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  • substrate
  • Further analyses reveal that the impairment is likely attributable to insufficient delivery of substrate proteins into the 20S proteasomes, and depletion of key components of the 19S subcomplex may be responsible. (ahajournals.org)
  • PPP1R subunits (also known as PP1-interacting proteins, or PIPs) direct the substrate specificity of protein phosphatase 1 catalytic (PPP1C) subunits. (genenames.org)
  • pathway
  • Signal transduction through the cAMP pathway starts by stimulation of G-protein-coupled-receptors (GPCRs), via specific extracellular ligands leading to activation of adenylyl cyclase (AC), which converts ATP into cAMP. (frontiersin.org)
  • the cytoprotective effects of DNAJB6 (S) may be mediated, at least in part, by the mitochondrial pathway of apoptosis. (antibodies-online.com)
  • Conceptual translation predicted 24,013 proteins, which were then subjected to detailed annotation which included pathway mapping of predicted proteins (including 112 excreted/secreted [ES] and 226 transmembrane peptides), domain analysis and GO annotation was carried out using InterProScan along with BLAST2GO. (biomedcentral.com)
  • cardiac
  • These PDE4s are targeted to different subcellular compartments of cardiac myocytes through interaction with several classes of scaffold proteins. (springer.com)
  • The UPS impairment was detected before cardiac hypertrophy, and failure became discernible, suggesting that defective protein turnover likely contributes to cardiac remodeling and failure in this model. (ahajournals.org)
  • Hsp20 has been shown to be a critical regulator of cardiomyocyte survival upon cardiac stress as well as a regulator of Ca2+-cycling and cardiac function. (oatd.org)
  • Furthermore, the effects of the S10F-Hsp20 human mutation on cardiac function and remodeling were assessed in female transgenic mice. (oatd.org)
  • interactions
  • Targeting AKAP coordinated protein complexes with high-affinity peptidomimetics or small molecules to tease apart distinct protein-protein interactions (PPIs) therefore offers important means to disrupt binding of specific components of the complex to better understand the molecular mechanisms involved in the function of individual signalosomes and their pathophysiological role. (frontiersin.org)
  • The existence of these specific complexes (illustrated in Figure 1 ) governed by protein-protein interactions (PPIs) creates an opportunity for new therapeutic strategies to control cAMP dependent signaling that is out of tune or involved in pathologies. (frontiersin.org)
  • Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease. (jove.com)
  • oligomers
  • The presence of increased ubiquitinated proteins and amyloid oligomers in failing human hearts strikingly resembles the characteristic pathology in the brain of many neurodegenerative diseases. (ahajournals.org)
  • Hsp27-oligomers probably consist of stable dimers, which are formed by two α-crystallin-domains of neighbouring monomers, which was shown with the proteins MjHSP16.5 from Methanocaldococcus jannaschii and wheat Hsp16.9. (wikipedia.org)
  • 1999). Dissociation of the oligomers is required for recognition of protein substrates (Shashidharamurthy et al. (atlasgeneticsoncology.org)
  • precursor
  • Amongst them, C-type single domain activation associated secreted protein ASP3 precursor, activation-associated secreted proteins (ASP-like protein), cathepsin B-like cysteine protease, cathepsin L cysteine protease, cysteine protease, TransThyretin-Related and Venom-Allergen-like proteins were the key findings. (biomedcentral.com)
  • stresses
  • The present review summarizes current knowledge concerning the cardioprotective role of the heat shock proteins as occurs in heart damage, including relevant information about the stresses that regulate the expression of these proteins and their potential role as biomarkers of heart disease. (bjcvs.org)
  • proteasome
  • Some examples of their role as "monitors" are that they carry old proteins to the cell's "recycling bin" (proteasome) and they help newly synthesised proteins fold properly. (wikipedia.org)
  • pathways
  • For ES proteins, key pathways, including Fc epsilon RI, T cell receptor, and chemokine signalling as well as leukocyte transendothelial migration were inferred to be linked to immune responses, along with other pathways related to neurodegenerative diseases and infectious diseases, which warrant detailed future studies. (biomedcentral.com)
  • KAAS could identify new and updated pathways like phagosome and protein processing in endoplasmic reticulum. (biomedcentral.com)
  • contractility
  • In this dissertation, it was further demonstrated that acute increases in constitutively phosphorylated Hsp20 (S16D) enhance cardiomyocyte contractility to a greater extent that WT-Hsp20 in rat cardiomyocytes. (oatd.org)
