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  • Haloperidol
  • First-generation antipsychotics, such as haloperidol, which mainly have dopamine D 2 antagonist action, are effective against positive symptoms, but they are relatively less beneficial in treating negative and associated mood symptoms ( Lieberman, 1993 ). (aspetjournals.org)
  • As a plausible explanation for the large interindividual variability in the pharmacokinetics of the neuroleptic agent haloperidol, the contributions of CYP3A isozymes (CYP3A4 and the polymorphic CYP3A5) predominantly involved in haloperidol bioactivation to the neurotoxic pyridinium species 4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-pyridinium (HPP + ) were assessed in human liver microsomes and heterologously expressed enzymes. (aspetjournals.org)
  • medication
  • Prospective study to quantify the prevalence of possible tardive dyskinesia (TD) in outpatient psychiatry practices in the United States (US), as well as to describe the associated disease burden in a cohort of patients with one or more psychiatric disorders and a cumulative lifetime exposure to antipsychotic medication of three months or more. (clinicaltrials.gov)
  • Patients must be 18 years or older with a cumulative lifetime exposure to antipsychotic medication of three months or more. (clinicaltrials.gov)
  • Results No difference in the incidence of glycaemic abnormalities between placebo cohorts and antipsychotic medication cohorts was identified. (nuigalway.ie)
  • Before or soon after initiation of antipsychotic medication, obtain a fasting lipid profile at baseline and monitor periodically during treatment. (drugs.com)
  • novel
  • There is a tremendous need to develop novel agents with unique mechanisms of action for the treatment of psychotic disorders. (primarypsychiatry.com)
  • These studies will allow us to rigorously test the hypothesis that selective allosteric activators of M1 have effects in animal models that predict efficacy as novel antipsychotic and cognition-enhancing agents. (grantome.com)
  • Lithium
  • Lithium is considered a first-line agent for long-term prophylaxis in bipolar illness, especially for classic bipolar disorder with euphoric mania. (medscape.com)
  • possesses
  • These results demonstrate that lurasidone possesses antipsychotic activity and antidepressant- or anxiolytic-like effects with potentially reduced liability for extrapyramidal and CNS depressant side effects. (aspetjournals.org)
  • antiemetic
  • Ondansetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. (pharmacycode.com)
  • Also, like most antipsychotics, chlorprothixene has antiemetic effects. (wikipedia.org)
  • efficacy
  • Furthermore, preliminary studies suggest that representative compounds have efficacy in animal models that predict antipsychotic and cognition-enhancing effects. (grantome.com)
  • undergo
  • It is recommended that patients with risk factors for diabetes mellitus starting treatment with atypical antipsychotics should undergo fasting blood glucose testing at the beginning of treatment, and periodically thereafter. (drugs.com)
  • compounds
  • ADMET studies coupled with a behavioral test using the amphetamine-induced hyperactivity model identified four compounds possessing drug-like profiles and having antipsychotic properties. (edu.au)
  • effects
  • We will perform a series of studies in to systematically determine the effects of representative M1 allosteric activators on cell signaling and electrophysiological responses in forebrain neurons important for antipsychotic and cognition-enhancing effects of these agents. (grantome.com)
  • In addition, we will determine the behavioral effects of M1 allosteric activators in rodent models that predict antipsychotic and cognition-enhancing effects. (grantome.com)
  • Most people on antipsychotics get side effects. (wikipedia.org)
  • diabetes
  • Patients with diabetes should be monitored for worsening control of blood glucose when treated with these agents. (drugs.com)
  • older
  • Although they are better tolerated and generally thought to be more effective than the older agents, the question remains: which ones should we choose to put on our formulary? (levelofhealth.com)