• solid tumors
  • A) DCs were enriched from the indicated solid tumors and analyzed for the expression of CD11c, CD11b, CD8α, and B220 by flow cytometry (log scale). (nih.gov)
  • B) DCs were enriched from peripheral lymph node or from the indicated solid tumors and the expression of MHC class II, CD40, and CD86 molecules was analyzed among gated CD11c+ cells (solid line) compared with isotype control (gray histograms) by flow cytometry (log scale). (nih.gov)
  • A Phase I Study of Cantuzumab Mertansine Administered as a Single Intravenous Infusion Once Weekly in Patients with Advanced Solid Tumors. (wikipedia.org)
  • reactivity
  • We are now focusing on the glycolipid analysis of surgical specimens of glioma tissue as well as on the factors participating in the antibody reactivity against those antigens. (nii.ac.jp)
  • In contrast to the studies performed in the past, immunohistochemical results using this antibody 82-A6 did not exhibit a reactivity clearly restricted to tumors. (wikipedia.org)
  • MUC1
  • Serologic responses by ELISA were largely IgM against each antigen with the exception of Tn-MUC1 where both IgM and IgG responses were induced. (aacrjournals.org)
  • It is typically linked to one of several cytotoxic agents, yielding antibody-drug conjugates : Cantuzumab mertansine Cantuzumab ravtansine "HuC242 binds to the extracellular domain of the tumor-associated carbohydrate antigen known as CanAg (a novel glycoform of MUC1). (wikipedia.org)
  • receptor
  • I-peptide inhibited lung colonization of FUT3-B16 cells in E-/P-selectin doubly deficient mutant mice, suggesting the existence of an as yet unidentified carbohydrate-binding endothelial receptor distinct from E-/P-selectins. (springer.com)
  • Hatakeyama S, Sugihara K, Nakayama J, Akama TO, Wong SM, Kawashima H, Zhang J, Smith DF, Ohyama C, Fukuda M et al (2009) Identification of mRNA splicing factors as the endothelial receptor for carbohydrate-dependent lung colonization of cancer cells. (springer.com)
  • 4) a segment of murine ULBP-like transcript 1, which binds to a natural killer group 2 member D receptor in tumor microenvironment with high affinity and stimulates innate immune response. (minervamedica.it)
  • Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody. (nih.gov)
  • alternatively, immune cells can be genetically engineered to express a tumor-specific receptor, cultured and returned to the patient. (wikipedia.org)
  • In 2017 Kymriah (or tisagenlecleucel), a chimeric antigen receptor (CAR) therapy, was approved by FDA to treat acute lymphoblastic leukemia. (wikipedia.org)
  • cells
  • 8, 9 Recent studies have shown that, in addition to cancer cells, immature cells which undergo vigorous proliferation in the developing lung of the human embryo and fetus also express the antigen, 18 and that the antigen is selectively expressed in the pulmonary epithelial cells that cover the remodelling alveolar septa in patients with IPF. (bmj.com)
  • Fukuda MN, Ohyama C, Lowitz K, Matsuo O, Pasqualini R, Ruoslahti E, Fukuda M (2000) A peptide mimic of E-selectin ligand inhibits sialyl Lewis X-dependent lung colonization of tumor cells. (springer.com)
  • Progressing tumors in man and mouse are often infiltrated by dendritic cells (DCs). (nih.gov)
  • Such strategies could produce organisms that perform multistep immune functions such as presenting antigen to and co-stimulating helper T cells in a specific manner, or providing integrated signals to B cells to induce affinity maturation and isotype switching during antibody production. (wikipedia.org)
  • One way that MUC16 helps the growth of tumors is by suppressing the response of natural killer cells, thereby protecting cancer cells from the immune response. (wikipedia.org)
  • Further evidence that MUC16 can protect tumor cells from the immune system is the discovery that the heavily glycosylated tandem repeat domain of MUC16 can bind to galectin-1 (an immunosuppressive protein). (wikipedia.org)
  • When M2-PK is mainly in the dimeric form, which is the case in tumor cells, all phosphometabolites above pyruvate kinase accumulate and are channelled into synthetic processes which branch off from glycolytic intermediates, such as nucleic acids, phospholipids and amino acids, important cell building blocks for highly proliferating cells such as tumor cells. (wikipedia.org)
  • In order to analyze the role of the carbohydrate structure Gal-GalNAc for gastrointestinal tumors, we immunized Balb/c mice with MCF-7 breast tumor cells together with synthetic Gal-GalNAc linked to a BSA carrier. (wikipedia.org)
