Applications dextrans. Medical search. Frequent questions

Novel drug delivery platforms, including dextran-albumin hydrogels and dextran-poly(ethylene glycol)-albumin hydrogels, were established in which human serum albumin acts simultaneously as an affinity-based drug carrier and crosslinker. (universiteitleiden.nl)
This thesis also explores emerging applications of hydrogels. (universiteitleiden.nl)
FITC-Dextran 250 (FD 250) may be used as a model compound for development of methods to deliver molecules into protoplasts and to study drug release from structures such as hydrogels and liposomes. (sigmaaldrich.com)
Magnetic Composite Thin Films of Fe(x)O(y) Nanoparticles and Photocrosslinked Dextran Hydrogels. (mpg.de)
Functional dextran-based hydrogels: synthesis and biomedical applications. (mpg.de)
The 3-D Life Dextran-CD Hydrogel SG Kit provides reagents for setting up slow gelling, cell-compatible hydrogels. (ilexlife.com)
Although PEG polymers may undergo enzymatic degradation, significant fluid uptake and swelling dominate the degradation of our formulated PEG:dextran hydrogels, resulting in hydrolytically sensitive materials. (nature.com)
The outcomes of this research will provide insights into the electrospinning process of dextran-based polysaccharides for fabricating nanofibers, and the characterization of resulting nanofibers and hydrogels. (unh.edu)
Future applications of electrospun hydrogels. (dokumen.pub)
Nanomaterials have demonstrated a wide range of applications and recently, novel biomedical studies are devoted to improving the functionality and effectivity of traditional and unmodified systems, either drug carriers and common scaffolds for tissue engineering or advanced hydrogels for wound healing purposes. (researchgate.net)

Dextran nanoparticles are 1-100 nm sized particles with drug encapsulation capability. (wikipedia.org)
The small size of these particles also encourages cellular uptake, which makes dextran nanoparticles a potential effective drug delivery system for targeting tumor cells. (wikipedia.org)
Dextran has indirect applications in nanoparticles as a coating. (wikipedia.org)
Iron oxide nanoparticles coated with dextran can be loaded with the microRNA miR-29a to selectively target breast cancer cells and down-regulate anti-apoptotic genes leading to successful breast cancer treatment. (wikipedia.org)
Dextran-coated iron oxide nanoparticles loaded with heparinase-like antisense nucleic acid effectively target uterine cancer cells and inhibit tumor growth. (wikipedia.org)
Gold magnetic nanoparticles coated with dextran can effectively target desired tissue sites with the aid of an externally applied magnetic field. (wikipedia.org)
Dextran coatings can further improve the drug targeting capability of other types of nanoparticles. (wikipedia.org)
Nanoparticles composted of dextran and stearic acid with a polyethylene glycol (PEG) coating can be loaded with antiviral drugs and be effectively internalized by cells. (wikipedia.org)
Dextran can be grafted with folic acid to develop doxorubicin-loaded nanoparticles. (wikipedia.org)
Dextran-folic acid nanoparticles effectively target tumors, reduce off-site toxicity, and prolong blood circulation. (wikipedia.org)
Dextran-spermine nanoparticles loaded with doxorubicin can achieve targeted and sustained drug release in tumors. (wikipedia.org)
Dextran nanoparticles have advantages such as increased drug-loading capacity, improved cellular uptake, reduce off-site toxicity, and increase local drug concentrations at the target tissue site. (wikipedia.org)
The current research indicates that dextran nanoparticles can potentially have applications in the delivery of anti-tumor therapeutics. (wikipedia.org)
One-pot synthesis of carboxymethyl-dextran coated iron oxide nanoparticles (CION) for preclinical fMRI and MRA applications. (bvsalud.org)

