Apoptosis nuclear proteins. Medical search. Frequent questions

He then did post-doctoral studies with Joseph Nevins at Duke University studying the control of Rb/E2F induction of proliferation and apoptosis. (umn.edu)
The inhibition of the tumor growth was accompanied with changes in proliferation and apoptosis as determined by reduced Ki-67 expression, increased expression of p21WAF/Cip1, cleaved caspase 3 and caspase-cleaved keratin 18. (lu.se)

Excessive apoptosis causes atrophy, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer. (wikipedia.org)

Bcl-2 is an intracellular membrane protein and resides primarily in the nuclear envelope, outer mitochondrial membrane and endoplasmic reticulum. (bdbiosciences.com)
Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. (bdbiosciences.com)
The nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) kills cells by inducing translocation of a mitochondrial suicide protein. (the-scientist.com)
they found that cells from the knockout mice failed to undergo apoptosis and lacked nuclear translocation of the mitochondrial flavoprotein apoptosis-inducing factor (AIF) . (the-scientist.com)
Apoptosis is induced through the mitochondrial pathway resulting in caspase-9 activation and downstream caspase-3 activation. (cdc.gov)
The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. (bvsalud.org)

and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
Regarding the underlying mechanism, inhibition of HSP90α could block the nuclear import of PPARγ to inhibit osteoclast differentiation and proliferation. (spandidos-publications.com)
The intermediate filament protein vimentin as differentiation marker in preimplantation porcine embryos. (mpg.de)
Small RNAs are important regulators that modulate development, proliferation, differentiation, and apoptosis of organisms [ 15 , 16 ]. (hindawi.com)
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. (hmdb.ca)

Whether SWCNT have the potential to induce apoptosis, BEAS-2B cells were exposed for different time points to SWCNT (50 mu g/cm2), and analyzed for PARP activation, as a molecular marker of apoptosis. (cdc.gov)

Apoptosis regulatory proteins are delicately balanced. (bmj.com)

Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. (cancerindex.org)

Caspase-3 (CPP-32, Apoptain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP) (1). (cellsignal.com)
PARP-1 (poly(ADP-ribose) polymerase-1) is a nuclear enzyme that is important for genome repair and DNA replication. (the-scientist.com)
The proteasome pathway is an enzyme complex existing in all cells, which degrades ubiquitinated proteins that control the cell cycle and cellular processes and maintains cellular homeostasis. (medscape.com)
PARP [Poly (ADP-ribose) polymerase] is a 116 kDa nuclear chromatin-associated enzyme that is cleaved during apoptosis by caspase-3 into a 24 kDa fragment containing the DNA binding domain and an 89 kDa fragment containing the catalytic and automodification domains. (novusbio.com)

The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. (wikipedia.org)
Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)
The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. (cancerindex.org)
Furthermore, SWCNT induced time- and dose-dependent apoptosis and phosphorylation of histone gamma-H2A.X, a variant of histone H2A that is activated following DNA damage. (cdc.gov)

2 , 3 A key feature of apoptosis has been defined as the maintenance of an intact cellular membrane (detectable as exclusion of impermeable dyes such as propidium iodide, PI) throughout the apoptotic program to prevent intracellular protein release and subsequent immunological activation. (nature.com)
Vincristine inhibits cellular mitosis by inhibition of intracellular tubulin function, binding to microtubules, and synthesis of spindle proteins in the S phase. (medscape.com)

In this study we focused our attention on the behavior of four nuclear matrix proteins during the various stages of apoptosis in the HL-60 cell line exposed to the DNA topoisomerase I inhibitor, camptothecin. (nih.gov)
BAG3 protein is an apoptosis inhibitor and is highly expressed in Anaplastic Thyroid Cancer. (oncotarget.com)

For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. (wikipedia.org)
7 Severe hypoxia in the presence of energy stimulates cells to undergo apoptosis, whereas oxygen levels above 0.5% prevent cell death. (bmj.com)
The cells with the NEMO mutation undergo selective apoptosis, which accounts for some of the X inactivation skewing seen in women. (medscape.com)

We also examined the ability of SWCNT to induce the transactivation of activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kB), transcription factors that are important members of signal transduction pathways. (cdc.gov)

