disproportionate rapidly to dehydroascorbic acid and ascorbate. (wikipedia.org)
  • activity
  • The intensity of the colored response is less subject to ascorbate interference due to the activity of the iodate ion. (google.com)
  • Use of massive doses of ascorbate will broaden the spectrum of activity of antibiotics against bacterial infections and prevent allergic reactions to the antibiotics. (breathing.com)
  • This means that defining an enzyme as an APX is not straightforward, but is usually applied when the specific activity for ascorbate is higher than that for other substrates. (wikipedia.org)
  • activity is somewhat stimulated by ascorbate. (wikipedia.org)
  • upon
  • It is possible to cure or ameliorate a disease with massive doses of ascorbate depending upon how important free radicals are in the perpetuation of the disease of its symptoms. (breathing.com)
  • These release ascorbate upon digestion. (wikipedia.org)