Approaches disease models animal. Medical search. Frequent questions

Alzheimer's disease (AD) is a chronic neurodegenerative disease that results in the loss of neurons and synapses in the cerebral cortex and certain subcortical structures, resulting in gross atrophy of the temporal lobe, parietal lobe, and parts of the frontal cortex and cingulate gyrus. (wikipedia.org)
Even with billions of dollars being used to find a treatment for Alzheimer's disease, no effective treatments have been found. (wikipedia.org)
However, clinical trials have developed certain compounds that could potentially change the future of Alzheimer's disease treatments. (wikipedia.org)
JADO Technologies GmbH, the leading developer of RAFT intervention therapeutics, announced the publication of a paper in Science demonstrating a potential novel strategy for therapeutic intervention in Alzheimer's and other diseases by targeting discrete sub-compartments in the cell membrane (RAFTS). (healthnewstrack.com)
secretase inhibitors for the treatment of Alzheimer's disease," noted Professor Kai Simons, Max-Planck Institute of Molecular Cell Biology and Genetics and co-founder of JADO. (healthnewstrack.com)
Alzheimer's disease has historically been an area of research for our company founders. (healthnewstrack.com)
The focus of the LCSB is on neurodegenerative diseases, with a particular interest in Parkinson's and Alzheimer's disease, with the willingness to expand the scope of neurodegenerative diseases covered. (nature.com)
This includes increased expression of genes involved in nerve function, neuroprotection and autophagy, a process that prevents the accumulation of damaged cellular components and protein aggregates, which are characteristic of neurodegenerative diseases such as Alzheimer's disease in humans. (drugdiscoverynews.com)
Nearly two dozen experimental therapies targeting the immune system are in clinical trials for Alzheimer's disease, a reflection of the growing recognition that immune processes play a key role in driving the brain damage that leads to confusion, memory loss and other debilitating symptoms. (worldhealth.net)
The findings, published on March 8 in the journal Nature , suggest that targeting T cells is an alternative route to preventing neurodegeneration and treating Alzheimer's disease and related diseases involving tau, collectively known as tauopathies. (worldhealth.net)
This could really change the way we think about developing treatments for Alzheimer's disease and related conditions," said senior author David M. Holtzman, MD, the Barbara Burton and Reuben M. Morriss III Distinguished Professor of Neurology. (worldhealth.net)
Before this study, we knew that T cells were increased in the brains of people with Alzheimer's disease and other tauopathies, but we didn't know for sure that they caused neurodegeneration. (worldhealth.net)
It's likely that some drugs that act on T cells could be moved into clinical trials for Alzheimer's disease and other tauopathies if these drugs are protective in animal models. (worldhealth.net)
She analyzed immune cells in the brains of mice genetically engineered to mimic different aspects of Alzheimer's disease in people, looking for changes to the immune cell population that occur over the course of the disease. (worldhealth.net)
T cells were similarly abundant at sites of tau aggregation and neurodegeneration in the brains of people who had died with Alzheimer's disease. (worldhealth.net)
Alzheimer's disease (AD) is the most common progressive neurodegenerative disease worldwide, but its cause remains unclear. (j-alz.com)
The ε4 allele of the Apolipoprotein E (APOE) gene in individuals infected by Herpes simplex virus type 1 (HSV-1) has been demonstrated to be a risk factor in Alzheimer's disease (AD). (j-alz.com)
One of the major challenges of medical sciences has been finding a reliable compound for the pharmacological treatment of Alzheimer's disease (AD). (j-alz.com)
These words have never rung more true than when it comes to Alzheimer's disease. (naturalgrocers.com)
One of the most debilitating degenerative diseases of our time, Alzheimer's robs a person of his or her mind, destroying brain cells and leading to extreme memory loss and behavior problems. (naturalgrocers.com)
As many as 5.3 million Americans are living with Alzheimer's and it is predicted that healthcare costs for the disease will exceed one trillion dollars by 2050. (naturalgrocers.com)
i However, researchers calculate that delaying Alzheimer's disease onset by one or two years could significantly decrease the disease burden by 2050 by 9.5 million or 23 million cases, respectively. (naturalgrocers.com)
Alzheimer's is a neurological disease in which brain nerve cells (neurons) deteriorate and die. (naturalgrocers.com)
xiii Later, in 2008, the same researchers reported that they gave mice that were engineered to develop Alzheimer's disease green tea extracts in water for six months. (naturalgrocers.com)
The therapy is currently in clinical trials for depression, Alzheimer's disease, addiction, and more. (the-scientist.com)
Impairment of the activity in circuits that control memory and cognitive function is characteristic of Alzheimer's disease. (the-scientist.com)
Allopregnanolone, a first-in-class regenerative therapeutic, has the potential to delay neurodegeneration in early Alzheimer's disease (AD) by promoting endogenous systems of renewal and repair, early clinical data show. (medscape.com)
In presenting the findings at the 16th Clinical Trials on Alzheimer's Disease (CTAD) conference, study investigator Roberta Brinton, PhD, with The Center for Innovation in Brain Science at the University of Arizona in Tucson, gave a "whirlwind tour of decades of research" into allopregnanolone - "from discovery to translation to now in clinical trials. (medscape.com)
Work in preclinical animal models suggests allopregnanolone may reduce some of the hallmarks of Alzheimer's disease, like amyloid plaque buildup, and even have an effect on learning and memory," Edelmayer explained. (medscape.com)
The early clinical data reported at CTAD builds off that initial work, "demonstrating that there may be the potential for delaying disease progression and treating Alzheimer's disease with this type of approach," she said. (medscape.com)
It's still very early days still for this medication, but it's innovative and it's exciting to see because we also know that combining approaches in the future might be really the most effective way that will treat Alzheimer's," Edelmayer told Medscape Medical News . (medscape.com)
16th Clinical Trials on Alzheimer's Disease (CTAD) conference: Abstract OC10. (medscape.com)
Alzheimer's disease and multiple sclerosis are neurodegenerative disorders with expensive and complex treatments aimed at reducing the progression of symptoms. (bvsalud.org)
an Adjunctive Treatment in Alzheimer's Disease and Multiple Sclerosis. (bvsalud.org)

