Antinuclear antibodies (ANAs, also known as antinuclear factor or ANF) are autoantibodies that bind to contents of the cell nucleus. (wikipedia.org)
According to our present understanding, the immunological defects resulting in the development of SLE can be categorized into two phases: (a) systemic autoimmunity resulting in increased serum antinuclear and antiglomerular autoantibodies and (b) immunological events that occur within the target organ and result in end organ damage. (biomedcentral.com)
It is well known that autoantibodies (such ANAs in SLE and rheumatoid factors and anti-cyclic citrullinated peptides antibodies in RA) can be detected many years before the onset of these ADs [ 14 , 15 ]. (biomedcentral.com)
Antinuclear and antinucleolar autoantibodies (ANA and ANoA) were measured by indirect immunofluorescence. (biomedcentral.com)
Including autoimmune1
Anti-Ro antibodies are also found less frequently in other disorders including autoimmune liver diseases, coeliac disease, autoimmune rheumatic diseases, cardiac neonatal lupus erythematosus and polymyositis. (wikipedia.org)
Antigen9
Many cells of the immune system are required for this process, including lymphocytes (T-cells and B-cells) and antigen presenting cells. (wikipedia.org)
Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)
c) Effect of antibodies and antigen-specific B cells on antigen uptake. (hindawi.com)
Likewise, antigen/antibody complexes are bound by the FcR of APCs and processed in a unique fashion dependent on the epitope specificity of the bound antibody. (hindawi.com)
The presence of anti-Sjögren's-syndrome-related antigen A (anti-SSA)/Ro and anti-SSB/La antibodies during pregnancy is associated with an increased risk of neonatal lupus, a condition that arises due to transplacental autoantibody transport [ 16 ]. (explorationpub.com)
The complex formed by the binding of antigen and antibody molecules. (lookformedical.com)
The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES. (lookformedical.com)
Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction. (lookformedical.com)
Interestingly, some common autoantibody specificities (such as anti-nuclear, anti-Ro, anti-La, and anti-phospholipid antibodies) can be detected in serum many years before clinical onset, whereas others (like anti-dsDNA and anti-Sm antibodies) appear closer to the appearance of overt disease [ 6 ]. (explorationpub.com)
Assay2
Serum antiendomysium antibody and transglutaminase assay (positive in celiac disease). (medscape.com)
We used indirect immunofluorescence, the crithidia assay for anti-dsDNA antibodies, and multiple ELISAs for extractable nuclear antigens. (biomedcentral.com)
Autoimmune diseases2
Through these mechanisms B cells are involved both in autoimmune diseases that are traditionally viewed as antibody mediated and also in autoimmune diseases that are commonly classified as T cell mediated. (hindawi.com)
While several of the antibody specificities observed in lupus have been documented in other autoimmune diseases as well, antibodies against dsDNA and the Sm protein are characteristic of lupus [ 5 ]. (explorationpub.com)
Apoptosis1
In normal physiology, lymphocytes that recognise human proteins (autoantigens) either undergo programmed cell death (apoptosis) or become non-functional. (wikipedia.org)
Systemic2
By injecting the antibodies in a subcutaneous slow-release delivery formulation in the tumor area, we show that an eight-fold lower dose of antibody is as effective in inducing tumor eradication as systemic delivery. (aacrjournals.org)
There was a significant correlation between PN and anti-SM antibody, and there was a trend showing decreased motor and sensory action potential amplitudes in our systemic lupus erythematosus group compared to the controls. (hku.hk)
Complexes2
Each of these antibody subtypes binds to different proteins or protein complexes within the nucleus. (wikipedia.org)
The Fc portion of antibodies in immune complexes can be bound by C1q of the classical complement pathway, which eventually leads to the release of C5a and C3a. (hindawi.com)
Immunoglobulin2
This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY. (lookformedical.com)
A lymphoproliferative disorder characterized by pleomorphic B-LYMPHOCYTES including PLASMA CELLS, with increased levels of monoclonal serum IMMUNOGLOBULIN M. There is lymphoplasmacytic cells infiltration into bone marrow and often other tissues, also known as lymphoplasmacytic lymphoma. (lookformedical.com)
These cells coordinate an immune response upon the detection of foreign proteins (antigens), producing antibodies that bind to these antigens. (wikipedia.org)
This self-tolerance means that lymphocytes should not incite an immune response against human cellular antigens. (wikipedia.org)
Sometimes, however, this process malfunctions and antibodies are produced against human antigens, which may lead to autoimmune disease. (wikipedia.org)
Extractable nuclear antigens (ENA) are a group of autoantigens that were originally identified as antibody targets in people with autoimmune disorders. (wikipedia.org)
Anti-centromere antibodies were mainly anti-CENP-B. ELISAs for extractable nuclear antigens and the assays for dsDNA were negative. (biomedcentral.com)
ANA production can precede symptoms and indications of disease by 5 or more years, with more complete serological evaluation demonstrating increasing creation of antibodies to nuclear antigens such as for example DNA, Sm, RNP, Ro, and La.4 This stage of disease could be known as preautoimmunity because symptomatology isn't manifest. (columbiagypsy.net)
Activation2
Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
