Apoptosis protein serine threonine kinases. Medical search. Frequent questions

The phosphoinositide 3-kinase (PI3K)/RAC seine/threonine-protein kinase (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway is a promising therapeutic target owing to its frequent dysregulation in HCC and the critical functions it has in regulating cell survival, proliferation, apoptosis, migration and angiogenesis through phosphorylation of distinct protein substrates ( 6 , 7 ). (spandidos-publications.com)
Exposure of BEAS-2B cells to SWCNT resulted in the phosphorylation of protein p42/44 (p42/44) and protein p38 (p38). (cdc.gov)
SWCNT did not induce protein serine-threonine kinase (AKT) phosphorylation. (cdc.gov)
This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. (cusabio.com)
Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)
Background: The phosphorylation of NF-kappaB inhibitor alpha (IκBα) protein is pivotal to the regulation of NF-κB transcription factor activity in the cell. (researchsquare.com)
The phosphorylation of IκBα by IκB kinase family have been so many identified, but the phosphorylation sites of IκBα by other kinases remain poorly understood. (researchsquare.com)
To identify the essential domains of IκBα for phosphorylation of IκBα by AURK, kinase assay was performed with a series of IκBα truncation mutants. (researchsquare.com)
Results: We identified two novel sites of serine phosphorylation at S63 and S262. (researchsquare.com)
Conclusions: Therefore, we identified novel phosphorylation site of IκBα by AURK, and its site was related to apoptosis and necroptosis pathway in breast cancer cells. (researchsquare.com)
Compound 51 inhibited the proliferation of 13 out of 15 cancer cell lines with IC50 values between 0.27 and 6.9 μM, which correlated with the complete suppression of retinoblastoma phosphorylation and the onset of apoptosis. (rcsb.org)
Zhu H, Dai Z, Liu X, Zhou H, Wang Y. Serine/threonine kinase 3 promotes oxidative stress and mitochondrial damage in septic cardiomyopathy through inducing Kelch-like ECH-associated protein 1 phosphorylation and nuclear factor erythroid 2-related factor 2 degradation. (ijbs.com)
STK3-mediated phosphorylation of Kelch-like ECH-associated protein 1 (KEAP1) was shown to suppress antioxidant gene transcription controlled by nuclear factor erythroid 2-related factor 2 (Nrf2) in macrophages. (ijbs.com)
The first antibody is selected for its specific binding to the phosphorylated motif on the protein, the second for its ability to recognize the protein independent of its phosphorylation state. (cisbio.net)
Protein phosphorylation enables an immune-complex formation involving both labeled antibodies and which brings the donor fluorophore into close proximity to the acceptor, thereby generating a FRET signal. (cisbio.net)
Its intensity is directly proportional to the concentration of phosphorylated protein present in the sample, and provides a means of assessing the protein s phosphorylation state under a no-wash assay format. (cisbio.net)