Animal models are increasingly used to understand disease mechanisms and to screen promising therapeutic approaches. (sbir.gov)
Novel therapeutic approaches to MG are now being explored in animal models. (nih.gov)
These findings open up exciting new therapeutic approaches. (worldhealth.net)
Two-dimensional bifurcation analyses uncovered synergistic parameter pairs that could act as efficient compound therapeutic approaches. (bvsalud.org)
And I've spent my life looking at cel therapies and other therapeutic approaches to two diseases, Parkinson's disease and Huntington's disease. (lu.se)
Ayuno intermitente y caused by first-line treatments, it's necessary to implement better complementary therapeutic approaches that do not restricción calórica como produce major side effects and improve symptoms. (bvsalud.org)

His postdoctoral research was conducted in the field of virology (filoviruses and hantaviruses) at the Institute of Virology in Marburg and the Centers for Disease Control and Prevention in Atlanta, USA ('National Research Council' fellowship). (nih.gov)
Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA. (cdc.gov)
At a national conference in 1984, Dr. James O. Mason, then Director of the Centers for Disease Control, challenged the public health community to develop a strategy to eliminate tuberculosis from the United States. (cdc.gov)
This plan was developed by the Centers for Disease Control/Department of Health and Human Services' Advisory Committee for Elimination of Tuberculosis. (cdc.gov)
The Centers for Disease Control is identifying activities for short- and long-term implementation. (cdc.gov)

We investigate the use of wearable sensors, worn on four limbs at home during natural behavior, to quantify motor function and disease progression in 376 individuals with amyotrophic lateral sclerosis. (cdc.gov)
We show that this approach produces scores that progress faster than the gold standard Amyotrophic Lateral Sclerosis Functional Rating Scale. (cdc.gov)

Parkinson's disease (PD) is the second most common neurodegenerative disorder. (wikipedia.org)
Experiments have revealed reduced transport rates of both wild-type and two familial Parkinson's disease-associated mutant alpha-synucleins through axons of cultured neurons. (wikipedia.org)
Membrane damage by alpha-synuclein could be another Parkinson's disease mechanism. (wikipedia.org)
Problems with the sense of smell is a widespread symptom of Parkinson's disease (PD), however, some neurologists question its efficacy. (wikipedia.org)
In recent years, it has been revealed that Parkinson's disease pathology may begin to manifest in the gastrointestinal track at a much earlier time point than in the brain. (nature.com)
Since rodent models cannot recapitulate many of the human disease features, human induced pluripotent stem cells derived from Parkinson's patients have been used to generate brain organoids, greatly contributing to our understanding of the disease pathophysiology. (nature.com)
To understand the multifaced aspects of Parkinson's disease, it may be desirable to expand the complexity of these models, to include different brain regions, vasculature, immune cells as well as additional diverse organ-specific organoids such as gut and intestine. (nature.com)
The synucleinopathy Parkinson's disease (PD), is a neurodegenerative disease characterized by abnormal accumulation of the alpha-synuclein (α-Syn) protein in the brain. (nature.com)
The genetic information facilitated modeling of some of the common monogenic Parkinson's mutations using genetic approaches in cellular and animal systems. (nature.com)
DBS is currently approved in the U.S. or Europe for the treatment of essential tremor, Parkinson's disease, dystonia (a motor disorder that causes extreme twisting and repetitive motions), epilepsy, and obsessive-compulsive disorder (OCD). (the-scientist.com)
In Parkinson's disease and dystonia, neurons in the motor circuits misfire, causing aberrant movements of the limbs and torso. (the-scientist.com)
More than 100,000 patients worldwide have received DBS, mostly to treat Parkinson's disease, according to Medtronic, a prominent supplier of DBS devices. (the-scientist.com)
We leveraged this experience and combined it with conceptual advances and surgical developments in the field of Parkinson's disease, and soon applied DBS to treat that disease and other movement disorders. (the-scientist.com)
Sam's SMP is looking at a mouse model of Parkinson's disease and a way of restoring movement to these animals. (smcm.edu)
My field of research is Parkinson's disease. (lu.se)
So degeneration of dopamine neurons is a cardinal symptom of Parkinson's disease patients. (lu.se)
We were working on animal models in particular of Parkinson's disease. (lu.se)
But at that stage, we probably had the most experience anywhere of looking at the effect of different types of cel s implanted in Parkinson's models on a whole range of motor and sensory motor functions. (lu.se)

Before the 2022 outbreak, CDC experts in poxviruses and associated MCMs had evaluated efficacy data from animal models and reports of MCM use for a few human cases of related OPXV infections (e.g., vaccinia virus and cowpox virus). (cdc.gov)

