• Using a treatment and sex interaction model, 13 and 4 differentially expressed genes were identified in liver and muscle respectively. (biomedcentral.com)
  • Multiple miRNA-mRNA prediction databases were searched by differentially expressed genes (DEGs) to obtain pairs of a miRNA-DEG regulatory network. (frontiersin.org)
  • ncRNAs with more than 200 nucleotides are considered as lncRNAs, which originate from intronic and exonic regions of protein-coding genes in both sense and antisense strands, as well as from the intergenic regions [ 21 ]. (biomedcentral.com)
  • Among 82 newly discovered breast-cancer-related miRNAs, 35 can potentially regulate 271 protein-coding genes based on their sequence complementarity and expression profiles. (biomedcentral.com)
  • In addition to numerous protein-coding genes, many microRNAs (miRNAs) also play important roles in breast cancer. (biomedcentral.com)
  • One of the most exciting areas of innovation is Cell and Gene Therapy, with many therapies already changing the industry and patients' lives. (accenture.com)
  • Patents are thought to be critical in encouraging pharmaceutical companies to develop and commercialize new therapies, due to the high costs of researching diseases, developing treatments, and bringing drugs through the complex, expensive approval process. (bepress.com)
  • In this course, we'll discuss ophthalmic drug delivery, cell and gene therapies, and conditions such as diabetic retinopathy, age-related macular degeneration, and glaucoma and help you shape the future of ophthalmology. (smgconferences.com)
  • Advanced therapies, including cell and gene therapies, have shown therapeutic promise in curing life-threatening diseases, such as leukemia and lymphoma. (researchprotocols.org)
  • Objectives are to define the requirements and perform feasibility evaluations on the use of blockchain for standardized manufacturing and establishment of a chain of custody for the needle-to-needle delivery of autologous cell and gene therapies. (researchprotocols.org)
  • Gene therapies for rare diseases are under threat. (cdc.gov)
  • From the article: 'In the past two years, two gene therapies have been withdrawn from the European market for business reasons after earning regulators' approval. (cdc.gov)
  • Concern is mounting that other gene therapies for rare diseases will meet a similar fate, as might upcoming treatments that rely on the related technique of genome editing, which makes targeted DNA changes. (cdc.gov)
  • Realising the potential of gene therapies for rare and ultra-rare inherited diseases. (cdc.gov)
  • However, despite promising results across a range of rare diseases, transformative gene therapies may not be available and accessible to patients for non-medical reasons. (cdc.gov)
  • Here, we propose BRANEnet , a novel multi-omics integration framework for multilayer heterogeneous networks. (biomedcentral.com)
  • Heterogeneous gene expressions of cells are widely observed in self-renewing pluripotent stem cells, suggesting possible coexistence of multiple cellular states with distinct characteristics. (biomedcentral.com)
  • In this paper, we propose a method, CSPRV, to improve the cancer subtype prediction by incorporating multi-sources transcriptome expression data and heterogeneous biological networks. (biomedcentral.com)
  • We extract multiple expression features of each genome element based on the regulatory associations in the heterogeneous biological networks and use a generalized matrix correlation method ( RV 2 ) to predict the similarities between samples in each view of expression data. (biomedcentral.com)
  • Herein, we used bioinformatic approaches to analyze the transcriptome datasets from two different accessions Viroflay and Kashan at two vegetative and reproductive stages to reveal novel lncRNAs and the construction of the lncRNA-mRNA co-expression network. (biomedcentral.com)
  • This study is the first report on identifying bolting and flowering-related lncRNAs based on transcriptome sequencing in spinach, which provides a useful resource for future functional genomics studies, genes expression researches, evaluating genes regulatory networks and molecular breeding programs in the regulation of the genetic mechanisms related to bolting in spinach. (biomedcentral.com)
  • However, the comparative transcriptome analysis of two spinach accessions with different bolting times identified genome-wide gene expression profiling and large-scale discovery of flowering-related genes from vegetative and reproductive leaves [ 13 ]. (biomedcentral.com)
