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MicrospheresPolyglycolic AcidDelayed-Action PreparationsParticle SizeDrug CarriersDrug CompoundingLactic AcidPolymersChitosanChemistry, PharmaceuticalDrug Delivery SystemsHolmiumMicroscopy, Electron, ScanningTechnology, PharmaceuticalGelatinHexuronic AcidsGlucuronic AcidPolyvinyl AlcoholPolystyrenesYttrium RadioisotopesCapsulesAlginatesBiocompatible MaterialsRegional Blood FlowScandiumCoronary CirculationDogsPolymethacrylic AcidsExcipientsCerium RadioisotopesSurface PropertiesTechnetium Tc 99m Aggregated AlbuminEmulsionsRadioisotopesAbsorbable ImplantsPolyglactin 910PorosityStrontium RadioisotopesIridoid GlycosidesSolubilityPolyestersAcrylic ResinsArteriovenous AnastomosisHydrogelSuspensionsBiodegradation, EnvironmentalHepatic ArteryAcrylatesSerum Albumin, BovineMagneticsHemodynamicsEmbolization, TherapeuticTin RadioisotopesGlassInjectionsRabbitsTablets, Enteric-CoatedPulmonary CirculationHydrogelsCollateral CirculationSpectroscopy, Fourier Transform InfraredMethylcelluloseOilsInjections, Intra-ArterialPancreatinStaphylococcal ToxoidCerium IsotopesGlycolatesDurapatiteDiffusionPolyethylene Glycols
Carboxylate MicrospheresSuspensionsDispersionParticlesLipid microspheresMagnetic microspheresPolyethylene microspheresMonodisperseSuspensionProteinsSurfactantPolymersDiameterPolymericFormulationPolybeadDensity marker beadsPreparationStabilityInjectableParticle sizeConcentrationsPolymer basedLiposomesPLGASilicaVitroSurfaceSolutionEvaporation techniqueTechniqueFormulationsBehaviorEmulsion-solventPowderSurfacesRADIESSEHighSuccessfullySolutionsCollagenAdditivesAcidSustained releaseFluorescentPatient complianceMethodStableChemicalYieldFormationPotentialSmallTechnology
Carboxylate Microspheres2
Suspensions6
Dispersion7
  • In addition, their size and distribution can be controlled by the dispersion manner of precursors into aqueous solution of ammonia . (rsc.org)
  • The fluorescent melamine resin particles are prepared by dispersion polycondensation in aqueous solution in the presence of various fluorophores, using melamine resin precursor and acid as catalyst. (selfgrowth.com)
  • These DiagPoly™ Plain Melamine Resin Microspheres are produced by a dispersion polycondensation reaction in aqueous solution using melamine resin precursors and acid as a catalyst. (selfgrowth.com)
  • The relative bioavailability of MTX-NS was found to be 8.83 times higher than that of MTX-aqueous dispersion. (pimac.org)
  • Most of drugs which are weakly acidic and basic show poor aqueous solubility hence various methods like, salt formation, co-solvency, micronization, addition of agent, solid dispersion, complexation etc., are some of the vital approaches routinely employed to enhance the solubility of poorly soluble drugs. (scialert.net)
  • Dispersion in both aqueous media or air are possible without degradation of their fluorescent properties. (meritics.com)
  • Microsphere drug delivery systems have been formulated by various techniques, including phase separation or precipitation, emulsion/solvent evaporation, and spraying, melt congeal /dispersion technique 7 . (ijpsr.com)
Particles4
  • Everything about microspheres and research utilizing precision spherical particles. (microspheres.us)
  • Rice-type microspheres have uniform particles with a diameter of 3-5μm. (dermaxmed.com)
  • Applied Microspheres can offer many batches of particles with a wide variety of diameters, that can be custom dyed with different fluorescent colours and intensity levels as required. (meritics.com)
  • Brownian particles suspended in water or other polar liquids are pushed out of the region next to hydrophilic polymers, leaving a microsphere-free region known as the "exclusion zone" (EZ). (pollacklab.org)
Lipid microspheres2
  • This work aimed to design a controlled-release drug-delivery system for lipid microspheres of Verapamil hydrochloride that would retain the drug in the stomach and continuously release the drug in a controlled manner up to a predetermined time. (ijpsr.com)
  • Lipid microspheres were prepared by using a melt solidification method. (ijpsr.com)
Magnetic microspheres1
  • The first section of this study involves the modification of SPIONs to obtain adequate stability of SPIONs in suspension and suitable interaction between hydrophobic PHBV solution and the surfaces of SPIONs during preparation of magnetic microspheres, which is presented in the second part of the study. (nature.com)
Polyethylene microspheres1
Monodisperse2
Suspension5
  • They reported that these magnetic biopolymer microspheres could exhibit significant effect on magnetic contrast capability suitable for MRI application, demonstrating that the microspheres could be suitable also as drug delivery vehicles, in addition, such PHBV/SPION microspheres exhibited biocompatibility towards human T-lymphoma suspension cells and adherent colon carcinoma HT-29 cells. (nature.com)