Johns Hopkins Medicine researchers develop an image-based computer model of tumor behavior that captures more of the complexity of cancer growth. (jhu.edu)
Researchers with the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins University School of Medicine received a $3 million grant to use computational modeling and software to understand biological data, in combination with unique in vitro and animal studies, to better treat liver cancer. (jhu.edu)
Researchers at West Virginia University want to know why people with Type 2 diabetes commonly develop heart disease, a major cause of death among this population. (wvu.edu)
Researchers will also approach the process from an additional perspective. (wvu.edu)
A breed of pigs called Wisconsin Miniature Swine - created by a team of UW-Madison scientists - will help researchers better model and under. (sflorg.com)
Researchers at FORT are using various approaches to provided needed information to resource managers to combat invasive plants, animals, and disease organisms. (usgs.gov)
To help ensure proper use of the modeling results, researchers are providing guidance on caveats and disclaimers for model results. (usgs.gov)
The Centre for Infectious Disease Genomics and One Health at SFU is an interdisciplinary group of researchers interested in solving practical health problems using multidisciplinary approaches and in a One Health framework. (sfu.ca)
The Centre for Infectious Disease Genomics and One Health at SFU is an interdisciplinary group of researchers with backgrounds in microbiology, molecular biology, computer science, cognitive science, statistics, public health, and genomics. (sfu.ca)
The researchers took an 'eco-epidemic' modelling approach, taking into account the mutual interaction between the effects of ecology and disease epidemiology. (eurekalert.org)
The researchers took a new approach, expressing norovirus capsid protein to create viruslike particles that cannot cause the disease but nevertheless stimulate an immune response. (medscape.com)

Collaborations between biologists, medical doctors, computer scientists, physicists, engineers and mathematicians offer new insights in complex systems essential for understanding principal mechanisms of disease pathogenesis and for developing new tools in diagnostics and therapy. (nature.com)
Animal modeling plays a pivotal role in all projects and therefore pathology and pathogenesis are key components of DMT's work. (nih.gov)
Environmental and infectious agents and/or their products have been implicated in the pathogenesis of autoimmune diseases. (nih.gov)
Such models can transform our approach to understanding pathogenesis, facilitating the development of therapies or preventive measures. (ed.ac.uk)
These pathogens will be examined in the laboratory as well as in swine disease models to investigate mechanisms of pathogenesis, transmission, immunity, evolution and methods of intervention. (usda.gov)
Animal experiments to be conducted involve one of three general designs: 1) disease pathogenesis and transmission studies, 2) vaccine efficacy studies, 3) sow/neonatal studies. (usda.gov)
A key approach in the study of disease pathogenesis is to better understand the host response to viral infection to various viruses. (usda.gov)

Ultimately, our hope is that what we learn from sea urchins will translate into preventative or therapeutic strategies for age-related degenerative diseases in humans. (drugdiscoverynews.com)
Comparative studies are used in investigating zoonoses, traumatic injuries and intoxications, and chronic and degenerative diseases. (cdc.gov)

Furthermore, the contribution of gut microbiota to disease progression cannot be underestimated. (nature.com)
Cancer biology has significantly benefited from the molecular-level detail provided by these tools, allowing elucidation of many perturbations underlying disease onset and progression. (nih.gov)
Previously, we proposed a mathematical model describing the key regulatory mechanisms underlying the pathological progression of TB. (bvsalud.org)
We identify parameter values corresponding to a latent-infection model of TB, where disease progression occurs significantly slower than in progressive TB. (bvsalud.org)
We sought to determine if mobile applications (apps) and wearable devices can be used to quantify ALS disease progression through active (surveys) and passive (sensors) data collection. (cdc.gov)

Our projects represent a translational study with the aim of generating and characterizing animal and cellular models relevant for specific diseases, to be used as research tools to understand the molecular and physiopathological mechanisms responsible for disease, to analyse potential biomarkers for prognosis and follow-up and to identify new therapeutical targets. (uam.es)
Moreover, we are focused on the analysis of the physiopathological mechanisms underlying PA, one of the most frequent organic acidemias in which we have demonstrated, using a mouse model, that mitochondrial dysfunction, oxidative stress and miRNA dysregulation contribute to the multiorganic complications of the disease. (uam.es)
Gradually fostering an approach to potential beneficial healing properties, there are renewed efforts through bioprospecting and evidence-based research to understand by means of rigorous investigations the mechanisms of action whether earthworms are used as food and/or as sources of potential medicinal products. (hindawi.com)
Animal models especially invertebrates (e.g., fruit flies, nematodes, and earthworms are inexpensive, require less ethical concerns, and are therefore noncontroversial) are crucial to understanding mechanisms that underlie biological processes. (hindawi.com)
The overarching goal of the Systems Biology Laboratory is to apply modern methods of biomedical engineering to better understand the mechanisms of cancer and to significantly advance treatments for this devastating disease. (jhu.edu)
1.B. Define mechanisms of immune evasion that contribute to PRRSV disease pathogenicity, and which can be targeted through recombinant vaccines to improve vaccine efficacy. (usda.gov)
It presents an updated literature review of IBD mouse models and a description of possible mechanisms relevant to relationships between IBD and smoking. (intechopen.com)
This will be accomplished through advancing our understanding of the underlying causal mechanisms by constructing whole-brain computational models of multimodal neuroimaging data of the different states of consciousness in health and disease (awake, sleep and anesthesia) in humans and experimental animal models. (upf.edu)
This approach has the potential to provide functional fingerprinting of conscious states and insights into the underlying necessary and sufficient brain networks as well as their underlying neural mechanisms. (upf.edu)

