Direct-acting anInfluenzaDevelopment of antiviral agentsExerted antiviral activityOseltamivirTherapeuticEfficacyVirusesReplicationInhibitsAntimicrob Agents ChInfectionTherapyBroad spectrumInhibitionAmantadineDrugsTreatmentActivityHepatitis C virImmuneAssayAntifungalSmallpoxPotentVitroDrugAntiretroviral agentsProphylacticallyClinicalPharmacokineticsInfectionsAnti-viral agentsHumansPromiseAnalogues
Direct-acting an2
- Since molecules with direct-acting antiviral (DAA) became available, the landscape of the treatment of hepatitis C virus (HCV) infection has completely changed. (wjgnet.com)
- Open in another window Introduction The introduction of direct-acting antiviral real estate agents (DAAs) GYKI-52466 dihydrochloride provides revolutionized the treating persistent hepatitis C pathogen (HCV) disease. (conferencedequebec.org)
Influenza20
- This report contains information on treatment and chemoprophylaxis of influenza virus infection and provides a summary of the effectiveness and safety of antiviral treatment medications. (cdc.gov)
- and 6) consideration of antiviral treatment for outpatients with confirmed or suspected influenza who do not have known risk factors for severe illness, if treatment can be initiated within 48 hours of illness onset. (cdc.gov)
- The two antiviral agents with specific activity against influenza A viruses are amantadine hydrochloride and rimantadine hydrochloride. (cdc.gov)
- Antivirals to treat influenza (oseltamivir) have limited activity against SARS-CoV-2, but favipiravir and umifenovir, two influenza antivirals available internationally, may have distinct viral targets and require further investigation. (ccjm.org)
- Oseltamivir and zanamivir are antiviral neuraminidase inhibitors that are used for chemoprophylaxis and treatment of influenza A and B infection. (medscape.com)
- Use of influenza-specific antiviral drugs for chemoprophylaxis or treatment of influenza is an important adjunct to vaccination, particularly for controlling outbreaks in closed populations. (medscape.com)
- Oseltamivir (Tamiflu) resistance emerged in the United States during the 2008-2009 influenza season, and the CDC issued revised interim recommendations for antiviral treatment and prophylaxis of influenza. (medscape.com)
- Because of this, zanamivir was recommended as the initial choice for antiviral prophylaxis or treatment when influenza A infection or exposure was suspected. (medscape.com)
- Local influenza surveillance data and laboratory testing can assist the physician regarding antiviral agent choice. (medscape.com)
- Most of the antiviral drugs currently available are used to treat infections caused by HIV , herpes viruses , hepatitis B and C viruses , and influenza A and B viruses . (amboss.com)
- The ACIP also publishes recommendations on the use of antiviral agents for prevention and treatment of influenza . (medscape.com)
- [ 2 ] Early antiviral therapy must be considered among hospitalized children diagnosed with or suspected to have influenza, especially if they have risk factors such as asthma, cardiac problems, or other conditions, to prevent severe complications and prolonged hospitalization. (medscape.com)
- Antiviral agents available for influenza treatment and/or prevention include neuraminidase inhibitors (oseltamivir, peramivir, zanamivir) and the cap-dependent endonuclease inhibitor (baloxavir marboxil). (medscape.com)
- Development of Novel Anti-influenza Thiazolides with Relatively Broad-Spectrum Antiviral Potentials. (bvsalud.org)
- In this study, we report a series of novel thiazolides derived from an FDA-approved drug , nitazoxanide, with antiviral activity against influenza and a broad range of viruses . (bvsalud.org)
- Together, the results of our study indicated the direction to optimize nitazoxanide as an anti- influenza drug and discovered two candidates with novel structures, compounds 4a/4d, that have relatively broad-spectrum antiviral potentials. (bvsalud.org)
- La información en esta página debería ser considerada como ejemplos de información de antecedentes para la temporada de influenza 2021-2022 para la práctica médica respecto del uso de medicamentos antivirales contra la influenza. (cdc.gov)
- Actualización sobre el virus la influenza aviar A (H5N1) en los seres humanos. (cdc.gov)
- Effectiveness of antiviral treatment in human influenza A(H5N1) infections: analysis of a Global Patient Registry. (cdc.gov)