  • Both the comb polymer and its homopolymer analog were synthesized and analyzed leading to the discovery that comb polymer-coated silicamicrospheres (green) remain stable over a broad range of solution conditions, whereas pure homopolymer-coated silica microspheres (red) rapidly fall out of suspension. (rpi.edu)
  • Let's look at three scenarios: (1) suspension of microspheres in a specific fluid, (2) fluid flow, performing flow visualizations, or particle image velocimetry, and (3) simulation or modeling of objects with specific density. (microspheres.us)
  • Supplied as 1% aqueous suspension. (gentaur.shop)
  • Most Polybead® Microspheres are packaged in an economical 2.5% solids (w/v) aqueous suspension with minimal surfactant in the final preparation. (parkscientific.com)
Proteins2
  • Microspheres for Proteins & Peptides. (routledge.com)
  • Microspheres can encapsulate many drugs, including small molecules, proteins, and nucleic acids, and are easily administered through a syringe needle. (ijpsr.com)
Surfactant3
  • Melamine resin microspheres are produced by acid-catalyzed hydrothermal polycondensation of methylol melamine in the temperature range of 70-100°C , without any surfactant. (selfgrowth.com)
  • Emulsification is one such method, whereby polymerisation of a mixture of monomers is induced in an aqueous surfactant containing an initiator. (manufacturingchemist.com)
  • They can also be suspended in aqueous solution if coated with a surfactant prior to suspending in water. (cospheric.com)
Polymers2
Diameter2
  • Based on this approach, the size of the W/O microspheres can be successfully controlled from 16 μm to 35 μm in diameter within about 5% of variation. (asme.org)
  • The present method has advantages such as good sphericity, few satellite droplets, active control of the microsphere diameter, and high throughput with the simple and low cost process. (asme.org)
Polymeric3
  • Polymeric microspheres are a key component of the push towards high potency therapeutics with controlled release capabilities. (manufacturingchemist.com)
  • Polymeric microsphere formulation involves a choice of methods, including evaporation, coacervation and spray drying. (manufacturingchemist.com)
  • With over 35 years experience, Estapor® Microspheres is a leading brand of polymeric supports for in vitro diagnostics, life sciences, biotechnology, cosmetics, electronics and environment applications. (merckmillipore.com)
Formulation12
  • The objective of this Statement of Need (SON) was to develop an alternative formulation for use in Department of Defense (DoD) Class B (flammable liquid) fire-suppression operations in lieu of Aqueous Film Forming Foam (AFFF) in accordance with Interim Amendment 3 of MIL-F-24385F. (serdp-estcp.org)
  • Novel approaches to product formulation incorporating microsphere technology may improve treatment tolerability, encourage adherence, and contribute to better long-term therapeutic outcomes. (jcadonline.com)
  • Given the extraordinary potential of microspheres as drug delivery systems (DDS) with far-reaching applicability, it should come as no surprise that various formulation methods have arisen over time. (manufacturingchemist.com)
  • So, how does microsphere formulation work? (manufacturingchemist.com)
  • Although there are many methods of microsphere formulation, PSL will outline several common methods, to give an overview of some common techniques. (manufacturingchemist.com)
  • The solvent evaporation technique is perhaps the most common method of microsphere formulation, as it is a relatively simple process. (manufacturingchemist.com)
  • Coacervation, or phase separation, is another common technique used in microsphere formulation. (manufacturingchemist.com)
  • A third method of microsphere formulation is the spray drying technique, where a solvent containing the dissolved polymer is atomised using high pressure. (manufacturingchemist.com)
  • However, a certain degree of processing will always be required following initial microsphere formulation. (manufacturingchemist.com)
  • Microspheres - Essential Components in Cosmetic Formulations Microspheres in cosmetics have become an appealing and essential aspect of the industry, considerably improving the formulation and efficacy of a variety of beauty and skincare products. (microspheres.us)
  • The microsphere formulation method is a governing factor in the encapsulation and release of therapeutics. (ijpsr.com)
  • In addition, difficult factors including the type of lipids, the lipids molecular weight, the nature of any excipients added to the microsphere formulation and the microsphere size, can strongly impact the delivery rates 6 . (ijpsr.com)
Polybead1
Density marker beads1
  • These spheres are also available in aqueous solution as Density Marker Beads . (cospheric.com)
Preparation3