The RAC serine/threonine-protein kinase (AKT) family of serine/threonine protein kinases, particularly the AKT1 isoform, has been identified abnormally expressed in hepatocellular carcinoma (HCC) cells, and is highly associated with cell behavior, including proliferation, survival, metabolism, and tumorigenesis. (spandidos-publications.com)
Molecular mechanisms and the influences of different regulation the expression of AKT1 on HCC cell growth, proliferation were determined by western blotting, MTT and colony formation assays, cell cycle and apoptosis were investigated by flow cytometry. (spandidos-publications.com)
However, the precise molecular mechanisms by which AKT1 promotes cell proliferation and regulates apoptosis ( 18 , 19 ) remain largely unclear. (spandidos-publications.com)
High expression of activated AKT can be detected in HCC, and AKT may promote cell proliferation and regulation of cells apoptosis in HCC ( 20 , 21 ). (spandidos-publications.com)
The present study confirmed a potential function for AKT1 in promoting proliferation and inhibiting apoptosis of HCC. (spandidos-publications.com)
Subsequent mechanism investigations revealed that AKT1 served a notable function in cell proliferation and anti-apoptosis by directly regulating the expression of phosphatase and tensin homolog (PTEN) and Notch1. (spandidos-publications.com)
Protein kinase A (PKA or cAMP-dependent protein kinase) is a serine/threonine kinase that plays essential roles in the regulation of proliferation, differentiation, and apoptosis. (nih.gov)
Sorafenib (Sor) can block receptor tyrosine kinases, which are involved in the development of new blood vessels, as well as cell proliferation as a result [ 22 ]. (biomedcentral.com)
Protein kinase C (PKC) is a key enzyme which regulates proliferation, apoptosis and differentiation, representing a pharmacological target for tumor therapy. (endocrine-abstracts.org)
Protein kinase C (PKC) is a family of serine-threonine kinases that regulate many cellular processes including proliferation and survival. (endocrine-abstracts.org)
Previous evidence has shown that PKC is involved in the control of human medullary thyroid carcinoma (MTC) proliferation and survival by modulating apoptosis, with a mechanism that implicates PKCβII isoform and translocation in different subcellular compartments.In this study, we investigated the role of PKCδ. (endocrine-abstracts.org)
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. (cusabio.com)
Considered vital to the modulation of cell proliferation, differentiation, matrix synthesis, and apoptosis, members of the TGF-β Superfamily are fundamental to prenatal development and the postnatal growth, remodeling, and maintenance of various tissues and organs. (peprotech.com)
P21-activated kinase 3 (PAK3) is a serine/threonine protein kinase, and PAK3 affects the EMT, proliferation, metastasis and invasion of HCC. (jcancer.org)
Here, we report that during intestinal inflammation, multiple inflammatory cytokines promote the activity of a master regulator of cell proliferation and apoptosis, serine/threonine kinase CK2. (diva-portal.org)
Many physiological processes, including proper tissue development and homeostasis, require a balance between apoptosis and cell 123653-11-2 manufacture proliferation. (bioinf.org)
Apoptosis and cell proliferation are linked by cell-cycle regulators and apoptotic stimuli that affect both processes. (bioinf.org)
A failure in regulating proliferation together with suppression of apoptosis are the 123653-11-2 manufacture minimal requirements for a cell to become cancerous [4]. (bioinf.org)
Two proteins involved intimately in regulating cell proliferation are Akt and the tumor suppressor p53 (p53). (bioinf.org)
Recently, the signaling proteins involved in LPLI-induced proliferation merit special attention, some of which are regulated by mitochondrial signaling. (biomedcentral.com)
Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)
Recently, a large number of signaling proteins reported play an important key role in the process of LPLI-induced cell proliferation, probably due to the fact that the molecular events they are involved in are the basic response of the cells to extracellular stimuli. (biomedcentral.com)
New anticancer therapy strategies refer to the inhibition of CDK-cyclin complexes as an important target to prevent uncontrolled proliferation and induce apoptosis in cancer cells ( 2 ). (spandidos-publications.com)
Also known as protein kinase B (PKB), Akt is an oncogene playing a key role in controlling apoptosis, cell proliferation, transcription, cell migration, and glucose metabolism. (cisbio.net)
Specifically, the RAS/MAPK pathway regulates the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (migration), and the self-destruction of cells (apoptosis). (medlineplus.gov)
This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell proliferation and may allow histiocytes to grow and divide uncontrollably, leading to the abnormal accumulation of histiocytes that occurs in Erdheim-Chester disease. (medlineplus.gov)
This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell proliferation. (medlineplus.gov)
Specify the components and their interactions and set up cluding proliferation, differentiation, apoptosis, embryonic the system of equations. (lu.se)

Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. (cancerindex.org)
SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)
Upon administration, berzosertib selectively binds to and inhibits ATR kinase activity and prevents ATR-mediated signaling in the ATR-checkpoint kinase 1 (Chk1) signaling pathway. (cancertreatmentsresearch.com)
This protein is part of a signaling pathway known as the RAS/MAPK pathway, which controls several important cell functions. (medlineplus.gov)
Almost all of these genetic changes abnormally activate the protein, which disrupts the tightly regulated RAS/MAPK signaling pathway in cells throughout the body. (medlineplus.gov)