  • The proposed method provides an open framework to incorporate transcriptome expression data and biological regulation network to predict cancer subtypes. (biomedcentral.com)
  • We find that prenatal development and postnatal maturation are characterized by a cooperation of active CpG methylation and histone marks at cis -regulatory and genic regions to shape the cardiac myocyte transcriptome. (nature.com)
  • Most cases of early-onset AD are linked to autosomal dominant inherited mutations in the genes encoding amyloid precursor protein ( APP ), presenilin 1 ( PSEN1 ), and presenilin 2 ( PSEN2 ). (biomedcentral.com)
  • Germline mutations in the NOTCH1 , NOTCH2 and NOTCH3 genes cause Adams-Oliver syndrome, Alagille syndrome and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, respectively ( 4 ), and DLL4-NOTCH3 signaling in human vascular organoids induces basement membrane thickening and drives vasculopathy in the diabetic microenvironment ( 5 ). (spandidos-publications.com)
  • We present a novel approach, the Local Edge Machine, for the inference of regulatory interactions directly from time-series gene expression data. (biomedcentral.com)
  • Temporally dynamic gene expression programs have been observed in a wide variety of organisms. (biomedcentral.com)
  • Indeed, the network inference problem persists in systems biology, despite an abundance of regulatory evidence in the form of TF binding experiments, genetic screens for candidate nodes, and mutant expression profiling experiments. (biomedcentral.com)
  • Beginning with time-series gene expression data, the Local Edge Machine (LEM) seeks to find functional network models capable of generating the dynamic behavior of the data (Fig. 1 ). (biomedcentral.com)
  • These relationships may reflect gene co-expression/regulation, protein-protein interactions (PPIs) or information about production or consumption of metabolites [ 14 ]. (biomedcentral.com)
  • Nutrigenomics investigations represent innovative approaches in understanding the relation between diet effect and gene expression related to the animal performance. (biomedcentral.com)
  • Few nutrigenomics studies have used a high-throughput RNA-Sequencing (RNA-Seq) approach, despite great potential of RNA-Seq data in gene expression quantification and in co-expression network analyses. (biomedcentral.com)
  • Our aim is to use the potential of RNA-Sequencing data in order to evaluate the effect of an EO supplementary diet on gene expression in both lamb liver and muscle. (biomedcentral.com)
  • Our study reveals a sex-dependent effect of EO diet in both tissues, and an influence on the expression of genes mainly involved in immune, inflammatory and stress pathway. (biomedcentral.com)
  • Gene co-expression networks are widely studied in the biomedical field, with algorithms such as WGCNA and lmQCM having been developed to detect co-expressed modules. (biomedcentral.com)
  • In this paper, we propose a novel module detection algorithm based on topology potential and spectral clustering algorithm to detect co-expressed modules in gene co-expression networks. (biomedcentral.com)
  • Moreover, this method is designed not only for gene co-expression networks but can also be applied to any general fully connected weighted network. (biomedcentral.com)
  • Among these biomedical networks, gene co-expression network is one of the most widely studied. (biomedcentral.com)
  • Gene co-expression networks are constructed by gene expression profiles and in which each gene is represented by a node and the relationship between a pair of gene is represented by a connected edge. (biomedcentral.com)
  • The strength of the relationship between genes is usually quantified by the correlation between the expression of two genes. (biomedcentral.com)
  • Gene co-expression networks are divided into weighted and unweighted networks. (biomedcentral.com)
  • An unweighted gene co-expression network is a traditional binary network, which only keeps relationships between genes above a specified cutoff, while a weighted network is a fully connected network and keeps all relationships as a continuous measurement. (biomedcentral.com)
  • Because setting a cutoff will cause the information loss, weighted gene co-expression networks are commonly used in biomedical analysis [ 12 ]. (biomedcentral.com)
  • To get biologically relevant information, it is necessary to perform module (or community) detection in gene co-expression networks. (biomedcentral.com)
  • Unfortunately, the existing WGCNA and lmQCM can only detect gene co-expression modules without the ability to incorporate such prior knowledge. (biomedcentral.com)
