• serum
  • Anti-β 2 glycoprotein I antibody (IgG and/or IgM isotype) present in medium or high titer (greater than 40 IgG or IgM phospholipid units, or greater than 99th centile) in serum or plasma, present on two or more occasions at least 12 weeks apart, measured by a standardized ELISA. (oncologynurseadvisor.com)
  • Groups of C57BL/6J mice (n=5) received either IgG from a patient with antiphospholipid syndrome (APS) or control IgG from normal human serum (NHS). (sigmaaldrich.com)
  • In the present study, the investigators will analyze the presence of antiphospholipid antibodies in the serum of the patients with gout/asymptomatic hyperuricemia, with a comparison to the patients of osteoarthritis but without hyperuricemia and gout. (clinicaltrials.gov)
  • And third, the intracytoplasmic antibodies target the constituents of the neuron cells and they are found in the CSF and serum. (wikipedia.org)
  • glycoprotein
  • These antibodies are identified by detecting their binding to beta-2 glycoprotein 1 in association with cardiolipin. (endocrinologyadvisor.com)
  • Antibeta-2 glycoprotein 1 antibodies are identified by their binding directly to the antibeta-2 glycoprotein 1 protein. (endocrinologyadvisor.com)
  • Anti-cardiolipin antibodies can be classified in two ways: As IgM, IgG or IgA As β2-glycoprotein dependent or independent In autoimmune disease ACA are beta-2 glycoprotein dependent syphilis ACA are beta-2 glycoprotein independent and can be assayed using the Venereal Disease Research Laboratory test β2-glycoprotein I has been identified as Apolipoprotein H and is required for the recognition of ACA in autoimmune disease. (wikipedia.org)
  • Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H)". Proc. (wikipedia.org)
  • Heparin
  • Heparin, which acts as a pro-survival factor in human trophoblast, attenuated the anti-beta(2)GPI antibody-mediated cell death, and also the pro-inflammatory response, but only at high concentrations. (nih.gov)
  • rheumatoid arthritis
  • This is in contrast to rheumatoid arthritis with systemic sclerosis (scleroderma) because anti-cardiolipin antibodies are present in both conditions, and therefore may tie the two conditions together. (wikipedia.org)
  • syndrome include
  • Nonthrombotic manifestations of antiphospholipid syndrome include a host of cardiovascular diseases, neurologic disorders, hematologic disorders, renal dysfunction, and cutaneous changes. (endocrinologyadvisor.com)
  • Risk factors for developing antiphospholipid syndrome include:[citation needed] Primary APS genetic marker HLA-DR7 Secondary APS SLE or other autoimmune disorders Genetic markers: HLA-B8, HLA-DR2, HLA-DR3 Race: Blacks, Hispanics, Asians, and Native Americans There is an additional elevated risk of adrenal gland bleeds leading to Waterhouse-Friderichsen syndrome (Neisseria meningitidis caused primary adrenal insufficiency). (wikipedia.org)
  • trophoblast
  • Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway. (nih.gov)
  • First trimester trophoblast cells were treated with anti-beta(2)GPI monoclonal antibodies and patient-derived aPL, after which cell survival and function was evaluated. (nih.gov)
  • We report that anti-beta(2)GPI antibodies trigger an inflammatory response in trophoblast, characterized by increased secretion of interleukin (IL)-8, MCP-1, GRO-alpha, and IL-1beta, and that this occurs in a TLR-4/MyD88-dependent manner. (nih.gov)
  • Enhanced IL-8, GRO-alpha, and IL-1beta secretion also occurred when trophoblast cells were incubated with antibodies from patients with antiphospholipid syndrome. (nih.gov)
  • assay
  • In some patients this may be due to international normalized ratio (INR) overestimating effect of warfarin therapy as a result of antibodies interfering with assay results (see section D/E). (oncologynurseadvisor.com)
  • proteins
  • VP1-proteins are incorporated into the capsid structure in a non-stochiometrical relation (based on antibody-binding analysis and X-ray structural analysis the VP1-unique region is assumed to be exposed at the surface of the virus particle. (wikipedia.org)
  • presence
  • The presence of prolonged clotting times on a routine plasma test often triggers functional testing of the blood clotting function, as well as serological testing to identify common autoantibodies such as antiphospholipid antibodies. (wikipedia.org)
  • blood
  • If possible, participants will then report to the study site to supply a detailed family and medical history and provide a blood sample for analysis for antiphospholipid antibodies and preparation of genomic DNA. (centerwatch.com)