Binding of the Fc portion of the antibodies to FcR leads to activation of effector cells and further release of proinflammatory cytokines and proteolytic enzymes, mediators of antibody-dependent cell-mediated cytotoxicity (ADCC). (hindawi.com)
Determinants1
Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies. (lookformedical.com)
Chronic2
The term chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) has been used to identify patients with a chronically progressive or relapsing symmetric sensorimotor disorder with cytoalbuminologic dissociation and interstitial and perivascular endoneurial infiltration by lymphocytes and macrophages. (medscape.com)
Chronic inflammatory demyelinating polyradiculoneuropathy is presumed to occur because of immunologic antibody-mediated reaction along with interstitial and perivascular infiltration of the endoneurium with inflammatory T cells and macrophages. (medscape.com)
Autoimmunity2
They are found in many disorders including autoimmunity, cancer and infection, with different prevalences of antibodies depending on the condition. (wikipedia.org)
A lower dose and slow release of the antibody results in thousand-fold decreased levels of antibody in the serum, reducing adverse events and the risk of autoimmunity. (aacrjournals.org)
React1
The majority of sera showing anti-mitochondrial antibodies did not react with the M2 component of pyruvate dehydrogenase, characteristic of primary biliary cirrhosis. (biomedcentral.com)
Proteins2
The ENAs consist of ribonucleoproteins and non-histone proteins, named by either the name of the donor who provided the prototype serum (Sm, Ro, La, Jo), or the name of the disease setting in which the antibodies were found (SS-A, SS-B, Scl-70). (wikipedia.org)
Further diagnostics showed markedly reduced activities of both ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 - also known as von Willebrand factor-cleaving protease) and factor H. Test results for antibodies against both proteins were positive. (biomedcentral.com)
Organs1
pathology is believed to be antibody-mediated, and multiple organs are targeted. (explorationpub.com)
Found6
Anti-Ro and anti-La antibodies, also known as SS-A and SS-B, respectively, are commonly found in primary Sjögren's syndrome, an autoimmune disorder that affects the exocrine glands. (wikipedia.org)
The presence of both antibodies is found in 30-60% of Sjögren's syndrome, anti-Ro antibodies alone are found in 50-70% of Sjögren's syndrome and 30% of SLE with cutaneous involvement, and anti-La antibodies are rarely found in isolation. (wikipedia.org)
The epub Computational Methods And Experiments In will cultivate found to antinuclear place plant. (southwayinc.com)
Lower circulating EPC count was found to be associated with high disease activity (P=0.04), abnormal forced vital capacity (P=0.003), longer disease duration (P=0.04), total skin score>20 (P=0.03) and lSSc subset (P<0.001). (hku.hk)
We found that both antibodies recognized mouse RANK with high affinity, while RANK-02 and R12-31 recognized human RANK with high and lower affinities, respectively. (cnrs.fr)
Interestingly, patients with polycystic ovarian syndrome (PCOS) express many of the antibodies found in SLE patients [ 11 ], prompting speculation that PCOS could have an autoimmune etiology. (explorationpub.com)
Pregnancy1
During pregnancy, anti-Ro antibodies can cross the placenta and cause heart block and neonatal lupus in babies. (wikipedia.org)
Abstract1
volume = {171}, number = {1879-0542 (Electronic)}, pages = {5--14}, abstract = {Antibodies play an important role in therapy and investigative biomedical research. (cnrs.fr)
We use different preclinical mouse models of cancer to investigate the local administration of CTLA-4 blocking antibody and its effect on cancer progression and the antitumor T-cell response. (aacrjournals.org)
Cells5
The main target and effector cells of the CTLA-4 blockade treatment in the studied tumor models are tumor-specific endogenous CD8 + T cells that are capable of eradicating also distant tumors, whereas CD4 + T cells do not play a prominent role in the antibody-mediated tumor eradication. (aacrjournals.org)
Although these studies warrant independent confirmation, they support the notion that apoptotic cells could harbor the immunogens responsible for antinuclear antibody formation. (biomedcentral.com)
Recent studies suggest that Th17 cells, a subset of CD4 + T cells, may directly contribute to lymphoneogenesis in labial glands of pSS patients [ 11 ], but it is unclear whether a similar process occurs in the kidney of pSS patients with Fanconi syndrome. (biomedcentral.com)
B cells have antibody-dependent and antibody-independent pathogenic functions. (hindawi.com)
Both antibodies recognized human Langerhans cells, previously shown to express RANK, while dermal dendritic cells were poorly labeled. (cnrs.fr)
Results1
IS-01] Treatment of STIs in the pre-antibiotic era Michael Anthony Waugh Nuffield Hospital Leeds Background: Invited Speaker -President IUSTI 1995-1999 Materials-Methods: Recognised Authority on History of Venereology Results: A Precise history of Treatment before antibiotics A concise account is given from Roman times, through Arab medicine and Europe before the Scientific Revolution of 19th. (paperzz.com)
Levels1
This administration method is associated with very low serum levels of antibody, which decreases the risk of treatment-induced side effects. (aacrjournals.org)
Clinical1
Blockade of CTLA-4 by antibodies has potentiated antitumor T-cell responses in both preclinical models and clinical trials. (aacrjournals.org)
Play1
Antibodies play an important role in therapy and investigative biomedical research. (cnrs.fr)
Large1
This defence mechanism produces antibodies (large glycoproteins) in response to an immune stimulus. (wikipedia.org)