• tumor
  • This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. (wikipedia.org)
  • Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. (wikipedia.org)
  • vitro
  • Its activity was defined in the mid 1960s by immunologists who sought to replicate, in vitro, key features of cell-mediated immunity ( 1 ). (rupress.org)
  • apoptotic
  • Paraptosis does not demonstrate nuclear fragmentation, formation of apoptotic bodies, or definitive demonstration of chromatin condensation - all seen in apoptosis. (wikipedia.org)
  • In apoptosis, HMGB1, a chromatin protein, is retained within the nucleus to result in formations of apoptotic bodies, while in paraptosis HMGB1 is released. (wikipedia.org)
  • Cyt A also activates c-Jun N-terminal kinase, and its apoptotic effects are inhibited by dominant negative c-Jun. (wikipedia.org)
  • cytoplasmic
  • Similar to apoptosis, staining techniques can be used to identify paraptotic cells by highlighting the translocation of phosphatidylserine from the plasma membrane cytoplasmic (inner) leaflet to the cell surface or outer leaflet. (wikipedia.org)
  • 1997
  • Simon H-U, Yousefi S, Schranz C, Schapowal A, Bachert C, Blaser K (1997) Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. (springer.com)
  • endothelial cells
  • We found that endothelin-1 (ET-1) is an autocrine/paracrine survival factor I from serum deprivation-induced apoptosis for cultured rat endothelial cells. (nii.ac.jp)
  • Endothelial cells also underwent apoptosis by the addition of nitric oxide donors and natriuretic peptides, whose effects were also antagonized by ET-1. (nii.ac.jp)
  • These observations suggest that apoptosis survival activity of ET-1 in endothelial cells is not restricted to serum deprivation-induced apoptosis. (nii.ac.jp)
  • Publications] Shichiri M.et al: 'Endothelin-1 as an autocrine/paracrine apoptosis survival tactor for endothelial cells' Hypertension. (nii.ac.jp)
  • Proteins
  • Once ruptured, particles and substances are released, including: (1) high mobility group B-1 (HMGB1) (2) heat shock proteins and (3) various other proteases. (wikipedia.org)
  • While the presence of inactive MST/Krs proteins and dominant negative c-Jun completely inhibited apoptosis. (wikipedia.org)
  • necrosis
  • The same was true for epithelial tightness, apoptosis (caspase-3 activity), and necrosis (lactate dehydrogenase release). (aspetjournals.org)
  • In the mentioned studies, we could show that OTA induces loss of cell number, necrosis and apoptosis, fibrosis, inflammation, and epithelial to mesenchymal transition in proximal tubular cells. (aspetjournals.org)
  • Paraptosis (from the Greek παρά para, "related to" and apoptosis) is a type of programmed cell death, morphologically distinct from apoptosis and necrosis. (wikipedia.org)
  • inhibitors
  • The use of specific kinases inhibitors may provide excellent tools to prevent RPE apoptosis specifically in RPE diseases involving ROS and other stress-related compounds such as in AMD. (epfl.ch)
  • Therefore, paraptosis was concluded to differ from apoptosis (cell death type 1) in being unaffected by inhibitors of apoptosis. (wikipedia.org)
  • induction
  • It is thought that erythroid differentiation is primarily dependent on the presence and induction of erythroid transcriptional factors such as GATA-1, FOG-1 and EKLF, as well as the suppression of myeloid/lymphoid transcriptional factors such as PU.1. (wikipedia.org)
  • CFU-e progenitors enter the cell cycle at the time of GATA-1 induction and PU.1 suppression in a developmental manner rather than due to EpoR signaling. (wikipedia.org)
  • cell cycle regu
  • The journal publishes original observations on genetic, cellular, biochemical, structural and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosis and other biological responses in cells exposed to genomic insult, as well as their relationship to human disease . (elsevier.com)
  • Endocrinology
  • Publications] Kato H.et al: 'Adreno medullin as an autocrine paracrine apoptosis survival factor for rat endothelia cells' Endocrinology. (nii.ac.jp)
  • Publications] Shichiri M.et al: 'Endothelin-1 is a potent survival tactor for c-Myc-dependent apoptosis' Molecular Endocrinology. (nii.ac.jp)
  • upregulation
  • In humans, upregulation of RASD1 leading to increased apoptosis has been observed in several human cancer cell lines such as DU-154 human prostate cancer cells and in human breast cancer cells MCF-7. (wikipedia.org)
  • mechanism
  • Publications] Suenobu N.et al: 'Natriuretic peptides and nitric oxide induee endothelial apoptosis via cyclic GMP-dependent mechanism' Arteriosclerosis Thrombosis & Vascular Biology. (nii.ac.jp)
  • Our results suggest a regulatory mechanism in which GF signaling antagonizes RXR-PPARgamma-mediated default apoptosis to sustain cell life. (inserm.fr)
  • proliferation
  • In the latter, high concentrations of calycosin significantly suppressed the proliferation of MCF-7 cells, thereby promoting apoptosis of the cells. (wikipedia.org)
  • At present, the most well-established function of EpoR is to promote proliferation and rescue of erythroid (red blood cell) progenitors from apoptosis. (wikipedia.org)
  • receptors
  • PACAPs are suggested to act as neuroprotective factors against glutamate-induced neurotoxicity by activating MAP kinase, which is due to PKA activation via PACAP receptors. (nii.ac.jp)