• p53, mdm-2, p21, and mib-1 expression were assessed by immunohistochemical methods in primary tumors derived from 134 patients who took part in a randomized multicenter trial comparing docetaxel to sequential methotrexate and 5-fluorouracil (MF) in advanced breast cancer. (lu.se)
  • Some examples include topical and intralesional 5-fluorouracil, methotrexate and bleomycin. (eyewiki.org)
  • Cisplatin is the agent used most commonly, although 5-fluorouracil also is used frequently. (medscape.com)
  • Low-dose cisplatin and 5-fluorouracil (LDPF) chemotherapy with daily radiotherapy (RT) is used as an alternative chemoradiotherapy regimen for locally advanced esophageal carcinoma. (nih.gov)
  • We evaluated whether RT plus LDPF chemotherapy had an advantage in terms of survival and/or toxicity over RT plus standard-dose cisplatin and 5-fluorouracil (SDPF) chemotherapy in this study. (nih.gov)
  • Docetaxel, cisplatin, and 5-fluorouracil (DCF) therapy can cause severe adverse events, including neutropenia and febrile neutropenia. (biomedcentral.com)
  • The identification of genetic factors associated with either responsiveness or resistance to 5-fluorouracil (5-FU) chemotherapy, as well as genetic factors predisposing patients to the development of severe 5-FU-associated toxicity, is increasingly being recognised as an important field of study. (nih.gov)
  • ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer. (ucdenver.edu)
  • Capecitabine is a prodrug of fluorouracil that undergoes hydrolysis in liver and tissues to form the active moiety (fluorouracil), inhibiting thymidylate synthetase, which in turn blocks methylation of deoxyuridylic acid to thymidylic acid. (medscape.com)
  • Antimicrotubular antineoplastic agents prevent cell growth and proliferation. (medscape.com)
  • Antineoplastic agents are employed to reduce tumor burden and induce remission. (medscape.com)
  • The most active agents for pancreatic cancer have been 5-fluorouracil (5-FU) and gemcitabine. (medscape.com)
  • Inhibition of AC activity sensitizes tumor cells to the effects of antineoplastic agents and radiation. (wikipedia.org)
  • Antineoplastic agents may cause nausea and vomiting so intolerable that patients may refuse further treatment. (medscape.com)
  • Some antineoplastic agents are more emetogenic than others. (medscape.com)
  • There are indications that certain antineoplastic agents at low dosages may exhibit abnormal pharmacological actions, such as promoting tumor growth. (researchsquare.com)
  • These findings urge further investigations to avoid the potential risks in current empiric continuous low-dose chemotherapy regimens with antineoplastic agents. (researchsquare.com)
  • This study observes a previously neglected pharmacological phenomenon and investigates its mechanism of that the continuous low-dose administration of some antineoplastic agents in certain dose ranges can promote tumorigenesis and tumor progression in vitro and in vivo , through stimulation of tumor cell functions directly as well as enhancement of tumor angiogenesis by BMDCs recruitment indirectly. (researchsquare.com)
  • However, the conventional chemotherapy with antineoplastic agents at the maximum tolerated dose (MTD) is typically administrated in short cycles, obligatorily separated by long treatment breaks (e.g., 3 weeks), and unfortunately accompanied by serious toxic side effects. (researchsquare.com)
  • This topical antineoplastic agent was approved for the treatment of slightly palpable and/or moderately thick hyperkeratotic actinic keratosis (Grade I/II) of the face, forehead and balding scalp in immunocompetent adult patients. (skintherapyletter.com)
  • Fluorouracil topical cream belongs to the class of medications called antineoplastics . (pharmachoice.com)
  • Fluorouracil topical cream is applied to the skin lesions and the area surrounding the lesions in a thin layer, once daily, for 4 weeks, unless otherwise directed by your doctor. (pharmachoice.com)
  • Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. (pharmacycode.com)
  • It is indicated for the reduction of cytotoxicity when used in combination with 5-fluorouracil in the treatment of colorectal cancer and for the treatment of megaloblastic anemia due to folic acid deficiency when folic acid cannot be replaced orally. (janusinfo.se)
  • 4. Pharmaceuticals used to destroy cancer cells are called anticancer, chemotherapeutic, antineoplastic, or cytotoxic 5. (studylib.net)
  • The impact of therapeutic drug management (TDM) on reducing toxicity and improving efficacy in colorectal cancer (CRC) patients receiving fluorouracil-based chemotherapy is still unclear. (medscimonit.com)
  • 5-Fluorouracil (5-FU) is widely applied in the treatment of various cancers, including colorectal cancer (CRC) [1,2]. (medscimonit.com)
  • We have recently reported that certain chemotherapeutics, including 5-fluorouracil (5-FU), may in fact stimulate angiogenesis in the tumor-free rat mesenteric window assay. (unboundmedicine.com)
  • Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. (wikipedia.org)
  • As fluorouracil, carmofur has been known to induce leukoencephalopathy, characterized by progressive damage to white matter in the brain with stroke-like symptoms. (wikipedia.org)
  • 12287987 NMNC 1230 Pharmacology Antineoplastic and Biological Response Modifiers Answer Key 1 Define the following terms: 1. (studylib.net)
  • 12287987 NMNC 1230 Pharmacology Antineoplastic and Biological Response Modifiers Answer Key excretion of cellular breakdown products and to reduce the risk of hemorrhagic cystitis. (studylib.net)
  • 12287987 NMNC 1230 Pharmacology Antineoplastic and Biological Response Modifiers Answer Key 3 greater, brimmed hats, and lightweight, long-sleeved shirts). (studylib.net)
  • Fluorouracil" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease. (pharmacycode.com)
  • It is a derivative of fluorouracil, being a lipophilic-masked analog of 5-FU that can be administered orally. (wikipedia.org)
  • Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. (pharmacycode.com)
  • Objective: We report a case of sequential interaction of phenytoin (PHT) and phenobarbital (PB) with fluorouracil (5-FU). (elsevierpure.com)
  • Emergency Central , emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/51321/all/fluorouracil. (unboundmedicine.com)
  • Case report: A male patient aged 60 under treatment with PHT and PB in which serum concentrations of PHT (32.8 μg/ml) and PB (26.7 μg/ml) increased ∼2-fold after the start of postoperative adjuvant therapy with calcium levofolinate (l-LV) and fluorouracil (5-FU). (elsevierpure.com)
  • Albertsson P, Lennernäs B, Norrby K. Low-dose continuous 5-fluorouracil infusion stimulates VEGF-A-mediated angiogenesis. (unboundmedicine.com)
  • TY - JOUR T1 - Low-dose continuous 5-fluorouracil infusion stimulates VEGF-A-mediated angiogenesis. (unboundmedicine.com)
  • Avoid using other medications on the areas you treat with fluorouracil unless your doctor tells you to. (drugs.com)