Aromatase. Medical search. Frequent questions

On the other hand, in December 2008, the Food and Drug Administration added a warning label to anastrozole, an aromatase inhibitor, which indicated potential increased risk for heart disease. (health.am)
The animals were randomized and subjected to four groups which were pre-treated with the selective aromatase inhibitor anastrozole (A group) and DES alone (DES group) or in combination (A+DES group) for 15 minutes prior to surgical intervention whereas the control group received 0.9% NaCl (CON group). (uni-wuerzburg.de)
A triazole and benzonitrile derivative that is a selective non-steroidal aromatase inhibitor, similar to ANASTROZOLE. (bvsalud.org)

Among postmenopausal women with hormone receptor-positive breast cancer, aromatase inhibitors (alone or after tamoxifen) offer the same or slightly greater benefit compared to tamoxifen alone [ 88,105-108 ]. (komen.org)
When an aromatase inhibitor is taken after tamoxifen, the drugs are taken for a combined total of 5-10 years. (komen.org)
Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early -stage breast cancer treated with ovarian suppression: a patient - level meta - analysis of 7030 women from four randomised trials. (nih.gov)
BACKGROUND: The optimal ways of using aromatase inhibitors or tamoxifen as endocrine treatment for early breast cancer remains uncertain. (nih.gov)
Tamoxifen blocks the effect of estrogen in breast tissue, whereas aromatase inhibitors prevent the production of estrogen. (health.am)
The researchers examined data from seven large randomized clinical trials that compared tamoxifen with aromatase inhibitors in postmenopausal women with early-stage breast cancer. (health.am)
As a secondary analysis, they determined if switching from treatment with tamoxifen to aromatase inhibitors had any effect on mortality or adverse effects. (health.am)
Results showed that the risk for serious adverse effects were similar when aromatase inhibitors were used as an initial treatment compared with switching to aromatase inhibitors after treatment with tamoxifen. (health.am)
This support group is for women who are currently taking aromatase inhibitors or tamoxifen, as well as for those trying to decide whether or not to take them. (sharecancersupport.org)
Objective Previous data hypothesise that women receiving aromatase inhibitors (AIs) exhibit worse cognitive functioning than patients on tamoxifen (TAM) since their oestrogen levels are lower. (bmj.com)
Men with breast cancer may be given an aromatase inhibitor, although another drug called tamoxifen is more commonly used. (breastcancernow.org)

Severe joint pain and muscle stiffness are common side effects of taking Aromatase Inhibitors. (facingourrisk.org)

To assess the effects of aromatase inhibitors in male children and adolescents with short stature. (nih.gov)
Learn more about the side effects of aromatase inhibitors . (komen.org)
Dawn Hershman, MD , of the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, reviews findings on survivorship care plans, interventions to reduce chemotherapy-induced peripheral neuropathy, and the cardiac effects of aromatase inhibitors (Poster Discussion 4). (ascopost.com)

Letrozole stops the activity of Aromatase, which consequently prevents estrogen formation, leading to a slowing down or reversal of breast cancer growth. (deusmedical.com)
Letrozole is an aromatase inhibitor with antiestrogenic effects that is being tested in LAM. (medscape.com)

This condition is due to mutations in the CYP19A1 gene which encodes aromatase. (wikipedia.org)
Mutations in the CYP19A1 gene cause aromatase deficiency. (medlineplus.gov)
The CYP19A1 gene provides instructions for making an enzyme called aromatase. (medlineplus.gov)
CYP19A1 gene mutations that cause aromatase deficiency decrease or eliminate aromatase activity. (medlineplus.gov)
The synthesis of estrogens in breast tissue is catalyzed by the enzyme aromatase, which is encoded by the gene cytochrome P450 family 19 subfamily A member 1 (CYP19A1). (spandidos-publications.com)
Aromatase (CYP19A1) is an enzyme in our body, which is responsible for producing estrogen. (american-supps.com)

