Arises apud cells. Medical search. Frequent questions

[ 1 ] Small cell carcinoma is a distinct clinical and pathologic entity that arises from cells of the amine precursor uptake and decarboxylation (APUD) system. (medscape.com)
however, tumors can originate from any cell of the amine precursor uptake and decarboxylation system and, therefore, produce several intestinal hormones. (medscape.com)
1,2,3] They originate in amine precursor uptake and decarboxylation (APUD) cells of the gastroenteropancreatic endocrine system and in adrenal or extra-adrenal neurogenic sites. (medscape.com)
In 1980, the World Health Organization (WHO) applied the term carcinoid to all tumors of the diffuse endocrine system (synonymous with amine precursor uptake and decarboxylation [APUD] and neuroendocrine cell system). (medscape.com)

Carcinoid tumors arise from neuroendocrine cells, which are widespread in the human body, especially in the organs derived from the primitive intestine (see the image below). (medscape.com)
In 1914, Gosset and Masson demonstrated that carcinoid tumors might arise from enterochromaffin cells (Kulchitsky cell) within glands of Lieberkühn using silver impregnation techniques. (medscape.com)
In 1928, Masson established characterization of carcinoids as argentaffin cell tumors. (medscape.com)

In pathology, an apudoma is an endocrine tumour that arises from an APUD cell from structures such as the ampulla of Vater. (wikipedia.org)

They were historically thought to be derived from neural crest cells, but this has since been shown to be untrue (see neuroendocrine tumor).The term dates back to at least 1975. (wikipedia.org)

The diagnostic criteria for EPSCC require that the tumor demonstrate histolgic features of small cell carcinoma in the absence of small cell lung cancer (SCLC). (medscape.com)
Rare catecholamine-secreting tumor derived from chromaffin cells. (preparingtobecome.com)
Microscopy: Hematoxylin and eosin staining revealed a monotonous population of round to polygonal tumor cells with round to oval nuclei and variable amounts of eosinophilic cytoplasm. (scirp.org)

however, it is not uncommon for these cells to arise in nonpulmonary sites, as extrapulmonary small cell carcinoma (EPSCC). (medscape.com)
Histologic criteria for diagnosis of extrapulmonary small cell carcinoma (EPSCC) are same as those for pulmonary small cell carcinoma: the presence of uniform small cells with sparse cytoplasm, dense nuclei, and inconspicuous nucleoli. (medscape.com)
Like pulmonary small cell carcinoma, small cell carcinomas arising from extrapulmonary sites may be associated with paraneoplastic syndromes , notably syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and hypercalcemia . (medscape.com)
Approximately 1000 cases of extrapulmonary small cell carcinoma (EPSCC) are reported annually in the United States, with an overall incidence of 0.1-0.4% of all cancers and 2.5-5% of all small cell carcinomas. (medscape.com)
Global incidence of extrapulmonary small cell carcinoma is unknown. (medscape.com)

Neural crest cells are precursors of APUDoma and neurogenic cells. (medscape.com)

VIPomas arise from the pancreas in 90% of cases, but they may also be found in periganglionic tissue or at other sites (eg, colon, bronchus, adrenal glands, and liver), especially in children. (medscape.com)

A section (on the right) of an intestinal carcinoid mass arising from the mucosa (150 X). Image courtesy of Professor Pantaleo Bufo, University of Foggia, Italy. (medscape.com)
insulin-secreting cells, the basolateral membrane of intestinal and kidney absorptive cells, in hepatocytes and in a subset of neurons (21,31,44). (justia.com)

[ 2 ] Since EPSCC has been reported in multiple sites, all cases are thought to have an identical cell of origin that derives from those originating in neural crest and then migrates to different epithelial sites within the body. (medscape.com)

Pancreatic non-beta-cell hyperplasia is rare but has been reported in children. (medscape.com)
In pancreatic islets, GLUT2 allows a rapid equilibration of glucose between the extracellular space and the interior of the cells and it may play a crucial role in the glucose signaling mechanism leading to insulin secretion (43). (justia.com)
pancreatic cells to glucose remains debated. (justia.com)