Accelerating the discovery of new therapeutics for treatment of lung injuries using patho/physiology mimicking models. (ddw-online.com)
The progress in the development of new therapeutics is hampered by the lack of reliable lung models that enable rapid, cost-effective and high throughput testing of therapeutics. (ddw-online.com)
Professor Chrzanowski will outline the development of advanced human mimicking lung models (aka lung-on-a-chip), which emulate both healthy (for safety studies) and diseased lungs (for therapeutics efficacy). (ddw-online.com)
Distinct bronchial and alveolar models have been constructed which can be used for precise understanding of Covid-19 biology and evaluation of therapeutics. (ddw-online.com)
We utilize a multidisciplinary approach, tailored diagnostics and therapeutics, patient education and psychological treatment to help patients gain control over their disease and dramatically improve their quality of life. (nationaljewish.org)
There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). (sbir.gov)
DMT's general work philosophy/strategy combines areas such as 'molecular biology', 'tissue culture', 'immunology' and 'animal models' with the goal to develop vaccines and therapeutics for emerging zoonotic viruses, the mission of the Laboratory of Virology, Division of Intramural Research (DIR) and NIAID. (nih.gov)

At JADO we have taken this approach to the next level and are building a pipeline of compounds targeting RAFTS for the treatment of allergic disorders and infectious diseases. (healthnewstrack.com)
It is being explored in research and clinical trials for a wide variety of diseases, including single-gene disorders such as cystic fibrosis , hemophilia , and sickle cell disease . (medlineplus.gov)
EpiZode: Noninvasive Seizure Screening in Preclinical Models of Epilepsy There is an urgent need for research into treatment options for epilepsy and other seizure disorders. (sbir.gov)
This study opens a new therapeutic approach for myasthenia gravis, as well as other autoimmune disorders," said one researcher. (sciencedaily.com)
This study opens a new therapeutic approach for myasthenia gravis, as well as other autoimmune disorders," said Kaminski. (sciencedaily.com)
The Brittle Bone Disorders Consortium is part of the National Institutes of Health Rare Diseases Clinical Research Network. (oif.org)

The FDA is home to world-class scientists whose groundbreaking research provides new insights to inform our regulatory approach on topics ranging from digital health to pathogen outbreaks to addiction. (fda.gov)
The FDA's approach to preventing and responding to infectious disease and foodborne pathogen outbreaks, including the use of the animal rule, emergency communication devices, rapid diagnostic tests, anti-microbial resistance, and protecting people from emerging infectious disease threats. (fda.gov)
Ecological niche modeling for filoviruses: a risk map for Ebola and Marburg virus disease outbreaks in Uganda. (who.int)

One Health is a comparative clinical approach which promotes better collaboration between human and animal health professionals in order to reduce the spread of zoonotic diseases. (who.int)

Considering that AD is a multifactorial disease, nutraceutical compounds offer the advantage of a multitarget approach, tagging different molecular sites in the human brain, as compared with the single-target activity of most of the drugs used for AD treatment. (j-alz.com)
To demonstrate the power of this technology, we will generate a molecular disease fingerprint allowing differentiation between three clinically indistinguishable yet biochemically distinct disease pathways underlying the deadly brain cancer glioblastoma multiforme. (nih.gov)

To date, we are using gene editing CRISPR/Cas9 technology for the generation of cellular and animal models with specific splicing mutations, to identify and test candidate therapeutical antisense oligonucleotides. (uam.es)

A neurodegenerative disease is caused by the progressive loss of structure or function of neurons, in the process known as neurodegeneration. (wikipedia.org)
Here we present to you three interesting approaches to understanding and treating neurological conditions in humans, with insights from sea urchins to machine learning advances to putting antibodies to work in treating neurodegeneration. (drugdiscoverynews.com)
From there, the disease quickly worsens: The brain shrinks, nerve cells die, neurodegeneration spreads, and people start having difficulty thinking and remembering. (worldhealth.net)
Microglial dysfunction worsens neurodegeneration and accelerates the course of the disease. (worldhealth.net)

In addition, we have included selected livestock species (i.e. pig, sheep and goat) and unconventional animal species such as reservoir species (i.e. rodents and bats). (nih.gov)
Animal testing is not only beneficial to human but also animals, at least to those who are not used in the experiments, such as pets and endangered species. (bartleby.com)
All three species of orangutans in Indonesia are listed as Critically Endangered, and moving animals between habitats is a fairly common practice as demands for agriculture, mining, and other natural resource use puts pressure on the forests they inhabit. (sflorg.com)
Covid 19 threw a big spotlight on the risks of releasing captive orangutans back into the wild, or moving them between habitats, but we've been concerned for several years about the ways in which these practices risk the transmission of pathogens such as TB from orangutans exposed to human disease into wild orangutan populations and to other wildlife species," explained the study's co-author, Dr Steve Unwin. (sflorg.com)
If we don't address this deficiency, we risk humans acting as a reservoir to transmit disease to endangered species which, if lost, contribute to the overall degradation of our environment. (sflorg.com)
While our study focused on orangutans, this approach offers workable solutions for reducing risk of disease transmission in any wild animal species. (sflorg.com)
One tool to forecast invasions is species distribution modeling, which can be used to detect current distributions of invasive species or to forecast their potential future distributions. (usgs.gov)
FORT scientists are exploring the latest in species distribution modeling techniques, including determination of which techniques work better with different datasets, taxa, and spatial extents and resolutions. (usgs.gov)
Simulation models can be used as virtual laboratories to inform management activities and assess potential impacts of invasive species through comparisons of "what if" scenarios across a wide variety of ecosystems. (usgs.gov)
One approach is allometric adjustment for species differences in the relationship between airborne exposure and internal dose. (cdc.gov)
Zoonoses are important threats to human and animal health, and animal research has played a role in assessing risk across species. (who.int)
it entails preventing and treating disease in one species in order to indirectly prevent and treat disease in another species [3]. (who.int)
As such, groups concerned with animal ethics would do well to further explore the applications of a One Health approach: what are the ethical guideposts as we move toward a future of health care that considers the health of multiple species as well as the environment? (who.int)