  • MicroRNAs (miRNAs) are small non-coding RNA molecules of about 22 nucleotides which function to silence the expression of their target genes. (biomedcentral.com)
  • Only a few studies have examined the expression profiles of miRNAs in luminal B breast cancer, and their regulatory roles in cancer progression have yet to be investigated. (biomedcentral.com)
  • We considered the expression of both miRNAs and messenger RNAs (mRNAs) at these time points to improve the identification of regulatory targets of miRNAs. (biomedcentral.com)
  • By integrating miRNA and mRNA expression profiles, we identified differentially expressed miRNAs and their target genes involved in several hallmarks of cancer. (biomedcentral.com)
  • An MC3T3-E1-based microarray dataset (accessioned as GSE46400) downloaded from the Gene Expression Omnibus included MC3T3-E1 cells with or without 14-day osteoblast differentiation osteoblast induction. (frontiersin.org)
  • It regulates Sp7 protein expression and induces expression of major bone matrix protein genes, such as Col1a1, Spp1, Ibsp, Bglap2, and Fn1 ( 7 , 8 ). (frontiersin.org)
  • Finally, gadB2 and mutant gadB1 were co-expressed under the optimal promoter and RBS combination, thus converted Glu into GABA completely and improved GABA production to more than 25 g/L. This study provides useful promoters and RBS sequences for gene expression in C. glutamicum . (springeropen.com)
  • When we tracked temporal changes in parasite VSA expression to ask whether variants associated with severe disease preferentially expand in naive hosts (as predicted by current theory) we found that var gene profiles were unchanged after 10-days of infection. (medrxiv.org)
  • In contrast, pathological gene expression in terminal heart failure is accompanied by changes in active histone marks without major alterations in CpG methylation and repressive chromatin marks. (nature.com)
  • Many of these transitions involve changes of gene expression. (nature.com)
  • In contrast to previous findings in heart tissue, expression of the pathological gene program in heart failure was not accompanied by changes in the CM DNA methylome but by active histone marks. (nature.com)
  • The combinations of TFs and their target genes can sometimes control gene expression which may determine cell identity. (biomedcentral.com)
  • Predicted target genes show expression and regulatory associations with immune features. (bvsalud.org)
  • By combining gene functional and pathway annotation with miRNA-mRNA interactions, we created a PyMT-specific tripartite miRNA-mRNA-pathway network and identified novel functional regulatory programs (FRPs). (biomedcentral.com)
  • The miRNA-mRNA interactions were verified by dual-luciferase reporter gene assays and experiments using mimics miRNA or their inhibitors. (frontiersin.org)
  • In terms of the gene regulatory network defining cellular potency, Nanog has direct mutual interactions with two other core stem cell specific genes Oct4 and Sox2. (biomedcentral.com)
  • The study highlighted several mechanisms underlying species diversification, including selection acting on existing standing variation, high rates of gene duplication, novel microRNAs and rapid sequence divergence in otherwise conserved non-coding elements. (biomedcentral.com)
  • We also identified miRNA-mRNA regulatory modules driving specific cancer-related biological processes. (biomedcentral.com)
  • We applied a novel clustering method to an annotated miRNA-mRNA regulatory network and identified network modules involved in specific cancer-related biological processes. (biomedcentral.com)
  • The diverse outcomes of CHMI therefore depend upon human immune variation and there is no evidence for switching or selection of var genes in naive hosts. (medrxiv.org)
  • Background: Immunity and immunocyte reaction play an essential role in periodontitis progress and we aim to investigate the underlying regulatory network of periodontitis immune alterations. (researchsquare.com)
  • Conclusions: This study systematically investigated periodontitis immune atlas and glimpse the underlying mechanism of periodontitis from gene-pathway-immunocyte networks, which can not only inspire researchers but also help them in periodontitis related immune researches. (researchsquare.com)
  • We also find that duplicated regions show enrichment for genes associated with "antigen processing and presentation" and other immune related categories. (biomedcentral.com)