- Impact of Prompt Influenza Antiviral Treatment on Extended Care Needs After Influenza Hospitalization Among Community-Dwelling Older Adults. (cdc.gov)
Development of antiviral agents2
Exerted antiviral activity1
- Pradimicin-S (PRM-S), a small-size non-peptidic CBA, exerted antiviral activity in MDDC but not in Raji/DC-SIGN(+) cells. (unboundmedicine.com)
Oseltamivir2
- Oseltamivir is an oral antiviral that is approved for children aged 2 weeks or older for treatment and aged 1 year or older for prophylaxis. (medscape.com)
- Notably, the combination using compounds 4a/4d and oseltamivir carboxylate or zanamivir displayed synergistic antiviral effects against oseltamivir -resistant strains . (bvsalud.org)
Therapeutic5
- For those with more severe illness or high risk for mortality or both, therapeutic strategies have emerged to combat severe acute respiratory syndrome coronavirus (SARS-CoV-2) directly with antivirals and indirectly with immune modulation. (ccjm.org)
- Initially, the first generics narrow therapeutic ranges, for instance patients with represented 'older' antiretroviral agents such as zido- organ transplants or epilepsy. (sagepub.com)
- There are many synthetic antiviral drugs that have a large number of side effects and have narrow therapeutic window range, while in the other hand herbal formulations have minimized side effects. (ijpsr.com)
- Did you mean topic:"antivirals agents - therapeutic use" ? (nshealth.ca)
- The purpose of this study is to evaluate the therapeutic efficacy between the combined blood expander therapy and the combined therapy of diuretics and antiviral agent in sudden sensorineural hearing loss patients with many variables known as prognostic factors. (ejao.org)
Efficacy5
- The natural products which are obtained from plants as antiviral agents against viruses have gone through researches to check the efficacy and potentials of the herbal products in the prevention of viral disorders. (ijpsr.com)
- Though, efficacy remains disputable for antiviral drugs that are employed for viral disorders. (ijpsr.com)
- However, ongoing research efforts are focused on addressing these limitations and optimizing the efficacy and safety profiles of peptide-based anti-viral agents. (researchpeptides.net)
- 1. Effectiveness: Peptide-based agents have demonstrated efficacy against a wide range of viruses, including drug-resistant strains. (researchpeptides.net)
- Antiviral efficacy of favipiravir against two prominent etiological agents of hantavirus pulmonary syndrome. (fujifilmpharma.com)
Viruses11
- Because antiviral agents taken prophylactically may prevent illness but not subclinical infection, some persons who take these drugs may still develop immune responses that will protect them when they are exposed to antigenically related viruses in later years. (cdc.gov)
- Being a promising antiviral target, helicase inhibition leads to the pause of the replication, proliferation and consequently, to the survival and transmission of Flaviviridae viruses ( 3 ). (spandidos-publications.com)
- The CBAs exerted broad spectrum antiviral activity against the four DENV serotypes, laboratory-adapted viruses and low passage clinical isolates, evaluated in Raji/DC-SIGN(+) cells and in primary MDDC. (unboundmedicine.com)
- Drugs targeting RNA respiratory viruses have resulted in few effective therapies, highlighting challenges for antivirals to treat COVID-19. (ccjm.org)
- In this discussion of proposed antiviral therapies that may hold some promise against SARS-CoV-2, it should be recognized that antiviral drug development against other RNA respiratory viruses has resulted in very few effective therapies. (ccjm.org)
- Remdesivir (GS-5734) is an adenosine analog antiviral drug that inhibits viral RNA polymerase and has demonstrated in vitro activity against various viruses including Ebola, SARS-CoV, and Middle Eastern respiratory syndrome (MERS-CoV). (ccjm.org)
- Substantial antiviral activity was observed in ca. 20%, which is higher than might be expected given the limited metabolic differences between viruses and their hosts. (umn.edu)
- The frequent antiviral activity may represent phytoalexins elaborated to protect against plant viruses. (umn.edu)
- In recent years, it has been reported that many herbal plants contain antiviral agents which combat a human disease that is caused by pathogenic viruses. (ijpsr.com)