The new 4-year PhD programme in One Health Models of Disease: Science, Ethics and Society will provide unique training in state-of-the-art techniques in the design and application of new One Health models of neurodegenerative, cardiovascular, developmental, and infectious diseases of humans and animals. (ed.ac.uk)
Students will be supervised by world-leading life scientists addressing important diseases of humans and animals, and social scientists and bioethicists conducting cutting-edge research into the social and ethical dimensions of 21st century science. (ed.ac.uk)
Therefore, the potential benefits of animal experimentation are greatly outweighed by the risks and collective harm of humans and animals which is why resources should be directed towards more human-based testing procedures. (bartleby.com)
The team's results suggest that there is a potential problem of pathogen transmission between humans and animals which needs to be properly understood and managed. (sflorg.com)
This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals - including their strengths and weaknesses. (lu.se)

Genome editing is of great interest in the prevention and treatment of human diseases. (medlineplus.gov)
It also holds promise for the treatment and prevention of more complex diseases , such as cancer, heart disease, mental illness, and human immunodeficiency virus (HIV) infection. (medlineplus.gov)
During the study, his team showed that tonabersat, a drug originally developed for treatment of migraine and epilepsy, could block astrocyte-induced motor neuron death in human ALS stem cell lines and animal models. (newswise.com)
This Wellcome programme combines training in experimental techniques, bioethics and social sciences for human and animal health. (ed.ac.uk)
Typically defended by arguments of reliability and human health benefits, recently the question of ethics and values placed on animal testing have caused it to become a relevant and pressing topic that has been more widely discussed and debated. (bartleby.com)
Most individuals would be saddened knowing that animals were being harshly experimented on for human benefits. (bartleby.com)
In some cases, formerly captive orangutans were released after long periods of contact and potential exposure to human diseases. (sflorg.com)
Yet, substantial progress has started to be made using perturbational approaches measuring the effects of direct stimulation to the human brain. (upf.edu)
Her overall research goal is to merge mouse modeling with clinical genetics to understand the basis of and develop treatments for human diseases. (biologists.com)
The internationally recognized program that she leads at Baylor has generated hundreds of new mouse models of human disease, which have enabled discoveries of gene functions in diverse areas, including cancer, reproduction, neurobiology, obesity, and blood, heart and bone development. (biologists.com)
I was convinced that my future path should be directed towards improving human health, primarily in the field of childhood diseases, and I planned to go to medical school. (biologists.com)
9: Determine if toll-like receptor/early response protein-1 signaling is mediating embryonic/placental inflammation and epigenetic dysregulation in offspring due to maternal obesity in rodent models/human subjects. (usda.gov)
Animal models, MCM use for human cases of related orthopoxviruses, unpublished data, input from clinician experts, and experience during CDC mpox consultations were also evaluated to develop interim clinical treatment considerations. (cdc.gov)
This report synthesizes data from animal models, MCM use for human cases of related OPXV, unpublished data, input from clinician experts, and experience during consultations (including follow-up) to provide interim clinical treatment considerations. (cdc.gov)
I started as a mathematician but very quickly switched into neurobiology, psychology, and animal models of human disease. (lu.se)
entitled "One health: perspectives on ethical issues and evidence from animal experiments" [1], touches on a number of important points, but fails to go far enough in exploring the innovative nature of a One Health approach to a number of scientific and ethical issues related to the overlap of human and animal health. (who.int)
Rabinowitz P, Scotch M, Conti L. Human and animal sentinels for shared health risks. (who.int)
In addition, we try to identify driver genes that are defined as being linked to human diseases such as cancer and fibrosis. (lu.se)

The ultimate aim is to develop personalized RNA targeted therapies (antisense oligonucleotides) as well as pharmacological therapies with antioxidant compounds and mitochondrial activators, performing preclinical studies in the specific disease models. (uam.es)

Huntington's disease (HD) is a rare autosomal dominant neurodegenerative disorder caused by mutations in the huntingtin gene (HTT). (wikipedia.org)
ALS, MS, Huntington's disease…) is also welcomed. (nature.com)

The interdisciplinary approach is emphasized using histoplasmosis and an apparent pesticide intoxication occurrence as examples. (cdc.gov)

We have generated iPS cells derived from patients' fibroblasts and differentiated them to neurons and cardiomyocytes, relevant cell lineages for the disease, to perform physiopathological studies and testing of pharmacological and genetic therapies. (uam.es)
Yeah, the idea is based on the possibility to replace the lost dopamine neurons with new cel s that would take over the function from the cel s that are lost to the disease. (lu.se)
This regulation is sive loss of neurons and white matter that believed to positively impact these diseases can lead to brain atrophy and different by promoting normal aging and delaying types of disability. (bvsalud.org)