Dextran, a neutral and hydrophilic polysaccharide, was functionalized with maleimide or vinyl sulfone groups which are able to form covalent bonds with nucleophilic thiols via a thiol-Michael addition reaction. (universiteitleiden.nl)
Dextran, a biocompatible, water-soluble polysaccharide, was modified at its hydroxyls with acetal moieties such that it became insoluble in water but freely soluble in common organic solvents enabling its use in the facile preparation of acid-sensitive microparticles. (edu.sa)
Electrospinning of Dextran-Based Polysaccharide to Fabricate Nanofiber" by Andrea Bartus, Sabby Clemmons et al. (unh.edu)

Supermagnetic nanospheres composed of iron oxide coated with dextran can be loaded with doxorubicin to effectively target tumor cells and limit off-site toxicity. (wikipedia.org)
A number of commercially available metal/metal oxide nanoparticle s (NPs) such as superparamagnetic iron oxide (SPION) are utilized by the medical field for a wide variety of applications. (cdc.gov)

Dextran is a polymer of anhydroglucose. (sigmaaldrich.com)
In one embodiment, the nanocage is covalently attached to a polymer shell (e.g. a dextran shell). (justia.com)
Dextran drug delivery systems involve the use of the natural glucose polymer dextran in applications as a prodrug, nanoparticle, microsphere, micelle, and hydrogel drug carrier in the field of targeted and controlled drug delivery. (wikipedia.org)
As a natural polymer, dextran is biocompatible and biodegradable in the human body. (wikipedia.org)
Dextran prodrugs are chemically linked drug-polymer complexes in which enzymatic processes and hydrolysis in vivo cause the drug to become pharmacologically active. (wikipedia.org)
First, solutions of varying concentrations of dextran, a branched polymer of dextrose, were synthesized. (unh.edu)

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals. (sigmaaldrich.com)

The functionalized dextran polymers are liable to be crosslinked to generate 3D networks. (universiteitleiden.nl)
groups of the polymers (Mal-PVA, Mal-Dextran, SG-PVA and SG-Dextran), which results in stable hydrogel. (thomassci.com)
Storage: -20C Application: TRUEPEG is used to crosslink PVA and dextran polymers to generate stable hydrogel. (thomassci.com)

The synthesis and applications of the peptides are gaining increasing popularity as a result of the developments in biotechnology and bioengineering areas and for a number of research purposes including cancer diagnosis and treatment, antibiotic drug development, epitope mapping, production of antibodies, and vaccine design. (intechopen.com)
The aim of this chapter is to review some applications of synthetic peptides providing a brief knowledge about peptide synthesis. (intechopen.com)

For biomedical applications such as cancer theranostics, magnetic NPs should be small enough to be superparamagnetic and stable in a biological medium. (researchgate.net)
These magneto-responsive devices can be used for a multitude of biomedical applications, from diagnostic to the treatment of tumors, and are actively being developed and tested for cancer theranostics. (researchgate.net)

When the two reagents are combined, thiol groups on CD-Link form stable thioether bonds with thiol-reactive groups on SG-Dextran, which results in the formation of the gel. (ilexlife.com)

Sigma typically tests the solubility of FITC dextrans in water at concentrations at or above 25 mg/ml. (sigmaaldrich.com)

In the present study we examined the protective potential of exogenously administered human umbilical cord derived mesenchymal stem cells (UCMSCs) against Dextran Sulfate Sodium (DSS) induced acute colitis in immunodeficient NOD.CB 17 - Prkdc scid /J mice with particular attention to endoplasmic reticulum (ER) stress. (biomedcentral.com)
We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. (molvis.org)
Therefore, in this study, we assessed the ability of human adipose mesenchymal stem cells (hADSCs) to express the characteristics of ECs after induction in vitro to evaluate the theoretical feasibility of maintaining or restoring the function of ECs after intraocular application. (molvis.org)

Dextran conjugates are also utilized in nanoparticle drug delivery system formulations. (wikipedia.org)
Among the fluorescent calcium indicator dextran conjugates, Cal-520 dextran conjugates might be the best choice due to their high fluorescence quantum yield and large fluorescence enhancement by calcium. (aatbio.com)