  • Active cellular therapies usually involve the removal of immune cells from the blood or from a tumor. (wikipedia.org)
  • Dendritic cells are antigen presenting cells (APCs) in the mammalian immune system. (wikipedia.org)
  • Dendritic cells can also be activated in vivo by making tumour cells express GM-CSF. (wikipedia.org)
  • This can be achieved by either genetically engineering tumor cells to produce GM-CSF or by infecting tumor cells with an oncolytic virus that expresses GM-CSF. (wikipedia.org)
  • The dendritic cells are activated in the presence of tumor antigens, which may be a single tumor-specific peptide/protein or a tumor cell lysate (a solution of broken down tumor cells). (wikipedia.org)
  • Antigens can be added to the antibody and can induce the dendritic cells to mature and provide immunity to the tumor. (wikipedia.org)
  • The treatment consists of removal of antigen-presenting cells from blood by leukapheresis and growing them with the fusion protein PA2024 made from GM-CSF and prostate-specific prostatic acid phosphatase (PAP) and reinfused. (wikipedia.org)
  • In patients who lack the Lewis antigen (a blood type antigen on red blood cells), which is about 10% of the Caucasian population, CA 19-9 is not expressed, even in those with large tumors. (wikipedia.org)
  • Each selectin has a carbohydrate recognition domain that mediates binding to specific glycans on apposing cells. (wikipedia.org)
  • The structure of LAMP1 correlates with differentiation and metastatic potential of tumor cells as it is thought to help mediate cell-cell adhesion and migration. (wikipedia.org)
  • immunology
  • In immunology, the CD57 antigen (CD stands for cluster of differentiation) is also known as HNK1 (human natural killer-1) or LEU7. (wikipedia.org)
  • chemically
  • citation needed] The Thomsen-Friedenreich antigen (Gal-GalNAc) represents a tumor-associated molecule, which is assumed to be one of the few chemically well-defined antigens with a proven association with malignancy. (wikipedia.org)
  • gastrointestinal
  • Studies from various international working groups have revealed a significantly increased amount of Tumor M2-PK in EDTA-plasma samples of patients with renal, lung, breast, cervical and gastrointestinal tumors (oesophagus, stomach, pancreas, colon, rectum), as well as melanoma, which correlated with the tumor stage. (wikipedia.org)
  • peptide
  • To induce sustained immunity against both LeY and GD2, we developed a carbohydrate mimicking peptide (CMP) as a surrogate pan-immunogen that mimics both. (oncotarget.com)
  • carcinoma
  • TIDCs purified from a subcutaneously implanted C26 colon carcinoma transduced with the 6Ckine chemokine (14) were CD11b+, CD8α−, and B220− in their vast majority (Fig. 1 A). As shown previously, this chemokine-induced model allowed us to recover large numbers of TIDCs, while these were identical to TIDCs isolated from parental C26 tumors. (nih.gov)
  • Cancer antigen 50 (CA50), a carcinoma associated carbohydrate antigen, has been found to be elevated in the blood of patients with colorectal cancer and other malignancies. (acris-antibodies.com)
  • CA-125 (cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) also known as mucin 16 or MUC16 is a protein that in humans is encoded by the MUC16 gene. (wikipedia.org)
  • sialyl
  • Background: Sialyl Lewis X-i antigen has been used as a diagnostic tool for lung adenocarcinoma. (bmj.com)
  • Conclusions: Western blotting analysis of serum samples from patients with raised levels of sialyl Lewis X-i antigen provides some clinical information for a differential diagnosis between lung adenocarcinoma and IPF. (bmj.com)
  • mediate
  • Among TACAs that mediate cell survival signals are the neolactoseries antigen Lewis Y (LeY) and the ganglioside GD2. (oncotarget.com)
  • sarcoma
  • Tumors of the blood vessels (angiosarcoma and hemangioendothelioma, embryonal sarcoma and fibrosarcoma are produced from a type of connective tissue known as mesenchyme. (wikipedia.org)
  • serum
  • Expression of the antigen in serum samples of patients with lung adenocarcinoma was evaluated and compared with that of patients with IPF by Western blotting in order to establish a specific laboratory test to differentiate lung adenocarcinoma from IPF. (bmj.com)
  • 1, 2 Serum levels of the antigens are frequently raised in patients with malignancies, and detection of these antigens may have an adjunctive role to play in their diagnosis. (bmj.com)
