• inhibitors
  • captopril enalapril fosinopril lisinopril moexipril perindopril quinapril ramipril trandolapril benazepril A systematic review of 63 trials with over 35,000 participants indicated ACE inhibitors significantly reduced doubling of serum creatinine levels compared to other drugs (ARBs, α blockers, β blockers, etc.), and the authors suggested this as a first line of defense. (wikipedia.org)
  • As such, ACE inhibitors should be the drug treatment of choice for patients with chronic kidney disease regardless of race or diabetic status. (wikipedia.org)
  • Angioedema High blood potassium level (particularly when used with ACE inhibitors in diabetic patients) Low blood pressure (particularly in volume-depleted patients) Diarrhea and other GI symptoms Headache Dizziness Cough Pregnancy: Other drugs such as ACE inhibitors, also acting on the renin-angiotensin system, have been associated with fetal malformations and neonatal death. (wikipedia.org)
  • However, these inhibitors had also limited drug-like properties. (wikipedia.org)
  • The cardioprotective effects of ACE inhibitors are mediated through a combination of angiotensin II inhibition and bradykinin proliferation. (wikipedia.org)
  • tablets
  • Consequently, the method was applied to the analysis of tablets and plasma of the patients using drugs including those substances. (hindawi.com)
  • medication
  • Generic Microzide is a term used to identify all drugs that are identical to the brand-name medication based on the active ingredient called Hydrochlorothiazide that is efficient in reducing arterial pressure and in alleviation of the symptoms of some other conditions such as diabetes insipidus, nephrocalcinosis, osteoporosis, swelling, and others. (rxshop.md)
  • Your therapist or other specialist can also prescribe you the medication for the therapy of osteoporosis, hypoparathyroidism, hypercalcinuria, Dent disease or other conditions if he thinks that the drug would be suitable. (rxshop.md)
  • In this medication guide you can find the general recommendations on the therapy with Generic Hydrochlorothiazide but please consult a qualified specialist before you buy Microzide or its generic and start using it. (rxshop.md)
  • In terms of activity, chlorothalidone is very similar to hydrochlorothiazide[citation needed] and is used as an independent medication or in combination with other antihypertensive agents for lowering arterial blood pressure, and also as an adjuvant drug for treating edema caused by heart failure and kidney disorders, such as nephrotic syndrome. (wikipedia.org)
  • class
  • Synthroid is a member of the drug class thyroid drugs . (drugs.com)
  • To what drug class does Lisinopril belong? (brainscape.com)
  • The class was discovered and developed at Merck and Co. in the 1950s, and the first approved drug of this class, chlorothiazide, was marketed under the trade name Diuril beginning in 1958. (wikipedia.org)
  • fetal
  • reports in the scientific literature reveal fetal malformations for pregnant women taking sartan-derived drugs. (wikipedia.org)
  • alcohol
  • Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions. (drugs.com)
  • potassium
  • In December 2011, Novartis halted a trial of the drug after discovering increased nonfatal stroke, kidney complications, high blood potassium, and low blood pressure in people with diabetes and kidney problems. (wikipedia.org)
  • therapy
  • In an attempt to confirm the safety of long-term antihypertensive therapy based on a dihydropyridine, the Syst-Eur patients remained in open follow-up after the end of Syst-Eur 1. (biomedsearch.com)
  • This material does not endorse drugs, diagnose patients, or recommend therapy. (drugs.com)
  • Further increase of the dosage is unreasonable because if the drug doesn't provide sufficient anti-hypertensive effect, other medications are added to the therapy. (rxshop.md)
  • The losartan/hydrochlorothiazide combination is not indicated as initial therapy except in severe cases. (medpagetoday.com)
  • Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. (wikipedia.org)
  • It is also used for liver cirrhosis, kidney impairment, nephrotic syndrome, in adjunct therapy for swelling of the brain or lungs where rapid diuresis is required (IV injection), and in the management of severe hypercalcemia in combination with adequate rehydration. (wikipedia.org)