Nodules are composed of irregularly large cells and sparse colloid. (teknon.es)

On the other hand, insulinoma cells that had lost their normal glucose responsiveness have low GLUT2 content, but some glucose sensitivity may be recovered after reintroducing GLUT2 expression through stable transfection of these cells (10,16). (justia.com)

Integrins are ubiquitous trans‐membrane adhesion molecules that mediate the interaction of cells with the extracellular matrix (ECM). (philpapers.org)

which doubtless has arisen from the imperfect state that all fruits and seeds commonly appear in, after double flowers, as in the present case. (google.la)

The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. (lookformedical.com)
In cases such as leukocyte binding, integrins mediate cell‐cell interactions and cell‐ECM interactions. (philpapers.org)

To download a certificate of origin for Melanotus hartii Ammirati apud Ammirati ( 42956 ), enter the lot number exactly as it appears on your product label or packing slip. (atcc.org)
The certificate of origin for that lot of Melanotus hartii Ammirati apud Ammirati ( 42956 ) is not currently available online. (atcc.org)
Charles Darwin 's 1859 book On the Origin of Species explained how species could arise by natural selection . (atozwiki.com)

EPSCC has been reported to arise in almost all body sites except the central nervous system. (medscape.com)

Recent research indicates that integrins also function as signal transduction receptors, triggering a number of intracellular signaling pathways that regulate cell behavior and development. (philpapers.org)

cells, the level of expression of GLUT2 is low and the intracellular glucokinase activity seems to be the rate-limiting step in the glycolytic pathway (5,11). (justia.com)
Issues of ambiguity arise at the word level (homonymy, accent), at the sentence level (syntactic ambiguity), or at the level of discourse. (cnrs.fr)

These cells share a characteristic feature of the ability to produce peptide hormones and the ability to synthesize amines from certain precursors, which gave rise to the concept known as Amine Precursor Uptake and Decarboxylation. (medscape.com)
[ 1 ] Small cell carcinoma is a distinct clinical and pathologic entity that arises from cells of the amine precursor uptake and decarboxylation (APUD) system. (medscape.com)
An apudoma is any endocrine tumor that arises from an APUD cell (APUD, meaning amine precursor uptake and decarboxylation) properties. (illnessopedia.org)
The cells in pancreatic endocrine neoplasms are termed amine precursor uptake and decarboxylation (APUD) cells because they have a high amine content, are capable of amine precursor uptake, and contain an amino acid decarboxylase. (medscape.com)
APUDomas or APUD tumors arise from APUD cells which have the ability of amine precursors uptake and intracellular decarboxylation, before converting them into active amines, hence the name, amine precursor uptake, and decarboxylation cells. (statpearls.com)
Other suggested cells of origin include the neural crest‒derived cell of amine precursor uptake and decarboxylation (APUD) system, dermal fibroblasts, pre or pro B cells, residual epidermal stem cells, and epithelial, non-Merkel cell progenitors. (medscape.com)
however, tumors can originate from any cell of the amine precursor uptake and decarboxylation system and, therefore, produce several intestinal hormones. (medscape.com)

Neuroendocrine tumors arise from cells that originate in the neural crest. (medscape.com)
[ 15 ] Instead, the tumors arise from APUD stem cells, which are pluripotential neuroendocrine cells located within the ductular epithelium of the exocrine pancreas and elsewhere in the distal foregut. (medscape.com)
Carcinoid tumors arise from neuroendocrine cells, which are widespread in the human body, especially in the organs derived from the primitive intestine (see the image below). (medscape.com)
Neuroendocrine tumors arise from enterochromaffin cells . (wikidoc.org)

Collectively, the tumors that arose from these cells were classified by Pearse as APUDomas, currently more commonly referred to as neuroendocrine tumors. (medscape.com)
[ 12 ] Pearse first used the term APUD in 1968 to unify a group of functionally and structurally similar neuroendocrine cells that are present throughout the body. (medscape.com)
These cells were originally described by Pearse in the 1960s, to arise from the neural crest. (statpearls.com)

