• We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
  • In addition, we suggest several computational tools for studying the distribution of double mutants in the space of model phenotype probabilities. (researchgate.net)
  • The American Institute for Medical and Biological Engineering has awarded its highest honor this year to Emery N. Brown , the Edward Hood Taplin Professor of Computational Neuroscience and Health Sciences and Technology in The Picower Institute for Learning and Memory and the Institute for Medical Engineering and Science at MIT. (mit.edu)
  • Biophysical computational models of the heart provide a quantitative framework for mapping changes in anatomy to whole heart function. (plos.org)
  • These computational organ and cell models can be used to study the impact of pharmaceutical drugs, test hypotheses, assess risk and for closed-loop validation of medical devices. (auckland.ac.nz)
  • The broad scope of the journal encompasses all computational and nonlinear problems occurring in aeronautical, biological, electrical, mechanical, physical, and structural systems. (asme.org)
  • Groves I, Placzek M & Fletcher AG (2020) Of mitogens and morphogens : modelling Sonic Hedgehog mechanisms in vertebrate development . (sheffield.ac.uk)
  • As for any other statistical analysis, one main issue has been finding the probabilistic model that best fits the data, as well as the optimal parameter estimates of this model. (frontiersin.org)
  • Probabilistic model checking is a formal verification technique that has been successfully applied to the analysis of systems from a broad range of domains, including security and communication protocols, distributed algorithms and power management. (gla.ac.uk)
  • We give a detailed description of how this case study can be modelled in the probabilistic model checker PRISM, discussing some of the issues that arise in doing so, and show how we can thus examine a rich selection of quantitative properties of this model. (gla.ac.uk)
  • The SIF-GPP relationship has been assessed at multiple scales using both process-based modelling and in situ and satellite observations. (nature.com)
  • In addition to that, your parents, family, friends, or lovers may have modeled addictive behaviors or inability to cope with emotions in a healthy manner . (psychologytoday.com)
  • 2018. A multi‐state, time‐removal model for population dynamics of cliff‐nesting raptors. (nps.gov)
  • This problem is shown by model-generated coefficient standard errors that are larger than true standard errors, which biases the interpretation towards the null hypothesis and increases the likelihood of a type II error. (cdc.gov)
  • In this work, we test the hypothesis that in a statistical shape model (SSM), the modes that are most relevant for describing anatomy are also most important for determining the output of cardiac electromechanics simulations. (plos.org)
  • Mark-recapture analysis and a preliminary epidemiological model developed for the population with the best longitudinal data both project local extinction in that area over a timeframe of 10 to 15 years from disease emergence. (springer.com)
  • "Historical Context and Recent Advances in Exposure-response Estimation for Deriving Occupational Exposure Limits" describes and contrasts traditional and advanced practices in dose-response modeling from both a toxicological and epidemiological perspective. (cdc.gov)
  • A new review article summarizes epidemiological and biological findings that support the existence of a novel model of human papillomavirus (HPV)-mediated carcinogenesis. (who.int)
  • The diffusion and reaction of the transmitter acetylcholine in neuromuscular junctions and the diffusion and binding of Ca 2+ in the dyadic clefts of ventricular myocytes have been extensively modeled by Monte Car. (biomedcentral.com)
  • Specifically, the method is used to model human and rabbit sinoatrial node, human ventricular myocyte and squid giant axon electrophysiology. (auckland.ac.nz)
  • 2021) Linking statistical shape models and simulated function in the healthy adult human heart. (plos.org)
  • Proceedings of Biological Sciences, 261(1362), 319-324. (scirp.org)
  • Through innovations in data sciences, human tissue culture models and the integration of transition management, we are accelerating the transition to animal-free safety assessments. (rug.nl)
  • "Setting Occupational Exposure Limits for Chemical Allergens-Understanding the Challenges" discusses the biological principles involved in the allergic response to highlight how the evolving sciences of toxicology and risk assessment techniques are enhancing the ability to address the complexities of allergy for developing health-based OELs. (cdc.gov)
  • A biological model is an organism or system representing a more complex biological entity. (wikipedia.org)
  • Though there are many mathematical methods for steering dynamic systems towards desired states, the methods are usually not feasible for applying to complex biological networks. (ict.ac.cn)
  • Then recent studies of theorems and algorithms for having complex biological networks controllable in general or specific application scenarios are reviewed. (ict.ac.cn)
  • In this paper we illustrate its applicability to a complex biological system: the FGF (Fibroblast Growth Factor) signalling pathway. (gla.ac.uk)