Knockdown of CASP5 greatly inhibited GBM proliferation and resulted in G1 cell cycle arrest along with higher apoptosis ratios in vitro and in vivo, while overexpression led to the opposite phenomenon. (cancerindex.org)
We observed that the WNV-Cp protein is a pathogenic protein, which drives apoptosis in vitro through the mitochodrial/caspase-9 pathway. (cdc.gov)
In vitro apoptosis in individual cells was determined by terminal desoxyriboxyl-desoxyriboxyl transferase-mediated DVTP nick-end labeling (TUNEL) assay with the In Situ Cell Death Assay Kit (Roche Diagnostic Corp., Indianapolis, IN) and visualized by fluorescent microscopy. (cdc.gov)
Tumor tissue and plasma samples from preclinical models showed that, in addition to decreased angiogenesis, the combined treatment mirrored the effects observed in vitro (increased apoptosis and decreased transcription factors and IL-6). (salesandmarketingnetwork.com)
From experimentally validated target genes of these 86 miRNAs, pan-sensitive and pan-resistant genes with concordant mRNA and protein expression associated with in-vitro drug response to 19 NCCN-recommended breast cancer drugs were selected. (cdc.gov)

The genes were identified by studies in the nematode C. elegans and homologues of these genes function in humans to regulate apoptosis. (wikipedia.org)
In the cytoplasm, the encoded protein may function to regulate apoptosis. (wikipedia.org)
Jalali et al reported that levels of soluble programmed cell death protein 1 (PD-1) ligands are elevated in patients with Waldenström macroglobulinemia and, in addition to surface-bound ligands in bone marrow, could regulate T-cell function. (medscape.com)
This gene provides instructions for making a protein that helps regulate nuclear factor-kappa-B. Nuclear factor-kappa-B is a group of related proteins that help protect cells from self-destruction (apoptosis) in response to certain signals. (medlineplus.gov)
However, enough protein is usually produced from the other, normal copy of the gene to regulate cell growth effectively. (medlineplus.gov)

A common feature, particularly evident for 125- and 160-kDa proteins, was their absence from cap-shaped chromatin marginations, whereas they were present in the areas of remaining decondensed chromatin. (nih.gov)
These results show that, in addition to the well-known chromatin changes, nuclear organization undergoes other rearrangements during the apoptotic process. (nih.gov)
Although their nuclear functions are currently being elucidated, it has been hypothesised that they are involved in membrane support, pore arrangement, envelope assembly, and chromatin organisation. (bmj.com)
The lamina is intimately associated with both the inner nuclear membrane and underlying chromatin, while at the same time providing anchoring sites for nuclear pore complexes ( Gerace and Burke 1988 ). (rupress.org)
During mitosis, PP1 appears largely chromatin bound, but in telophase it is recruited to the nuclear periphery to dephosphorylate B-type lamins and thereby enable polymerization and lamina assembly. (rupress.org)

Pregnane X receptor (PXR) is a nuclear receptor that regulates a number of genes encoding drug metabolism enzymes and transporters and plays a key role in xeno- and endobiotic detoxification. (greenmedinfo.com)

In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's life cycle. (wikipedia.org)
Dying cells have been defined as apoptotic by distinguishing features, including cell contraction, nuclear fragmentation, blebbing, apoptotic body formation and maintenance of intact cellular membranes to prevent massive protein release and consequent inflammation. (nature.com)
The SignalStain ® Proliferation/Apoptosis IHC Sampler Kit from Cell Signaling Technology allows the researcher to examine paraffin-embedded tissues or cells with antibodies that will detect cellular apoptosis or proliferation. (cellsignal.com)
Through these associations, the lamins may have more expanded roles at the cellular level and control diverse functions such as DNA synthesis, gene expression, and apoptosis. (bmj.com)
Lamins are integral structural components of the nuclear lamina hypothesised to be involved in numerous cellular processes. (bmj.com)
SUMOylation of proteins is an important mechanism in cellular responses to environmental stress ( 21 , 22 ). (frontiersin.org)
During Adv DNA replication, host cellular proteins such as nuclear factor I and POU2F1 are used by Adv [ 13 , 14 ]. (hindawi.com)