APUDomas, currently known as neuroendocrine tumors (NETs), are a group of heterogeneous tumors that arise from the diffuse neuroendocrine system. (statpearls.com)

[2] This was then disproven by the concept of the origin of APUD cells from multipotent stem cells before being implanted in different body organs, hence the diffuse endocrine system. (statpearls.com)
Moreover, in adults, Merkel cells undergo slow turnover and are replaced by cells originating from epidermal stem cells, not through the proliferation of differentiated Merkel cells. (medscape.com)
Autologous haematopoietic stem cell transplantation (auto-HSCT) as a treatment for B-cell acute lymphoblastic leukaemia (B-ALL) has been rigorously debated in recent years. (bvsalud.org)
This is a small phase I study examining the safety and efficacy of a cladribine (CLAD)-containing conditioning regimen prior to autologous hematopoietic stem cell transplantion (auto-HSCT) for patients with acute myeloid leukemia (AML). (bvsalud.org)
All 22 AML patients received peripheral blood stem cell transplantation. (bvsalud.org)

Neuroendocrine tumors include such tumors as adenomas from the pituitary gland, islet cell tumors from the pancreas, pheochromocytoma and neuroblastoma from the adrenal medulla, medullary thyroid carcinoma from the C-cells of the thyroid gland, carcinoid tumors from the gastrointestinal tract (or less often from the lung), and paragangliomas. (medscape.com)
The first report of a hormone-producing pancreatic tumor syndrome was published in 1927, when Wilder et al described insulinoma syndrome in a patient with a metastatic islet cell tumor who had hyperinsulinism and hypoglycemia. (medscape.com)
Although the term islet cell tumor is often used to identify neoplasms of the endocrine pancreas, this is a misnomer because many pancreatic neuroendocrine tumors do not develop directly from islet cells. (medscape.com)

A section (on the right) of an intestinal carcinoid mass arising from the mucosa (150 X). Image courtesy of Professor Pantaleo Bufo, University of Foggia, Italy. (medscape.com)
Carcinoid tumors are normally found throughout the gastrointestinal tract from mouth to anus , with the highest concentration of cells in the appendix and small intestine . (wikidoc.org)

More than half of NETs arise from the gastrointestinal tract and pancreas, while about 25% originate from the bronchopulmonary tree. (statpearls.com)
Pancreatic neuroendocrine tumors Neuroendocrine tumors Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. (lecturio.com)

These APUD cells reside in various organ systems such as the pituitary gland, the pancreas, the adrenal medulla, the thyroid gland, and the gastrointestinal tract. (medscape.com)
Gastrinoma (PanNETs) arise from the endocrine pancreas Pancreas The pancreas lies mostly posterior to the stomach and extends across the posterior abdominal wall from the duodenum on the right to the spleen on the left. (lecturio.com)
Benign Bone Tumors are from the exocrine pancreas Exocrine pancreas The major component (about 80%) of the pancreas composed of acinar functional units of tubular and spherical cells. (lecturio.com)

Within skin, Merkel cells have also been shown to cluster in the basal layers of the interfollicular epidermis in specialized epithelial structures called touch domes, where they are juxtaposed with epidermal keratinocytes. (medscape.com)
[ 5 , 6 ] Furthermore, experiments have demonstrated that epidermal progenitors in the touch domes are capable of producing Merkel cell lines and that epithelial progenitor populations in adults have the capacity to give rise to both neuroendocrine and squamous lineages. (medscape.com)
this is followed by the accumulation of interstitial edema and later by necrosis of Type I epithelial cells. (nih.gov)
In normal repair, rapid proliferation of Type II cells, followed by differentiation to Type I, restores the epithelial surface without fibrosis. (nih.gov)
Fibroblast proliferation accompanies this abnormal epithelial response which is related either to selective retention of bleomycin by epithelial cells or to the toxic effects of administering more drug at the time of Type II cell division. (nih.gov)

[ 7 , 8 ] Sunshine et al offer that perhaps there are multiple cell-line precursors of Merkel cell carcinoma. (medscape.com)

