• aquaporins
  • A limited number of aquaporins are found within the central nervous system (CNS): AQP1, 3, 4, 5, 8, 9, and 11, but more exclusive representation of AQP1, 4, and 9 are found in the brain and spinal cord. (wikipedia.org)
  • renal
  • siRNA directed to candidate genes, including p53, has prevented multiple forms of acute kidney injury (AKI) and renal fibrosis in animal models [ 10 - 14 ]. (hindawi.com)
  • Although megalin has an extended half-life [ 25 ], other investigators have succeeded in providing serial daily or twice weekly administration of siRNA to reduce renal expression of other genes and proteins [ 11 - 13 ]. (hindawi.com)
  • AQP2
  • AQP1 is expressed in apical and basolateral membranes of proximal tubules and descending limbs of Henle, AQP2 predominantly in apical membranes of principal and inner medullary collecting duct cells and AQP3 in basolateral membranes of kidney collecting duct cells. (springer.com)
  • Mutations in the AQP2 gene were shown to cause autosomal recessive nephrogenic diabetes insipidus. (springer.com)
  • human
  • The candidate gene approach is used to study genes that are hypothesized to play a role in the etiology of a complex human disease with genetic contributions. (molvis.org)
  • We cloned promoter regions of CDC6, POLD1, CKS1B, MCM2, and PLK1 genes into pGL3 reporter vector and studied their ability to drive heterologous gene expression in transfected cancer cells of different origin and in normal human fibroblasts. (ibch.ru)
  • Differences in gene expression levels between early and later stages of human lung development are opposite to those between normal lung tissue and non-small lung cell carcinoma. (ibch.ru)
  • We, for the first time, directly compared gene expression profiles in human non-small cell lung carcinomas (NSCLCs) and in human fetal lung development. (ibch.ru)
  • Previously reported correlations of gene expression profiles between lung cancer and lung development, deduced from matching data on mouse development and human cancer, have brought important information, but suffered from different timing of mouse and human gene expression during fetal development and fundamental differences in tumorigenesis in mice and humans. (ibch.ru)
  • The human Rh50 glycoprotein gene. (wikipedia.org)
  • proximal
  • In both constructs, only the promoter proximal to the transcribed gene retained its ability to initiate transcription, whereas the distal promoter was silent, the phenomenon never reported before. (ibch.ru)
  • Kidney
  • 0.5 ug/mL of PAB28849 was sufficient for detection of Aqp1, ~28.5kDa and somtimes larger glycosylated bands ~35-50kDa, in 10ug of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody. (abnova.com)
  • Immunofluorescence staining of Aqp1 in rat kidney with Aqp1 polyclonal antibody (Cat # PAB28838) at 1:200 dilution, DAPI merged. (abnova.com)
  • expression
  • Cohen DM, Wasserman JC, Gullans SR (1991) Immediate early gene and HSP70 expression in hyperosmotic stress in MDCK cells. (springer.com)
  • In surgical samples of NSCLC, these genes were down-regulated as compared to surrounding normal tissues and normal lungs, thus demonstrating opposite expression profiles for the genes up-regulated during fetal lung development. (ibch.ru)
  • control
  • Eleven tagging single nucleotide polymorphisms (SNPs) for AQP1 and SLC4A10 were genotyped in the POAG and control subjects, using allelic discrimination assays. (molvis.org)
  • however, these reductions are relative to a scrambled control condition in the setting of gene upregulation. (hindawi.com)
  • We put forward the hypothesis that promoters of genes involved in the control of cell proliferation should possess intrinsic cancer specific activity. (ibch.ru)
  • project
  • "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (tcdb.org)
  • shown
  • Both versions of CDC6 promoters were shown to be most active while the activities of others were close to that of BIRC5 gene (survivin) gene promoter. (ibch.ru)