• prostaglandins
  • Cycloxygenase: Cells can use prostaglandin-endoperoxide synthase 1 (i.e. cyclooxygenenase-1 or COX-1) and Prostaglandin-endoperoxide synthase 2 (COX-2) to metabolize arachidonic acid primarily to prostaglandins but also to small amounts of 11(R)-HETE and a racemic mixture of 15-HETEs composed of ~22% 15(R)-HETE and ~78% 15(S)-HETE. (wikipedia.org)
  • Therefore
  • Therefore, these data suggest that in rabbit aorta, arachidonic acid-induced relaxations are mediated by an endothelium-dependent factor (or factors) that differs from the factor (or factors) released by acetylcholine. (ahajournals.org)
  • release
  • These data suggest that cPLA2α contributes to Ang II-induced hypertension and associated cardiovascular pathophysiology, most likely due to release of arachidonic acid and activation of NADPH oxidase and generation of ROS. (ahajournals.org)