  • However, non-phosphorylatable Hsp20 (S16A) abolishes these stimulatory effects on contractility, indicating a dual beneficial role for phosphorylated (S16D) Hsp20. (oatd.org)
  • Hsp27
  • The phosphorylated form of Hsp27 inhibits Daxx apoptotic protein and prevents the association of Daxx with Fas and Ask1. (wikipedia.org)
  • Annotation
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • molecules
  • The actual proteolytic activity resides in the interior of the 20S, whereas the 19S plays a critical role in channeling ubiquitinated protein molecules into the 20S. (ahajournals.org)
  • findings
  • Six cysteine motif (SXC1) proteins, transthyretin proteins, C-type lectins, activation-associated secreted proteins (ASPs), which could represent potential candidates for developing novel anthelmintics or vaccines were few other important findings. (biomedcentral.com)
  • In contrast to the findings in rat cardiomyocytes, S16D-Hsp20 transgenic mice exhibited early fibrotic remodeling, which culminated in left ventricular dysfunction, heart failure and early death. (oatd.org)
  • heart
  • The literature survey was carried out based on the PubMed data using the descriptors "Heat shock protein" and "heart" as components of the search field title. (bjcvs.org)
  • lens
  • The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. (wikipedia.org)
  • pathway
  • The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma. (abcam.com)
  • the cytoprotective effects of DNAJB6 (S) may be mediated, at least in part, by the mitochondrial pathway of apoptosis. (antibodies-online.com)
  • Based on the gene expression analysis of moso bamboo in response to high light, we thus identified the global gene expression patterns, refined the annotations of LHC protein, LHC-like protein and PsbS, detected the pathway of ROS as well as identified ROS-scavenging genes and transcription factors in the regulation of photosynthetic and related metabolisms. (biomedcentral.com)
  • Conceptual translation predicted 24,013 proteins, which were then subjected to detailed annotation which included pathway mapping of predicted proteins (including 112 excreted/secreted [ES] and 226 transmembrane peptides), domain analysis and GO annotation was carried out using InterProScan along with BLAST2GO. (biomedcentral.com)
  • precursor
  • Aβ is the major element of neuritic/amyloid plaques and is approximately a 4 kDa polypeptide, formed because of inappropriate cleavage of amyloid precursor protein (APP). (ijpsonline.com)
  • Amongst them, C-type single domain activation associated secreted protein ASP3 precursor, activation-associated secreted proteins (ASP-like protein), cathepsin B-like cysteine protease, cathepsin L cysteine protease, cysteine protease, TransThyretin-Related and Venom-Allergen-like proteins were the key findings. (biomedcentral.com)
  • stresses
  • The present review summarizes current knowledge concerning the cardioprotective role of the heat shock proteins as occurs in heart damage, including relevant information about the stresses that regulate the expression of these proteins and their potential role as biomarkers of heart disease. (bjcvs.org)
  • They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light, and during wound healing or tissue remodeling. (wikipedia.org)
  • Increased synthesis of selected proteins in Drosophila cells following stresses such as heat shock was first reported in 1974. (wikipedia.org)
  • The expression of αBC can be increased during various stresses, like heat shock, osmotic stress or exposure to heavy metals, which then may lead to prolonged survival of cells under these conditions. (wikipedia.org)
  • lipid
  • In addition, ala6 displays higher ion-leakage during heat treatment, suggesting that the lipid flippase activity of ALA6 plays a vital role in heat stress responses. (frontiersin.org)
  • The membrane proteins that carry out these lipid translocation processes are classified into two categories based on whether the lipid transportation across the bilayer is driven by ATP ( Pomorski and Menon, 2006 , 2016 ). (frontiersin.org)
  • Of these, SXC1, protein kinase domain-containing protein, trypsin family protein, trypsin-like protease family member (TRY-1), putative major allergen and putative lipid binding protein were identified which have not been reported in the published T. circumcincta proteomics analysis. (biomedcentral.com)
  • oligomeric
  • The aggregate formation is due to the structural refitting of α-helical sheet of normal, soluble amyloid-β-protein to the β-sheets, which lead to oligomeric, fibrillar, insoluble and disease causing amyloid-β 42. (ijpsonline.com)
  • family
