• leukocyte
  • Supertypes are groups of human leukocyte antigen (HLA) alleles which bind overlapping sets of peptides due to sharing specific residues at the anchor positions-the B and F pockets-of the peptide-binding region (PBR). (springer.com)
  • bind
  • This process favors, by selection for the ability to bind antigen with higher affinity, the activation and growth of B cell clones able to secrete antibodies of higher affinity for the antigen. (wikipedia.org)
  • When a cutaneous lymphocyte antigen is expressed in the skin, the CD4+ Lutzner cell travels to the epidermis and dermis layers of the skin in order to bind to the antigen. (wikipedia.org)
  • receptors
  • This rearrangement occurs early in the differentiation process and creates novel T-cell receptors that mimic the structure of normal antibodies but are not able to function properly. (wikipedia.org)
  • predominant
  • Rituximab is used to treat cancers of the white blood system such as leukemias and lymphomas, including non-Hodgkin's lymphoma and lymphocyte predominant subtype, of Hodgkin's Lymphoma. (wikipedia.org)
  • cytokines
  • The lifespan, class of antibodies produced, and the location that the plasma cell moves to also depends on signals, such as cytokines , received from the T cell during differentiation. (wikipedia.org)
  • antibodies
  • Since B cell maturation also involves somatic hypermutation (a process completed before differentiation into a plasma cell), these antibodies frequently have a very high affinity for their antigen. (wikipedia.org)
  • In other words, every B cell is specific to a single antigen, but each cell can produce several thousand matching antibodies per second. (wikipedia.org)
  • Once this antigen is lost, the T-cell antibodies will never be able to detect the pathogen, allowing the pathogen to increase in size and cause an infection to occur. (wikipedia.org)
  • process
  • They demonstrated that cell fusion provided a general method for the amalgamation of different cell types across the barriers imposed by species differences and by the process of differentiation. (wikipedia.org)