The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. (ptglab.com)
Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. (ptglab.com)
Full length human recombinant protein of human AKT1(NP_005154) produced in HEK293T cell. (origene.com)

This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. (antibodies-online.com)
Background Glycogen synthase kinase 3 (GSK3) encodes a serine/threonine proteins kinase, may play functions in lots of biological procedures. (techblessing.com)

Encompassing a plethora of growth, differentiation and morphogenic factors, the Transforming Growth Factor-β (TGF-β) Superfamily is comprised of signaling proteins that have been universally conserved throughout the animal kingdom and presently consists of over forty members, the likes of which include: TGF-β isoforms, bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), activins, and inhibins. (peprotech.com)
This interaction can be responsible for the regulation of cellular events ranging from glucose and lipid homeostasis to cell differentiation and apoptosis [ 12 ]. (biomedcentral.com)

Noted for activating Smad signaling cascades through interactions with a conserved family of cell surface serine/threonine-specific protein kinase receptors, the complexity of TGF-β signaling has been demonstrated through the additional regulation of physiological processes by TGF-β Superfamily Ligand through non-canonical pathways, and the activation of signaling molecules other than Smad proteins. (peprotech.com)

This inhibition of AMPK ultimately leads to inhibition of mTOR and thus induces apoptosis in the HepG2 cells. (biomedcentral.com)
This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. (antibodypedia.com)

SWCNT induced a significant activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF-kB), and the effect was inhibited by mitogen-activated protein kinase (MAPK) inhibitors. (cdc.gov)
Subfamily members are mitogen-activated protein kinase (MAPK) kinase kinases (MAPKKKs or MKKKs or MAP3Ks) and include ASK1, ASK2, and MAPKKK15. (umbc.edu)

Introduction: CDKN1B gene, which encodes a cyclin-dependent kinase (Cdk) inhibitor, regulates the progression throughout G1 to S cell cycle progression. (endocrine-abstracts.org)
These researchers have explored the use of rho-kinase (ROCK) inhibitor drops as an alternative to corneal transplantation, which could greatly impact the way we treat and manage corneal diseases. (reviewofoptometry.com)
Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2. (bioquote.com)
Utilization of JNK inhibitor SP600125 or knockdown of JNK by siRNA potentiate the cytotoxicity of C-2 through down-regulation of p62 and LC3II proteins and up-regulation of active-Caspase3 proteins, enhance the cell death effect, facilitating the switch from autophagy to apoptosis. (biomedcentral.com)
Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. (spandidos-publications.com)
As reported in The Lancet Oncology by Panagiotis A. Konstantinopoulos, MD, Dana-Farber Cancer Institute, and colleagues, a U.S. Experimental Therapeutics Clinical Trials Network phase II trial has shown significantly prolonged progression-free survival with the addition of the ATR (ataxia telangiectasia and Rad3-related) kinase inhibitor berzosertib to gemcitabine in women with recurrent platinum -resistant high-grade serous ovarian cancer. (cancertreatmentsresearch.com)
An inhibitor of ataxia telangiectasia and rad3-related (ATR) kinase, a DNA damage response kinase, with potential antineoplastic activity. (cancertreatmentsresearch.com)

Exposure of BEAS-2B cells to SWCNT induced apoptosis, DNA damage, and oxidative stress. (cdc.gov)
The p53 protein is a transcription factor that normally inhibits cell growth and stimulates cell death in response to myriad stressors, including DNA damage (induced by either UV or chemical agents such as hydrogen peroxide), oxidative stress, and deregulated oncogene expression [6-10]. (bioinf.org)
Various physiological and pathological conditions such as glucose starvation, inhibition of protein glycosylation and oxidative stress may cause an accumulation of unfolded proteins in the endoplasmic reticulum (ER), leading to the unfolded protein response (UPR) and autophagy. (spandidos-publications.com)
Serine/threonine kinases (STK3) is a core component of the Hippo pathway and modulates oxidative stress and inflammatory responses in cardiovascular diseases. (ijbs.com)

