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Receptors, Aryl HydrocarbonAryl Hydrocarbon HydroxylasesHydrocarbonsTetrachlorodibenzodioxinAryl Hydrocarbon Receptor Nuclear TranslocatorCytochrome P-450 CYP1A1Polycyclic Hydrocarbons, AromaticProcollagen-Proline DioxygenaseDioxinsMixed Function OxygenasesBenzo(a)pyreneMethylcholanthreneHydrocarbons, AromaticBenz(a)AnthracenesProlyl HydroxylasesHypoxia-Inducible Factor-Proline DioxygenasesSteroid HydroxylasesEnvironmental PollutantsEnzyme InductionPolycyclic CompoundsCytochrome P-450 Enzyme SystemHydroxylationbeta-NaphthoflavoneBenzoflavonesBenzopyrenesHypoxia-Inducible Factor 1, alpha SubunitHydrocarbons, HalogenatedBenzopyrene HydroxylaseAlkanesHypertension, PortalBasic Helix-Loop-Helix Transcription FactorsHydrocarbons, ChlorinatedXenobioticsTeratogensHypoxia-Inducible Factor 1Cytochrome P-450 CYP1A2Alkane 1-MonooxygenaseLysosomesKetoglutaric AcidsInfectious Disease Transmission, Professional-to-PatientAldehyde OxidaseDioxygenasesLiverMolecular Sequence DataCarcinogensPhenylalanine HydroxylaseGene Expression Regulation, EnzymologicLigandsCholestanetriol 26-MonooxygenaseMice, Inbred C57BLCell Line, TumorChloracneBiodegradation, EnvironmentalTranscription FactorsPetroleumMicrosomes, LiverPyrenesOxygenasesAmino Acid SequenceSoil Pollutants9,10-Dimethyl-1,2-benzanthraceneSteroids, FluorinatedGene Expression RegulationCell HypoxiaTryptophan HydroxylaseTranscription, GeneticXanthine DehydrogenaseBenzofuransCell LineMolybdenumOxygenBase SequenceJaw AbnormalitiesFundulidaeWater Pollutants, ChemicalSignal TransductionDNA AdductsCells, CulturedReverse Transcriptase Polymerase Chain ReactionAnoxiaProtein Binding7-Alkoxycoumarin O-DealkylaseCarcinogens, EnvironmentalMolecular StructureDNA-Binding ProteinsMethylococcusDose-Response Relationship, DrugKineticsPalladiumHSP90 Heat-Shock ProteinsSteroids, ChlorinatedCatalysisHelix-Loop-Helix MotifsAmino Acids, DicarboxylicVon Hippel-Lindau Tumor Suppressor ProteinMetabolic Detoxication, DrugFlavonoidsBinding SitesMicrosomesMice, Knockout
Polycyclic aromatic hydReceptor nuclear translocatorCytochromeAromaticReceptorsMicrosomalCYP1A1CarcinOgenicInhibitorEnzymatic reactionsMetabolismDifferentiationFunctionalActivationLevelsTermsInductionProlyl-4-hydroxylaAlpha-hydroxylaseTryptophan hydroxylaseMetabolitesCYP2D6Polychlorinated dibenzofuranActivityVIVOMeSHP450TCDDHumanSubstancesMouseLiver
Polycyclic aromatic hyd2
  • It is involved in the metabolic activation of aromatic hydrocarbons (polycyclic aromatic hydrocarbons, PAH), for example, benzo[a]pyrene (BaP), by transforming it to an epoxide. (wikipedia.org)
  • In addition, a variety of substances such as fuel, water, antifreeze, dust, and various combustion products such as polycyclic aromatic hydrocarbons (PAHs), metals, and metallic oxides accumulate in the oil. (cdc.gov)
Receptor nuclear translocator1
Cytochrome4
  • A cytochrome P450 aryl hydrocarbon hydroxylase that has specificity for ESTROGENS which it converts into 4-hydroxy estrogens. (umassmed.edu)
  • A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. (curehunter.com)
  • The hepatic nuclear fraction isolated from 3-methylcholanthrene (MC)-treated rats contained enhanced levels of cytochrome P-450 and aryl hydrocarbon hydroxylase [benzo(a)pyrene (BP) monooxygenase], whereas the activities of epoxide hydrase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase and the concentration of cytochrome b5 were not altered. (lookformedical.com)
