• neurons
  • Systemic administration of the alpha 2-antagonist piperoxane before difluoromethyl-DOPA perfusion markedly increased the DOPA concentration during both the accumulation and the steady-state periods, showing that the present technique is a suitable in vivo approach to monitor changes in tyrosine hydroxylase activity occurring in the locus ceruleus neurons. (biomedsearch.com)
  • Norepinephrine is synthesized from the amino acid tyrosine by a series of enzymatic steps in the adrenal medulla and postganglionic neurons of the sympathetic nervous system. (wikipedia.org)
  • ascorbic acid
  • Research shows that ascorbic acid (also known as ascorbate or vitamin C) is effective at recycling BH3 into BH4, preventing the BH3 radical from reacting with other free radicals (superoxide and peroxynitrite specifically). (wikipedia.org)
  • Ascorbic acid is oxidized to dehydroascorbic acid during this process, although it can be recycled back to ascorbic acid. (wikipedia.org)
  • protein
  • The word "tyrosine" is from the Greek tyros, meaning cheese, as it was first discovered in 1846 by German chemist Justus von Liebig in the protein casein from cheese. (wikipedia.org)
  • Full length native protein (purified) corresponding to Rat Tyrosine Hydroxylase. (abcam.cn)
  • We show here that PCP is actually converted to tetrachlorobenzoquinone, which is subsequently reduced to tetrachlorohydroquinone by PcpD, a protein that had previously been suggested to be a PCP hydroxylase reductase. (antievolution.org)
  • These amino acids are found in nearly every protein and, as such, are provided by ingestion of protein-containing food, with tyrosine being the most common. (wikipedia.org)
  • These amino acids are found in nearly every protein and so are readily available in food, with tyrosine being the most common. (wikipedia.org)
  • proceeds
  • Although initially an arene oxide or radical intermediate was proposed, analyses of the related tryptophan and tyrosine hydroxylases have suggested that the reaction instead proceeds through a cationic intermediate that requires Fe(IV)=O to be coordinated to a water ligand rather than a hydroxo group. (wikipedia.org)