Pregabalin, sold under the brand name Lyrica among others, is an anticonvulsant, analgesic and anxiolytic medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, opioid withdrawal and generalized anxiety disorder (GAD). (wikipedia.org)
Essential oils and the constituents in them exhibit different pharmacological activities, such as antinociceptive, anxiolytic-like, and anticonvulsant effects. (mdpi.com)
Taken together these results reveal a mode of action of CBD on specifically configured GABAA receptors that may be relevant to the anticonvulsant and anxiolytic effects of the compound. (researchgate.net)
Analgesic1
In this regard, CBD inhibition of 5-HT 3 receptors may contribute to its role in modulation of nociception and emesis, potentiation of GABA receptors may account for its anti-seizure, anxiolytic and analgesic effects, and potentiation of glycine receptors may be relevant for CBD anti-nociceptive actions [3,16, 22] . (researchgate.net)
Effects2
Pregabalin appears to have anxiolytic effects similar to benzodiazepines with less risk of dependence. (wikipedia.org)
The potency of CBD increased and efficacy preserved in binary α1/α2β2 receptors indicating that their effects do not involve the classic benzodiazepine site. (researchgate.net)
This thesis compares the cognitive and affective effects of two anxiolytic compounds in the goldfish, Carassius auratus: fluoxetine (Prozac�), an antidepressant, and allopregnanolone, a neurosteroid native to the brain of vertebrates. (ufl.edu)
Similar1
Those fish treated with anxiolytics and cortisol presented a similar pattern, but with only allopregnanolone+cortisol demonstrating hippocampal-dependent avoidance behavior on par with the control group by the end of the experiment. (ufl.edu)
Treat1
Benzodiazepine (BZ) drugs treat seizures, anxiety, insomnia, and alcohol withdrawal by potentiating γ2 subunit containing GABA type A receptors (GABAARs). (bvsalud.org)
Effect2
Long-term trials have shown continued effectiveness without the development of tolerance, and, in addition, unlike benzodiazepines, it has a beneficial effect on sleep and sleep architecture, characterized by the enhancement of slow-wave sleep. (wikipedia.org)
Moreover, PTAT decoction dose-dependently reversed the alterations induced by PTZ in GABA, GABA-T, L-GAD and glutamate levels in kindling mice, showing an effect on the modulation of the GABA neurotransmission. (bvsalud.org)