• The approach involves using regression analysis to examine the relationship between linkage disequilibrium scores and the test statistics of the single-nucleotide polymorphisms (SNPs) from the GWAS. (wikipedia.org)
  • SNPs with tight Cr4-linkage were further converted to TaqMan assays to confirm their effectiveness as MAS tools. (frontiersin.org)
  • Current genome-wide surveys of common diseases and complex traits fundamentally aim to detect indirect associations where the single nucleotide polymorphisms (SNPs) carrying the association signals are not biologically active but are in linkage disequilibrium (LD) with some unknown functional polymorphisms. (ox.ac.uk)
  • RESEARCH DESIGN AND METHODS: In all, 5,290 single nucleotide polymorphisms (SNPs) were successfully genotyped in 3,179 type 2 diabetes case and control subjects from eight populations with evidence of 1q linkage. (ox.ac.uk)
  • Two large projects have recently been launched: one to produce a SNP diversity map of the entire grapevine genome and the other to estimate linkage disequilibrium between SNPs in four genomic regions. (biomedcentral.com)
  • Now comes the prospect, first seriously proposed a decade ago by Risch and Merikangas ( 2 ), of testing virtually all ∼10 million common single nucleotide polymorphisms (SNP) in the human genome for associations with a given disease, either directly or by linkage disequilibrium with other SNPs. (aacrjournals.org)
  • Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q. (ox.ac.uk)
  • OBJECTIVE: Linkage of the chromosome 1q21-25 region to type 2 diabetes has been demonstrated in multiple ethnic groups. (ox.ac.uk)
  • Chromosome 18 was chosen because a previous genome-screening linkage study of two Costa Rican families had suggested a BP-I locus on this chromosome. (umn.edu)
  • Based on linkage disequilibrium (LD)-based association mapping used to detect single nucleotide polymorphism (SNP) markers associated with MGR against C. ribicola , MGR in these seed families appears to be controlled by Cr4 or other R genes in very close proximity to Cr4 . (frontiersin.org)
  • The rapid development of a dense single-nucleotide-polymorphism marker map has stimulated numerous studies attempting to characterize the magnitude and distribution of background linkage disequilibrium (LD) within and between human populations. (princeton.edu)
  • [ 19 ] the results of which were corroborated by a linkage study with high-density, single-nucleotide polymorphisms. (medscape.com)
  • Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene. (ox.ac.uk)
  • A genome-wide map of single nucleotide polymorphisms (SNP) and a pattern of linkage disequilibrium (LD) between their alleles are being established in three main ethnic groups. (ox.ac.uk)
  • Linkage disequilibrium and recombination make a telomeric site for the Huntington's disease gene unlikely. (bmj.com)
  • Allele and haplotype frequencies, strength of linkage disequilibrium, and signatures of recombination varied considerably among populations. (srirajlab.com)
  • Among these, the 1q41 locus is of particular interest, because evidence for linkage has been found in several independent SLE family collections. (elsevierpure.com)
  • The finding of linkage together with significant transmission disequilibrium provides strong evidence for a susceptibility locus at 1q41 in human SLE. (elsevierpure.com)
  • We performed common variant fine-mapping across a 23-Mb interval in a multiethnic sample to search for variants responsible for this linkage signal. (ox.ac.uk)
  • Samples were ascertained using strategies designed to enhance power to detect variants causal for 1q linkage. (ox.ac.uk)
  • Two genetic variants in strong linkage disequilibrium (rs9536314 and rs9527025) in the Klotho (KL) gene, encoding a transmembrane protein, implicated in longevity and associated with brain resilience during normal aging, were recently shown to be associated with Alzheimer disease (AD) risk in cognitively normal participants who are APOE ε4 carriers. (lu.se)
  • In statistical genetics, linkage disequilibrium score regression (LDSR or LDSC) is a technique that aims to quantify the separate contributions of polygenic effects and various confounding factors, such as population stratification, based on summary statistics from genome-wide association studies (GWASs). (wikipedia.org)
  • Genome-wide association study (GWAS) is a powerful tool to identify loci associated to target traits based on linkage disequilibrium (LD) using natural populations. (biomedcentral.com)
  • Linkage disequilibrium (LD) analysis has been promoted as a method of mapping disease genes, particularly in isolated populations, but has not yet been used for genome-screening studies of complex disorders. (umn.edu)
  • Analysis of linkage disequilibrium in Scottish families showed significant non-random association between the HD gene and alleles at the D4S95 and D4S98 loci. (bmj.com)
  • Hemmings, G P. / A study of linkage disequilibrium between polymorphic loci for monamine oxidases A and B in schizophrenia . (uhi.ac.uk)
  • Wei, J & Hemmings, GP 1999, ' A study of linkage disequilibrium between polymorphic loci for monamine oxidases A and B in schizophrenia ', Psychiatric Genetics , vol. 9, no. 4, pp. 177-81. (uhi.ac.uk)
  • We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABA A receptor genes. (wustl.edu)
  • the second mapped within an extensive region of linkage disequilibrium that includes the ASH1L and PKLR genes (lead SNP: rs11264371, odds ratio 1.48 [1.18-1.76], P = 1.0 x 10(-5), under a dominant model). (ox.ac.uk)
  • Standard linkage analysis has the potential to localize major susceptibility genes to within a few million base pairs using as few as 300 microsatellite markers for a genome-wide scan. (aacrjournals.org)
  • However, it has increasingly been recognized that linkage analysis may not be powerful enough to detect genes involved in "complex diseases" like cancer, which are caused by multiple genes and multiple environmental factors, interacting in complicated ways. (aacrjournals.org)
  • Among other methodological limitations are that discrepancies between the linkage disequilibrium structure of the samples used for the GWAS and that of the reference panel may have biased estimates underlying MiXeR. (medscape.com)
  • A meta-analysis of original data from 11 previous linkage studies in 1067 bipolar disorder families yielded significant findings in chromosomal regions 6q for bipolar I and 8q for bipolar I/II, as well as suggestive findings at chromosomal regions 9p and 20p for bipolar I. (medscape.com)
  • Another extension of LDSC, known as stratified LD score regression (abbreviated SLDSR), aims to partition heritability by functional annotation by taking into account genetic linkage between markers. (wikipedia.org)
  • Multiple markers in the region exhibit transmission disequilibrium, with the peak single marker multiallelic linkage disequilibrium noted at D1S490 (pedigree disequilibrium test [PDT] global P value = 0.0091). (elsevierpure.com)
  • Many chromosomal regions have shown linkage to bipolar disorder, but meta-analyses of microsatellite marker-based linkage studies have not provided consistent findings of susceptibility regions. (medscape.com)
  • Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. (mdpi.com)
  • CONCLUSIONS: Detailed fine-mapping of the 23-Mb region of replicated linkage has failed to identify common variant signals contributing to the observed signal. (ox.ac.uk)
  • For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. (mdpi.com)
  • A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)
  • See the original article for disclosures of other authors. (medscape.com)
  • All relevant data are within the article and its Supporting Information files. (plos.org)