Androstenedione + 3O2 + 3NADPH + 3H+ ⇌ {\displaystyle \rightleftharpoons } Estrone + Formate + 4H2O + 3NADP+ Testosterone + 3O2 + 3NADPH + 3H+ ⇌ {\displaystyle \rightleftharpoons } 17β-estradiol + Formate + 4H2O + 3NADP+ Aromatase is expressed in the gonads, placenta, brain, adipose tissue, bone, and other tissues. (wikipedia.org)
Aromatase deficiency is a condition characterized by reduced levels of the female sex hormone estrogen and increased levels of the male sex hormone testosterone. (medlineplus.gov)
As a result of the essential role of oestrogens in epiphyseal closure, aromatase inhibitors have been trialled as an intervention to improve height outcomes in male children and adolescents by inhibiting the conversion of testosterone to oestradiol. (nih.gov)
Recently, aromatase inhibitors use has been shown to increase free testosterone and lean mass in breast cancer survivors without concomitant changes in body fat. (ironmagazine.com)
Aromatase metabolizes testosterone to 17b- estradiol (E2) and thereby significantly contributes The volatile anesthetic desflurane (DES) effectively reduces cardiac infarct size following experimental ischemia/reperfusion injury in the mouse heart. (uni-wuerzburg.de)
Aromatase metabolizes testosterone to 17b- estradiol (E2) and thereby significantly contributes to local estrogen synthesis. (uni-wuerzburg.de)
as suppress the enzyme aromatase, which is responsible for the conversion of testosterone to estrogen. (american-supps.com)
General reaction for the conversion of testosterone to estradiol catalyzed by aromatase. (wikidoc.org)
Blocking the aromatase is crucial for decreasing estrogen, whether you have high testosterone or not. (men-elite.com)
Lower aromatase activity will leaves more testosterone to bind with androgen receptors to exert its anabolic effect, as well as to be converted to DHT via 5-AR (5 alpha reductase). (men-elite.com)
Arimigen™ - APS Nutrition's novel Aromatase Inhibitor is a new ground breaking formula designed to optimize an anabolic environment by decreasing estrogen and increasing testosterone levels. (hitechpharma.com)
Arimigen™ acts as an anti-aromatase agent and is thus a powerful elevator of total testosterone and maximum liberator of free testosterone. (hitechpharma.com)
As a powerful aromatase inhibitor, Arimigen™ also possesses notable testosterone stimulating properties. (hitechpharma.com)
The aromatase inhibiting action reduces the signal that estrogen sends to the brain to suppress endogenous testosterone production (estrogen is a main feedback signal to control the release of testosterone, thus increasing the testicular output of testosterone). (hitechpharma.com)

Prolia was later approved to treat men with osteoporosis, glucocorticoid induced osteoporosis, bone loss in men receiving androgen deprivation therapy for prostate cancer and in women receiving aromatase inhibitor therapy for breast cancer. (medlineplus.gov)

Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)

Have you been diagnosed with breast cancer and prescribed an aromatase inhibitor as part of your treatment? (bccr.org)

Available evidence suggested that aromatase inhibitors improved short-term growth outcomes. (nih.gov)

Aromatase (EC 1.14.14.14), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. (wikipedia.org)
While antiestrogen therapy has become an accepted practice, clinical utilization of selective aromatase (estrogen synthetase) inhibitor only began in the last few years. (umaryland.edu)

The findings of the present study suggest that zeranol promotes breast cancer cell growth by stimulating aromatase activation and increasing estrogen biosynthesis in adipose tissue. (spandidos-publications.com)
Estrogen production in adipose tissue has previously been demonstrated to provide excessive estrogen for the stimulation and progression of postmenopausal breast cancer cells, and elevated enzymatic activity of aromatase has been detected in the adjacent adipose stroma of breast carcinoma ( 8 , 9 ). (spandidos-publications.com)
The product of this enzyme, the proinflammatory eicosanoid prostaglandin E2 (PGE2), stimulates adipose tissue aromatase expression and subsequent estrogen production, which could promote breast cancer progression. (aacrjournals.org)

Who can take aromatase inhibitors? (komen.org)
Postmenopausal women who take aromatase inhibitors as a treatment for breast cancer may be at an increased risk for developing cardiovascular disease, according to the results of a meta-analysis. (health.am)

Previous studies have reported that some endocrine disruptors may interact with in situ steroidogenesis by altering tissue components, such as increased aromatase expression, in certain tissues ( 12 , 13 ). (spandidos-publications.com)

Alternatively, TST can be converted into estradiol through aromatization by the action of the enzyme aromatase. (biomedcentral.com)

In particular, aromatase is responsible for the aromatization of androgens into estrogens. (wikipedia.org)
During fetal development, aromatase converts androgens to estrogens in the placenta, which is the link between the mother's blood supply and the fetus. (medlineplus.gov)
A shortage of functional aromatase results in an inability to convert androgens to estrogens before birth and throughout life. (medlineplus.gov)
Aromatase is a crucial enzyme for the biosynthesis of estrogens and is involved in the process of breast carcinogenesis. (spandidos-publications.com)
Concerns have been raised regarding the effects of environmental estrogens as potential regulators of aromatase expression in human breast cells. (spandidos-publications.com)
The present study hypothesized that aromatase expression and activity may be elevated by low dose zeranol exposure, providing a source of estrogens that may stimulate cell proliferation. (spandidos-publications.com)
Aromatase is a cytochrome P450, which synthesizes estrogens by converting C19 androgens to aromatic C18 estrogenic steroids, thus catalyzing the rate-limiting or final step of estrogen synthesis ( 5 , 6 ). (spandidos-publications.com)