Capsid gene delivery into the striatum of mouse brain or interskeletal muscle resulted in cell death and inflammation, likely through capsid-induced apoptosis in vivo. (cdc.gov)
We also observed that expression of Cp protein in mouse muscle resulted in apoptosis and inflammation of muscle cells. (cdc.gov)
These pro- has been implicated as contributing apoptosis, inflammation, and several liferating cel s replace dead cel s to the cancer phenotype, through pleiotropic responses. (who.int)

We have shown that LTD4 via its receptor CysLT1 induces expression of proteins associated with colorectal cancer and promotes proliferation, survival and migration in intestinal epithelial cells. (lu.se)

After Fas stimulation, Daxx is activated and plays its role of pro-apoptotic protein in activating the c-JUN-N-Terminal Kinase (JNK) pathway. (wikipedia.org)
When the cell is treated with TGF-β, HIPK2, a nuclear kinase, phosphorylates Daxx and the activated Daxx in turn activates the JNK pathway (see "The Daxx Pathway" figure). (wikipedia.org)
The NEMO protein is required for the activation of the kinase complex. (medscape.com)
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)
The most frequently analyzed family member, p38 alpha, also known as SAPK2a and MAPK14, was initially purified as a kinase critical to the signaling cascade linking IL-1 to MAPKAPK-2 and the small heat shock protein HSP27. (rndsystems.com)
have previously shown that reassembly of B-type lamins is under the control of both protein phosphatase 1 (PP1) and an A-kinase anchoring protein, AKAP149. (rupress.org)
Anaplastic lymphoma kinase (ALK) protein may be detected in most cases (60-70%) of systemic ALCL by immunohistochemistry. (medscape.com)

Some factors like Fas receptors and caspases promote apoptosis, while some members of the Bcl-2 family of proteins inhibit apoptosis. (wikipedia.org)
Proliferating cell nuclear antigen (PCNA) is a member of the DNA sliding clamp family of proteins that assist in DNA replication (6). (cellsignal.com)

Some of these mediators bind to cell surface receptors and activate nuclear factor kappa B (NF κ B), which leads to production of additional cytokines and nitric oxide (NO), a potent vasodilator. (msdmanuals.com)

The major components of the nuclear lamina are the A- and B-type lamins. (rupress.org)

propose a mechanism in which DNA damage induces PARP-1 activation leading to NAD + consumption that is sensed by mitochondria and results in AIF translocation to the nucleus, nuclear condensation and death. (the-scientist.com)

