Lipid formulationsSolubilityUnilamellar vesiclesLiposomalSurfactantsPhysicochemical propertiesBioavailabilityAntifungalCaspofunginDeoxycholateNanoparticlesLiquid formulationsEfficacyToxicityCompoundsExtractsIntolerant2020SodiumPharmaceuticalShelf LifeSolutionFewerDrugsSolutionsTreatmentDevelopEnvironmentSide effectsReleasePrimary
Lipid formulations3
- In order to improve the tolerability of amphotericin and reduce toxicity, several lipid formulations have been developed. (wikipedia.org)
- Less commonly used than the lipid formulations because of higher rates of nephrotoxicity but less costly and more widely available. (medscape.com)
- Treatment of invasive aspergillosis in patients who are refractory to or intolerant of other therapies (e.g., amphotericin B, lipid formulations of amphotericin B, itraconazole). (wikidoc.org)
Solubility14
- The original formulation uses sodium deoxycholate to improve solubility. (wikipedia.org)
- The amphipathic nature of amphotericin along with its low solubility and permeability has posed major hurdles for oral administration given its low bioavailability. (wikipedia.org)
- Aqueous Solubility, pKa and Log P measurements were done following literature methods of poorly soluble drugs. (ac.ke)
- The compounds under test exhibited low aqueous solubility as all were below 65 μg/ml. (ac.ke)
- According to literature most drugs that are orally active have xvi aqueous solubility greater than 65 μg/ml but when the solubility is 20 μg/ml or less as was the case here, the probability of useful oral activity is very low. (ac.ke)
- However, the challenge for oral and topical formulation of this drug is its poor aqueous solubility which will lead to low bioavailability. (ac.ke)
- Amphotericin B (AMB) is a polyene antibiotic with broad spectrum antifungal activity, but its clinical toxicities and poor solubility limit the wide application of AMB in clinical practice. (dovepress.com)
- In recent years, approximately 70% of new drugs candidate and 40% of marketed new drugs in oral immediate release dosage form exhibits low aqueous solubility. (ijpsr.com)
- The most challenging task in development of a formulation is the solubility of drug, availability at the site of action and stability of drug. (scialert.net)
- Aqueous solubility of any therapeutically active substance is a key property as it governs dissolution, absorption and thus the in vivo efficacy. (scialert.net)
- Drug efficacy can be severely limited by poor aqueous solubility and some drugs also show side effects due to their poor solubility. (scialert.net)
- Therefore, drug release profiles are exhibited by such formulations for poorly soluble drugs to improve the solubility of such poorly soluble drugs. (scialert.net)
- Most of drugs which are weakly acidic and basic show poor aqueous solubility hence various methods like, salt formation, co-solvency, micronization, addition of agent, solid dispersion, complexation etc., are some of the vital approaches routinely employed to enhance the solubility of poorly soluble drugs. (scialert.net)
- This article reviews various methods used for improving the solubility of hydrophobic drugs and improve the drug release profiles which are exhibited by such formulations for poorly soluble drugs. (scialert.net)
Unilamellar vesicles2
- AmBisome (LAMB) is a liposomal formulation of amphotericin B for injection and consists of a mixture of phosphatidylcholine, cholesterol and distearoyl phosphatidylglycerol that in aqueous media spontaneously arrange into unilamellar vesicles that contain amphotericin B. It was developed by NeXstar Pharmaceuticals (acquired by Gilead Sciences in 1999). (wikipedia.org)
- Consists of a mixture of phosphatidylcholine, cholesterol, and distearoyl phosphatidylglycerol that arrange into amphotericin B-containing unilamellar vesicles in aqueous media. (medscape.com)
Liposomal2
- Liposomal formulations have been found to have less renal toxicity than deoxycholate, and fewer infusion-related reactions. (wikipedia.org)
- This is an alternate therapy to liposomal amphotericin B. (medscape.com)
Surfactants2
- The strong alkaline mixture of non-ionic surfactants and amphotericin in an aqueous solution that incorporates a sequestrant for effectiveness in hard water makes Biosolve an efficient remover for manure, grease, fat, dirt, etc. (nexles.com)