The latest on methods, tools, materials, and products used either to make or evaluate products FDA regulates, such as genome editing or sequencing (in food safety), predictive tools for toxicity and efficacy, and modeling and simulation for medical devices. (fda.gov)
using large datasets for predictive modeling of polypharmacy issues. (fda.gov)
Predictive models developed at FORT are being used to create regional and national-scale assessments of invasion patterns, vulnerable habitats, and potential distributions of specific invaders, and to examine how all of these may be affected by changing climate. (usgs.gov)
Some scientists even claim that "the scientific method itself is becoming obsolete" as giant computers and data analytic software sift through the digital world to provide predictive models for health and disease based on the information available. (cdc.gov)

Ischemic cardiovascular diseases such as Peripheral Arterial Disease (PAD) are caused by atherosclerosis that results in impaired blood flow to the tissues. (jhu.edu)

Fingolomid, for example, is commonly used to treat multiple sclerosis, which is an autoimmune disease of the brain and spinal cord. (worldhealth.net)

2) the role of genetic factors in modulating the induction or perpetuation of autoimmune diseases by environmental or infectious agents and 3) the interaction of hormones and gender differences with environmental or infectious agents in development of autoimmune diseases. (nih.gov)
This RFA, Environment/Infection/Gene Interactions in Autoimmune Diseases, is related to one or more of the priority areas. (nih.gov)
Women and some minorities are disproportionately affected by many autoimmune disease. (nih.gov)
Several environmental chemicals have been associated with autoimmune diseases, including silica dust and lupus, vinyl chloride and organic solvents in scleroderma, mercury, gold or perchloroethylene in autoimmune kidney disease, and polybrominated biphenyls in autoimmune thyroid disease. (nih.gov)
This paradigm shifting work shows that the very same inhibitors of apoptosis, or cell destruction, in tumors are also expressed in cells that produce autoimmune diseases. (sciencedaily.com)
Together they discovered that survivin, an inhibitor of apoptosis, is also expressed in the white blood cells, called lymphocytes, of patients with the autoimmune disease myasthenia gravis, but not in normal individuals. (sciencedaily.com)
We found these cells to be part of the dysfunction underlying the autoimmune disease. (sciencedaily.com)

Sea urchins and humans actually share a close genetic relationship and these genetic similarities have made sea urchins a valuable animal model for scientific research into questions ranging from early embryonic development to tissue regeneration and aging. (drugdiscoverynews.com)
Further, reports oriented towards the application of genetic analyses in oncological disease are not to be primarily targeted to the Immunogenetics unless they evolve in detail around the MHC (HLA) or other major immunogenetic systems and how those affect immune response and or therapy documented by real laboratory and/or clinical data, not solely bioinformatic analyses. (frontiersin.org)
Cystic Fibrosis is one of the most common, life-limiting genetic diseases, and is estimated to affect 30,000 Americans. (nih.gov)
The Abdominal Aortic Aneursym integrates new insights into the etiology and pathology of aneurismal disease, including physiologic and genetic causes. (chipsbooks.com)

We will review several projects based on the use of panels of biomarkers for a better understanding of risk of disease and prognosis. (lu.se)

Our approaches to this disease include multiscale computational modeling and bioinformatics combined with animal experiments. (jhu.edu)
We further show how network-based approaches can be integrated into the multiscale modeling framework of response to toxicological exposure. (intechopen.com)
Finally, we combine biological knowledge assembly and multiscale modeling to report on the promising developments of the "quantitative adverse outcome pathway" concept, which spans multiple levels of biological organization, from molecules to population, and has direct relevance in the context of the "Toxicity Testing in the 21st century" vision of the US National Research Council. (intechopen.com)

1.A. Characterize virus-host interactions and determine innate and adaptive immune pathways that contribute to PRRSV disease susceptibility or immunity to inform the development of highly effective vaccines against very virulent strains. (usda.gov)

The research in the laboratory is broad and uses a combination of experimental and computational approaches. (jhu.edu)
As of 2015, 200 to 225 million animals are said to used in laboratory research for the biomedical industry annually worldwide. (bartleby.com)
First off, the laboratory conditions that are instigated upon millions of animal models for the sake of medical research has been said to be unethical and cruel. (bartleby.com)
3.C. Develop SVA swine laboratory models to inform the development of vaccines. (usda.gov)
Experimental trials are constrained by laboratory capacity, insufficient funds, low number of laboratory animals and obsolete technology. (bvsalud.org)
The ethical justification and scientific utility of laboratory animal experimentation are rightly criticized, necessitating efforts to enhance humane aspects of animal research as well as to address biases and difficulties in extrapolating data from animal research to humans. (who.int)
The authors also provide four proposals to improve the ability to apply data from laboratory animal experimentation to humans. (who.int)