  • Recalibration of deep learning models for abnormality detection in smartphone-captured chest radiograph. (cdc.gov)
  • A few individual design examples of programmable device-based biological neuron model implementations are available in the literature, but there is no comprehensive study that examines analog and digital programmable design examples of frequently studied biological neuron model implementations. (tubitak.gov.tr)
  • The aim of this paper is to present a comparative study about programmable and reconfigurable implementations of the FitzHugh--Nagumo, Izhikevich, and Hindmarsh--Rose neuron models. (tubitak.gov.tr)
  • Since field programmable analog array (FPAA) and field programmable gate array (FPGA) devices offer several advantages such as flexible design possibilities, reduction of the complexity of design, real-time modification, and software control for programmable and reconfigurable implementations of neuron models and neural structures, they are preferred in these implementations as analog and digital programmable devices. (tubitak.gov.tr)
  • Epigenetic aging models, particularly epigenetic clocks (ECs), promise to improve the aging of wild animals and thereby make valuable contributions to wildlife conservation and population biology 4 , 6 . (nature.com)
  • Systems biology models can be reused within new simulation scenarios, as parts of more complex models or as sources of biochemical knowledge. (force11.org)
  • Minimum requirements for published systems biology models have been formulated by the MIRIAM initiative. (force11.org)
  • Their tiny size, rapid growth by clonal propagation, and facile uptake of labeled compounds from the media were attractive features that made them a well-known model for plant biology from 1950 to 1990. (osti.gov)
  • Nanowires are increasingly used in biology, as sensors, as injection devices, and us model systems for toxicity studies. (lu.se)
  • This funding opportunity announcement (FOA) encourages highly innovative research to develop, characterize or improve animal models and related biological materials for human health and disease or to improve diagnosis and control of diseases that might interfere with animal use for biomedical research purposes. (governmentgrant.com)
  • The section on Biological Control in the PNW Weed Management Handbook provides details on various biocontrol methods. (oregonstate.edu)
  • After a brief review of the main issues, methods and tools related to the DE analysis of RNA-Seq data, this article focuses on the impact of both the replicate number and library size in such analyses. (frontiersin.org)
  • The difficulties come from the lack of accurate model that can capture the dynamics of interactions between biological elements and the fact that many mathematical methods are computationally intractable for large-scale networks. (ict.ac.cn)
  • The Pri-Sci-Net project aims to support and coordinate inquiry-based teaching methods in primary science using networking as a model of professional development for teachers across Europe. (southampton.ac.uk)
  • Methods: The article lists the major objectives of nanotoxicology and briefly reviews the literature concerning biological responses to pulmonary exposure. (cdc.gov)
  • "Advances in Inhalation Dosimetry Models and Methods for Occupational Risk Assessment and Exposure Limit Derivation" focuses on inhalation dosimetry, offering several practical examples of dose estimation and OEL derivation are provided for inhaled gases and particulates. (cdc.gov)
  • Yet these adaptation models, while pointing in the right direction, fail because they do not directly explain the pharmacological role the substance plays in addiction. (healthyplace.com)
  • This review article provides insights into the pharmacological activities of pumpkin seeds and the possible processes which, might reduce the chance of a wide range of problems. (researchgate.net)
  • Due to their biological activities and pharmacological properties, they have been the subject of many studies in recent years. (researchsquare.com)
  • We applied a hierarchical model to camera- and live-trapping data from a region in Borneo, and estimated the relative abundance (controlling for imperfect detection) of 57 terrestrial mammal species, as a function of either categorical or continuous metrics of land-use change. (imperial.ac.uk)
  • In the first case study, we observed that the real biological networks were most sensitive to overexpression/state-flip and edge-addition/-reverse mutations among node-based and edgetic mutations, respectively. (researchgate.net)
  • Finally, applications to real biological networks manifest that investigating the controllability of biological networks can shed lights on many critical physiological or medical problems, such as revealing biological mechanisms and identifying drug targets, from a systematic perspective. (ict.ac.cn)
  • This modeling technique leads to the understanding of cellular immune deficiency diseases of living systems in the form of logical (electrical) faults in a circuit. (scirp.org)
  • Future of biomedical, agricultural and biological systems research using domesticated animals. (usda.gov)