- 3. Broad-spectrum activity: Unlike many conventional antivirals that are specific to a particular virus or family of viruses, peptide-based agents can be designed to have broad-spectrum activity. (researchpeptides.net)
- Here we report the antiviral activities of GS-5734 and the parent nucleoside analog across multiple virus families, providing evidence to support new indications for this compound against human viruses of significant public health concern. (nih.gov)
Replication9
- Previous studies have demonstrated that viral RNA helicases represent promising pharmacological targets for antiviral drugs/inhibitors, as they are implicated in viral replication and proliferation. (spandidos-publications.com)
- We evaluated various carbohydrate-binding agents (CBAs) against all four described serotypes of DENV replication in Raji/DC-SIGN(+) cells and in monocyte-derived DC (MDDC). (unboundmedicine.com)
- It is a first-in-class oral small antiviral molecule which blocks HIV replication through a unique mechanism of action and, separately, also has a strong anti-inflammatory effect. (evotec.com)
- Unlike other antimicrobials, antiviral drugs do not deactivate or destroy the microbe (in this case, the virus ) but act by inhibiting replication. (amboss.com)
- Most antiviral agents target key enzymes required for viral replication (see " Viral life cycle " for details). (amboss.com)
- 6. The antiviral agent, amantadine, inhibits the replication of which strain of virus? (remixeducation.in)
- This study was designed to assay the antiviral activity of curcumin and its new derivatives like gallium-curcumin and Cu-curcumin on replication of HSV-1 in cell culture. (greenmedinfo.com)
- These agents are designed to target specific components or processes involved in viral replication and entry into host cells. (researchpeptides.net)
- These mechanisms highlight the diverse ways in which peptide-based agents can disrupt viral replication and reduce viral load within infected individuals. (researchpeptides.net)
Inhibits3
- This agent inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. (medscape.com)
- This agent inhibits bacterial protein synthesis by binding with the 30S and, possibly, the 50S ribosomal subunit(s). (medscape.com)
- The antiviral agent cidofovir, a nucleoside analogue that inhibits adenovirus DNA polymerase, 2 was successfully tested through phase II clinical trials for this indication. (arvojournals.org)
Antimicrob Agents Ch1
- Antimicrob Agents Chemother;64(7)2020 06 23. (bvsalud.org)
Infection7
- The conclusion of the panel was that it would be appropriate, and possibly essential, to develop antiviral drugs for PV infection, as an additional tool to address the problems that might arise in the "postpolio" era ( 6 ). (cdc.gov)
- Ibalizumab was approved for use in the United States in 2018 for therapy (in combination with other antiretroviral agents) of patients with multidrug resistant HIV-1 infection. (nih.gov)
- HBV infection is considered the most important causative agent of HCC, with approximately 240 million people infected worldwide, especially in the Asia-Pacific and African regions [ 6 , 7 , 8 ]. (biomedcentral.com)
- Conclusion: These results suggest that the combined therapy with diuretics and antiviral agents seems to be more effective than the com bined therapy with blood expanders to the recovery of sudden sensorin eural hearing loss in the cases of who have a history of vertigo and upper respiratory tract infection. (ejao.org)
- One part of this defense system is a chemical called squalamine, which resists viral infection and just might serve as an antiviral therapy for humans. (asknature.org)
- GRFT can inhibit human immunodeficiency virus (HIV) infection at picomolar concentrations, surpassing the ability of most anti-HIV agents. (mdpi.com)
- Efavirenz is a non-nucleoside reverse transcriptase inhibitor indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus type 1 infection in adults and in pediatric patients at least 3 months old and weighing at least 3.5 kg. (nih.gov)
Therapy15
- The goal of therapy for postherpetic neuralgia (PHN) is to reduce morbidity through the use of tricyclic antidepressants, anticonvulsants, anesthetics, analgesics, corticosteroids, and antiviral agents. (medscape.com)