A diverse range of physiological stimuli induce Akt kinase activity, including many trophic factors which promote survival, at least in part, through Akt activation via the phosphatidylinositide 3-OH kinase 123653-11-2 manufacture (PI3K) signaling cascade. (bioinf.org)
Lacking proteosomal function on aggregates of unfolded proteins, ER stress may induce autophagic machinery. (spandidos-publications.com)

The ASK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)

It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. (antibodypedia.com)

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a central regulator of inflammatory cell function that coordinates inflammation, apoptosis and necroptosis in response to inflammatory stimuli. (neurosciencenews.com)
A substantial synergistic interaction between Amy and Sor was observed (CI 50 = 0.56), which was connected to cell cycle arrest at the S and G2/M stages and increased apoptosis and potential necroptosis. (biomedcentral.com)

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. (nih.gov)

This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. (nih.gov)
Ser-9 in GSK3) catalyzed by either MAPKAP kinase-1/or p70S6K [11,12], whereas proteins kinase C phosphorylates and partly inhibits GSK3, however, not GSK3 [13]. (techblessing.com)

To identify kinase target substrates in a high-throughput manner, we first quantified the change of phosphoproteome in the cells of which PKA activity was perturbed by drug stimulations. (nih.gov)
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. (umbc.edu)
Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)

Ca 2+ /CaM binds to the death-associated protein kinase 1 (DAPK1) to regulate intracellular signaling pathways. (frontiersin.org)
Upon Ca 2+ binding, CaM is capable of interacting with hundreds of protein targets to regulate the wealth of intracellular signaling pathways. (frontiersin.org)
CRT effects are related to alterations in genes and microRNAs (miRs) expression, which regulate cardiac processes involved in cardiac apoptosis, cardiac fibrosis, cardiac hypertrophy and angiogenesis, and membrane channel ionic currents. (hindawi.com)

DAPK1, located in human chromosomal locus 9q34.1, is a member of the DAPK family that belongs to the serine/threonine kinase (STK) superfamily. (frontiersin.org)
Given the intricacies and significance associated with the activities of TGF-β Superfamily proteins, the impairment of proper signaling has been understandably connected to a variety of clinical indications, such as tumor cell growth, fibrosis, skeletal defects, and autoimmune disease. (peprotech.com)

One-hour treatment with 10 µM Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages. (bioquote.com)
Accordingly, transfection of phosphodefective KEAP1 mutant protein in cardiomyocyte restored Nrf2 expression and mitochondrial performance upon LPS, while expression of a phosphomimetic KEAP1 mutant abolished the mitochondria-protective and pro-survival effects of STK3 deletion. (ijbs.com)
AKT (or protein kinase B) plays a key role in controlling survival and apoptosis. (cisbio.net)
This serine/threonine protein kinase is regulated by insulin and various growth and survival factors, to work in a wortmannin-sensitive pathway involving PI 3 kinase. (cisbio.net)

The mutation affects a single amino acid in the BRAF protein. (medlineplus.gov)
The BRAF gene mutations change single amino acids in the BRAF protein: One mutation replaces the amino acid threonine with the amino acid proline at position 241 (written as Thr241Pro or T241P) and the other mutation replaces the amino acid leucine with the amino acid phenylalanine at position 245 (written as Leu245Phe or L245F). (medlineplus.gov)

SUMOylation of proteins is an important mechanism in cellular responses to environmental stress ( 21 , 22 ). (frontiersin.org)
In addition, SARS-COV- 2 The expression of apoptosis-related factors in infected organoids is up-regulated, which provides an important tool for the study of neocoronavirus cell tropism, pathogenic mechanism and subsequent drug development. (medicaltrend.org)
Although purvalanol-induced cell cycle arrest and apoptotic cell death were demonstrated in prostate ( 5 ), breast ( 6 ) and colon cancer cells ( 7 ), the exact molecular mechanism of purvanol-induced apoptosis has not been elucidated yet. (spandidos-publications.com)
ER alerts a self-protective mechanism that is called ER stress during nutrient deprivation, pathogen infection, alterations in redox status, intraluminal Ca 2+ levels and folding defective protein conditions ( 9 ). (spandidos-publications.com)