  • TORONTO , Oct. 4, 2023 /PRNewswire-PRWeb/ -- As the somatic cell and gene therapy platforms continue to advance, so do the US Food and Drug Administration (FDA) and international council for harmonisation of technical requirements for pharmaceuticals for human use (ICH) regulatory guidelines and the competent authority requirements associated with these product classes. (prweb.com)
  • By contrast, somatic alterations in the genes encoding Notch signaling components drive various types of human cancer, such as breast cancer, small-cell lung cancer (SCLC) and T-cell acute lymphoblastic leukemia (T-ALL) ( 6 - 9 ). (spandidos-publications.com)
  • Regulatory compliance has to be ensured from preclinical research to market authorization, whereby different legal frameworks that go beyond quality, efficacy or patient safety aspects need to be taken into account. (intechopen.com)
  • This session will provide an in-depth discussion of the overall non-clinical and clinical considerations (focusing on safety and efficacy) and regulatory requirements for the development of COVID-19 vaccines from the Agency's perspective. (pda.org)
  • Many cell and gene therapy clinical trials come with their own challenges and have unique safety and efficacy considerations before they can be approved for marketing. (prweb.com)
  • Join this webinar to get insights on the US FDA guidelines and the managing of safety considerations and efficacy endpoints of these cell and gene therapy products. (prweb.com)
  • Artificial neural networks (ANNs) were inspired by information processing and distributed communication nodes in biological systems. (wikipedia.org)
  • Specifically, artificial neural networks tend to be static and symbolic, while the biological brain of most living organisms is dynamic (plastic) and analog. (wikipedia.org)
  • Regulatory practices, legal norms and even ideas of statehood were renegotiated along with new biological concepts and constructs in processes that we now recognize as having constitutional significance. (ethz.ch)
  • To this end, networks are widely used to represent individual bio-molecules (nodes) and their biological relationships (edges). (biomedcentral.com)
  • Recently, miRNA-messenger RNA (mRNA) regulatory relationships have been confirmed during biological processes, including osteogenic differentiation. (frontiersin.org)
  • The consideration of regulatory associations between biological features and data-views contribution is important to improve the understanding of cancer subtypes. (biomedcentral.com)
  • An informed consent is not required regarding the approval of the secondary use of biological samples within the framework of the COVID-19 pandemic. (bvsalud.org)
  • We demonstrate the applicability of the learned features for targeted omics inference tasks: transcription factor (TF)-target prediction, integrated omics network (ION) inference, and module identification. (biomedcentral.com)
  • As academia and start-ups are often focused on gathering scientific evidence, the regulatory maze is often regarded by applicants as challenging in the overall pathway to clinical translation. (intechopen.com)
  • From the abstract: 'Rare and ultra-rare diseases have been central to the field of gene therapy since its earliest stage, and we are now witnessing more and more effective treatments entering the clinical realm for patients in need. (cdc.gov)
  • We are particularly interested in the functional components of networks (rather than the most expansive or inclusive network), where the function of the network is manifested by the dynamics of the network. (biomedcentral.com)
  • By functional network, we mean a network such that an experimental perturbation will likely alter the dynamical phenotype of the network. (biomedcentral.com)
  • One of the best examples of a large functional network is the mammalian circadian oscillator, for which the current core network contains about 30 nodes. (biomedcentral.com)
  • Join new and seasoned professionals from all facets of the field, including global industry, academia, and regulatory authorities, to share insights on how to best prepare for the future through the sharing of best practices, development of standards, and integration of innovative technologies. (pda.org)
  • In this free webinar, gain insights into how to successfully navigate the regulatory framework for novel interventional agents. (prweb.com)
  • It is widely accepted that the regulatory associations between features play important roles in cancer subtype studies. (biomedcentral.com)
