• HLA-A*02 appears to stimulate peripheral blood mononuclear cells in a manner that inhibits HIV replication. (wikipedia.org)
  • [ 72 ] The AIRE gene has a major role in enhancing the expression of peripheral antigens such as insulin within the thymic medullary epithelial cells. (medscape.com)
  • [ 73 , 74 ] Tiny amounts of "peripheral" (i.e., not in the thymus) antigens such as insulin, antigens expressed within the thymus, are associated with negative selection of autoreactive T cells and protection from autoimmunity. (medscape.com)
  • In essence, there are indicators, albeit from a small study comparing HLA expression in fertile and infertile couples, that HLA-A*02 may induce increased maternal immune response to the fetus. (wikipedia.org)