In this pathway LATS1 binds to and sequesters the ubiquitin ligase Mdm2 causing stabilization of the tumor suppressor p53 and apoptosis. (ox.ac.uk)
Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
Methods: Previously we observed that aurora kinase (AURK) binds IκBα in the cell. (researchsquare.com)
When the Pleckstrin Homology (PH) domain of AKT binds to phosphoinositides, AKT can be phosphorylated by two different kinases, PDK1 at threonine 308 and mTORC2 (mammalian target of rapamycin) at serine 473, which switch on AKT activation. (cisbio.net)

The full-length sequence of DAPK1 has 1,430 residues ( Farag and Roh, 2019 ), which consists of the catalytic domain (CD), the autoregulatory domain (ARD), eight ankyrin repeats, two P-loop motifs, the cytoskeletal binding domain, the death domain, and the serine-rich C-terminal tail. (frontiersin.org)
AURK significantly promotes activation of IκBα at serine 32, but not serine 36 residues, unlike IκB kinase (IKK) family proteins activate both IκBα serine residues. (researchsquare.com)

Several years later, Kerr and co-workers 2 defined the morphological changes in cells undergoing this process, also known as apoptosis. (nature.com)
Therefore, the current study used integrated in vitro and in silico approaches to figure out Amy and Sor's possible synergistic activity in targeting AMPK/mTOR and BCL-2 for anti-angiogenesis and apoptosis cell death in HepG2 cells. (biomedcentral.com)
Furthermore, the RL-akt gene conferred resistance to the apoptosis induced by the calcium ionophore A23187 and by ultraviolet irradiation of NIH/3T3 cells. (elsevierpure.com)
This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. (nih.gov)
The protein is expressed in the epithelial cells that form primary cilia. (ericmcmillandesigner.com)
In MDA-MB-231 cells stably depleted of PKD3, the expression of several surface proteins was dysregulated compared with control cells (shNon_CTRL). (ericmcmillandesigner.com)
C-2 exhibits cytotoxic effect on bladder cancer cells, and JNK activated by C-2 triggers autophagy and up-regulates SQSTM1/p62 proteins, contributing to activation of Nrf2 pathway. (biomedcentral.com)
It reveals a series of molecular mechanisms about SP600125 potentiate the cytotoxicity and tumor inhibition of C-2 in bladder cancer cells through promoting C-2-induced apoptosis, expecting it provides research basis and theoretical support for new drugs development. (biomedcentral.com)
C-2 significantly reduced the viabilities of human bladder cancer cells and induced apoptosis associated with the mitochondrial pathway. (biomedcentral.com)
d Active-casepase 3, PARP and CF-PARP proteins expression were detected by western blotting at a dose- and time- dependent manner in BIU87 cells. (biomedcentral.com)
a The expression levels of C-2-induced autophagy related protein Beclin-1, LC3, p62, ATG3, ATG5 and ATG7 were detected by western blotting in BIU87 and EJ cells at the indicated concentrations or treated with 4 μM of C-2 at the indicated time points. (biomedcentral.com)
b The expression levels of C-2-induced autophagy related protein Beclin-1, p62 and LC3 were detected by western blotting in EJ cells at the indicated concentrations. (biomedcentral.com)
Enhanced mucosal CK2 protein expression and activity were observed in animal models of chronic colitis, particularly within intestinal epithelial cells (IECs). (diva-portal.org)
Conclusions These findings ascertained an conversation between p53, c-myc, p21, p27, Bcl-2, PI3K/Akt pathway, and CF-induced apoptosis in MSTO-211H and HCT-116 cells, suggesting that CF acts as an important regulator of cell growth in human malignancy cell lines. (bioinf.org)
Apoptosis (programmed cell death) occurs in a wide variety of physiological NIK settings, where its role is to remove harmful, damaged or unwanted cells. (bioinf.org)
Cyclin-dependent kinases (CDKs), are members of the serine-threonine protein kinase family and are responsible for taking control of cell cycle regulation in eukaryotic cells. (spandidos-publications.com)