  • ID theorists also believe that the self-organizational capacities of physical systems are limited, falling far short of the order we observe, so the ultimate source of information for the origin of life and hierarchically integrated morphogenesis in both organismal development and speciation must be extrinsic to biological systems and their physical environments. (evolutionnews.org)
  • We use a range of animal model systems (chick, mouse, zebrafish) and combine in vivo and ex vivo approaches with state-of-the-art transcriptomic, imaging, and gain-and loss-of-function approaches. (sheffield.ac.uk)
  • Results: Interactions of nanoparticle s with biological systems depend on particle size, shape, oxidant generation, surface functionalization, and rate of dissolution. (cdc.gov)
  • Based on this understanding, I model systems for sustainable, performative and circular construction practice based on large-scale 3d printing. (lu.se)
  • 3 MHz has been observed in a variety of aqueous biological systems. (lu.se)
  • For biological systems, Q peaks were first observed in protein from different perspectives [3,7,9,13,15,21-23] , the detailed molec- powders and attributed to 1H-14N spin pairs [9], which were also ular mechanism of the ubiquitous 1H-14N Q peaks in biological sys- thought to be of critical importance for the background 1H relaxa- tems has not been established. (lu.se)
  • https://orcid.org/0000-0001-7476-9267 the creation of a semantic network that was analyzed using the Cognitive Network Analysis model. (bvsalud.org)
  • The use of this methodology for validating mathematical models from experimental data and designing new experiments is discussed. (researchgate.net)
  • Newly-available satellite-derived sun-induced chlorophyll fluorescence (SIF) data offer a promising direction for addressing this issue by constraining regional-to-global scale modelled GPP. (nature.com)
  • However, while there is considerable improvement in the simulation of leaf phenology and/or NEE in these studies, there is often a remaining model-data discrepancy in the gross C fluxes. (nature.com)
  • Another important issue was the need for normalization of the data to correctly compare two different biological conditions by assessing and erasing all eventual technical and/or biological biases. (frontiersin.org)
  • Neuroscientist, anesthesiologist, and statistician Emery Brown earned the highest recognition of the American Institute for Medical and Biological Engineering for advancing neuroscience data analysis and the understanding of how anesthesia affects the brain. (mit.edu)
  • The Resonant models are validated with experimental data and with other published models. (auckland.ac.nz)
  • Does your article include visual data and would you like to enhance the presentation and interpretation of it? (karger.com)
  • Accepted: 24 October 2012 cell yield data, our models require that adult DN1 cells divide multiple times before becoming competent to progress into DN2 stage. (lu.se)
  • Most of the data cited in this article are from studies performed on patients in an inpatient setting. (medscape.com)
  • Multilocus genetic models of handedness closely resemble single-locus models in explaining family data and are compatible with genome-wide association studies. (medlineplus.gov)
  • It also covered the use of surveillance data for epidemic modelling, programme design and monitoring and evaluation. (who.int)
  • The model not only accounts quantitatively for the extensive data set, but also explains why Q peaks are hardly observed from gelatin gels. (lu.se)
  • Outcome of a workshop on archiving structural models of biological macromolecules. (rostlab.org)
  • Experimentally characterized genetic interaction networks in model organisms provide important insights into relationships between different biological functions. (researchgate.net)
  • The GaInP photoluminescence stability, combined with the fact that the nanowires can be coated with different materials while retaining their fluorescence, make these nanowires promising tools for biological and nanotoxicological studies. (lu.se)
  • BACKGROUND:The currently used kth order Markov models estimate the probability of generating a single nucleotide conditional upon the immediately preceding (gap = 0) k units. (umd.edu)
  • Because the strain is in part determined by the presence of these toxins, including both strain and genotype in the model means that the standard errors for variables for the Shiga-containing strains and bloody diarrhea symptom are likely to be too high, and hence the significance levels (p values) obtained from the regression models are higher than the true probability because of a type I error. (cdc.gov)
  • This paper summarizes the progress of HIV surveillance for 20 countries in the region, covering population size estimates of key populations at higher risk, HIV case reporting, HIV sentinel surveillance and probability surveys of behavioural and biological markers. (who.int)
  • HIV sentinel surveillance (HSS) and probability surveys of risk behaviours, including those integrated with biological markers. (who.int)
  • Our work provides a synthesis of previous algorithms, mechanistically based on HLA-DPB1 immunopeptidome divergence 5 and expression by residual leukemia cells, 6 , 7 respectively, into a new and integrative model for intelligent mismatching in UD-HCT, to improve survival for future patients. (haematologica.org)
  • Particle-based reaction-diffusion algorithms facilitate the modeling of the diffusional motion of individual molecules and the reactions between them in cellular environments. (biomedcentral.com)
