• renal
  • We characterized the inhibitory activity of several acetylenic and olefinic compounds on cytochrome P450 (CYP)-derived arachidonic acid ω-hydroxylation and epoxidation using rat renal cortical microsomes and recombinant CYP proteins. (aspetjournals.org)
  • These studies provide information useful for evaluating the role of the CYP-derived arachidonic acid metabolites in the regulation of renal function and blood pressure. (aspetjournals.org)
  • The potential role of the CYP-derived arachidonic acid metabolites in the regulation of renal function and in hypertension has been documented in numerous studies. (aspetjournals.org)
  • Since the kidneys were nonfiltering, the increase of renal blood flow during infusion of arachidonic acid cannot be explained by prostaglandins being transported from renal medulla to the cortex through renal tubules. (ahajournals.org)