The average adult human loses between 50 and 70 billion cells each day due to apoptosis. (wikipedia.org)
Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytes are able to engulf and remove before the contents of the cell can spill out onto surrounding cells and cause damage to them. (wikipedia.org)
[ 6 ] NF-KB protects cells from apoptosis in response to tumor necrosis factor-alpha (TNF-alpha). (medscape.com)
In regulating the action of nuclear factor-kappa-B, the CYLD protein allows cells to respond properly to signals to self-destruct when appropriate, such as when the cells become abnormal. (medlineplus.gov)
By this mechanism, the CYLD protein acts as a tumor suppressor, which means that it helps prevent cells from growing and dividing too fast or in an uncontrolled way. (medlineplus.gov)
The loss of CYLD protein in these cells leads to the growth of skin appendage tumors. (medlineplus.gov)
A hypoxic environment devoid of nutrients prevents the cell undergoing energy dependent apoptosis and cells become necrotic. (bmj.com)
Cells adapt to this environmental stress, so that after repeated periods of hypoxia, selection for resistance to hypoxia induced apoptosis occurs. (bmj.com)
Abundant evidence implicates this protein in the suppression of apoptosis in many types of cells. (bdbiosciences.com)
Apoptosis allows for efficient and immunologically silent removal of damaged or superfluous cells in multicellular organisms. (nature.com)
In addition to maintenance of membrane integrity, apoptotic cells can be discriminated from viable counterparts based on several morphological hallmarks, including cell contraction, nuclear condensation and fragmentation, and actomyosin contraction-dependent membrane blebbing and apoptotic body formation. (nature.com)
Lamins are intermediate filament proteins comprising a major structural component of the nuclear lamina, which underlies the inner membrane of the nuclear envelope in most somatic cells. (bmj.com)
Effects of expressing lamin A mutant protein causing Emery-Dreifuss muscular dystrophy and familial partial lipodystrophy in HeLa cells. (mpg.de)
New monoclonal antibodies recognizing phosphorylated proteins in mitotic cells. (mpg.de)
Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)
Ginkgolide B (30-300μmol/L) did not change the mRNA and protein levels of PXR in the cells, but dose-dependently increased nuclear translocation of PXR protein. (greenmedinfo.com)
The nuclear lamina is a thin (20 nm) yet insoluble protein meshwork that, in higher cells, lines the nucleoplasmic face of the nuclear envelope (NE). (rupress.org)
We treated TMZ-resistant cells U251-TMZ and T98G-TMZ to normoxia or hypoxia and silenced NUPR1 in hypoxia-treated U251-TMZ and T98G-TMZ cells to assess cell viability, proliferation, apoptosis, LC3-II/LC3-I and p62 expressions, and autophagic flux under different concentrations of TMZ. (techscience.com)
We investigated the entire set of proteins modulated by BAG3 silencing in the human anaplastic thyroid 8505C cancer cells by using the Stable-Isotope Labeling by Amino acids in Cell culture strategy combined with mass spectrometry analysis. (oncotarget.com)
By this approach we identified 37 up-regulated and 54 down-regulated proteins in BAG3-silenced cells. (oncotarget.com)
Our analyses confirm the association of the proteome profile observed in BAG3-silenced cells with an increase in cell survival and a decrease in cell proliferation and invasion, and highlight the possible involvement of four tumor suppressor miRNAs and TP53/63 proteins in BAG3 activity. (oncotarget.com)
Although the levels of Nestin and DMP1 proteins did not exceed those associated with the clinical reference treatment (i.e., mineral trioxide aggregate), the GelMA+20%TCP scaffold exhibited comparable levels, thus suggesting the emergence of differentiated odontoblast-like cells capable of dentin matrix secretion. (bvsalud.org)
In other cells, apoptosis may be augmented, increasing cell death and thus worsening organ function. (msdmanuals.com)

JNK activates HIPK2, which stands for the translocation of nuclear Daxx to the cytoplasm. (wikipedia.org)
Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation. (bdbiosciences.com)
Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma. (bvsalud.org)

Daxx, a Death domain-associated protein, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. (wikipedia.org)
Protein transport between the nuclear and the cytoplasmic compartment is a key factor for cell viability and proliferation. (massgeneral.org)
NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. (hmdb.ca)
Once activated, p38 alpha phosphorylates a number of targets, including the cytoplasmic kinases MNK 4 and PRAK5 and the nuclear transcription factors ATF2 1 and STAT1. (rndsystems.com)

Kerr had initially used the term programmed cell necrosis, but in the article, the process of natural cell death was called apoptosis. (wikipedia.org)
We now show that during early apoptosis limited membrane permeabilization occurs in blebs and apoptotic bodies, which allows release of proteins that may affect the proximal microenvironment before the catastrophic loss of membrane integrity during secondary necrosis. (nature.com)
These results indicate that limited membrane permeabilization occurs in blebs and apoptotic bodies before secondary necrosis, leading to acute and localized release of immunomodulatory proteins during the early phase of active apoptotic membrane blebbing. (nature.com)
Therefore, the shift from apoptosis to secondary necrosis is more graded than a simple binary switch, with the membrane permeabilization of apoptotic bodies and consequent limited release of DAMPs contributing to the transition between these states. (nature.com)

The advanced pathological grade was associated with strong TGFB1, VEGFA, and Ki67 protein expression and absent Tp53 staining. (hindawi.com)
It permits the nuclear export of p53/TP53. (researchandmarkets.com)

It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1 (ETS1). (wikipedia.org)

The p38 Mitogen-activated Protein Kinases (MAPKs) are a family of four related Ser/Thr kinases activated by proinflammatory cytokines and environmental stresses. (rndsystems.com)

