• Functional analysis of COX-2 by structure-guided mutagenesis has uncovered new strategies for synthesizing COX-2 inhibitors and has suggested new biological roles for the enzyme. (vanderbilt.edu)
  • The enzyme cytosolic phospholipase A 2 alpha (cPLA 2 α) has been implicated in the progression of cerebral injury following ischemia and reperfusion. (biomedcentral.com)
  • cPLA 2 α-derived arachidonic acid is also tightly coupled to the 5-lipoxygenase enzyme [ 16 ] and in the gerbil model of global cerebral ischemia 15 minutes of reperfusion caused translocation of 5-LO to the neuron membranes and resulted in increased levels of leukotriene C 4 [ 17 ]. (biomedcentral.com)
  • This enzyme catalyzes the committed step in the production of prostaglandins and is the molecular target for non-steroidal antiinflammatory drugs. (vanderbilt.edu)