  • They are organized into sections on genetic theories (inherited mechanisms that cause or predispose people to be addicted), metabolic theories (biological, cellular adaptation to chronic exposure to drugs), conditioning theories (built on the idea of the cumulative reinforcement from drugs or other activities), and adaptation theories (those exploring the social and psychological functions performed by drug effects). (healthyplace.com)
  • Conclusions: Significant biological responses occur in animal models after pulmonary exposure to certain nanoparticle s. (cdc.gov)
  • Organ level simulation of bioelectric behavior in the body benefits from flexible and efficient models of cellular membrane potential. (auckland.ac.nz)
  • They are often considered-even by those who formulate them-as adjuncts to biological models, as in the suggestion that the addict uses a substance to gain a specific effect until, inexorably and irrevocably, physiological processes take hold of the individual. (healthyplace.com)
  • Macromolecular diffusion plays a fundamental role in biological processes. (biomedcentral.com)
  • Demonstrating dynamic biological processes. (karger.com)
  • On the one hand this entails understanding the way biological structures utilise complex shape to drive physiological functions (in this case air-flow), and the self-organising morphogenetic processes that enable this. (lu.se)
  • For example, the simultaneous equations approach, such as that outlined by Greene ( 7 ), would have used predicted values of bloody diarrhea from the first stage of the model as instrumental variables for the actual value in the model for hemolytic uremic syndrome. (cdc.gov)
  • Dynamic changes in biological conditions are modeled with changing model coefficients and this approach enables ionic channel alterations to be captured. (auckland.ac.nz)
  • It has become a prevalent technology, allowing an efficient genome-wide relative quantification of gene expression and, in particular, it is the method of choice to find differentially expressed genes between two or more biological conditions of interest. (frontiersin.org)
  • These models can be easily implemented in low-cost digital hardware and an alternative, resource-efficient implementations of sine and cosine functions are presented and it is shown that a Fourier term is produced with two additions and a binary shift. (auckland.ac.nz)
  • Resonant model-A new paradigm for modeling an action potential of biological cells. (auckland.ac.nz)
  • To move closer to the real-time requirements of this modeling a new flexible Fourier based general membrane potential model, called as a Resonant model, is developed that is computationally inexpensive. (auckland.ac.nz)
  • The Resonant model is used to simulate entrainment between competing sinoatrial node cells. (auckland.ac.nz)
  • Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. (researchgate.net)
  • We demonstrate this methodology on three published models for each of which we derive the genetic interaction networks and analyze their properties. (researchgate.net)
  • Studies endeavoring to separate genetic from environmental factors, such as those in which adopted-away offspring of alcoholics were compared to adopted children with nonalcoholic biological parents, have claimed a three to four times greater alcoholism rate for those whose biologic parents were alcoholic (Goodwin et al. (healthyplace.com)
  • The second, on biological information and genetic theory, was edited by John C. Sanford, Courtesy Professor in the Department of Horticulture at Cornell, and notoriously the primary inventor of the gene gun. (evolutionnews.org)
  • Both self-organizational theorists and intelligent design (ID) theorists believe that natural selection operating on random genetic mutation is an insufficient basis on which to explain the origins of biological complexity and irrelevant to the origin of life. (evolutionnews.org)
  • This model also accounts for the heredity of addiction, or genetic predisposition. (psychologytoday.com)
  • Genome-wide association study of handedness excludes simple genetic models. (medlineplus.gov)
  • If certain nanoparticle s induce adverse effects in vitro or in animal models, then occupational health surveillance and exposure control may be prudent steps in the protection of worker health. (cdc.gov)
  • Accurate terrestrial biosphere model (TBM) simulations of gross carbon uptake (gross primary productivity - GPP) are essential for reliable future terrestrial carbon sink projections. (nature.com)
  • Uncertainty in its strength and location contributes to high terrestrial biosphere model (TBM) spread in future C sink projections between models 2 . (nature.com)
  • A Unesco biosphere is an area with high cultural-historical and biological landscape values. (lu.se)
  • This paper develops a digital CMOS circuit model of phagocytosis: the immune response biochemical pathway of a pha- gocyte. (scirp.org)
  • Epigenetic aging models are promising developments because they estimate individual age with high accuracy, accurately predict age in related species, and do not require invasive sampling or intensive long-term studies. (nature.com)