  • Microsphere Preparation: What Happens Next? (manufacturingchemist.com)
  • Traditionally, after preparation, microsphere production transitions to downstream processing where the product is harvested. (manufacturingchemist.com)
  • The principle of lipid microsphere preparation offers a simple and practical approach to achieve increased gastric residence time for the dosage form and controlled drug release 8 . (ijpsr.com)
Stability1
  • Circular Dichroism and SDS-PAGE analysis indicated good stability and structural integrity of hCG in the microspheres. (pimac.org)
Injectable2
  • Comprehensive release studies on biocompatible, depot injectable microspheres have demonstrated their bioavailability and sustained release capacity over long periods. (manufacturingchemist.com)
  • RADIESSE® is an injectable filler made of hydroxylapatite microspheres suspended in an aqueous gel solution. (ivogwanmesia.com)
Particle size2
  • Cisplatin-loaded chitosan microspheres were prepared by emulsification and ionotropic gelation method, and characterized for drug content, particle size, densities, flow properties, moisture content, and surface topography by SEM and in vitro drug release was evaluated in simulated lung fluid at 37 0 at pH 7.4. (ijpsonline.com)
  • Molecular interactions between the various components underlie critical properties in microsphere formation, including particle size and size distribution. (manufacturingchemist.com)
Concentrations3
  • When present in certain concentrations in aqueous solutions, proteinoids form small microspheres. (wikipedia.org)
  • It was revealed that the magnetic PHBV microspheres were non-toxic when assessed with mouse embryotic fibroblast cells (MEF) at different concentrations of microspheres. (nature.com)
  • Microsphere technology eliminates the rapid delivery of high concentrations of active drug to the application site and instead facilitates controlled release of potentially irritating drugs. (jcadonline.com)
Polymer based2
  • To achieve the promising results, this integrating method reveals high potential for production of polymer based microspheres. (asme.org)
  • Controlled-release drug delivery employs devices such as polymer-based disks, rods, pellets, or microspheres - that encapsulates the drug and release it at controlled rates. (ijpsr.com)
Liposomes1
  • Delivery platforms such as microspheres, liposomes, complexes with cyclodextrins, and conjugation with macromolecules have been explored for inhalational application [8]. (ijpsonline.com)
PLGA3
  • The long-acting PLGA depot microspheres (MS) approach with hCG can improve patient compliance, increase the efficacy of hCG with a lower total dose and improve quality of life. (pimac.org)
  • The aim of this work was therefore to develop, formulate and optimize sustained release triptolide microspheres with poly (lactide-co-glycolide) (PLGA). (bvsalud.org)
  • Triptolide-loaded microspheres were prepared using PLGA as the matrix polymer, dichloromethane as the oil phase, and polyvinyl alcohol (PVA) as the matrix forming emulsifier. (bvsalud.org)
Silica1
  • The framework components indicated the presence of silica and polymethylsilsesquioxane, and polymethylsilsesquioxane was distributed on the surface of the microspheres. (rsc.org)
Vitro2
  • The prepared microspheres exhibited a sustained release profile of triptolide in vitro over 4 weeks, which was wellfitted with a Korsmeyer-Peppas equation. (bvsalud.org)
  • In most cases, good in vitro microsphere behavior was observed, and a broad variety of drug release patterns could be achieved by variation of the drug-lipid ratio. (ijpsr.com)
Surface2
Solution3
  • tration of cyanuric chloride solution in the probe activation step to achieve a more complete and efficient coupling of Accurately detecting and identifying biological warfare DNA probes to microspheres. (cdc.gov)
  • The Microsphere Refiner (MSR) is an innovative, automated solution with predictive scale-up to the kilogram level with a high product yield. (manufacturingchemist.com)
  • Any drug to be absorbed must be present in the form of an aqueous solution at the site of absorption. (scialert.net)
Evaporation technique1
  • An oil-in-water (O/W) emulsion solvent evaporation technique was utilized to prepare the microspheres. (bvsalud.org)
Technique1
  • This work describes a novel microfluidic method to generate uniform water-in-oil (W/O) microspheres using the phase separation technique. (asme.org)
Formulations1
  • Microsphere formulations of topical tretinoin and benzoyl peroxide currently on the market have demonstrated good efficacy and tolerability and are expected to encourage adherence and long-term therapeutic benefit. (jcadonline.com)
Behavior1
Emulsion-solvent2
  • In this work, the solid-in-oil-in-water (S/O/W) emulsion-solvent extraction/evaporation method was utilized to fabricate magnetic polymer microspheres incorporating SPIONs in PHBV. (nature.com)