The group belongs to CIBER Rare Diseases (CIBERER) and to Health Research Institute Hospital La Paz (IdiPAZ) and actively collaborates with Centro de Diagnóstico de Enfermedades Moleculares (CEDEM, Science Faculty, UAM). (uam.es)
Our research is focused in neurometabolic diseases, propionic acidemia (PA) and hyperphenylalaninemias (HPAs) among others, enzymatic deficiencies of autosomal recessive inheritance, characterized by the toxic accumulation of precursors and lack of downstream metabolites. (uam.es)
The research group has ample experience in the in vitro and in vivo use of antisense therapy to revert splicing defects in different rare diseases including HPAs, participating in EU-COST Actions within this topic. (uam.es)
This free webina r discussed the development of these multi-layered coculture models, their validation for Covid-19 research and use in therapeutic evaluation. (ddw-online.com)
Biomedical research has revealed many similarities between these diseases at the subcellular level, including atypical protein assemblies (like proteinopathy) and induced cell death. (wikipedia.org)
With this position, the LCSB would like to strengthen its experimental research pillar and in particular the use of animal as well as cellular models. (nature.com)
Currently, genome editing is used in cells and animal models in research labs to understand diseases. (medlineplus.gov)
Models that can elucidate these kinds of complex patterns are data-hungry, and assembling huge sets of brain data is challenging, particularly for small research groups. (drugdiscoverynews.com)
Asthma treatment at National Jewish Health helps address this health problem using a multidisciplinary and multispecialty care approach that integrates clinical and research efforts to deliver the best care possible and expedite the bench-to-bedside process resulting in successful asthma care, management and research. (nationaljewish.org)
The 'Disease Modeling and Transmission' (DMT) Section was established in August 2008 and conducts innovative research on viral pathogens requiring high or maximum containment. (nih.gov)
The goal of our research is to develop better treatments for the disease. (jhu.edu)
A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)
Animals are used by scientists to develop research for new medications and experiments daily. (bartleby.com)
According to the US-based foundation of Biomedical Research, animal testing has made a major advance within the last century- for veterinary health and humans. (bartleby.com)
Does federal law ensure that animals used in research are treated humanely? (bartleby.com)
The essential need for animal research and observation is supported by health agencies and medical associations around the world. (bartleby.com)
This research project will focus on swine diseases caused by viruses that are top concerns for United States pork producers: porcine reproductive and respiratory syndrome, porcine coronaviruses, and new and emerging diseases such as Seneca A virus. (usda.gov)
A major research approach will be the use of reverse engineering and infectious clones to identify virulence components of each virus under study through mutational studies. (usda.gov)
Using a vaccine technique, the research team was able to eliminate the survivin-expressing cells and demonstrate improvement in the animal models with myasthenia gravis. (sciencedaily.com)
Here, she shares her start in rare disease research, exciting discoveries, and future goals. (oif.org)
Experts from the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal Traits translational Network") Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. (lu.se)
Approaching zoonotic and environmental risks from a One Health perspective involves considering what research and disease control and prevention methods are mutually beneficial to humans, animals and the environment. (who.int)
One key type of research that the One Health approach encourages is the use of epidemiological studies of naturally occurring populations using techniques such as case-control and cohort studies to assess correlation between environmental exposures and health risks [4]. (who.int)

Animal testing provides a useful model for treatments of diseases and possible cures. (bartleby.com)
Animal testing is essential for developing lifesaving treatments. (bartleby.com)
Due to experiments on animals we have treatments for diabetics, tuberculosis, breast cancer, malaria and brain injuries. (bartleby.com)

To appropriately analyze big data, the field of genomics requires use of epidemiologic studies, animal models, and other work in addition to big data analysis. (cdc.gov)

The platform was developed to counteract emerging neglected viral pathogens with low worldwide infectious disease impact but of significant local/regional public health concern utilizing the concept of emergency immunization in the form of ring vaccination. (nih.gov)

Of note, we have demonstrated the beneficial effect of antioxidants (resveratrol, MitoQ) both in vitro (patients' fibroblasts) and in vivo (mouse model) and are currently testing other antioxidants and mitochondrial biogenesis activators. (uam.es)
Relating in vitro to in vivo exposures with physiologically-based tissue dosimetry and tissue response models. (cdc.gov)

All of these diseases result from an attack of the immune system on the body's own tissues. (nih.gov)

Making a norovirus vaccine has proved challenging because the virus cannot be cultivated and there are no animal models for the disease, Dr. Bernstein explained. (medscape.com)

Various animal models have been used to assess the impact of CS on intestinal pathophysiology. (intechopen.com)

Adding nutrients to the sea could decrease viral infection rates among phytoplankton and enhance the efficiency of the biological pump, a means by which carbon is transferred from the atmosphere to the deep ocean, according to a new mathematical modelling study. (eurekalert.org)

12: Determine if reprogramming of offspring energy metabolism/mitochondrial function can occur by promoting neonatal physical activity or dietary factors in rodent models. (usda.gov)

Future functional studies will determine if the observed changes in gene expression act to preserve tissue function and mitigate aging in these long-lived animals. (drugdiscoverynews.com)
We will analyze how the early exposure to protein sources and fruits normally consumed by infants and children prevents the initiation of and protects against development of chronic diseases by altering tissue differentiation, inflammation, and/or oxidative status. (usda.gov)