  • Omics technologies give access to these regulatory mechanisms and are thus able to provide large amounts of data at each molecular level. (biomedcentral.com)
  • Hence, how immunocytes mediate the occurrence and development of periodontal inflammation and alveolar bone destruction and how the molecular regulation network function in immunocytes reaction and differentiation are the focus of current research on periodontitis. (researchsquare.com)
  • The times below were that site-specific selection of self-esteemproblems has on the survival of the & of splines so that higher gene strains and larger promoter saponins show more adjacent biomarkers. (scoutconnection.com)
  • We next introduce LPRI (Lung Cancer Prognostic Regulon Index), a precision oncology framework to identify new biomarkers associated with prognosis by leveraging the single cell regulon atlas and bulk RNA sequencing or microarray datasets. (biomedcentral.com)
  • To tackle this issue, the development of network-based methods has become an effective tool in analyzing complex relationships among great number of entities such as genes and proteins. (biomedcentral.com)
  • A company scientist told him that Roundup Ready cotton plants contained new, unintended proteins that had resulted from the gene insertion process. (naturalnews.com)
  • Previous methods for network inference from dynamics data may be broadly classified according to the tools involved. (biomedcentral.com)
  • Most recently, several studies have developed inference methods based on nonlinear ordinary differential equations (ODEs) for the chemical kinetics and a Bayesian formalism on the network structure [ 24 - 27 ]. (biomedcentral.com)
  • ADCs and CAR‑Ts could alter the therapeutic framework for refractory cancers, especially diffuse‑type gastric cancer, ovarian cancer and pancreatic cancer with peritoneal dissemination. (spandidos-publications.com)
  • Accelerating and streamlining Cell & Gene Therapy enrollment and coordination across the patient journey. (accenture.com)
  • Other key areas will be gene therapy and artificial Intelligence with developments on the latest drug pipelines and clinical trials for you to expand your ophthalmic medicine portfolios. (smgconferences.com)
  • This study aims to create a novel connected supply chain logistics and manufacturing management platform based on blockchain, with cell and gene therapy as a use case. (researchprotocols.org)
  • Successful preclinical to clinical transition requires careful consideration of these agency guidance documents to minimize the risk of avoidable delays in the development of cell and gene therapy clinical trials in a regulated environment. (prweb.com)
  • For more information, or to register for this event, visit Cell and Gene Therapy Clinical Trials' Regulatory Strategies and Safety Considerations . (prweb.com)
  • The 12th Annual Conference of BSMA in Burlingame, CA, on October 15, brought together over 170 executives discussing Commercialization of the embryonic industry of Cell and Gene Therapy. (biosupplyalliance.com)
  • Leveraging the Digital Supply Chain for delivery of personalized patient solutions in case of Cell and Gene Therapy is more urgent and stringent than it is for traditional bio-pharma. (biosupplyalliance.com)
  • Conversely, the cell and gene therapy supply chain require a make-to-order manufacturing strategy with a batch size of one per patient lot and the time period is less than a month from blood sample collection to drug infusion. (biosupplyalliance.com)
  • Controversy also marked the approval of GM animals for food, the patenting of human genes, the screening of embryos through preimplantation genetic diagnosis and direct-to-consumer genetic testing. (ethz.ch)
  • With the advent of next-generation genome sequencing technologies, gene panel sequencing as a first-tier newborn screening test is a promising strategy, potentially enabling comprehensive and accurate diagnosis of a broad spectrum of genetic conditions at birth. (cdc.gov)
  • Based on the state-of-play in Belgium, this chapter discusses examples of regulatory journeys of applications with genetically modified viral vectors and novel vaccine candidates that have been reviewed by GMO national competent authorities in Belgium and in Europe. (intechopen.com)
  • So they redefined themselves as a "life sciences" company, and then proceeded to pollute the landscape with toxic herbicide, contaminate the gene pool for all future generations with genetically modified plants, and get fined and convicted of deception and wrongdoing. (naturalnews.com)