IκBα inhibits the NF-κB by keeping them in a state isolated from the inactive cytoplasmic mask and the nuclear localization signal of NF-κB proteins. (researchsquare.com)

This study is to investigate the expression changes of lymphocyte migration regulation related proteins in urine exosomes of lung cancer patients, and further verify their correlation with the development and progression of lung cancer. (biomedcentral.com)
Enzyme-linked immunosorbent assay and western blotting were used to detect the expression changes of lymphocyte migration regulation related proteins in lung cancer patients. (biomedcentral.com)
Lung cancer patients had reduced expression of WASL and increased expression of STK10 and WNK1 proteins in urine exosomes compared to normal people. (biomedcentral.com)
Lymphocyte migration regulation related proteins were differentially expressed in the urine exosome of lung cancer patients, and WASL, STK10 and WNK1 may serve as potential biomarkers for lung cancer diagnosis. (biomedcentral.com)

This domain occurred 421 times on human genes ( 960 proteins). (umbc.edu)
We suggest that the SELL and ICAM1 genes and L-selectin and LFA-1 protein expression may help confirm malignancy and assist in the histological characterization of follicular patterned lesions, but we were unable to correlate these CAMs with patient outcomes. (bvsalud.org)

GSK3 and GSK3 are extremely homologous of their kinase domains [6]. (techblessing.com)
The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. (antibodypedia.com)

Endoplasmic reticulum (ER) is an essential organelle responsible for protein synthesis, folding, post-translational modification of proteins and protein trafficking in eukaryotes ( 8 ). (spandidos-publications.com)

Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)

MAPKKKs phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. (umbc.edu)
ASK1 (also called MAPKKK5) functions in the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. (umbc.edu)

K-Ras mutations are frequent in colorectal cancer (CRC), albeit K-Ras is the only Ras isoform that can elicit apoptosis. (ox.ac.uk)

A member of the family of PI3Ks/mTOR is a physiologically stable serine/threonine protein kinase [ 11 ]. (biomedcentral.com)
The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. (bioquote.com)
The PKD family members are serine/threonine protein kinases that function in diverse cellular processes. (ericmcmillandesigner.com)

Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. (rcsb.org)
The profiling of compound 51 against a panel of 339 kinases revealed high selectivity for CDKs, with preference for CDK2 and CDK5 over CDK9, CDK1, CDK4, and CDK6. (rcsb.org)

The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. (antibodypedia.com)

Nevertheless, these inhibitors aren't just inhibiting GSK3, but will also be influencing CDK kinase (2 and 5) and several other kinases. (techblessing.com)

LPLI-induced cell cycle progression can be regulated by the activation or elevated expressions of cell cycle-specific proteins. (biomedcentral.com)

Rhodopsin is a G protein-coupled receptor essential for vision and rod photoreceptor viability. (nih.gov)
However, mutant Ras also stimulates autocrine activation of the EGF receptor (EGFR) which counteracts mutant K-Ras-induced apoptosis. (ox.ac.uk)
Intrinsic brain RAS is an enzyme-neuropeptide system having functional components (angiotensinogen, peptidases, angiotensin, and specific receptor proteins) with important biological and neurobiological activities in the brain. (hindawi.com)

This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. (cusabio.com)

Tumor-infiltrated macrophages were isolated from human GC tissues using magnetic beads, gene transcription was determined by real-time PCR, protein expression was monitored using western blots, metabolites were determined using HPLC, and transcriptional regulation was analyzed by the luciferase-based reporter gene system. (cancerindex.org)
But changes in the expression of lymphocyte migration regulation related proteins in urine exosomes remain unclear. (biomedcentral.com)
Mass spectrometry was used to screen and explore the expression changes of lymphocyte migration regulation related proteins in healthy people of different ages. (biomedcentral.com)
Analyzing the data of urine exosome proteomics, a total of 12 lymphocyte related proteins were identified, 5 of which were lymphocyte migration regulation related proteins. (biomedcentral.com)