These studies demonstrate that the capsid protein of WNV may be responsible for aspects of viral pathogenesis through induction of the apoptotic cascade. (cdc.gov)
More importantly, direct in vivo expression of WNV-Cp protein in mouse brain resulted in an induction of apoptosis similar to what is observed in natural infection. (cdc.gov)
Induction of a regular nuclear lattice by overexpression of NuMA. (mpg.de)

Recently, heat shock protein (HSP)90α has been identified as an important molecular chaperone with PPARγ, which regulates the effect of the PPARγ pathway. (spandidos-publications.com)

Apoptosis can be initiated through one of two pathways. (wikipedia.org)
Both pathways induce cell death by activating caspases, which are proteases, or enzymes that degrade proteins. (wikipedia.org)
The two pathways both activate initiator caspases, which then activate executioner caspases, which then kill the cell by degrading proteins indiscriminately. (wikipedia.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
We also examined the dataset of proteins obtained by the quantitative proteomics analysis using two tools, Downstream Effect Analysis and Upstream Regulator Analysis of the Ingenuity Pathways Analysis software. (oncotarget.com)

We identified 231 proteins released from actomyosin contraction-dependent blebs and apoptotic bodies by adapted SILAC (stable isotope labeling with amino acids in cell culture) combined with mass spectrometry analysis. (nature.com)

Taken together, our study demonstrated that GO-AgNPs potentially induce oxidative damage to DNA, which result in toxicity and cell apoptosis in caprine fetal fibroblast cell due to an increased generation of ROS. (researchsquare.com)

Monoclonal antibody is produced by immunizing animals with a recombinant Protein A-PCNA fusion protein, or with a synthetic peptide corresponding to residues surrounding Cys60 of human Survivin. (cellsignal.com)

Genotyping of ASFV isolates by partial sequencing of the B646L gene that encodes the major capsid protein p72 has identified 22 genotypes ( 6 ). (cdc.gov)

The key regulator of this process, hypoxia inducible factor 1 (HIF-1), can initiate apoptosis by inducing high concentrations of proapoptotic proteins, such as BNIP3, and can cause stabilisation of p53. (bmj.com)

The membrane protein EsaA is a conserved component of the type VIIb secretion system. (uni-wuerzburg.de)
The latter is a membrane protein localized to both the ER and nuclear membranes, and contains a specific binding site for PP1. (rupress.org)

In the skin, NF-KB regulates cell growth in the stratified epithelium and apoptosis. (medscape.com)

Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. (cancerindex.org)

The mRNA and protein expression of the 26 genes was associated with sensitivity or resistance to 18 NCCN-recommended drugs for treating breast cancer. (cdc.gov)

The 2002 Nobel Prize in Medicine was awarded to Sydney Brenner, H. Robert Horvitz and John Sulston for their work identifying genes that control apoptosis. (wikipedia.org)

Novel selective inhibitors of nuclear export (SINE) have achieved outstanding preclinical results and are currently in Phase I trials. (massgeneral.org)
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. (bvsalud.org)

We report that the WNV-capsid (Cp) by itself induces rapid nuclear condensation and cell death in tissue culture. (cdc.gov)

Daxx interacts with the TGF-β type II receptor by binding of C-terminal domain of the protein. (wikipedia.org)
Recently, we isolated a novel negative regulator of epidermal growth factor receptor (EGFR), termed EGFR-related protein (ERRP), whose expression attenuates EGFR activation. (aacrjournals.org)
Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
Oligomerisation of initiating proteins such as AIM2 (absent in melanoma-2) and NLRP3 (NOD-like receptor family, pyrin domain-containing-3) recruits procaspase-1 via the inflammasome adapter molecule ASC (apoptosis-associated speck-like protein containing a CARD). (nih.gov)

Steen and Collas 2001 (this issue) now provide some tantalizing data that links nuclear lamina organization to cell survival. (rupress.org)

It has been associated with heterochromatin and PML-NBs (Promyelocytic Leukaemia nuclear bodies) and has been implicated in many nuclear processes including transcription and cell cycle regulation. (wikipedia.org)
Understanding the regulation of apoptosis during hypoxia and the mechanisms of resistance to apoptosis might lead to more specific treatments for solid tumours. (bmj.com)
The protein product of the murine double minute gene 2 (mdm-2) plays a central role in the regulation of p53. (lu.se)