This thesis describes the design, characterization and application of dextran based crosslinked network. (universiteitleiden.nl)

Prostate Specific Antigen Biosensor Based on Long Range Surface Plasmon-Enhanced Fluorescence Spectroscopy and Dextran Hydrogel Binding Matrix. (mpg.de)
Compared to Oregon Green BAPTA-1 dextran, Cal-520 dextran exhibits much lower background and much larger calcium-induced fluorescence enhancement. (aatbio.com)
1. Fluorescence intensity increase of Cal-520®-Dextran (Cat# 20600), Cal-520®-Dextran (Cat# 20601) and Calcium-Green™-1-Dextran upon binding saturated amount of calcium. (aatbio.com)
We harnessed non-invasive fluorescence imaging to sequentially follow in vivo material-mass loss to model the degradation of materials hydrolytically (PEG:dextran hydrogel) and enzymatically (collagen). (nature.com)
As material shape dictates fluid uptake, we examined whether fluorescence tracking could distinguish the fate of PEG:dextran formulations cast in a series of shapes, sizes and varying PEG solid content. (nature.com)

In vivo, FITC-dextran is stable for more than 24 hours. (sigmaaldrich.com)
Therapeutic agents can be linked to dextran via an ester bond which can be hydrolyzed slowly by esterases to produce sustained, stable drug release. (wikipedia.org)
TRITC-lysine-dextran is stable for more than 6 years when stored dry in well-sealed containers at ambient temperature. (tdblabs.se)

FITC-dextran is used in cardiovascular, microcirculation, perfusion, cell monolayer and cell membrane permeability research as fluorescent flux tracer compound that supports the measurement of processes such as blood flow, membrane damage, vascular drainage and renal elimination. (sigmaaldrich.com)
Indeed, the swelling and erosion kinetics ( Supplementary Fig. S1a ), gelation time ( Supplementary Fig. S1b ) and adhesion to biological tissues ( Supplementary Fig. S1c ) of PEG:dextran were unaffected by 5% fluorescent PEG (demonstrated using the following formulation of dextran, D10-50-14, and PEG, P8-10-40, as described in Supplementary Table S2 ). (nature.com)
TRITC-lysine-dextran is a dextran derivative carrying both free primary amines and free carboxylates as well as the fluorescent dye Tetramethylrhodamine (TRITC). (tdblabs.se)
The method consisted of a single intravenous injection of 12 mg of a large 150-kDa carboxy-methyl dextran conjugated to a fluorescent rhodamine-derived dye as the PV marker (PVM), and 35 mg of a small 5-kDa carboxy-methyl dextran conjugated to fluorescein, the renal clearance marker. (karger.com)

In this study, we aimed to fabricate nanofibers using dextran-based polysaccharides and investigate their potential for cell culture. (unh.edu)

FITC-dextran is used extensively in microcirculation and cell permeability research utilizing microfluorimetry. (sigmaaldrich.com)
FITC-dextran has been used to study plant cell wall porosity and capillary permeability. (sigmaaldrich.com)
Plasma proteins have been shown not to bind to FITC-dextran. (sigmaaldrich.com)
Small FITC-dextrans are also used to measure processes such as endocytosis. (sigmaaldrich.com)
These particles degrade in a pH-dependent manner: FITC-dextran was released with a half-life at 37 °C of 10 h at pH 5.0 compared to a half-life of approximately 15 days at pH 7.4. (edu.sa)

Dextrans with MW greater than 10,000 behave as if they are highly branched. (sigmaaldrich.com)
Dextrans with MW of 2,000 to 10,000, exhibit the properties of an expandable coil. (sigmaaldrich.com)

