• CD20
  • CD19 and CD20 play an important role in the development, differentiation, and activation of B cells. (aacrjournals.org)
  • CD19 is a signal-transduction molecule and CD20 is part of a multimeric receptor complex regulating cell cycle progression and B-cell differentiation. (aacrjournals.org)
  • In this study we set out to determine whether cytotoxic CD8 + T-cell responses specific for peptides derived from CD19 and CD20 antigens occur in healthy individuals and patients with B-cell malignancies. (aacrjournals.org)
  • B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. (wikipedia.org)
  • Antibody FMC7 (Flinder Medical Centre) appears to recognise a conformational variant of CD20 also known as the FMC7 antigen. (wikipedia.org)
  • self-antigen
  • These observations suggest that high TCR density compensates for the low affinity of individual TCRs for self-antigen. (aacrjournals.org)
  • Because HER-2 is a self-antigen, most T cells of high affinity for HER-2 epitopes are deleted (6) , and the remainder cells recognize HER-2 peptides with low avidity (at about 10 −6 mol/L). Nevertheless, because the same HER-2 CTL epitopes are presented by substantial proportions of tumors, the CTL epitopes from HER-2 become significant for cancer therapy (7) . (aacrjournals.org)
  • iGb3, a self antigen which has been implied in iNKT selection. (wikipedia.org)
  • lipid
  • The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. (wikipedia.org)
  • They are non-classical MHC proteins, related to the class I MHC proteins, and are involved in the presentation of lipid antigens to T cells. (wikipedia.org)
  • CD1d-presented lipid antigens activate a special class of T cells, known as natural killer T (NKT) cells, through the interaction with the T-cell receptor present on NKT membranes. (wikipedia.org)
  • human
  • Stage-specific embryonic antigens (SSEA-3 and SSEA-4) are epitopes of a unique globoseries ganglioside isolated from human teratocarcinoma cells. (springer.com)
  • Knowles BB, Rappaport J and Solter D (1982) Murine embryonic antigen SSEA-1 is expressed on human cells and structurally related human blood group antigen I is expressed on mouse embryos. (springer.com)
  • Human CD8 + cells expressing higher-than-average numbers of TCR (TCR hi ) reportedly have high functional avidity for their tumor targets (1-3) , as shown by their ability to lyse targets pulsed with smaller amounts of exogenous antigen (10 −7 to 10 −8 mol/L) than do CTLs expressing fewer TCR. (aacrjournals.org)
  • Altogether, the present data indicate that PGE2 stimulates human CD40-activated B cell growth, but differently modulates cytokine-induced differentiation. (jimmunol.org)
  • Immune system Immune tolerance Antibodies Leukocytes List of human clusters of differentiation Major histocompatibility complex Signal transduction CD13 marker for kidney disorder CD33 marker for AML treatment CHAN, J. K. C. (wikipedia.org)
  • And importantly, his team treated the monkeys with the anti-ICAM1 epitope antibody before xenotransplantation process, expecting the induction of immune-tolerance to the pancreatic antigens of other species in the non-human primates. (wikipedia.org)
  • CD1E Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD1A genome location and CD1A gene details page in the UCSC Genome Browser. (wikipedia.org)
  • A differentiation of these two types can be obtained in human by using an antibody against the TCR Vα24 chain, which is specific of type I NKT cells. (wikipedia.org)
  • tumor
  • These findings suggest that tumor antigen transmitted a negative signal to block the differentiation of those CTLs and that the cytokines used for CTL expansion apparently amplified the negative signal. (aacrjournals.org)
  • Studies of their tumor antigens (Tags) have led to appreciation of the role of tyrosine phosphorylation, PI3K and p53 in oncogenic transformation. (tufts.edu)
  • molecule
  • The TCR complex and CD4 each bind to distinct regions of the antigen-presenting MHCII molecule - α1/β1 and β2, respectively. (wikipedia.org)
  • cytotoxic