In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. (wikipedia.org)
Once activated, p38 phosphorylates a number of targets, including the nuclear transcription factors ATF2 and Max. (rndsystems.com)
Part of the rationale for this combination stems from the inhibition of the nuclear transcription factors, NFkappaB and HIF-1alpha, by VELCADE and Panzem , respectively. (salesandmarketingnetwork.com)
The enhanced growth inhibition obtained with the combination was associated with an increase in apoptosis-related proteins, decreased levels of the nuclear transcription factors, HIF-1alpha, pSTAT3 and NFkappaB, and a decrease in the autocrine growth factor, IL-6. (salesandmarketingnetwork.com)

We focused our attention on an oncogenic protein, CAV1, and a tumor suppressor protein, SERPINB2, that had not previously been reported to be modulated by BAG3. (oncotarget.com)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
NEMO consists of 10 exons, and most mutations cause deletions of exons 4-10, resulting in a truncated protein. (medscape.com)
Hypomorphic mutations may impair but not abolish NEMO protein function. (medscape.com)

Apoptosis is a fundamental homeostatic mechanism essential for the normal growth, development and maintenance of every tissue and organ. (nature.com)

Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle through inhibiting apoptosis and promoting cell division (4,5). (cellsignal.com)
GAS 41, a highly conserved protein in eukaryotic nuclei, binds to NuMA. (mpg.de)

The most enriched proteins released were the nucleosomal histones, which have previously been identified as damage-associated molecular pattern proteins (DAMPs) that can initiate sterile inflammatory responses. (nature.com)

Prognostic significance of tumor cell proliferation rate as determined by the MIB-1 antibody in breast carcinoma: Its relationship with vimentin and p53 protein. (mpg.de)

While studying tissues using electron microscopy, John Kerr at the University of Queensland was able to distinguish apoptosis from traumatic cell death. (wikipedia.org)
For many years, neither "apoptosis" nor "programmed cell death" was a highly cited term. (wikipedia.org)
This occurred in 1988 when it was shown that BCL2, the gene responsible for follicular lymphoma, encoded a protein that inhibited cell death. (wikipedia.org)
Bcl-2 protein blocks apoptosis (programmed cell death), and thereby may contribute to tomorigenesis by prolonging cell survival rather than by accelerating the rate of cell proliferation. (bdbiosciences.com)
DeMarini, and Chapter 20, by Rice and cell death determine the size protein in several signal ing path- and Herceg). (who.int)

Moreover, the ultrastructural localization of both 125- and 160-kDa proteins was investigated by electron microscope immunocytochemistry with gold-conjugated secondary antibodies. (nih.gov)

Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. (abcam.com)

Multiple proteins involved in DNA replication, DNA repair, and cell cycle control bind to PCNA rather than directly associating with DNA, thus facilitating fast processing of DNA (reviewed in 7). (cellsignal.com)

Anatomy27

Organisms8

Diseases6

Chemicals and Drugs125

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes65

Disciplines and Occupations1

Information Science3

Proliferation and apoptosis2

Uncontrolled cell proliferation1

Mitochondrial6

Differentiation6

Induce apoptosis1

Regulatory proteins1

Induces apoptosis1

Enzyme4

Phosphorylation4

Intracellular2

Inhibitor2

Undergo3

Signal transduction1

Vitro5

Regulate5

Chromatin5

Metabolism1

Cellular7

Inflammation3

Colorectal Cancer1

Kinase8

Family of proteins2

Receptors1

Components of the nuclear lamina1

Mitochondria1

Cells24

Translocation3

Cytoplasmic4

Necrosis4

Tp532

Antigen1

Mitogen-Activat1

Induction3

Heat shock p1

Pathways5

Mass Spectrometry1

Oxidative1

Monoclonal1

Capsid protein1

Inducible1

Membrane protein2

Regulates1

Caspases1

MRNA and protein1

20021

Inhibitors2

Condensation1

Receptor4

20011

Regulation3

Transcription factors4

Tumor suppressor1

Mutations3

Mechanism1

Binds2

Initiate1

Vimentin1

Cell death5

Localization1

Gene expression1

Replication1