Additionally, this dextran derivative was found to be nontoxic in preliminary in vitro cytotoxicity assays. (edu.sa)

and microbial resources, such as dextran and xanthan gum. (bharatbook.com)
1.B Evaluation of oxidizing agents and dextranase enzyme to control microbial growth and dextran levels in sugarcane juice. (usda.gov)
This can be accomplished by * reducing chemicals used to control starch and dextran in raw sugar manufacturing, * improving the quality of the raw sugar to minimize refining costs, * reducing sugar losses by microbial action by improving sanitation, and * more effectively utilizing the byproducts to make coproducts. (usda.gov)

TRITC-lysine dextrans are synthesised from well-characterised dextran fractions derived from Leuconostoc mesenteroides. (tdblabs.se)
The isolated plasmid could be a useful genetic tool for high-level gene expression in Leuconostoc , and for extending the applications of this useful bacteria to various areas in the dairy and pharmaceutical industries. (biomedcentral.com)
Leuconostoc produces flavor-enhancing aromatic compounds in food products [ 5 ] and synthesizes dextrans which are used as food additives and industrial products like Sephadex [ 6 ]. (biomedcentral.com)
Thus, preliminary, it is necessary to develop key tools such as plasmids, efficient transformation methods, and gene expression systems to make Leuconostoc a more promising host for use in a wide variety of applications. (biomedcentral.com)

Its major components are SG-Dextran and the crosslinker CD-Link. (ilexlife.com)

As the MW increases, dextran molecules attain greater symmetry. (sigmaaldrich.com)

Native dextran has been found to have a molecular weight (MW) in the range of 9 million to 500 million. (sigmaaldrich.com)
We find applications both in the biophysical/molecular biology field and in the industrial area. (lu.se)

PEG replete with amine groups and oxidized dextran react at body temperature in a Schiff base reaction to form adhesive materials as aldehydes bind to tissue amines. (nature.com)

According to several in vitro and animal research studies, dextran carriers reduce off-site toxicity and improve local drug concentration at the target tissue site. (wikipedia.org)

Dextran can also be chemically modified to produce derivatives at a low cost, which can address a few of the undesirable characteristics including its low mechanical strength and uncontrollable hydration rate [4]. (wikipedia.org)
Application: EncapGel(TM)-Cx Kit is a ready-to-use, chemically crosslinked hydrogel kit for the encapsulation and delivery of drugs, biomolecules, and cells. (thomassci.com)

The nanoparticle's biocompatibility and imaging performance may prove advantageous in a broad range of preclinical and clinical applications of MRI. (nature.com)
Preclinical studies of Mg or its alloys for orthopedic application. (dokumen.pub)

The dextran forms of our calcium indicators show a dramatic reduction in both leakage and compartmentalization compared to the AM ester forms. (aatbio.com)

Then the synthetic peptide vaccine application of peptides was reviewed. (intechopen.com)

A lateral flow immunoassay for the detection of anti-drug antibodies against a biological drug includes a membrane having a capture area, a sample application area, a flow path from the sample application area to the capture area, and a conjugate area located in the flow path. (justia.com)
Twenty micro litres of dextran loaded phosphate buffer were then added and the silicon nitride membrane window cell sealed. (2spi.com)
covering the major aspects of the science, technology and application of membrane operations and related fields. (lu.se)

Microspheres composed of dextran have several advantages as a drug delivery system including controlled drug release, localized drug concentration, and reduced adverse reactions. (wikipedia.org)

The MW of dextran is measured by one or more of the following methods: low angle laser light scattering, size exclusion chromatography, copper-complexation and anthrone reagent colorometric reducing-end sugar determination and viscosity. (sigmaaldrich.com)
To maximize performance, it is strongly recommended that the reagent be titrated for each application, and that you centrifuge the antibody dilution before adding to the cells at 14,000xg at 2 - 8°C for 10 minutes. (biolegend.com)

Deadline for the referees identified in the application for admission to submit references. (ubc.ca)
A minimum of three references are required for application to graduate programs at UBC. (ubc.ca)

can be covalently attached to a portion of the SH-reactive groups on SG-Dextran to provide a cell-adhesive matrix. (ilexlife.com)

