MitochondriaApoptosisMitochondria, LiverCaspasesCaspase 3Proto-Oncogene Proteins c-bcl-2Apoptosis Regulatory ProteinsMitochondria, HeartCaspase 9Cytochromes cbcl-2-Associated X ProteinCaspase 8Membrane Potential, MitochondrialCell Line, TumorBH3 Interacting Domain Death Agonist ProteinMitochondrial ProteinsMitochondria, MuscleSignal TransductionCaspase Inhibitorsbcl-X ProteinDNA FragmentationInhibitor of Apoptosis ProteinsX-Linked Inhibitor of Apoptosis ProteinCell SurvivalIn Situ Nick-End LabelingEnzyme ActivationCASP8 and FADD-Like Apoptosis Regulating ProteinTumor Suppressor Protein p53Apoptotic Protease-Activating Factor 1Reactive Oxygen SpeciesCytochrome c GroupFas Ligand ProteinAntigens, CD95Cells, CulturedMitochondrial Membranesbcl-2 Homologous Antagonist-Killer ProteinCaspase 7TNF-Related Apoptosis-Inducing LigandBlotting, WesternApoptosis Inducing FactorCell LineAmino Acid Chloromethyl KetonesMitochondrial SwellingReceptors, Death DomainTumor Cells, CulturedProto-Oncogene ProteinsAntineoplastic AgentsCysteine Proteinase InhibitorsPoly(ADP-ribose) PolymerasesCell DeathIntracellular MembranesOxidative PhosphorylationAnnexin A5Carrier ProteinsFlow CytometryOxidative StressFas-Associated Death Domain ProteinCell ProliferationModels, BiologicalMembrane ProteinsJurkat CellsCaspase 2RNA, Small InterferingTime FactorsGenes, bcl-2TransfectionMyeloid Cell Leukemia Sequence 1 ProteinOxygen ConsumptionEnzyme InhibitorsCell RespirationStaurosporineCell CycleDown-RegulationProtein Transportbcl-Associated Death ProteinMitochondrial Membrane Transport ProteinsMolecular Sequence DataDNA, MitochondrialHeLa CellsDose-Response Relationship, DrugMice, Inbred C57BLRNA, MessengerUncoupling AgentsEndoplasmic ReticulumReceptors, TNF-Related Apoptosis-Inducing LigandDeath Domain Receptor Signaling Adaptor ProteinsReverse Transcriptase Polymerase Chain ReactionTumor Necrosis Factor-alphaElectron Transport Complex IVMutationPhosphorylationMembrane PotentialsNitrophenolsGene Expression Regulation, NeoplasticAdenosine TriphosphateDrug Resistance, NeoplasmAmino Acid SequenceOligomycinsMice, KnockoutDNA Damage