Treatment of HeLa cells with Antimycin A results in the loss of mitochondrial membrane potential and inhibition of cell growth through apoptosis. (cellsignal.jp)
Rotenone and antimycin1
The course was developed to meet the US EPA registration requirements that rely on the label and standard operation procedures for the pesticides rotenone and antimycin. (infish.org)
FCCP3
Antimycin A and FCCP cause mitochondrial depolarization. (elifesciences.org)
Wild-type cells were treated with Antimycin A ( A ) or FCCP ( B ) for 4 hr, stained with the mitochondrial membrane potential fluorescent dye DiOC 6 , and analyzed by flow cytometry. (elifesciences.org)
Each pouch contains one (1) each of oligomycin, FCCP, and rotenone/antimycin A. For use with Seahorse XFe/XF96 and XF/XF24 analyzers. (agilent.com)
Inhibitor3
Antimycin A is an inhibitor of electron transport from cytochrome b to cytochrome complex III (cytochrome c reductase). (cellsignal.jp)
A T. gondii strain selected under ELQ-316 drug pressure was found to possess a Thr222-Pro amino acid substitution that confers 49-fold resistance to ELQ-316 and 19-fold resistance to antimycin, a well-characterized Q i site inhibitor. (elsevierpure.com)
In the presence of antimycin-A, electron transport chain inhibitor, as evidenced by antimycin-A insensitive O 2 consumption, Arnica inhibited lipid peroxidation of mitochondrial membranes. (thieme-connect.de)
In BV2 cells, the APN receptor agonist AdipoRon alleviated the mitochondrial deficits and aging markers induced by rotenone or antimycin A. HDAC1 antagonism by Compound 60 (Cpd 60) improved mitochondrial dysfunction and age-related inflammation, as validated in D-galactose-treated APN KO mice. (biomedcentral.com)
Apoptosis1
Compared with the corresponding parental cells, the SP cells of SWCNT-transformed and H460 cells acquired apoptosis resistance to various chemotherapy including antimycin A, cisplatin, doxorubicin and etoposide. (cdc.gov)
Inhibits3
Binding of Antimycin A to cytochrome c reductase inhibits the oxidation of ubiquinol, disrupts the Q-cycle of enzyme turnover, and halts cellular respiration (1). (cellsignal.jp)
Antimycin A binds and inhibits Bcl2/Bcl-xL-related anti-apoptotic proteins, which are commonly over-produced by cancer cells (5,6). (cellsignal.jp)
Antimycins are produced by a non-ribosomal peptide synthetase (NRPS)/polyketide synthase (PKS) assembly complex which acts as an assembly line for antimycin production. (wikipedia.org)
Oligomycin2
The results indicate that transport is insensitive to glycolytic inhibitors (fluoride, iodoacetate) but is blocked by respiratory inhibitors (N 2 , cyanide, Antimycin A) and by inhibitors of oxidative phosphorylation (dinitrophenol, oligomycin). (rupress.org)
Respiratory inhibitors, oligomycin, FCCP (uncoupling agent), and rotenone/antimycin A were used to measure basal oxygen consumption rate, maximal/spare respiration, as well as extracellular acidification rate from peripheral blood mononuclear cells (PBMC) collected from a healthy control. (nih.gov)
13. Antimycin A as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells. (nih.gov)
On the right, the two cell types are treated with Antimycin A, a molecule that blocks electron transfer to oxygen in the electron transport chain. (mit.edu)
NADH1
Peroxidase activity was also detected with NADH as a substrate, which was significantly inhibited by antimycin A. NADH oxidase activity of Δ ZmcytC was found to be about 80% of that of the parental strain. (karger.com)
Biosynthesis1
An unprecedented 1,2-shift in the biosynthesis of the 3-aminosalicylate moiety of antimycins. (mpg.de)
Mitochondrial respiration1
ATM was not required for activating p53 when mitochondrial respiration was inhibited by chronic exposure to antimycin A. Also, ATM was not further activated by mitochondrial ROS, which were enhanced by depleting manganese superoxide dismutase (SOD2). (nih.gov)
10. Growth inhibition in antimycin A treated-lung cancer Calu-6 cells via inducing a G1 phase arrest and apoptosis. (nih.gov)
Passage control and SWCNT-transformed human lung epithelial cells were treated with known inducers of apoptosis via the intrinsic (antimycin A and CDDP) or extrinsic (FasL and TNF-a) pathway and analyzed for apoptosis by DNA fragmentation, annexin-V expression, and caspase activation assays. (cdc.gov)
Streptomyces2
Antimycins are produced as secondary metabolites by Streptomyces bacteria, a soil bacteria. (wikipedia.org)
Antimycin A is a bacterial metabolite complex produced by Streptomyces . (enzolifesciences.com)
Lactones1
Volatile lactones from Streptomycetes arise via the Antimycin biosynthetic pathway. (mpg.de)
Growth1
1. The effects of N-acetyl cysteine, buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on antimycin A-treated Calu-6 lung cells in relation to cell growth, reactive oxygen species and glutathione. (nih.gov)