  • In this study, the production of PHBV microspheres with modified SPIONs was chosen via emulsion-solvent extraction/evaporation method. (nature.com)
Powder2
  • In the present study, chitosan-loaded cisplatin microspheres were prepared and evaluated for dry powder inhalation delivery of cisplatin for local action of the drug in lungs, and thereby achieve improved therapy in lung cancer. (ijpsonline.com)
  • Bright fluorescent orange microspheres are supplied in dry powder form. (cospheric.com)
Surfaces2
  • The curved surfaces were obtained as tapers and microspheres fabricated from optical fibers and were coated with a nm-thick layer of the polycation polyallylamine hydrochloride, causing irreversible adsorption of the negatively charged spheres. (cdc.gov)
  • EZs were created in aqueous media using Nafion tubes as EZ-nucleating surfaces. (pollacklab.org)
RADIESSE1
High3
  • We developed a fiber-optic, microsphere-based, high- racy, the performance of this multiplexed, high-density density array composed of 18 species-specific probe array was assessed by examining the detection limits and microsensors to identify biological warfare agents. (cdc.gov)
  • However, the initial drug release (~14%) of triptolide-loaded microspheres was very high and should be specifically investigated in future studies. (bvsalud.org)
  • Heterostructured bimetallic-sulfide@ layered Ti3C2Tx-MXene as a synergistic electrode to realize high-energy-density aqueous hybrid-supercapacitor. (lzu.edu.cn)
Successfully1
Solutions2
  • one of them, amidinium carbodiimide, is formed in primitive Earth experiments and is effective in dilute aqueous solutions. (wikipedia.org)
  • Aqueous solutions of chitosan and cisplatin (in 0.5% w/v acetic acid) were emulsified in oil phase (100-200 ml) consisting of dichloromethane and light liquid paraffin using homogenizer (Silverson, India) for 15 min. (ijpsonline.com)
Collagen2
Additives1
  • Carbon Microspheres (CMS) have great potential as additives for enhancing the performance of base lubricants. (aiche.org)
Acid1
  • The presence of functional groups of lauric acid, oleic acid and iron oxide in the PHBV microspheres was confirmed by Fourier Transform Infrared spectroscopy (FTIR). (nature.com)
Sustained release1
  • Toxicology & Biocompatibility Evaluation of Microsphere & Liposome Sustained-Release Delivery Systems. (routledge.com)
Fluorescent2
  • The fluorescent microspheres can be detected with a flow cytometer, epifluorescence microscope, confocal microscope, fluorescence spectrophotometer, amongst others. (meritics.com)
  • For some applications, the polymer microspheres can be dissolved and the fluorescent dyes measured directly. (meritics.com)
Patient compliance1
  • Microspheres drug delivery system have improved patient compliance, decreased toxicity, and increased efficacy. (ijpsr.com)
Method4
  • Microspheres were prepared by emulsificationionotropic gelation and heat crosslinking method as shown in fig. 1 . (ijpsonline.com)
  • Though this method is relatively easy to upscale, it is difficult to achieve the tight levels of polydispersity needed for pharmaceutical grade microspheres, requiring time-consuming post processing (sieving, washing, etc. (manufacturingchemist.com)
  • The integration of hydrodynamic flow focusing method and crossflow method is realized in a microfluidic device with oil phase and aqueous phase. (asme.org)
  • By the hydrodynamic flow focusing method, the width of the dispersed focused aqueous phase is controlled. (asme.org)
Stable1
  • The drug in microspheres was found to be stable and compatible with waxes, as confirmed by DSC and FTIR methods. (ijpsr.com)
Chemical1
  • citation needed] Fox thought that the microspheres may have provided a cell compartment within which organic molecules could have become concentrated and protected from the outside environment during the process of chemical evolution. (wikipedia.org)
Yield1
  • The mixing ratio of lipids with drug affected the size, size distribution, Yield, drug content, and drug release of microspheres. (ijpsr.com)
Formation1
  • While the probes were selected to avoid the trast, the fiber-optic, microsphere-based, multiplexed formation of secondary structures, such structures were not arrays described in this paper can rapidly screen and simul- completely eliminated and probably affected the hybridiza- taneously identify multiple potential BWAs, enabling an tion efficiency, resulting in higher detection limits for some efficient response to a bioterrorism attack. (cdc.gov)
Potential1
  • These results confirmed that the fabricated magnetic PHBV microspheres are potential candidates for use in biomedical applications. (nature.com)
Small1
  • Applied Microspheres' unique technology ensures exceptionally small fluorescence C.V.'s. (meritics.com)
Technology1