Even as they secrete neuropeptides, Merkel cells additionally express intermediate filaments characteristic of primitive and simple epithelia such as cytokeratin (CK) 8, CK18, and CK20. (medscape.com)
Conversely, morphological observations of characteristic types of cell-specific injury in the lung may suggest a likely biochemical mechanism of toxicity for the particular chemical involved. (nih.gov)

The APUD cells produce peptides and amines that act as hormones or as neurotransmitters throughout the body. (medscape.com)

Merkel cell carcinoma is a rare primary cutaneous neuroendocrine carcinoma with growing incidence and high metastatic potential. (medscape.com)
Friedrich Sigmund Merkel discovered the Merkel cell in 1875. (medscape.com)
[ 6 ] As they are primarily postmitotic, Merkel cells putatively have low sensitivity to oncogenic stimuli, and they are found in the basal epidermis, whereas cutaneous neuroendocrine carcinomas arise in the dermis. (medscape.com)
Ultimately, it is unclear whether the eponymous Merkel cell is truly a histiogenic precursor of Merkel cell carcinoma. (medscape.com)
[ 9 ] Since our understanding of the histogenesis is still evolving, some authors choose to refer to Merkel cell carcinoma as neuroendocrine carcinoma of the skin or cutaneous neuroendocrine carcinoma. (medscape.com)
Also see Merkel Cell Tumors of the Head and Neck and Merkel Cell Carcinoma and Rare Appendageal Tumors . (medscape.com)
Even as the nature of the exact cell in which Merkel cell carcinoma oncogenesis occurs is controversial, there is strong support for the notion that Merkel cell carcinoma results from of one of two distinct pathways. (medscape.com)
Feng et al established in 2008 that approximately 80% of Merkel cell carcinomas in the Northern hemisphere occur after genomic integration by a ubiquitous skin commensal virus, Merkel cell polyoma virus (MCPyV). (medscape.com)

Like pulmonary small cell carcinoma, small cell carcinomas arising from extrapulmonary sites may be associated with paraneoplastic syndromes , notably syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and hypercalcemia . (medscape.com)
Approximately 1000 cases of extrapulmonary small cell carcinoma (EPSCC) are reported annually in the United States, with an overall incidence of 0.1-0.4% of all cancers and 2.5-5% of all small cell carcinomas. (medscape.com)

These cells are characterized by the presence of intracytoplasmic neurosecretory granules and positive staining with chromogranin. (medscape.com)
Furthermore, neuroendocrine cells typically have neurosecretory granules. (statpearls.com)

Histologic criteria for diagnosis of extrapulmonary small cell carcinoma (EPSCC) are same as those for pulmonary small cell carcinoma: the presence of uniform small cells with sparse cytoplasm, dense nuclei, and inconspicuous nucleoli. (medscape.com)
Well-differentiated NETs are composed of small cells organized in islets, gyriform, and trabeculae, with finely granular cytoplasm, commonly referred to as "salt and pepper" chromatin pattern. (statpearls.com)
On the other hand, poorly differentiated NECs usually appear as sheets of pleomorphic cells with irregular nuclei and less granular cytoplasm. (statpearls.com)

Although these cells have a common embryological origin, they are distributed to various sites and organ systems throughout the body, where they can give rise to a variety of tumor types that are related by their common embryological origin. (medscape.com)
EPSCC has been reported to arise in almost all body sites except the central nervous system. (medscape.com)
disruptive ProstateProstate case is to instead all cells as the body. (reconcile-int.org)

However, after bleomycin, Type II cell proliferation is frequently followed by abnormal differentiation to a metaplastic form of epithelium. (nih.gov)

The lung is a primary target of cell injury in patients receiving cytotoxic drugs, and in many cases the reaction is severe enough to produce diffuse pulmonary fibrosis. (nih.gov)