  • The classic pathway is the predominant pathway, with the first and rate-limiting reaction catalyzed by a cytochrome P450 enzyme, cholesterol 7 α -hydroxylase (CYP7A1). (aspetjournals.org)
Aromatic1
  • It is inhibited by hesperetin (a flavonoid found in lime, sweet orange), fluoroquinolones and macrolides and induced by aromatic hydrocarbons. (wikipedia.org)
Receptors1
Microsomal1
  • Ellagic acid, a common plant phenol , was shown to be a potent inhibitor of epidermal microsomal aryl hydrocarbon hydroxylase (AHH) activity in vitro, and of benzo[a]pyrene (BP)-binding to both calf thymus DNA in vitro and to epidermal DNA in vivo. (cdc.gov)
CYP1A12
  • CYP1A1 is also known as AHH (aryl hydrocarbon hydroxylase). (wikipedia.org)
  • Galangin functions as an antagonist of the aryl hydrocarbon receptor and also inhibits CYP1A1 (IC50 1 M). It belongs to flavonoids and can be extracted from the rhizome of Zingiber officinale Roscoe with anti-inflammatory properties. (csnpharm.com)
CarcinOgenic1
  • Induction of aryl hydrocarbon hydroxylase, an enzyme that may produce carcinOgenic epaxide derivative of polycyclic hydrocarbons, has been shown to occur with THC and cannabis. (erowid.org)
Inhibitor1
Enzymatic reactions1
  • Subsequent enzymatic reactions catalyzed by sterol 12 α -hydroxylase (CYP8B1) and sterol 27-hyroxylase (CYP27A1), respectively, yield the primary BAs, cholic acid (CA) and chenodeoxycholic acid (CDCA). (aspetjournals.org)
Metabolism1
  • Vitamin E status and metabolism in adult and aged aryl hydrocarbon receptor null mice. (oregonstate.edu)
Differentiation1
  • The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. (umassmed.edu)
Functional1
  • N2a-Rα cells expressed tyrosine hydroxylase (TH) mRNA as a functional marker of catecholaminergic neurotransmitter production. (biomedcentral.com)
Activation2
  • Aryl hydrocarbon receptor activation in lactotropes and gonadotropes interferes with estradiol-dependent and -independent preprolactin, glycoprotein alpha and luteinizing hormone beta gene expression. (umassmed.edu)
  • The neurological properties of N2a-Rα based on AhR activation were evaluated by immunohistochemical analysis of cytoskeletal molecules and by RT-PCR analysis of mRNA expression of neurotransmitter-production related molecules, such as tyrosine hydroxylase (TH). (biomedcentral.com)
Levels1
  • We have investigated the correlation between DNA adduct levels and aryl hydrocarbon hydroxylase (AHH) activity in peripheral lymphocyte samples obtained from 42 lung cancer patients. (elsevierpure.com)
Terms1
  • In this topic, when discussing study results, we will use the terms "woman/en" or "patient(s)" as they are used in the studies presented. (medilib.ir)
Induction2
  • Decreased induction of aryl hydrocarbon hydroxylase activity in hyperproliferative hairless mouse epidermis. (cdc.gov)
  • Induction of aryl hydrocarbon hydroxylase, an enzyme that may produce carcinOgenic epaxide derivative of polycyclic hydrocarbons, has been shown to occur with THC and cannabis. (erowid.org)
Prolyl-4-hydroxyla1
  • Prolyl-4-hydroxylase-domain (PHD) proteins regulate the hypoxia-inducible factors (HIFs), the master regulators of the hypoxic response. (jneurosci.org)
Alpha-hydroxylase2
  • Studies were performed in eight healthy extensive metabolizers of mephenytoin and debrisoquine to determine the effect of fluvoxamine on the activities of S-mephenytoin 4'-hydroxylase (CYP2C19) and metoprolol alpha-hydroxylase (CYP2D6). (nih.gov)
