• This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. (wikipedia.org)
  • Apoferritin-encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells. (nottingham.ac.uk)
  • Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. (nih.gov)
  • Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. (deathbase.org)
  • We have developed a PCR approach to clone new apoptotic Ced-3/Ice-like cysteine protease genes. (deathbase.org)
  • Our data suggest that Mch2 is a Ced-3/interleukin-1 beta converting enzyme-like cysteine protease and could be another important mediator of apoptosis in mammalian cells. (deathbase.org)
  • Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene. (wikipedia.org)
  • Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. (wikipedia.org)
  • 2007) (S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18. (guidetopharmacology.org)
  • Caspase 1 is also known as interleukin-1beta (IL-1α) converting enzyme (ICE). (guidetoimmunopharmacology.org)
  • PARP [Poly (ADP-ribose) polymerase] is a 116 kDa nuclear chromatin-associated enzyme that is cleaved during apoptosis by caspase-3 into a 24 kDa fragment containing the DNA binding domain and an 89 kDa fragment containing the catalytic and automodification domains. (novusbio.com)
  • A cysteine peptidase is a proteolytic enzyme that hydrolyses a peptide bond using the thiol group of a cysteine residue as a nucleophile. (embl.de)
  • Ligand binding to cognate receptors activates initiator caspases directly in a death-inducing signaling complex. (deathbase.org)
  • In Drosophila, TNF ligand binding activates initiator caspases indirectly, through JNK. (deathbase.org)
  • The calpains ostensibly participate in a variety of cellular processes including remodelling of cytoskeletal/membrane attachments, different signal transduction pathways, and apoptosis. (embl.de)
  • The apoptosis was transduced by multiple signaling pathways mediated by FasL and TNFR2 and mainly activated the mitochondrial control of apoptosis via Bid and Bim, which was rescued by silencing Bid or/and Bim . (biomedcentral.com)
  • These outcomes present sturdy proof that Cu-NPs can set off each intrinsic and extrinsic apoptotic pathways to mediate uterine harm, leading to oxidative stress-related modifications in gene expression. (caspase-14.com)
  • Knockdown of CASP5 greatly inhibited GBM proliferation and resulted in G1 cell cycle arrest along with higher apoptosis ratios in vitro and in vivo, while overexpression led to the opposite phenomenon. (cancerindex.org)
  • CPP32 and Mch2 alpha can also cleave poly(ADP-ribose) polymerase in vitro, suggesting that these enzymes participate in poly(ADP-ribose) polymerase cleavage observed during cellular apoptosis. (deathbase.org)
  • The antibody recognizes an epitope in the large domain subunit of Caspase-3. (thermofisher.com)
  • As such it will recognize pro Caspase-3 and the large subunit cleavage fragment. (thermofisher.com)
  • Untreated and Staurosporine treated Jurkat cells were subjected to SDS PAGE followed by western blot with 19677-1-AP (Caspase 3 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. (ptgcn.com)
  • Western Blot analysis of (A) RAW264.7 and (B) NIH-3T3 cell lysate using Active/Pro-Caspase 3 Monoclonal Antibody (31A1067) (Product # MA1-91637). (thermofisher.com)
  • The tumor tissues were analyzed using apoptosis antibody arrays, real time PCR and western blot. (biomedcentral.com)
  • Inhibition of zHDR, zOTR, the adaptor zFADD, or caspase-8-like proteases blocked ligand-induced apoptosis, as did antiapoptotic Bcl-2 family members. (deathbase.org)
  • Caspase (Casp) family proteases regulate not only lymphocyte apoptosis but also lymphocyte activation and development. (deathbase.org)
  • This approach uses degenerate oligonucleotides encoding the highly conserved pentapeptides QACRG and GSWFI that are present in all known apoptotic cysteine proteases. (deathbase.org)
  • In this study, we tried to examine the anti-metastasis and apoptosis/autophagy actions of Coenzyme Q0 (CoQ0, 2,3-dimethoxy-5-methyl-1,4-benzoquinone), a derivative of Antrodia camphorata in HNCC TWIST1 overexpressing (FaDu-TWIST1) cells as well as in vivo tumor xenograft mice model. (bvsalud.org)
  • Likewise, ROS-mediated AKT inhibition regulates CoQ0-induced apoptosis/autophagy in FaDu-TWIST1 cells. (bvsalud.org)
  • The results suggested that BF-rTK + GCV induced tumor apoptosis without autophagy and necroptosis occurrence. (biomedcentral.com)
  • BF-rTK + GCV induced tumor apoptosis mediated by FasL and TNFR2 through the mitochondrial control of apoptosis via Bid and Bim without inducing necroptosis and autophagy. (biomedcentral.com)
  • Abnormal autophagy is related to the pathogenesis and clinical symptoms of myelodysplastic syndrome (MDS). (frontiersin.org)
  • However, the effect of autophagy-related genes (ARGs) on the prognosis of MDS remains unclear. (frontiersin.org)
  • MDS was found to be related to genetic mutations or epigenetic modifications, which lead to abnormal autophagy, apoptosis of mature cells, chromosomal abnormalities, and a high level of inflammation in the bone marrow microenvironment ( 4 - 8 ). (frontiersin.org)
  • Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. (nih.gov)
  • The mammalian extrinsic apoptosis pathway is triggered by Fas ligand (FasL) and Apo2 ligand/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL). (deathbase.org)
  • Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 19677-1-AP (Caspase 3 antibody) at dilution of 1:200 (under 10x lens. (ptgcn.com)
  • Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 19677-1-AP (Caspase 3 antibody) at dilution of 1:200 (under 40x lens. (ptgcn.com)