  • However, few of them consider the regulatory associations between genome features and the contribution weights of different data-views in data integration. (biomedcentral.com)
  • For recurrent neural networks, in which a signal may propagate through a layer more than once, the CAP depth is potentially unlimited. (wikipedia.org)
  • These regulatory processes are affected by specific bio-molecules potentially in separate cellular compartments with interconnected steps [ 1 ]. (biomedcentral.com)
  • They identified genomic islands of speciation between them, containing potentially adaptive genes associated with mate choice. (biomedcentral.com)
  • By testing on TCGA data, our novel method can provide more complete coverage of genes, more balanced module size and finer granularity than current methods in detecting modules with significant overall survival difference. (biomedcentral.com)
  • The Arhgap11a, H2afx, Chek2, Dlgap5, and Chek1 were hub genes downregulated in MC3T3-E1 cells after osteogenic differentiation, verified by RT-qPCR results. (frontiersin.org)
  • Our approach offers a general method for analyzing key regulatory factors controlling cell differentiation and reprogramming. (biomedcentral.com)
  • Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. (nature.com)
  • SNF integrates multiple types of genomic data to identify cancer subtypes, while it uses iterative method to fuse similarity networks between samples, and the model is complex and hard to be interpreted in practice [ 16 ]. (biomedcentral.com)
  • WSNF incorporates the mRNA-TF-miRNA regulatory network information to predict the importance of each feature, and thus to identify cancer subtypes using SNF framework based on the weighted similarity information between samples. (biomedcentral.com)
  • These regulatory mechanisms have strong connections with cellular metabolism. (biomedcentral.com)
  • Active communication between applicants and competent authorities or advisory bodies early in the development stages facilitates a correct implementation of the regulatory frameworks and is of utmost importance to identify challenges or hurdles in order to avoid unnecessary delay in scientific review. (intechopen.com)
  • Like these historical financiers, drug company executives have captured the legal apparatus and regulatory bodies that oversee them. (bepress.com)
  • Deep learning is part of a broader family of machine learning methods, which is based on artificial neural networks with representation learning. (wikipedia.org)
  • The performance of BRANEnet is compared to existing network integration methods. (biomedcentral.com)
  • Our proposed method performs better than current methods with complete coverage of input genes and finer granularity. (biomedcentral.com)
  • Implementation of this plan with emphasis on extramural programs will strengthen the public health infrastructure in the United States at the local, state, and federal levels, and contribute to strengthening global surveillance networks. (cdc.gov)
  • And PJS is the recipient of a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (grant no. 107668/Z/15/Z). The clinical trials were originally funded by the PATH Malaria Vaccine Initiative, US Agency for International Development (USAID) and the European Union Seventh Framework Programme (FP7/2007-2013) under the grant agreement for MultiMalVax (number 305282). (medrxiv.org)
  • An overview of the clinical trials and regulatory considerations, safety follow-ups and requirements will be discussed. (pda.org)
  • It uses a local approximation to the system of differential equations that relies on sparse priors, which localizes uncertainty and renders the algorithm scalable to complex networks. (biomedcentral.com)
  • The SCENIC algorithm infers the TFs and their potential target genes, which are jointly named a regulon. (biomedcentral.com)
  • A way of lowering overall regulatory compliance costs for running a network of facilities operating similar or parallel processes will be evaluated by lowering the monitoring costs through publishing zero-knowledge proofs and product release by exception. (researchprotocols.org)
  • One interesting feature of our approach is that it provides a coherent framework for modeling both the local motifs (e.g., edges) within the network and the global dynamical behavior of the system. (biomedcentral.com)
  • Finally, we use an atlas of transcription data in a mammalian circadian system to illustrate how the method can be used for discovery in the context of large complex networks. (biomedcentral.com)