  • 13- 16 In patients with IPF the incidence of lung cancer is much higher than that in the general population 17 so, when increased serum levels of the antigen are seen in patients with IPF, further invasive and costly tests are often undertaken to rule out adenocarcinoma of the lung or other organs. (bmj.com)
  • 5- 7 However, raised serum levels of this antigen are observed in some patients with the abovementioned respiratory diseases. (bmj.com)
  • 7 Although increased serum levels of the antigen have been found not to be specific to patients with lung adenocarcinoma, there is as yet no specific test to differentiate lung adenocarcinoma from other pathophysiological conditions in which the antigen levels are increased. (bmj.com)
  • epithelial
  • To characterize the safety and immunogenicity of a heptavalent antigen-keyhole limpet hemocyanin (KLH) plus QS21 vaccine construct in patients with epithelial ovarian, fallopian tube, or peritoneal cancer in second or greater complete clinical remission. (aacrjournals.org)
  • Hepatic adenomas: These benign epithelial liver tumors develop in the liver and are also an uncommon occurrence, found mainly in women using estrogens as contraceptives, or in cases of steroid abuse. (wikipedia.org)
  • immune
  • Deficient antitumor immunity could be related to a lack of tumor-associated antigen (TAA) presentation by tumor-infiltrating DCs (TIDCs) or to a functional defect of TIDCs.In particular, CpG plus anti-IL-10R enhanced the TAA-specific immune response and triggered de novo IL-12 production.Subsequently, CpG plus anti-IL-10R treatment showed robust antitumor therapeutic activity exceeding by far that of CpG alone, and elicited antitumor immune memory. (nih.gov)
  • immunity
  • Deficient antitumor immunity could be related to a lack of tumor-associated antigen (TAA) presentation by tumor-infiltrating DCs (TIDCs) or to a functional defect of TIDCs. (nih.gov)
  • EDTA
  • As a biomarker, the amount of Tumor M2-PK in stool and EDTA-plasma reflects the specific metabolic status of the tumors. (wikipedia.org)
  • An important application of the Tumor M2-PK test in EDTA-plasma is for follow-up during tumor therapy, to monitor the success or failure of the chosen treatment, as well as predicting the chances of a "cure" and survival. (wikipedia.org)
  • detection
  • Ultrasonography of liver tumors involves two stages: detection and characterization. (wikipedia.org)
  • Tumor detection is based on the performance of the method and should include morphometric information (three axes dimensions, volume) and topographic information (number, location specifying liver segment and lobe/lobes). (wikipedia.org)
  • Therefore, the measurement of tumor M2-PK in stool samples, with follow-up by colonoscopy to clarify the tumor M2-PK positive results, may prove to be an advance in the early detection of colorectal carcinomas. (wikipedia.org)
  • antibody
  • There should be a variety of factors that influence the antibody reactions against glycolipid antigens. (nii.ac.jp)
  • This heptavalent-KLH conjugate plus QS21 vaccine safely induced antibody responses against five of seven antigens. (aacrjournals.org)
  • One monoclonal antibody (82-A6) was established which recognizes the Thomsen-Friedenreich antigen according to the biochemical and serological analysis presented here. (wikipedia.org)
  • novel
  • He discovered novel blood group and tumor antigen specific lectins and made original contribution towards elucidation of the energetics and mechanism of protein-sugar recognition. (wikipedia.org)
  • He delineated the molecular basis of carbohydrate recognition by legume lectins and demonstrated the novel C-H…O/N hydrogen bond in protein-sugar interactions. (wikipedia.org)
  • biochemical
  • Publications] B.O.Choi: 'Biochemical analysis of cytokine effect on the glycosphingolipid expression of human glioma cell lines' Tumor Res.28. (nii.ac.jp)
  • lectins
  • His studies showed that the monomers of legume lectins have the necessary structural features for carbohydrate recognition and that oligomerization imparts them with topology necessary for their biologic activities such as agglutination, mitogenesis etc. (wikipedia.org)
  • The name selectin comes from the words "selected" and "lectins," which are a type of carbohydrate-recognizing protein. (wikipedia.org)
  • invasion
  • MUC16 and mesothelin interactions are thought to provide the first step in tumor cell invasion of the peritoneum. (wikipedia.org)
  • affinity
  • In the present article, we constructed a humanized anti-GM2 MAb, KM8969, and studied its antigen-binding affinity and effector functions such as CDC and ADCC. (aacrjournals.org)