Aromatase inhibitors are a hormone therapy (also called endocrine therapy). (komen.org)

Tumors developed from the cells and their growth was dependent on estrogen synthesized by intratumoral aromatization of supplemented {dollar}\Delta\sp4{dollar}A. Both aromatase inhibitors and antiestrogen inhibited tumor growth. (umaryland.edu)

However, some premenopausal women may take an aromatase inhibitor when combined with ovarian suppression . (komen.org)

Formestane(Lentaron(R)) is a second generation selective aromatase inhibitor with an IC50 of 80 nM. (biochempartner.com)
Fadrozole is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM. (biochempartner.com)

Aromatase inhibitor musculoskeletal symptoms have a negative effect on a woman's physical function and quality of life. (facingourrisk.org)
Patricia A. Ganz, MD , of the UCLA Jonsson Comprehensive Cancer Center, summarizes two studies on using duloxetine for aromatase inhibitor-associated musculoskeletal symptoms, and aromatase inhibitors' effect on endothelial function and heart disease (Abstracts S5-06 and S5-07). (ascopost.com)

How do aromatase inhibitors work? (komen.org)

There are other features associated with aromatase deficiency that can affect both males and females. (medlineplus.gov)
so people with aromatase deficiency can have abnormally high blood sugar (glucose), a condition known as hyperglycemia. (medlineplus.gov)
Women who are pregnant with fetuses that have aromatase deficiency often experience mild symptoms of the disorder even though they themselves do not have the disorder. (medlineplus.gov)
In affected individuals, these abnormal hormone levels lead to impaired female sexual development, unusual bone growth, insulin resistance, and other signs and symptoms of aromatase deficiency. (medlineplus.gov)
In women who are pregnant with an affected fetus, excess androgens in the placenta pass into the woman's bloodstream, which may cause her to have temporary signs and symptoms of aromatase deficiency. (medlineplus.gov)

Vorozole is an imidazole based competitive inhibitor of the aromatase enzyme. (biochempartner.com)
It is a nonsteroidal competitive inhibitor of the aromatase enzyme system. (medscape.com)

Factors known to increase aromatase activity include age , obesity , insulin , gonadotropins , and alcohol . (wikidoc.org)

Learn about aromatase inhibitors and other hormone therapies for metastatic breast cancer . (komen.org)

Arora A., Potter J.(2004) Aromatase Inhibitors: Current indications and future prospects for treatment of postmenopausal breast cancer. (bvsalud.org)

Aromatase is localized in the endoplasmic reticulum where it is regulated by tissue-specific promoters that are in turn controlled by hormones, cytokines, and other factors. (wikipedia.org)
Aromatase inhibitors lower estrogen levels in the body by blocking aromatase, an enzyme that converts other hormones into estrogen. (komen.org)
Aromatase inhibitors block the enzyme aromatase (found in the body's muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogen. (chemocare.com)

Thus, the aromatase gene evolved early in chordate evolution and does not appear to be present in nonchordate invertebrates (e.g. insects, molluscs, echinoderms, sponges, corals). (wikipedia.org)
It varies from species to species whether it is the aromatase protein that has different activity at different temperatures or whether the amount of transcription undergone by the aromatase gene is what is temperature-sensitive, but in either case, differential development is observed at different temperatures. (wikipedia.org)
Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system. (reference.md)
bone age suggested a diagnosis of aromatase excess syndrome, which prompted further investigations into mutations of the CYP19 gene. (symptoma.com)
In MCF-7 human breast cancer cells transfected with aromatase gene (MCF-7Ca), growth was stimulated by aromatizable androgen, androstenedione ({dollar}\Delta\sp4{dollar}A) in cell culture. (umaryland.edu)

Protein localization studies revealed that aromatase was abundant in the murine cardiovascular system with the highest expression levels in endothelial and smooth muscle cells. (uni-wuerzburg.de)
This process involves an enzyme (a type of protein) called aromatase. (breastcancernow.org)

Steroids are composed of four fused rings (labeled A-D). Aromatase converts the ring labeled "A" into an aromatic state. (wikidoc.org)

The results demonstrated that low dose zeranol (2‑50 nM) was able to significantly promote cell proliferation, aromatase mRNA expression, aromatase activity and estrogen production in primary cultured human breast preadipocytes, thus suggesting that zeranol may act as an aromatase activator. (spandidos-publications.com)
In addition, mRNA levels for aromatase in the oSDN were higher in males than in females and were higher in female-oriented rams than in male-oriented rams. (oregonstate.edu)

Aromatase activity is decreased or antagonized by prolactin, anti-Müllerian hormone and glyphosate. (wikipedia.org)