  • clinical
  • They had more drug-like rather than substrate-like properties, and in 1990 they went to clinical trials. (wikipedia.org)
  • Cardiovascular
  • Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. (drugs.com)
  • A hypothesis initially proposed by Wald and Law had recommended a six-drug combination to be taken by patients over age 55 at risk of cardiovascular disease events, which would include three half-dose antihypertensives drugs, aspirin, a statin, and folic acid. (wikipedia.org)
  • ramipril
  • Bioavailability of the components of the Polycap (aspirin, ramipril, simvastatin, atenolol and hydrochlorothiazide) when formulated as a single capsule was compared to identical capsules with each of its components administered separately in a five arm, randomized, single-dose, two-period, two-treatment, two-sequence, crossover trial with at least 2 week washout period in a total of 195 healthy humans. (wikipedia.org)
  • blood
  • Many patients will require more than one drug to achieve blood pressure goals. (drugs.com)
  • Based on the initial blood pressure response and/or losartan-hydrochlorothiazide side effects, the dosage may be increased or decreased. (wikipedia.org)
  • With each change in dosage, it may take up to a month to see the full effect of losartan-hydrochlorothiazide on lowering blood pressure. (wikipedia.org)
  • The blood pressure lowering effects of this combination may be additive. (drugs.com)
  • This approval was based on study data in 2,492 patients that showed that after eight weeks of treatment, Tribenzor produced statistically significantly greater reductions in both systolic and diastolic blood pressures compared to three dual combination therapies. (empr.com)
  • There are many classes of antihypertensives, which lower blood pressure by different means. (wikipedia.org)
  • Many drugs control blood pressure by interfering with angiotensin or aldosterone. (wikipedia.org)
  • However, when these drugs are used chronically, the body increases renin production, which drives blood pressure up again. (wikipedia.org)
  • The U.S. Food and Drug Administration (FDA) has determined that the benefits of Benicar continue to outweigh its potential risks when used for the treatment of patients with high blood pressure according to the drug label. (wikipedia.org)
  • A prominent 2009 study found that this pill's combination of three blood pressure medications, a cholesterol reducer, and aspirin had cut the risk of heart attack and stroke in half, with no more adverse effects than taking the components separately. (wikipedia.org)
  • dosage
  • According to the rules established by the World Health Organization, generics can be called only those drugs which are identical to the original in the route of administration, effect, dosage per pill, and composition. (rxshop.md)
  • If the fixed combination represents the dosage so determined, its use may be more convenient in patient management. (drugs.com)
  • pregnancy
  • The generic drugs will also carry the same warnings as the brand name products, including a black box warning against use during the second and third trimesters of pregnancy. (medpagetoday.com)
  • The full prescribing information for Benicar notes as with all drugs that act directly on the renin-angiotensin system, olmesartan is contraindicated in pregnancy and can cause injury and even death to the developing fetus. (wikipedia.org)
  • inhibit
  • Therefore, pharmacologists have been looking for a drug to inhibit renin directly. (wikipedia.org)
  • These drugs inhibit the first and rate-limiting step of the renin-angiotensin-aldosterone system (RAAS), namely the conversion of angiotensinogen to angiotensin I. This leads to a totality in absence of Angiotensin II based on the rationale that renin only acts to inhibit this step unlike Angiotensin Converting Enzyme which is also involved in other biochemical reactions. (wikipedia.org)
  • India
  • A study called The Indian Polycap Study (TIPS) was sponsored by Cadila Pharmaceuticals Limited, (where the drug development program was coordinated by JP Parswani, President, and Dr. Arun Maseeh, Vice-President Medical Affairs), and led by Dr. Salim Yusuf of McMaster University in Hamilton, Ontario, and Dr. Prem Pais of St. John's Medical College in Bangalore, India. (wikipedia.org)