- They are composed of cholesterol and non-ionic surfactants in aqueous media. (pakiscience.pk)
Physicochemical properties2
- Materials and methods: We studied the physicochemical properties of aqueous extracts of leaves (fresh) and flowers (fresh and dry) of Sambucus nigra L collected from the Rhodope region of Bulgaria. (researchgate.net)
- It is a challenging task for pharmaceutical researchers and industry to develop a suitable formulation with improved physicochemical properties. (jrpsjournal.com)
Bioavailability3
- Therefore, several formulations have been devised to improve its intravenous bioavailability. (wikipedia.org)
- However, all formulations require parenteral administration because AmB has low oral bioavailability (0.2-0.9%) due to the precipitation of drug in aqueous media. (strath.ac.uk)
- Thus, one of the greatest challenges the pharmaceutical industries faces today is the application of technological strategies towards improving the dissolution performance of drugs, producing formulations with adequate bioavailability and therapeutic effectiveness. (ijpsr.com)
Antifungal3
- Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. (wikipedia.org)
- The 2 main classes of antifungal medications used to treat mucormycosis are the polyenes (amphotericin formulations) and triazoles (isavuconazole and posaconazole). (medscape.com)
- In the in vivo experiment, SE was effective in the treatment of infection after only two days of treatment and was more effective than E and amphotericin B. The S. nitens is active against Candida albicans (C. albicans) and the antifungal potential is being enhanced after incorporation into liquid crystal precursor systems (LCPS). (who.int)
Caspofungin1
- The pH of a saturated aqueous solution of caspofungin acetate is approximately 6.6. (theodora.com)
Deoxycholate3
- Amphotericin B deoxycholate (ABD) is administered intravenously. (wikipedia.org)
- They are more expensive than amphotericin B deoxycholate. (wikipedia.org)
- Owing to decreased risk of nephrotoxicity at this dose, it can be used in the setting of preexisting renal dysfunction and when nephrotoxicity develops during amphotericin B deoxycholate therapy. (medscape.com)
Nanoparticles2
- However, recently novel nanoparticulate drug delivery systems such as AmbiOnp, nanosuspensions, lipid-based drug delivery systems including cochleates, self-emulsifying drug delivery systems, solid lipid nanoparticles and polymeric nanoparticles-such as Amphotericin B in pegylated polylactide coglycolide copolymer nanoparticles-have demonstrated potential for oral formulation of amphotericin B. Amphotericin B is well known for its severe and potentially lethal side effects. (wikipedia.org)
- 13] D. Maity, D.C. Agrawal, Synthesis of iron oxide nanoparticles under oxidizing environment and their stabilization in aqueous and non-aqueous media, J. Magn. (mrforum.com)
Liquid formulations1
- For liquid formulations, reduction of the dielectric constant of the vehicle by the addition of nonaqueous cosolvents such as alcohol, glyc-erin, and propylene glycol may reduce hydrolysis. (pharmacy180.com)
Efficacy2
- These vaccines exhibit a number of advantages over conventional vaccines that are based on proteins in terms of efficacy, safety, ease of formulation, scale up ability and cost. (pakiscience.pk)
- According to http://en.wikipedia.org/wiki/Imatinib, Imatinib was developed in the late 1990s by biochemist Nicholas Lydon, a former researcher for Novartis, oncologist Brian Druker of Oregon Health and Science University (OHSU), and Charles Sawyers of Memorial Sloan-Kettering Cancer Center, who led the clinical trials confirming its efficacy in CML. (medkoo.com)
Toxicity1
- The most widely used secondary treatment is amphotericin B which is highly active but has extensive toxicity complications with the newer formulations being too expensive for use by the majority of endemic countries. (ac.ke)
Compounds1
- The decomposition of these compounds in aqueous solution is catalyzed by hydrogen ion, solvent, hydroxide ion, and sugars. (pharmacy180.com)
Extracts1
- [10] In this study, the aqueous extracts from Sambucus nigra L. demonstrated a notable inhibition of Salmonella (7 mm). (researchgate.net)