When an aromatase inhibitor is the only hormone therapy given, it's taken for 5-10 years. (komen.org)
AIMS: Aromatase inhibitors are now a standard of care in the management of hormone-responsive early breast cancer in postmenopausal women. (ox.ac.uk)
The purpose of this study was to determine the effects of 6-OXO, a purported nutritional aromatase inhibitor, in a dose dependent manner on body composition, serum hormone levels, and clinical safety markers in resistance trained males. (biomedcentral.com)
Find out about aromatase inhibitors, a type of hormone therapy normally used to treat breast cancer in women who have gone through the menopause, including side effects and how they work. (breastcancernow.org)
If you're finding it hard to cope with side effects from one aromatase inhibitor, your specialist may recommend changing to a different aromatase inhibitor or another hormone therapy drug. (breastcancernow.org)

A number of investigators have reported on a rather rare syndrome of excess aromatase activity. (wikipedia.org)
The effects of zeranol on cell proliferation were measured using the MTS assay, aromatase expression levels were determined by immunocytochemical staining and reverse transcription‑polymerase chain reaction, and aromatase enzyme activity and estrogen production were analyzed using corresponding assay kits. (spandidos-publications.com)
In addition, CM from macrophage/preadipocyte cocultures exposed to sera from obese patients stimulated greater breast cancer cell ERα activity, proliferation, and migration compared with sera from normal-weight patients, and these differences were eliminated or reduced by the addition of an aromatase inhibitor during CM generation. (aacrjournals.org)
In this study, we tested the hypothesis that desflurane effects local estrogen synthesis by modulating enzyme aromatase expression and activity in the mouse heart. (uni-wuerzburg.de)
We conclude that desflurane efficiently regulates aromatase expression and activity which might lead to increased local estrogen synthesis and thus preserve cellular integrity and reduce cardiac damage in an acute myocardial infarction model. (uni-wuerzburg.de)
The Aromatase Inhibitor I, also referenced under CAS 331684-05-0, controls the biological activity of Aromatase. (emdmillipore.com)
[5] Aromatase activity appears to be enhanced in certain estrogen-dependent local tissue next to breast tissue, endometrial cancer , endometriosis , and uterine fibroids . (wikidoc.org)
Although all inhibited aromatase activity competitively, pretreatment with 4-OHA induced profound and sustained inhibition (inactivation of the enzyme) via an irreversible interaction at the active site. (umaryland.edu)
In contrast, the inhibitory effect of AG was completely reversible and caused an increase in aromatase activity when AG was removed after pretreatment. (umaryland.edu)
dollar}90% inhibition of aromatase activity. (umaryland.edu)
While neither of the 6-OXO dosages appears to have any negative effects on clinical chemistry markers, supplementation at a daily dosage of 300 mg and 600 mg for eight weeks did not completely inhibit aromatase activity, yet significantly increased FT, DHT, and T/E. (biomedcentral.com)
an activity not clearly addressed by any of the aromatase inhibiting or anti-estrogen products. (hitechpharma.com)
In this study, we have evaluated Centella asiatica compounds for their activity on aromatase with clinically significant SNPs rs700519, rs78310315 and rs56658716. (bvsalud.org)
Aromatase activity rises, resulting in higher levels of potent estrogen in the breast. (lu.se)

Aromatase inhibitors help reduce the amount of oestrogen made in the body. (breastcancernow.org)

Keywords: Aromatase inhibitors, constitutional delay of puberty, hypogonadism How to cite this article: Singh SK. (symptoma.com)

Aromatase Inhibitor for Post Cycle Therapy. (bodypharm.biz)

Aromatase is an enzyme that helps in the production of estrogen. (deusmedical.com)

Aromatase inhibitors other than arimidex? (excelmale.com)

Anatomy24

Organisms10

Diseases17

Chemicals and Drugs71

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Psychiatry and Psychology3

Phenomena and Processes18

Disciplines and Occupations1

Information Science2

Health Care1

Anastrozole3

Tamoxifen11

Taking aromatase inhibitors1

Effects of aromatase inhibitors3

Letrozole2

CYP19A16

Testosterone14

Inhibitor therapy1

Combination with an aromatase inhibitor1

Prescribed an aromatase inhibitor1

Suggested that aromatase inhibitors1

Synthetase2

Adipose3

Take aromatase inhibitors2

Increased aromatase expression1

Estradiol1

Estrogens7

Endocrine therapy1

Antiestrogen1

Premenopausal women1

Selective2

Musculoskeletal symptoms2

Inhibitors work1

Deficiency5

Competitive inhibitor2

Insulin1

Metastatic breast cancer1

Treatment of postmenopausal1

Hormones3

Gene5

Protein2

Converts1

MRNA2

Glyphosate1

Hormone5

Activity14

Oestrogen1

Hypogonadism1

Therapy1

Production of estrogen1

Arimidex1