• Haloperidol
  • First-generation antipsychotics, such as haloperidol, which mainly have dopamine D 2 antagonist action, are effective against positive symptoms, but they are relatively less beneficial in treating negative and associated mood symptoms ( Lieberman, 1993 ). (aspetjournals.org)
  • As a plausible explanation for the large interindividual variability in the pharmacokinetics of the neuroleptic agent haloperidol, the contributions of CYP3A isozymes (CYP3A4 and the polymorphic CYP3A5) predominantly involved in haloperidol bioactivation to the neurotoxic pyridinium species 4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-pyridinium (HPP + ) were assessed in human liver microsomes and heterologously expressed enzymes. (aspetjournals.org)
  • tricyclic
  • brand names Clotepin, Clopiben), also known as octoclothepin or octoclothepine, is an antipsychotic of the tricyclic group which was derived from perathiepin in 1965 and marketed in the Czech Republic by Spofa in or around 1971 for the treatment of schizophrenic psychosis. (wikipedia.org)
  • Piquindone (Ro 22-1319) is an atypical antipsychotic with a tricyclic structure that was developed in the 1980s but was never marketed. (wikipedia.org)
  • Lithium
  • Lithium is considered a first-line agent for long-term prophylaxis in bipolar illness, especially for classic bipolar disorder with euphoric mania. (medscape.com)
  • antiemetic
  • Ondansetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. (pharmacycode.com)
  • Also, like most antipsychotics, chlorprothixene has antiemetic effects. (wikipedia.org)
  • therapeutic
  • Active ingredients of central nervous system agents will remain the largest therapeutic group served by pharmaceutical chemicals based on value and will post above average revenue growth. (freedoniagroup.com)
  • efficacy
  • Furthermore, preliminary studies suggest that representative compounds have efficacy in animal models that predict antipsychotic and cognition-enhancing effects. (grantome.com)
  • Medication
  • Before or soon after initiation of antipsychotic medication, obtain a fasting lipid profile at baseline and monitor periodically during treatment. (drugs.com)
  • undergo
  • It is recommended that patients with risk factors for diabetes mellitus starting treatment with atypical antipsychotics should undergo fasting blood glucose testing at the beginning of treatment, and periodically thereafter. (drugs.com)
  • effects
  • We will perform a series of studies in to systematically determine the effects of representative M1 allosteric activators on cell signaling and electrophysiological responses in forebrain neurons important for antipsychotic and cognition-enhancing effects of these agents. (grantome.com)
  • In addition, we will determine the behavioral effects of M1 allosteric activators in rodent models that predict antipsychotic and cognition-enhancing effects. (grantome.com)
  • Most people on antipsychotics get side effects. (wikipedia.org)
  • older
  • Although they are better tolerated and generally thought to be more effective than the older agents, the question remains: which ones should we choose to put on our formulary? (levelofhealth.com)
  • protein
  • In addition, our studies suggest that these agents may differentially regulate coupling of M1 to protein kinase pathways. (grantome.com)