The magnetic beads consist of a single-crystal Fe 3 O 4 sphere core and dextran coating layer. (gbiosciences.com)
Through chemical modification of dextran, the primary amino group (-NH 2 ) are joined to the magnetic beads through a short hydrophilic linker. (gbiosciences.com)

When used in a model vaccine application, particles loaded with the protein ovalbumin (OVA) increased the presentation of OVA-derived peptides to CD8 + T-cells 16-fold relative to OVA alone. (edu.sa)

Using stereomicroscopy and microscopic examination of plastic sections, dextran dyes dispersed in SNOT are demonstrated in the neuroepithelium of the nose and olfactory bulb of B6;129P2-Omp(tm3Mom)/MomJ mice after intranasal instillation in SNOT. (cdc.gov)

With advances in nanotechnology, engineered nanomaterial applications are a rapidly growing sector of the economy. (cdc.gov)

Electrospun nanocomposites for medical applications. (dokumen.pub)
Application of nanocomposites. (dokumen.pub)
Nanocomposites in orthopedic drug delivery applications. (dokumen.pub)
Nanocomposites in bone tissue engineering applications. (dokumen.pub)

Applicants from a university outside Canada in which English is not the primary language of instruction must provide results of an English language proficiency examination as part of their application. (ubc.ca)

Research must address several challenges and obstacles associated with dextran before it can become a viable, clinically approved drug delivery strategy. (wikipedia.org)
A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)
Cell-Ess can deliver fats and cholesterol, boosting the ability of cells to make membranes in either basic research and bioprocessing applications. (genengnews.com)

A final part of the program is to apply the understanding obtained in the basic studies for solving application problems. (lu.se)

Although there are many FDA approved natural polymeric-based drug carriers available for clinical use, dextran has failed to obtain any clinical applications. (wikipedia.org)
Dextran has many favorable properties that make it an ideal candidate for applications as a drug delivery system. (wikipedia.org)
Drug-dextran complexes can also be formed by chemical linkage through an amide bond, which is hydrolyzed by amidase. (wikipedia.org)
Owing to its ease of preparation, processability, pH-sensitivity, and biocompatibility, this type of modified dextran should find use in numerous drug delivery applications. (edu.sa)
Dextran 40 is a blood volume expansion drug, mainly used to treat patients due to burns, trauma, and blood loss caused by shock, or toxic shock. (xawanlong.net)

the applied, absorbed energy is usually depleted non-homogeneously, and the intricacy of biological processes modifies the intended impact of application. (spandidos-publications.com)
However, dextran has a very diverse application area ranging from vaccines over ophthalmic use to stabilizer of biological components. (xawanlong.net)

Cells may be physically loaded with the cell-impermeant salt forms of these dextran-conjugated calcium indicators using patch pipette or microinjection. (aatbio.com)
To test this hypothesis, the effects of dextran-coated SPION of different sizes (15-50 nm) and manufacturers (MicroMod, Rostock-Warnemunde, Germany and KTH-Royal Institute of Technology, Stockholm, Sweden) were evaluated in two cell lines: normal human epidermal keratinocytes (HEK) and murine epidermal cells (JB6 P(+)). HEK cells exposed to 20 nm (KTH and MicroMod) had a decrease in viability, while the 15 and 50 nm particles were not cytotoxic. (cdc.gov)

New method to form giant unilamellar vesicles was established by assisting the hydration process of a lipid film with a dextran-poly(ethylene glycol) hydrogel film. (universiteitleiden.nl)

The encyclopeida cover a multitude of applications in diverse disciplines such as biotechnology, medicine, agro-food and petrochemical industries, environmental protection, as well as drinking water supply. (lu.se)

We give some theoretical concepts about the design and production of such systems while providing a critical review of applications in clinical practice. (researchgate.net)

Anatomy4

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Chemicals and Drugs24

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Phenomena and Processes14

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10,0002

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