However, deletions of chromosome arm 3p and c-myc amplification described in small cell pulmonary carcinoma have not been reported in extrapulmonary sites. (medscape.com)
Metabolic activation and lung toxicity: a basis for cell-selective pulmonary damage by foreign chemicals. (nih.gov)
Administration of amphiphilic drugs to experimental animals causes formation of myelinoid bodies in many cell types, accumulation of foamy macrophages in pulmonary alveoli and pulmonary alveolar proteinosis. (nih.gov)

The name " enterochromaffin " refers to the ability to stain the cell with potassium chromate (chromaffin), a feature of cells that contain serotonin . (wikidoc.org)

Her letters were promptly answered, as the reader has seen, and always with the endeavour to set her mind at ease by giving the cheerful view-his hopes and general expectations-though not wholly concealing, as time went on, the conflict that under discouragement arose in his own. (newmanreader.org)
TOGETHER With the right ordering of them from time to time: and the sweet Profit arising thereof. (libarynth.org)

The diagnostic criteria for EPSCC require that the tumor demonstrate histolgic features of small cell carcinoma in the absence of small cell lung cancer (SCLC). (medscape.com)
EPSCC may have a similar prognosis to that of small cell lung cancer. (medscape.com)
The specific types of lung cells damaged may depend upon factors such as preferential exposure or accumulation of parent compounds and/or metabolites, differences in cellular defense mechanisms, or the specific mechanism of activation of the toxicant. (nih.gov)
Prior knowledge about the metabolism, disposition and mechanism of bioactivation of a particular compound may allow prediction of the type of lung cell damage it is likely to produce. (nih.gov)

Aplastic anemia is a condition wherein the bone marrow does not produce enough new cells to replenish the blood cells. (illnessopedia.org)

online production solutionsChubb is an 2-cell attention of technologies, memoir and innovation to understand your problem. (lesche.name)

In order to assist in assessing potential odor problems arising from chemical manufacturing operations, the odor thresholds of 53 commercially important odorant chemicals have been determined using a standardized and defined procedure. (researchgate.net)

Text version The download early tales sketches currently was the international page, and temporarily a philosophical instructions come of the end network on townpopulated: she was like the way Athena, arose server read with location teachers, with hardware at experience, Sadak case and page. (uebersetzungen-kovac.de)

To download a certificate of analysis for Pholiota nameko (Ito) Ito et Imai apud Imai ( 42262 ), enter the lot number exactly as it appears on your product label or packing slip. (atcc.org)
One download of NAAT arises within two hands the leukemia of M. therein, NAAT arthritis is long add AFB patients. (reconcile-int.org)
What far arise I proposed to take with my download? (katrin-aldag.de)

Regulatory peptides that are released by neuroendocrine cells may function as hormones, neurotransmitters, or as paracrine hormones. (medscape.com)
Anemia is the disorder that results in having lesser red blood cells than normal, which are needed to function properly. (illnessopedia.org)
He observed tastzellen (touch cells) in the skin of the snouts of pigs and moles and deduced a mechanosensory function. (medscape.com)
NADPH, reduced glutathione) necessary for normal cell function. (nih.gov)

The onset of injury was insidious, arising 1 to 5 months after starting treatment. (nih.gov)

Flowkkless plants, witli sporules surrounded by elastic clavate filaments, and inclosed in thecse arising from the scales of term- inal cones. (nih.gov)

Anatomy1

Diseases6

Amine precursor uptake and decarboxylation4

Tumors3

Endocrine1

Neuroendocrine1

Tumor3

Small cell carc5

Apudoma1

Adrenal1

Intestinal2

Neural1

Pancreatic3

Sparse1

INSULINOMA1

Extracellular1

Commonly1

Cases2

Origin3

System1

Development1

Level2

Amine Precursor Uptake7

Tumors arise4

Pearse3

APUDomas1

Stem5

Islet3

Carcinoid2

Originate2

Pancreas3

Epithelial5

Precursors1

Characteristic2

Amines1

Merkel8

Carcinomas2

Neurosecretory granules2

Cytoplasm3

Body3

Proliferation1

Diffuse1

Pulmonary3

Stain1

Time2

Lung4

Produce1

Production1

Order1

Read1

Download3

Function4

Injury1

Term1