• Peptides
  • Conceptual translation predicted 24,013 proteins, which were then subjected to detailed annotation which included pathway mapping of predicted proteins (including 112 excreted/secreted [ES] and 226 transmembrane peptides), domain analysis and GO annotation was carried out using InterProScan along with BLAST2GO. (biomedcentral.com)
  • cells
  • Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. (wikipedia.org)
  • It is known that rapid heat hardening can be elicited by a brief exposure of cells to sub-lethal high temperature, which in turn provides protection from subsequent and more severe temperature. (wikipedia.org)
  • Increased synthesis of selected proteins in Drosophila cells following stresses such as heat shock was first reported in 1974. (wikipedia.org)
  • Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. (wikipedia.org)
  • Furthermore, αBC may confer stress resistance to cells by inhibiting the processing of the pro-apoptotic protein caspase-3. (wikipedia.org)
  • The expression of αBC can be increased during various stresses, like heat shock, osmotic stress or exposure to heavy metals, which then may lead to prolonged survival of cells under these conditions. (wikipedia.org)
  • Reduced proliferation and enhanced apoptosis of β cells in diabetes mellitus are associated with a deficiency of brain-derived neurotrophic factor (BDNF). (readbyqxmd.com)
  • Ganetespib is a unique non-geldanamycin heat shock protein 90 ( HSP90 ) inhibitor, with IC 50 of 4 nM in OSA 8 cells. (medchemexpress.com)
  • pathway
  • Signal transduction through the cAMP pathway starts by stimulation of G-protein-coupled-receptors (GPCRs), via specific extracellular ligands leading to activation of adenylyl cyclase (AC), which converts ATP into cAMP. (frontiersin.org)
  • The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma. (abcam.com)
  • gene
  • Expression of the hspb4 gene, which codes for alpha crystallin, increases considerably in the lens in response to heat shock. (wikipedia.org)
  • Defects in this gene/protein have been associated with cancer and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. (wikipedia.org)
  • Transcriptome analysis reveals differences in gene expression between ala6 and wild-type plants with or without heat stress. (frontiersin.org)
  • facilitates
  • The detection of these proteins facilitates understanding of the redox modification of a specific protein that undergoes redox modifications occurring early in disease processes, allowing earlier intervention in the disease process and the prevention of further damage. (patentsencyclopedia.com)
  • substrate
  • Further analyses reveal that the impairment is likely attributable to insufficient delivery of substrate proteins into the 20S proteasomes, and depletion of key components of the 19S subcomplex may be responsible. (ahajournals.org)
  • oligomers
  • The presence of increased ubiquitinated proteins and amyloid oligomers in failing human hearts strikingly resembles the characteristic pathology in the brain of many neurodegenerative diseases. (ahajournals.org)
  • 1999). Dissociation of the oligomers is required for recognition of protein substrates (Shashidharamurthy et al. (atlasgeneticsoncology.org)
  • precursor
  • Amongst them, C-type single domain activation associated secreted protein ASP3 precursor, activation-associated secreted proteins (ASP-like protein), cathepsin B-like cysteine protease, cathepsin L cysteine protease, cysteine protease, TransThyretin-Related and Venom-Allergen-like proteins were the key findings. (biomedcentral.com)
  • Furthermore
  • Furthermore, key markers of apoptosis, caspase-3 activity and cytochrome c release, were reduced in the hearts of diabetic RAGE-modified mice compared with wild-type diabetic littermates in I/R. (diabetesjournals.org)
  • interactions
  • Targeting AKAP coordinated protein complexes with high-affinity peptidomimetics or small molecules to tease apart distinct protein-protein interactions (PPIs) therefore offers important means to disrupt binding of specific components of the complex to better understand the molecular mechanisms involved in the function of individual signalosomes and their pathophysiological role. (frontiersin.org)
  • The existence of these specific complexes (illustrated in Figure 1 ) governed by protein-protein interactions (PPIs) creates an opportunity for new therapeutic strategies to control cAMP dependent signaling that is out of tune or involved in pathologies. (frontiersin.org)
  • Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease. (jove.com)
  • lipid
  • In addition, ala6 displays higher ion-leakage during heat treatment, suggesting that the lipid flippase activity of ALA6 plays a vital role in heat stress responses. (frontiersin.org)
  • The membrane proteins that carry out these lipid translocation processes are classified into two categories based on whether the lipid transportation across the bilayer is driven by ATP ( Pomorski and Menon, 2006 , 2016 ). (frontiersin.org)
  • Annotation
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • novel
  • Six cysteine motif (SXC1) proteins, transthyretin proteins, C-type lectins, activation-associated secreted proteins (ASPs), which could represent potential candidates for developing novel anthelmintics or vaccines were few other important findings. (biomedcentral.com)
  • molecules
  • AKAPs also scaffold other signaling molecules into multi-protein complexes that function as crossroads between different signaling pathways. (frontiersin.org)
  • The actual proteolytic activity resides in the interior of the 20S, whereas the 19S plays a critical role in channeling ubiquitinated protein molecules into the 20S. (ahajournals.org)
  • stresses
  • They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light, and during wound healing or tissue remodeling. (wikipedia.org)
  • family
  • Some members of the HSP family are expressed at low to moderate levels in all organisms because of their essential role in protein maintenance. (wikipedia.org)
  • DNAJB6 encodes a member of the DNAJ protein family. (antibodies-online.com)
  • Overexpression of ALA6 improves seedling resistance to heat stress, while mutated ALA6 transgenic plants, in which the conserved functional site of the ALA family has a point mutation, are still susceptible to heat stress like ala6 loss-of-function mutant. (frontiersin.org)
  • pathways
  • For ES proteins, key pathways, including Fc epsilon RI, T cell receptor, and chemokine signalling as well as leukocyte transendothelial migration were inferred to be linked to immune responses, along with other pathways related to neurodegenerative diseases and infectious diseases, which warrant detailed future studies. (biomedcentral.com)
  • KAAS could identify new and updated pathways like phagosome and protein processing in endoplasmic reticulum. (biomedcentral.com)
  • cyclic
  • Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes. (jove.com)
  • hypertrophy
  • The UPS impairment was detected before cardiac hypertrophy, and failure became discernible, suggesting that defective protein turnover likely contributes to cardiac remodeling and failure in this model. (ahajournals.org)
  • lens
  • The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. (wikipedia.org)
  • genes
  • Brg1 Enables Rapid Growth of the Early Embryo by Suppressing Genes That Regulate Apoptosis and Cell Growth Arrest. (abcam.com)
  • diseases
  • Embodiments will open doors to unraveling the functional significance of protein modifications in human diseases where changes in redox balances have been documented. (patentsencyclopedia.com)