The creation of the Medical Marijuana Access program was forced on Health Canada by a judicial ruling that if there was reason to believe that cannabis might be helpful in the treatment of disease, it would be a violation of the Canadian Charter of Rights and Freedoms 3 to not permit access to it. (jrheum.org)
HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. (nih.gov)
Comparative medicine has contributions to make in animal modeling, environmental quality, alcoholism, and mental health. (cdc.gov)
Experts at the University of Birmingham are calling on local and national health authorities and wildlife managers to adopt a robust approach. (sflorg.com)
The team has put together a set of recommendations that can be used by health authorities worldwide which will minimize the risk of disease transmission. (sflorg.com)
We describe how the genome-wide transcriptional profiling can be used in network-based systems toxicology, an approach leveraging biological networks for assessing the health risks of exposure to chemical compounds. (intechopen.com)
We are interested in solving practical health problems using multidisciplinary approaches and in a One Health framework. (sfu.ca)
Sustainability is feasible only through an integrated approach to surveillance and control activities undertaken within reinforced health systems that are able to face this responsibility. (who.int)
Existing tools, however, make it difficult for health systems to participate in control of the disease. (who.int)
The two main technical impediments are the lack of a sensitive and specific diagnostic test that is inexpensive and easy to perform in field conditions and that could be used at any level of the health system, and the absence of an oral medicine that is cheap, safe and easy to administer, and able to cure both forms of the disease. (who.int)
Public Health Approach to Big Data in the Age of Genomics: How Can we Separate Signal from Noise? (cdc.gov)
In particular, the lungs are the most commonly involved organ, with NTM pulmonary diseases causing serious health issues in patients with underlying lung disease. (bvsalud.org)
Tuberculosis disease (TB), caused by Mycobacterium tuberculosis, is a major global public health problem, resulting in more than 1 million deaths each year. (bvsalud.org)
Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. (cdc.gov)
While agreeing with their premise, I would disagree with the conclusion and would argue that the authors fail to adequately describe how the One Health approach provides alternatives to traditional use of animal experimentation. (who.int)
The American Veterinary Medical Association has defined One Health as "…the collaborative efforts of multiple disciplines working locally, nationally and globally, to attain optimal health for people, animals, and our environment" [2]. (who.int)
The One Health paradigm, whether applied to zoonotic disease or other health issues affecting both animals and humans, can provide important alternatives to animal experimentation. (who.int)
Our article focuses on One Health in relation to ethics and a pathway to generating robust evidence from animal experiments and certainly not, as seems to be understood by Dr Lederman, that One Health provides an alternative to the conventional animal experiments. (who.int)
In addition we will address important areas of modern epidemiology such as the influence of early life factors on adult health and disease, but also the importance of the gene-diet-microbiota interaction for body function and health. (lu.se)

Scientists are still working to determine whether this approach is safe and effective for use in people . (medlineplus.gov)
To understand why the system that carries proteins needed to fuel the heart dysfunctions in people with Type 2 diabetes, scientists will use diabetic animal models to examine the part of cells - the mitochondria - that generates the primary energy source for fueling all the heart's activities. (wvu.edu)
They choose animals that have a life span of two to three years because that allows the scientists to observe what happens during the "fast forward" stage. (bartleby.com)

Predict and characterize the ecology and evolution of emerging viral diseases of swine. (usda.gov)

Of interest, we have observed in a rodent transgenerational model of intrauterine growth restriction (IUGR) that a diet supplemented with essential nutrients, yet unaltered in its caloric content, prevents adult metabolic disease and is associated with abrogation of reprogrammed gene expression. (nih.gov)
11: Determine if interventions prior to/during pregnancy that alter maternal hyperinsulinemia, gastrointestinal microbiome and/or inflammation prevent obesity-induced metabolic programming in animal models. (usda.gov)

The philosophy of comparative medicine is based on the exposure of both man and animals to multiple environmental factors. (cdc.gov)
This chapter examines the suitability of animal inhalation/smoke exposure models for assessing the contrary effects of CS on UC and CD. (intechopen.com)

Sam will be determining the reason for this restoration through optogenetic and pharmacological approaches. (smcm.edu)

Here we discuss how this need can be met and propose that additional brain diseases can benefit from this approach. (nature.com)
Accumulation of the α-Syn protein in the brain occurs rather late in the disease. (nature.com)
Mirroring the early phase of the disease in people, two of the mouse strains build up extensive amyloid deposits but do not develop brain atrophy. (worldhealth.net)
A fundamental problem in neuroscience is how to force a transition from one brain state to another by external driven simulation in, for example, wakefulness, sleep, coma, or neuropsychiatric diseases. (upf.edu)
More importantly, we propose to use this highly specific new knowledge to directly alter the conscious state in relevant animal models by electrical stimulation of specific brain regions. (upf.edu)
The whole-brain modeling approach, permits the systematic study in silico of how simulated brain stimulation can force transitions between different brain states. (upf.edu)
When we were looking at a number of different models, it was the dopamine depletions in the rat brain that was our first and most effective results. (lu.se)

Roughly ninety-five percent of all lab animals are special-bred mice and rats. (bartleby.com)
During this time, she helped to pioneer chemical mutagenesis approaches in mice. (biologists.com)

The Professor in Translational Neuroscience with a focus on biomedical imaging should develop and establish sophisticated imaging approaches including optogenic or chemogenic modulation of cellular activity, light sensitive activation, inactivation of substances or genes, state of the art cerebral imaging methods (small animal MRI, PET) and Multiphoton laser scanning microscopy. (nature.com)

Conventional therapies may improve the disease, but have numerous complications. (sciencedaily.com)

Tay-Sachs disease (TSD) and its variants are caused by absence or defects of the alpha subunit of Hex A. (medscape.com)

Genetics plays an important role in PD, with disease-susceptibility loci including more than 90 genes, including SNCA (Synuclein Alpha), LRRK2 (Leucine Rich Repeat Kinase 2), GBA (Glucosylceramidase Beta) , and MAPT (Microtubule Associated Protein Tau) [ 4 ]. (nature.com)
Monica Justice was born in western Kansas and spent her early years on the family farm, which inspired an enduring interest in biology and animal genetics. (biologists.com)
my early interest in cattle and animal genetics was passed down to me from my grandfather, who was a veterinarian and cattle rancher. (biologists.com)

Organisms2

Diseases8

Chemicals and Drugs2

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Psychiatry and Psychology1

Alzheimer's34

Therapeutic approaches6

Centers7

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20221

Researchers11

Pathogenesis7

Degenerative diseases2

Progression5

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Humans and animals5

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