  • Although deleterious effects of proinflammatory cytokines are well characterized, direct cytotoxic effects of invading immune cells on the ischemic brain and the importance of their antigen-dependent activation are essentially unknown. (sigmaaldrich.com)
  • Our findings underscore the importance of antigen-dependent, direct cytotoxic immune responses in stroke and suggest modulation of CTLs and their effector pathways as a potential new strategy for stroke therapy. (sigmaaldrich.com)
  • cells
  • These cells were HLA-A*0201 specific and lytic for peptide-loaded antigen-presenting cells but not to malignant or unpulsed B cells. (aacrjournals.org)
  • Stimulating undifferentiated, apoptosis-resistant CD8 + cells expressing high levels of E75-TCR (TCR hi ) with variants of the CTL epitope E75, HER-2 (369-377), induced their stepwise differentiation, first to IFN-γ + Perf − and to TCR hi IFN-γ + Perf + cells. (aacrjournals.org)
  • Blocking caspase-9 activation at antigen stimulation also enhanced the generation of TCR hi Perf hi cells, demonstrating that TCR density dictated the pathway of death activated by stimulation with the same agonist. (aacrjournals.org)
  • in another study, TCR hi cells expanded in response to antigen but required interleukin 7 (IL-7) and IL-10 for survival (2) . (aacrjournals.org)
  • To elucidate the significance of TCR density in the differentiation of TCR hi cells to cytolytic effectors, we modified the affinity of the ligand (antigen) for the receptor (TCR) and simultaneously analyzed the responses of two polyclonal CD8 + populations from the same individual that differed in the levels of TCR by one order of magnitude. (aacrjournals.org)
  • Using mRNA differential display, we have compared 3T3-L1 cells treated to differentiate in the presence of BRL49653 with untreated 3T3-L1 cells and identified Fos-related antigen 1 (Fra-1), a member of the Fos protein family, as a novel molecular target for BRL49653 action in 3T3-L1 cells. (aspetjournals.org)
  • Due to the unavailability of antibodies from the rest of the body (few antibodies are small enough to cross the blood-brain barrier), microglia must be able to recognize foreign bodies, swallow them, and act as antigen-presenting cells activating T-cells. (wikipedia.org)
  • Through the development of an anti-ICAM1 antibody against the newly found epitope, he succeeded in inducing antigen-specific T cell tolerance via the development of tolerogenic semi-mature dendritic cells (J Exp Med. (wikipedia.org)
  • CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells. (wikipedia.org)
  • The related β-D-glucopyranosylceramide is accumulated in antigen-presenting cells after infection, where it serves to activate invariant NKTs (iNKTs), a special kind of NKT. (wikipedia.org)
  • Mesothelin is a tumour differentiation antigen that is normally present on the mesothelial cells lining the pleura, peritoneum and pericardium. (wikipedia.org)
  • receptor
  • These compounds act as high-affinity ligands for a member of the nuclear hormone receptor superfamily PPARγ, which has been shown to play an important role in adipocyte differentiation. (aspetjournals.org)
  • protein
  • The protein has no known natural ligand and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. (wikipedia.org)
  • induction
  • His another important achievement is the induction of antigen-specific T cell tolerance, which has been a distant dream of immunologists for pinpoint-targeted control of the immune system. (wikipedia.org)
  • activation
  • Their transfer did not increase the infarct size of Rag1 knock-out mice, indicating antigen-dependent activation as an essential component of CTL neurotoxicity. (sigmaaldrich.com)
  • Akt inhibitor could block SV40ST activation of myoblast differentiation in a dose dependent manner. (tufts.edu)
  • role
  • Although both PyST and SV40ST replace the B subunit of PP2A, PyST targets Abeta associated enzymes, while SV40ST only bound A. Abeta proved to play a role in differentiation and apoptosis, as an Abeta binding mutant SV40ST, 130AA, showed PyST like inhibition of differentiation. (tufts.edu)
  • taken together, these results strongly indicate that ligand-activated/inactivated PPARγ plays an important role in adipocyte differentiation. (aspetjournals.org)