- Current treatment choices for Bell's palsy include corticosteroids, antiviral therapy or a combination of the two. (news-medical.net)
- The aim of antiviral therapy is to minimize symptoms and infectivity as well as to shorten the duration of illness. (amboss.com)
- Currently, antiviral therapy is available only for a limited number of infections. (amboss.com)
- Socio-demographic information was collected and patients answered the adapted questionnaire ("Assessment of adherence to antiviral therapy questionnaire for chronic hepatitis B patients", CEAT-VHB) and Morisky test. (usp.br)
- Progressively numerous studies on therapy of antivirals have been increased. (ijpsr.com)
- Antiviral therapy has been shown to benefit long-term survival after curative hepatectomy in patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) with high levels of HBV-DNA, but the impact of antiviral therapy on patient recurrence in patients with low levels of HBV-DNA remains less clear. (biomedcentral.com)
- 2000 IU/mL who underwent hepatectomy at Zhongnan Hospital of Wuhan University between March 2013 and December 2017, of whom 157 patients received antiviral therapy (antiviral group) and 139 patients did not receive antiviral therapy (non-antiviral group), propensity score matching was used for survival analysis of patients in both groups, and subgroup analysis of major risk factors was performed. (biomedcentral.com)
- 130 IU/L, and the presence of satellite nodules, and subgroup analysis showed that compared to HBeAg-positive patients, antiviral therapy could significantly prolonged the recurrence-free survival of HBeAg-negative patients. (biomedcentral.com)
- Antiviral therapy reduces early tumor recurrence after hepatectomy in patients with low levels of HBV-DNA. (biomedcentral.com)
- These findings suggest that antiviral therapy may have a positive impact on reducing recurrence in patients with HBV-associated hepatocellular carcinoma. (biomedcentral.com)
- However, some studies have also shown no difference in prognosis of HBV-associated HCC patients with antiviral drug therapy [ 20 , 21 ]. (biomedcentral.com)
- Overall, there are relatively few data regarding the effectiveness of antiviral therapy after curative hepatectomy for HCC, especially in patients with HBV-associated HCC with low levels of HBV-DNA, and it is still not well known whether antiviral therapy is effective in preventing recurrence of metastasis after curative hepatectomy in patients. (biomedcentral.com)
- To this end, we conducted a retrospective study to assess the effect of antiviral drug therapy on recurrence and survival after hepatectomy in patients with HBV-associated HCC with low levels of HBV-DNA. (biomedcentral.com)
- Hazardous drugs can include those used for cancer therapy, some antiviral drugs, hormone agents, and bioengineered drugs. (cdc.gov)
Broad spectrum1
- However, broad-spectrum antiviral agents (BSAAs) could provide additional protection of general population from emerging and re-emerging viral diseases reinforcing the arsenal of available antiviral options. (preprints.org)
Inhibition2
- ABIVAX's antiviral platform is based on its technology of inhibition mRNA biogenesis and its chemical library of more than one thousand small molecules. (evotec.com)
- Ombitasvir, paritaprevir, and dasabuvir combine exclusive antiviral systems of actions (nonstructural proteins 5A inhibition, non-structural proteins 3/4A protease inhibition, and non-nucleoside non-structural proteins 5B polymerase inhibition, respectively). (conferencedequebec.org)
Amantadine2
- These recommendations provide information about two antiviral agents: amantadine hydrochloride and rimantadine hydrochloride. (cdc.gov)
- Amantadine and rimantadine are older antiviral agents that are no longer recommended by the CDC because of resistance. (medscape.com)
Drugs9
- A panel convoked by the National Research Council concluded that the use of antiviral drugs may be essential in the polio eradication strategy. (cdc.gov)
- Therefore, research initiatives leading to the successful development of anti-PV drugs will have to rely on the current knowledge of existing picornavirus antiviral agents. (cdc.gov)
- Antipicornavirus compounds that reached clinical trials are scarce, and despite the fact that some of these drugs have demonstrated activity against certain picornavirus-associated conditions in humans, no specific antipicornavirus agent has yet been approved by the US Food and Drug Administration (FDA) ( 8 ). (cdc.gov)
- Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. (preprints.org)
- Unlike traditional antiviral drugs, which often target viral enzymes or proteins, peptide-based agents utilize short chains of amino acids to disrupt viral mechanisms. (researchpeptides.net)
- 4. Resistance development: While resistance to traditional antiviral drugs can emerge over time, peptide-based agents have shown a lower propensity for resistance development. (researchpeptides.net)
- The Secretariat also acknowledges that it is not possible to predict how long the research on antiviral drugs will take. (who.int)
- Some classes of drugs are more hazardous than others and, as a group, antineoplastic drugs have been shown in animal studies to be some of the most potent teratogenic agents known, at doses typically used in cancer treatment. (cdc.gov)
- Those at risk of severe complications receive postexposure prophylaxis with immune globulin and, if disease develops, are treated with antiviral drugs (eg, valacyclovir, famciclovir, acyclovir). (msdmanuals.com)
Treatment10
- Adding an antiviral agent to corticosteroids for treatment of Bell's palsy (a condition characterized by partial facial paralysis) is not associated with improved recovery of facial movement function, according to a meta-analysis of previously published studies in the June issue of Archives of Otolaryngology-Head & Neck Surgery . (news-medical.net)
- However, based on the currently available evidence, the addition of an antiviral agent to corticosteroids for the treatment of patients with Bell's palsy is not justified. (news-medical.net)
- Famciclovir is a human antiviral agent used in the treatment of Feline Herpes (FHV-1) infections. (medi-vet.com)
- 1 Although many of these infections are self-limiting, patients would benefit greatly from antiviral treatment, because it would reduce the significant morbidity that results in lost time from school and work and would limit the spread of these very contagious infections within households and communities. (arvojournals.org)
- 1 At present, there is no U.S. Food and Drug Administration (FDA)-approved antiviral agent for the treatment of these infections. (arvojournals.org)
- Antivirals with evidence of clinical activity must be studied as treatment and prophylaxis for those at high risk for severe COVID-19. (ccjm.org)
- When used for treatment, these agents should be started as soon as possible after the onset of symptoms, but no later than 2 days after onset. (medscape.com)
- The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. (nshealth.ca)
- Peptide-based agents have emerged as a promising approach for the treatment of viral infections. (researchpeptides.net)
- This early increase in disease incidence highlights the importance of optimizing respiratory virus prevention and treatment measures, including prompt vaccination and antiviral treatment, as outlined below. (cdc.gov)
Activity9
- Only weak antiviral activity of the CBAs was detected when administered after the virus attachment step. (unboundmedicine.com)
- To determine whether N -chlorotaurine (NCT) demonstrates antiviral activity against adenovirus (Ad) in vitro and in the Ad5/NZW rabbit ocular model. (arvojournals.org)
- NCT demonstrated antiviral activity against adenovirus in vitro and in vivo. (arvojournals.org)
- An improved plaque reduction assay for antiviral activity was developed and used to examine extracts from sixty-one higher plants. (umn.edu)
- The research was performed as an in vitro study in which the antiviral activity of different concentrations of three substances including curcumin, Gallium-curcumin and Cu-curcumin were tested on HSV-1. (greenmedinfo.com)
- In this paper, the activity of antiviral agents from medicinal plants which have importance in Ayurveda, are discussed along with their source. (ijpsr.com)
- The antiviral activity GYKI-52466 dihydrochloride of paritaprevir is usually boosted by its co-formulation with a minimal dosage of ritonavir (i.e., 100?mg), facilitating the usage of a lower dosage of paritaprevir and once-daily dosing. (conferencedequebec.org)
- Griffithsin's antiviral activity stems from its ability to bind terminal mannoses present in high-mannose oligosaccharides and crosslink these glycans on the surface of the viral envelope glycoproteins. (mdpi.com)