  • Nanog has been recognized as a critical pluripotency gene in stem cell regulation. (biomedcentral.com)
  • We first constructed the regulatory networks from single-cell RNA sequencing data in human lung adenocarcinoma (LUAD). (biomedcentral.com)
  • Up until now, the underlying gene regulatory networks (GRNs) at the single cell resolution for human LUAD remain unclear. (biomedcentral.com)
  • The GO and KEGG analyses carried out on the cis target gene of lncRNAs showed that the lncRNAs play an important role in the regulation of flowering spinach. (biomedcentral.com)
  • Dual-luciferase reporter gene assays demonstrated Arhgap11a as the target of miR-211-5p. (frontiersin.org)
  • Economic and technological superpowers cannot agree not only about how to promote biotechnology in agriculture and medicine, but even about what counts as science for regulatory purposes and how science and ethics should be integrated in managing biotechnology. (ethz.ch)
  • I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. (medrxiv.org)
  • ETHICS AND DISSEMINATION: Ethical approval was obtained from the University Institute Foundation for Primary Health Care Research Jordi Gol i Gurina ethics committee. (bvsalud.org)
  • Network analysis pinpointed several well-known flowering-related genes such as ELF , COL1 , FLT , and FPF1 and also some putative TFs like MYB, WRKY, GATA, and MADS-box that are important regulators of flowering in spinach and could be potential targets for lncRNAs. (biomedcentral.com)
  • The acquisition requires approvals by AT&T's shareholders, and regulators. (techlawjournal.com)
  • We present a gene regulatory network model to investigate the bimodal Nanog distribution in stem cells. (biomedcentral.com)
  • In terms of the goal to make precision care mainstream, the field's most boast-worthy accomplishment has been in oncology where molecularly guided strategies - using those multi-gene panels that just a few years ago were thought too complex and expensive - have made their way into most large cancer research centers and are becoming a routine part of care. (genomeweb.com)
  • Here, we present and study a computational framework, termed as LPRI, to help prognostic stratification of patients. (biomedcentral.com)
  • INTIENT is both a platform-of-platforms and a network of services designed to put scientific and health data directly into the hands of those who can create treatments and solutions that drive better patient outcomes. (accenture.com)
  • We evaluate our framework using multi-omics data of Saccharomyces cerevisiae , a well-studied yeast model organism. (biomedcentral.com)
  • Officials from the European Medicines Agency (EMA) and member state national health technology assessment (HTA) agencies recently announced they were going forward with plans to improve the quality of real-world data (RWD) resources for use in regulatory decision-making. (healtheconomics.com)
  • Second, a robust business network that can support business process data collaboration across various value chain entities like hospitals, contract development and manufacturing organizations. (biosupplyalliance.com)
  • It takes advantage of combining data from all transplant programmes in one unique system to perform comprehensive nationwide reporting and to promote translational and clinical post-transplant outcome research in the framework of Swiss transplantation medicine. (bmj.com)
  • Robert Sachs, the outgoing P/CEO of the National Cable Telecommunications Association (NCTA), stated in a release that 'The proposed combination of the largest and second largest telephone providers in SBC's 13-state region raises obvious antitrust concerns that regulatory authorities will have to scrutinize carefully. (techlawjournal.com)
  • We will work closely with federal and state regulatory authorities as they examine the proposed SBC-AT&T transaction. (techlawjournal.com)
  • Most modern deep learning models are based on multi-layered artificial neural networks such as convolutional neural networks and transformers, although they can also include propositional formulas or latent variables organized layer-wise in deep generative models such as the nodes in deep belief networks and deep Boltzmann machines. (wikipedia.org)
  • Phylogenetic analyses showed that no single species tree can efficiently represent all species relationships, suggesting high levels of repeatedly occurring gene flow. (biomedcentral.com)
  • And businesses don't like risk," J&J's Mark Curran told PGx Reporter of the regulatory uncertainties in the personalized medicine space. (genomeweb.com)