Intolerant1
- Posaconazole can be used off-label for salvage treatment in patients intolerant to amphotericin B. It has also been used as step-down therapy after initial control of the disease with amphotericin. (medscape.com)
20201
- The 1st International Electronic Conference on Pharmaceutics (IECP 2020) brings together experts from academia and industry to share new ideas, technologies, and innovations in the broad areas of pharmaceutical formulation, process development, drug delivery, pharmacokinetics, and biopharmaceutics. (mdpi.com)
Sodium3
- Amphotec is a complex of amphotericin and sodium cholesteryl sulfate in a 1:1 ratio. (wikipedia.org)
- Each 5 mL (teaspoonful) of Millipred Oral Solution contains 13.4 mg prednisolone sodium phosphate (10 mg prednisolone base) in a palatable, aqueous vehicle. (drugs.com)
- Betamethasone Sodium Phosphate and Betamethasone Acetate Injectable Suspension is a sterile aqueous suspension containing 3 mg per milliliter betamethasone (equivalent to 3.95 mg betamethasone sodium phosphate USP) and 3 mg per milliliter betamethasone acetate. (nih.gov)
Pharmaceutical1
- Water is the solvent of choice for liquid pharmaceutical formulations. (scialert.net)
Shelf Life1
- For solid formulations, minimizing the exposure of the drug product to moisture during manufacture and shelf life storage can minimize hydrolytic drug degradation. (pharmacy180.com)
Solution1
- Any drug to be absorbed must be present in the form of an aqueous solution at the site of absorption. (scialert.net)
Fewer1
- Lipid-based formulations of amphotericin B are no more effective than conventional formulations, although there is some evidence that lipid-based formulations may be better tolerated by patients and may have fewer adverse effects. (wikipedia.org)
Drugs2
- Amphotericin B and Pentostam were used as standard drugs in in vitro evaluation of anti-leishmania activity. (ac.ke)
- Diblock copolymers composed of hydrophilic and hydrophobic blocks with variable lengths can encapsulate hydrophobic drugs in the core of the nanomicelle and/or attach hydrophilic drugs on the surface in the aqueous medium ( 25 ). (brieflands.com)
Solutions2
- Aim: The present article aims to study and compare the antioxidant activity of aqueous solutions of leaves and flowers of Sambucus nigra L obtained at different exposure times and assess the antibacterial activity of these solutions against Escherichia coli ATCC 8739, Salmonella NCTC 6017, Listeria monocytogenes NCTC 11994, and Staphylococcus aureus ATCC 25093. (researchgate.net)
- For exam-ple, the addition of caffeine to the aqueous solutions of benzocaine, procaine, and tetracaine was shown to decrease their base-catalyzed hydrolysis. (pharmacy180.com)
Treatment2
- There is no current evidence-based recommendation for the addition of an echinocandin to amphotericin B or isavuconazole for the treatment of mucormycosis. (medscape.com)
- Amphotericin B is one such drug used for the treatment of fungal infections. (pakiscience.pk)
Develop1
- My research is focused on the application of novel analytical and formulation strategies to develop new medicines and biomedical devices, primarily via 3D printing, and in particular with colleagues in Additive Manufacturing in the Faculty of Engineering and a number of industrial collaborators. (nottingham.ac.uk)
Environment1
- This is because amphotericin B resistance requires sacrifices on the part of the pathogen that make it susceptible to the host environment, and too weak to cause infection. (wikipedia.org)
Side effects1
- There is a lipid formulation that has a lower risk of side effects. (wikipedia.org)
Release2
- Extrusion 3D Printing of Paracetamol Tablets from a Single Formulation with Tunable Release Profiles Through Control of Tablet Geometry. (nottingham.ac.uk)
- A Reactive Prodrug Ink Formulation Strategy for Inkjet 3D Printing of Controlled Release Dosage Forms and Implants Advanced Therapeutics. (nottingham.ac.uk)
Primary2
- Amphotericin B is used for life-threatening protozoan infections such as visceral leishmaniasis and primary amoebic meningoencephalitis. (wikipedia.org)
- Amphotericin B and isavuconazole are the 2 agents currently FDA approved for the primary therapy of mucormycosis. (medscape.com)