  • Overexpression of ALA6 improves seedling resistance to heat stress, while mutated ALA6 transgenic plants, in which the conserved functional site of the ALA family has a point mutation, are still susceptible to heat stress like ala6 loss-of-function mutant. (frontiersin.org)
  • DNAJB6 encodes a member of the DNAJ protein family. (antibodies-online.com)
  • Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. (wikipedia.org)
  • Some members of the HSP family are expressed at low to moderate levels in all organisms because of their essential role in protein maintenance. (wikipedia.org)
  • expressed genes
  • For instance, 154 differentially expressed genes were detected in 0.5H vs . CK, those in 8H vs . CK were 710, and 429 differentially expressed genes were also identified in 0.5H vs .8 H. Besides, 47 gene annotations closely related to photosynthesis were refined, including 35 genes annotated as light-harvesting chlorophyll a/b-binding (LHC) proteins, 9 LHC-like proteins and 3 PsbSs. (biomedcentral.com)
  • chaperone
  • Many members of this group perform chaperone function by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress. (wikipedia.org)
  • stable
  • Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. (wikipedia.org)
  • novel
  • Six cysteine motif (SXC1) proteins, transthyretin proteins, C-type lectins, activation-associated secreted proteins (ASPs), which could represent potential candidates for developing novel anthelmintics or vaccines were few other important findings. (biomedcentral.com)
  • neurodegenerative
  • For ES proteins, key pathways, including Fc epsilon RI, T cell receptor, and chemokine signalling as well as leukocyte transendothelial migration were inferred to be linked to immune responses, along with other pathways related to neurodegenerative diseases and infectious diseases, which warrant detailed future studies. (biomedcentral.com)
  • Defects in this gene/protein have been associated with cancer and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. (wikipedia.org)
  • cells
  • Reduced proliferation and enhanced apoptosis of β cells in diabetes mellitus are associated with a deficiency of brain-derived neurotrophic factor (BDNF). (readbyqxmd.com)
  • It is known that rapid heat hardening can be elicited by a brief exposure of cells to sub-lethal high temperature, which in turn provides protection from subsequent and more severe temperature. (wikipedia.org)
  • diseases
  • Embodiments will open doors to unraveling the functional significance of protein modifications in human diseases where changes in redox balances have been documented. (patentsencyclopedia.com)
  • role
  • Some examples of their role as "monitors" are that they carry old proteins to the cell's "recycling bin" (proteasome) and they help newly synthesised proteins fold properly. (wikipedia.org)
  • expression
  • Transcriptome analysis reveals differences in gene expression between ala6 and wild-type plants with or without heat stress. (frontiersin.org)
  • Dorsal (DHP) and ventral hippocampus (VHP) were dissected, and protein expression of GluN1, GluN2A, GluN2B, and PSD-95 was assessed by Western blot analysis. (readbyqxmd.com)
  • This discovery eventually led to the identification of the heat-shock proteins (HSP) or stress proteins whose expression this puffing represented. (wikipedia.org)
  • Expression of the hspb4 gene, which codes for alpha crystallin, increases considerably in the lens in response to heat shock. (wikipedia.org)
  • prevention
  • The detection of these proteins facilitates understanding of the redox modification of a specific protein that undergoes redox modifications occurring early in disease processes, allowing earlier intervention in the disease process and the prevention of further damage. (patentsencyclopedia.com)
  • factor
  • Mounting data suggests that another factor, the tau protein ripens into highly phosphorylated form by several kinases after Aβ-stimulation leads to tangle formation resulting in neuronal bereavement in hippocampus and entorhinal regions as the disease progresses further. (ijpsonline.com)
  • mutant
  • ER-anchored αBC can suppress aggregate formation mediated by the disease mutant.Thus, modulation of the micromilieu surrounding the ER membrane can serve as a potential target in developing pharmacological interventions for protein deposition disease. (wikipedia.org)
  • lens
  • The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. (wikipedia.org)
  • alpha
  • A missense mutation in alpha B-crystallin that changes proline 20 to an arginine leads to diminished anti-apoptotic activity compared with the native protein. (antibodies-online.com)
  • domain
  • Some of the important domain families identified included the SCP-like extracellular proteins which belong to the pathogenesis-related proteins (PRPs) superfamily along with C-type lectin, saposin-like proteins. (biomedcentral.com)