- We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a. (napier.ac.uk)
Hepatitis C vir1
- The objective of this research was to investigate the potential use of bromelain enzyme, a proteolytic enzyme contained in the flesh and stem of a pineapple fruit, as antiviral agent against HIV (Human Immunodeficiency Virus) that causes AIDS (Acquired Immuno Deficiency Syndrome), Hepatitis C Virus (HCV), and Human Papiloma Virus (HPV) that causes cervical cancer. (medwelljournals.com)
Immune3
- To do this ABIVAX leverages three technology platforms for drug discovery: antiviral, immune enhancing and polyclonal antibodies. (evotec.com)
- 4. Modulation of host immune response: Some peptides can enhance the host immune response against viral infections by stimulating the production of antiviral cytokines or activating immune cells. (researchpeptides.net)
- Example: Synthetic peptides known as Toll-like receptor agonists can activate immune cells and promote antiviral responses. (researchpeptides.net)
Assay2
Antifungal1
- 4. Which antifungal agent is NOT indicated for use in fungal infections of the skin and nails? (remixeducation.in)
Smallpox2
Potent1
- 7. Which anti-herpetic agent is most potent? (remixeducation.in)
Vitro1
- On the basis of randomized controlled studies and in-vivo studies, and in-vitro studies, some agents are utilized all across the globe. (ijpsr.com)
Drug3
- A panel was convened by the National Research Council to evaluate the potential for an antiviral drug as one of the tools to minimize poliomyelitis risk after OPV cessation. (cdc.gov)
- Antiviral drug resistance is one of the most common problems in medicine, and, therefore, finding new antiviral agents, especially from natural resources, seems to be necessary. (greenmedinfo.com)
- abbreviation TFT or FTD) is an anti-herpesvirus antiviral drug, used primarily on the eye. (wikipedia.org)
Antiretroviral agents2
- Article Commentary: Generic Substitution of Antiretroviral Agents: Never a Problem? (sagepub.com)
- 24:389-391 (doi: 10.3851/IMP3321) Commentary Generic substitution of antiretroviral agents: never a problem? (sagepub.com)
Prophylactically1
- Antiviral agents do not confer immunity but could be used prophylactically as well as therapeutically. (cdc.gov)
Clinical2
- The goal of antivirals is to shorten the clinical course, prevent complications, prevent the development of latency and/or subsequent recurrences, decrease transmission, and eliminate established latency. (medscape.com)
- Several antivirals are being investigated for symptomatic COVID-19 but no definitive data support their clinical use. (ccjm.org)
Pharmacokinetics2
- Pharmacokinetics of the Antiviral Agent Carbocyclic 3-Deazaadenosine" by Roger A. Coulombe Jr., J. Michael Huie et al. (usu.edu)
- Data from this first investigation of the pharmacokinetics of Cc3Ado indicate that this antiviral agent is rapidly distributed and eliminated from the plasma and that distribution to tissues is widespread and rapid. (usu.edu)
Infections2
- Antivirals are a class of medications that are used to treat viral infections. (amboss.com)
- By targeting specific steps in the viral life cycle, these agents offer a unique approach to managing viral infections. (researchpeptides.net)
Anti-viral agents3
- and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. (nshealth.ca)
- Peptide-based anti-viral agents offer several advantages over conventional treatments. (researchpeptides.net)
- Peptide-based anti-viral agents exert their effects through various mechanisms depending on the specific target virus. (researchpeptides.net)
Humans2
- Some antiviral and antineoplastic agents and other pharmaceutical agents : views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Lyon, 12-19 October 1999. (who.int)
- There's strong evidence that the agent responsible for bovine spongiform encephalopathy (BSE) in cows, commonly called "mad cow disease," is also responsible for one form of acquired CJD in humans, called "variant CJD. (healthline.com)
Promise1
- While peptide-based agents hold great promise, there are still challenges that need to be addressed. (researchpeptides.net)
Analogues1
- The work described in this thesis was aimed at distinguishing between two possible mechanisms for the antiviral mode of action of pyrophosphate analogues. (warwick.ac.uk)