We discuss here the contribution of glycan-lectin interactions to the initiation, execution and resolution of apoptosis and their emerging roles in other cell death programs including autophagy. (nature.com)

The protein serine/threonine kinase Akt (also known as protein kinase B or PKB) plays an important role in averting cell death. (bioinf.org)

Y-27632 inhibited the kinase activity of both ROCK-I and ROCK-II in vitro, and this inhibition was reversed by ATP in a competitive manner. (bioquote.com)
These observations identify CK2 as a key regulator of homeostatic properties of the intestinal epithelium that serves to promote wound healing, in part through inhibition of apoptosis under conditions of inflammation. (diva-portal.org)

Most of the important molecular processes in the cell, such as DNA replication, are performed by large molecular network of protein-protein interactions. (researchsquare.com)

c A dose-dependent induction of apoptosis by C-2 was demonstrated through flow cytometric analysis of Annexin V/PI stain assay. (biomedcentral.com)

Further in vitro studies revealed that CK2 activity promotes epithelial restitution, and protects normal IECs from cytokine-induced apoptosis. (diva-portal.org)

These mutations change single protein building blocks (amino acids) in the BRAF protein. (medlineplus.gov)

What pathways are this gene/protein implicaed in? (cancerindex.org)

We need to acquire more knowledge of various protein-protein interactions in order to understand biological phenomena, including diseases, and to provide the basis for new therapeutic approaches. (researchsquare.com)

In LPS-challenged HL-1 cardiomyocytes, shRNA-mediated STK3 knockdown normalized mitochondrial membrane potential and ATP production, attenuated apoptosis, and rescued antioxidant gene expression by preventing Nrf2 downregulation. (ijbs.com)

We propose that early disruption of rhodopsin protein homeostasis in photoreceptors could contribute to retinal degeneration. (nih.gov)

Disease-associated rhodopsin mutations, such as P23H rhodopsin, cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating the unfolded protein response (UPR). (nih.gov)

Moreover, induced Akt activity (p-AKT) (due to overexpression) is sufficient to block apoptosis triggered by many death stimuli [5]. (bioinf.org)

Trichothecene mycotoxins are extremely stable proteins that are resistant to heat and ultraviolet light inactivation. (medscape.com)

Phosphatidyl serine (PS) is a phospholipid nutrient found in fish, green leafy vegetables, soybeans and rice, and is essential for the normal functioning of neuronal cell membranes and activates Protein kinase C (PKC) which has been shown to be involved in memory function. (drugbank.com)

Anatomy20

Organisms7

Diseases3

Chemicals and Drugs152

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes50

Disciplines and Occupations1

Information Science3

Phosphorylation16

Proliferation28

Signaling pathway5

AKT13

Encodes a serine2

Differentiation2

Receptors1

Induces apoptosis2

Mitogen-activa2

Inhibitor7

Oxidative stress4

Induce2

Phosphoinositide1

Oncogene1

Necroptosis2

Gene encodes1

Phosphorylates2

Substrates3

Regulate3

Superfamily2

Survival4

Mutation2

Mechanism4

Binds4

Residues2

Cells16

Inhibits1

Lung Cancer4

Genes2

Homologous2

Post-translational modificati1

Intracellular1

MAPK2

Isoform1

Family3

CDKs2

Modulate1

Inhibitors1

Progression1

Receptor3

Recombinant1

Regulation4

Autophagy1

Known as protein1

Inhibition2

Processes1

Assay1

Promotes1

Amino Acids1

Pathways1

Interactions1

Mitochondrial1

Homeostasis1

Endoplasmic reticulum1

Stimuli1

Stable1

Neuronal1