  • I3C elevated EROD, estradiol 2-hydroxylase and testosterone 6 alpha-hydroxylase activities in a dose-dependent manner. (nih.gov)
Tryptophan hydroxylase1
  • Further studies exhibited that TGF- induces M2-like tryptophan hydroxylase 1 (TPH-1) macrophages via zinc finger proteins (SNAIL) upregulation depending on the SMAD2/3 and PI3K/AKT signaling pathways [129]. (azd1152.com)
Metabolites1
  • Kiyohara, C & Hirohata, T 1994, ' Effects of vitamin C and PCB metabolites on the inhibition of aryl hydrocarbon hydroxylase and suppression of mutagenicity of benzo[a]pyrene ', Toxicology in Vitro , vol. 8, no. 6, pp. 1185-1189. (elsevierpure.com)
CYP2D61
  • Genetic polymorphism and Parkinson's disease in Taiwan: study of debrisoquine 4-hydroxylase (CYP2D6). (musc.edu)
Polychlorinated dibenzofuran1
  • Inducing potency of aryl hydrocarbon hydroxylase activity in human lymphoblastoid cells and mice by polychlorinated dibenzofuran congeners. (nih.gov)
Activity3
  • Liver microsomes from treated and untreated mice were subsequently assayed for CYP1A-mediated ethoxy-resorufin O-deethylase (EROD) activity, estradiol 2-hydroxylase activity and seven different testosterone hydroxylase activities. (nih.gov)
  • Testosterone 6 beta-hydroxylase, the major testosterone hydroxylase activity in untreated mice, was significantly inhibited (IC50 approximately 12 micrograms/ml) by the acid condensation products of I3C. (nih.gov)
  • The aryl hydrocarbon hydroxylase (AHH) activity in the epidermis was monitored. (cdc.gov)
VIVO1
  • The other six testosterone hydroxylase activities were not significantly affected by in vivo treatment with I3C. (nih.gov)
MeSH1
  • Aniline Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
P4501
  • The anti-carcinogenic plant compound indole-3-carbinol differentially modulates P450-mediated steroid hydroxylase activities in mice. (nih.gov)
TCDD1
  • TCDD toxicity is mediated through the aryl hydrocarbon receptor (AHR), and RT-PCR experiments confirmed AHR2, ARNT2b, and TCDD-dependent CYP1A expression in the regenerating tissue. (oregonstate.edu)
Human2
  • 13. Human skin aryl hydrocarbon hydroxylase. (nih.gov)
  • Toxicological studies Special studies on the bioavailability of polynuclear hydrocarbons adsorbed on carbon blacks In vitro studies Samples of 3 different carbon blacks (rubber-grade oil furnace blacks, ASTM designation N-234, N-351, and N-375) were extracted with the following tissue fluids and cellular components: human plasma, swine serum, the supernatant of swine lung homogenates, and swine lung washings. (inchem.org)
Substances1
  • Decades of research around the subject of the dioxin receptor (aryl hydrocarbon receptor) not only permits us an insight into the relationships between exposures to hazardous substances and the occurrence of most severe diseases, but it also explains the cross-generational damage in our genome. (dioxin-rezeptor.de)
Mouse1
  • Nebert and his colleagues discovered that the mouse strains differed from each other by an unequally strong production of a certain enzyme (aryl hydrocarbon hydroxylase). (dioxin-rezeptor.de)
Liver1
  • Litters from the F 0 , F 1 , and F 2 generations were killed at day 28, breeders from the F 2 generation were killed, and arylhydrocarbon hydroxylase activities of the liver and lungs were determined. (inchem.org)