  • 1X10^6 HepG2 cells were intracellularly stained with 0.2 ug Anti-Human Caspase 3/p17/p19 (19677-1-AP) and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) at dilution 1:1000 (green), and 0.2 ug Control Antibody. (ptgcn.com)
  • The following product was used in this experiment: Active/Pro-Caspase 3 Monoclonal Antibody (31A1067) from Thermo Fisher Scientific, catalog # MA1-91637, RRID AB_1954999. (thermofisher.com)
  • A colorectal cancer model was used to decipher the molecular mechanism of BF-rTK + GCV (bifidobacterial recombination thymidine kinase/ganciclovir) using a human apoptosis antibody array kit in a murine cancer model in vivo . (biomedcentral.com)
  • It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. (thermofisher.com)
  • Apoptosis produced by CoQ0 was mostly related with caspase-3 activation, PARP cleavage, and VDAC-1 expression. (bvsalud.org)
  • Here we report that beta-amyloid precursor protein (APP) and death receptor 6 (DR6, also known as TNFRSF21) activate a widespread caspase-dependent self-destruction program. (deathbase.org)
  • Caspase 6 regulates B cell activation and differentiation into plasma cells. (deathbase.org)
  • 1. Avivi-Green C, Polak-Charcon S, Madar Z, Schwartz B. (2002) Different molecular events account for butyrate-induced apoptosis in two human colon cancer cell lines. (guidetoimmunopharmacology.org)
  • Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. (wikipedia.org)
  • The caspase activation and recruitment domain (CARD) of caspase-4 recognises the lipid A moiety of LPS. (guidetopharmacology.org)
  • Activation of caspase-4 results in pyroptosis, and induction of NLRP3 inflammasome activation which promotes IL-1β and IL-18 maturation and secretion. (guidetopharmacology.org)
  • Involved in the activation cascade of caspases responsible for apoptosis execution. (lu.se)
  • Apoptotic signaling is initiated either through extrinsic or intrinsic stimulation, resulting in the activation of caspases [ 12 ]. (biomedcentral.com)
  • These nematodes are only distantly related to Caenorhabditis elegans and have evolved to occupy an unusual niche, tunneling through epithelial cells of the large intestine. (nature.com)
  • The outcomes indicated that publicity to Cu-NPs led to vital decreases within the relative uterine weight coefficients and will increase in inflammatory cell infiltration, mitochondrial swelling and vacuolization, shortened and lowered endometrial epithelial cell microvilli, and apoptosis. (caspase-14.com)
  • Delineation of the cell-extrinsic apoptosis pathway in the zebrafish. (deathbase.org)
  • Thus, the extrinsic apoptosis pathway in zebrafish closely resembles its mammalian counterpart and cooperates with the intrinsic pathway to trigger tissue-specific apoptosis during embryogenesis in response to ectopic Apo2L/TRAIL expression. (deathbase.org)
  • On the basis of whole-transcriptome analyses, we identify many genes that are expressed in a sex- or life stage-specific manner and characterize the transcriptional landscape of a morphological region with unique biological adaptations, namely, bacillary band and stichosome, found only in whipworms and related parasites. (nature.com)
  • In the present study, we analyzed prognosis model, immunocyte infiltration characterization, and competing endogenous RNA (ceRNA) network of GBM on the basis of pyroptosis-related genes (PRGs). (researchsquare.com)
  • However, BF + GCV only induced apoptosis via Fas/FasL signal pathway accompanied with increased P53 expression. (biomedcentral.com)
  • These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs, and our study suggests that the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution. (deathbase.org)
  • niban apoptosis regulator 1 [Sourc. (gsea-msigdb.org)
  • 2 (Bcl-2) expression, and elevated the expression of apoptotic peptidase activating issue 1 (Apaf-1), BCL2-associated X, apoptosis regulator (Bax), and cytochrome c. (caspase-14.com)
  • Among the enzymatic activities, special attention must be paid to the activity similar to metalloproteinase and dipeptidyl peptidase observed during reconstruction in an aqueous product. (grenboel.eu)
  • Our research shows that mucus also has caspase-like activity. (grenboel.eu)
  • Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
  • Is p53-dependent ferroptosis sufficient for tumor suppression in the absence of cell cycle arrest, senescence, and apoptosis? (nature.com)
  • To date, various mechanisms have been suggested to explain the powerful tumor-suppressive effect of p53, including the induction of cell cycle arrest, senescence, and apoptosis. (nature.com)
  • Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. (wikipedia.org)
  • Caspase-8, a member of the caspase family, plays an important role in apoptotic signal transduction in mammals. (deathbase.org)
  • In only one family of cysteine peptidases, is the role of the general base assigned to a residue other than a histidine: in peptidases from family C89 (acid ceramidase) an arginine is the general base. (embl.de)
  • Belongs to peptidase family C14. (lu.se)
  • Here we report the identification and characterization of the caspase-8 (casp8) gene in the zebrafish Danio rerio. (deathbase.org)
  • Caspases are a specific class of enzymes that play a major role in the processes of apoptosis and inflammation in mammals, including humans. (grenboel.eu)
  • Pyroptosis and TME-related independent prognostic markers were screened in this study, and a prognosis risk score formula was established for the first time according to the prognosis PRGs. (researchsquare.com)