  • The results of this study clearly show that the presence of bloody diarrhea is an endogenous variable in the model showing predictors of hemolytic uremic syndrome, in that the diarrhea is shown to be predicted by, and therefore strongly correlated with, several other variables used to predict hemolytic uremic syndrome. (cdc.gov)
  • The underlying problem in the study is the theoretical specifications for the model, in which genotypes, strains, and symptoms are mixed, despite reasonable expectations that differences in 1 level may predict differences in another. (cdc.gov)
  • In this article, we review and update current knowledge about the distribution and spatial spread of the disease, its observed impact on affected host populations, and models to predict its consequences for host population dynamics. (springer.com)
  • In this article, recent advances on the controllability of complex networks and applications to biological networks are reviewed. (ict.ac.cn)
  • Other articles explore possibilities for incorporating advances in risk assessment, toxicology, and occupational hygiene into the process to develop OELs. (cdc.gov)
  • A preliminary investigation on a deep learning convolutional neural networks based pulmonary tuberculosis CT diagnostic model]. (cdc.gov)
  • The evaluation was done on four classes of biological sequences - CpG-poor promoters, all promoters, exons and nucleosome positioning sequences. (umd.edu)
  • Therefore, evaluation of the biological effects of nanoparticle s is critical. (cdc.gov)
  • Finally, we show how standards can facilitate the construction of large metabolic network models. (force11.org)
  • We model counts of marked and unmarked animals as multinomial random variables, using the capture frequencies of marked animals for inference about the latent multinomial frequencies for unmarked animals. (usgs.gov)
  • The application provides valuable insights into subtleties of implementing Bayesian inference for latent multinomial models. (usgs.gov)
  • We tie the discussion to our application, though the insights are broadly useful for applications of the latent multinomial model. (usgs.gov)
  • However, the prediction of extinction from the model is sensitive to the estimate of the latent period, which is poorly known. (springer.com)
  • Diagnosis of malignant pleural effusion with combinations of multiple tumor markers: A comparison study of five machine learning models. (cdc.gov)
  • The rem is calculated by multiplying the absorbed dose (rad) by a quality (Q) factor or the radiation weighting factor (RWF), which reflects the differences in the amount of potential biological effect for each type of radiation. (medscape.com)
  • An often overlooked problem in building statistical models is that of endogeneity, a term arising from econometric analysis, in which the value of one independent variable is dependent on the value of other predictor variables. (cdc.gov)
  • We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. (imperial.ac.uk)
  • Additionally, the correlation between the dependent variables can create significant multicollinearity, which violates the assumptions of standard regression models and results in inefficient estimators. (cdc.gov)
  • Biological elements usually exert their functions through interactions with others to form various types of biological networks. (ict.ac.cn)
  • A number of models have addressed the dynami- cal features of the differentiation stages, for instance with studies on the way a & 2012 The Author(s) Published by the Royal Society. (lu.se)
  • Multiple perspectives on the hardware implementations of biological ne" by NİMET KORKMAZ, İSMAİL ÖZTÜRK et al. (tubitak.gov.tr)
  • The volume Biological Information: New Perspectives is an interdisciplinary volume. (evolutionnews.org)
  • For individuals working on tomato research, on the basis of the meta-analysis, we recommend at least four biological replicates per condition and 20 M reads per sample to be almost sure of obtaining about 1000 DE genes if they exist. (frontiersin.org)
  • Applications to develop models that relate strictly to a specific disease or category of research will not be accepted and should be proposed to the appropriate categorical Institute or Center of the NIH. (governmentgrant.com)
  • The ability of controlling the dynamics of biological networks is of enormous benefits to pharmaceutical and medical industry as well as scientific research. (ict.ac.cn)
  • The purpose of the present article is to discuss various medicinal and biological potentials of pumpkin that can impart further research developments with this plant for human health benefits. (researchgate.net)
  • Examples include research into how black holes evolve, the return of colonial heritage, water management at the foot of the Himalayas, our biological clock and an open source quantum computer in the cloud. (rug.nl)
  • We welcome both original research and review articles. (hindawi.com)
  • The article, by researchers from the International Agency for Research on Cancer (IARC) and partners, was published today in the Journal of Virology . (who.int)
  • Deep learning creates high-quality AI models that have a significant impact. (rug.nl)
  • The first article, "State-of-the-Science: The Evolution of Occupational Exposure Limit Derivation and Application," gives a background on OELs, including how they evolved and how they can be used to assess risk and manage workplace hazards. (cdc.gov)