• Mechanisms by which the surface expression of the glycosyl-phosphatidylinositol-anchored complement regulatory proteins decay-accelerating factor (CD55) and CD59 is lost in human leukaemia cell lines. (nih.gov)
  • It is genetically characterized by a somatic mutation in the PIG-A gene (phosphatidylinositol glycan anchor biosynthesis, class A), in which the best known antigens are DAF (decay accelerating factor or CD55) and MIRL (membrane inhibitor of reactive lysis or CD59). (bvsalud.org)
  • The mutation in the PIGA gene causes the deficit or lack of glycosylphosphatidylinositol (GPI)-anchored proteins, and as a result, GPI-anchored type factors regulating the complement system on the membrane of red blood cell [CD55 or decay-accelerating factor (DAF) and CD59] are deficient. (biomedcentral.com)
  • PNH-deficient monocytes expressed only marginally lower CD59, making it a less robust marker for highlighting PNH+ monocytes compared with CD14 or CD55. (elsevierpure.com)
  • Interestingly, NPSC and iPS expressed mRNA of complement regulatory proteins (CRP) such as membrane cofactor protein (CD46), decay accelerating factor (DAF or CD55), and protectin (CD59), but CD59 mRNA expression was negligible in iPS. (johnshopkins.edu)
  • Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion . (wikidoc.org)
  • Antibody CD59 (Clone MEM-43) reacts with the CD59-antigen, a PI-linked glycoprotein, molecular weight 18-20kDa, found in all types of leukocytes including platelets. (immunostep.com)
  • CD59 is a membrane-bound glycoprotein that protects host cells from lysis by inhibiting the terminal pathway of complement, preventing the formation and insertion of the membrane attack complex (MAC). (ox.ac.uk)
  • The family is named for two representative groups of members, the small globular protein lymphocyte antigen 6 (LY6) family and the urokinase plasminogen activator receptor (uPAR). (wikipedia.org)
  • Structure of a soluble, glycosylated form of the human complement regulatory protein CD59. (lu.se)
  • Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins. (lu.se)
  • CD59 (Clone MEM-43) is a mAb used for the idenfitication of CD59 protein expressed on all hematopoietic cells. (immunostep.com)
  • The glycosylation of the complement regulatory protein, human erythrocyte CD59. (ox.ac.uk)
  • A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. (wakehealth.edu)
  • The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. (wakehealth.edu)
  • The GMO MVA-HBV is a modified vaccinia virus Ankara vector (MVA) encoding a fusion of sequences derived from two hepatitis B virus (HBV) protein antigens. (biosafety.be)
  • Qualitative or quantitative defect in protein S. ELISA for free protein S antigen. (medscape.com)
  • 1990) Human protectin (CD59), an 18,000 20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers. (sdbonline.org)
  • To reach the stated goal, there are two specific aims: 1) Analysis of the role of costimulatory adhesion pathways LFA-l/ICAM-1, VLA-4/VCAM-1 and CD2/LFA-3 + CD59, in post-thymus differentiation and maturation of human CD4+ T-cells under in vitro cell culture conditions. (grantome.com)
  • In particular focussed on regulation of cell surface expression of activation and differentiation antigens, and production of T-cell cytokines. (grantome.com)
  • We also evaluated bone marrow specimens, which generally are considered less suitable than blood owing to variable expression of glycosyl phosphatidylinositol (GPI)-linked antigens during hematopoietic cell differentiation. (elsevierpure.com)
  • Results: Our immortalized SC line (iPS) proliferated stably and had a phenotype similar to NPSC, as indicated by the immunoexpression of follicle stimulating hormone receptor (FSHR), and mRNA expression of androgen receptor (AR), and Wilms' tumor antigen (WT1). (johnshopkins.edu)
  • A Phase 1b-2, open-label study of JNJ-68284528, a Chimeric Antigen Receptor T cell (CAR-T) therapy directed against BCMA in subjets with relapsed or refractory multiple myeloma. (biosafety.be)
  • CD59 antibody LS-C44071 is an RPE-conjugated mouse monoclonal antibody to human CD59. (lsbio.com)
  • A mechanistic study of the dissociation of individual antibody-antigen pairs by atomic force microscopy. (degruyter.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Lymphocyte Function Associated Antigen 3 (LFA3) in serum, plasma, cell lysatesand other biological fluids. (envite.org)
  • Other LU domain proteins are small globular proteins such as CD59 antigen, LYNX1, SLURP1, and SLURP2. (wikipedia.org)
  • Other LU proteins, such as the CD59 antigen, have well-studied functions in regulation of the immune system. (wikipedia.org)
  • Crystal structure of CD59: implications for molecular recognition of the complement proteins C8 and C9 in the membrane-attack complex. (sdbonline.org)
  • One of the proteins which regulate MAC is CD59. (alternativenarrative.net)
  • CONCLUSION: These results show the importance of flow cytometry to identify cases in which patients are deficient in only one antigen (CD59). (bvsalud.org)
  • Antigens, CD47" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • This graph shows the total number of publications written about "Antigens, CD47" by people in this website by year, and whether "Antigens, CD47" was a major or minor topic of these publications. (rush.edu)
  • Below are the most recent publications written about "Antigens, CD47" by people in Profiles. (rush.edu)
  • High-resolution structures of bacterially expressed soluble human CD59. (ox.ac.uk)
  • Crystals of bacterially expressed and nonglycosylated recombinant soluble human CD59 have been obtained from three crystallization conditions, each of which gave rise to a distinct crystal form. (ox.ac.uk)
  • CD59 inhibits formation of membrane attack complex (MAC), thus protecting cells from complement mediated lysis Has a signaling role, as a GPI-anchored molecule, in T cell activation. (immunostep.com)
  • CD2 has also been reported to bind CD48, CD59, and CD15. (biolegend.com)
  • Description: A sandwich ELISA kit for detection of Lymphocyte Function Associated Antigen 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (envite.org)
  • In humans, the carcinoembryonic antigen family consists of 29 genes, 18 of which are normally expressed. (wikidoc.org)
  • The combination of a specific environmental precipitant represented by the hepatitis C virus infection, an altered metabolic detoxification pathway due to treatment with pegylated interferon alpha 2a and a facilitating genetic background such as polymorphism in metabolic detoxification pathways and specific human leukocyte antigen genes possibly conspired synergistically in the development of aplastic anemia in this patient. (biomedcentral.com)
  • Methods: SC line was established following the transfection of primary SC (NPSC) from the testis of neonatal pig with plasmid pRNS-1 carrying genes for neomycin resistance and the SV40 large T antigen. (johnshopkins.edu)
  • Also, CD4 antigen, IL-4 and IL-10 mRNA decreased in young 3 week HRLF rats, but not in aged HRLF rats. (cdc.gov)
  • In this study, we explored the role of CD59 on human CD4+ T cells. (cardiff.ac.uk)
  • Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. (wikidoc.org)
  • Similar to RBC Blood Group antigen the Human Platelet Antigen (HPAs) are each defined by antigen specific alloantibody sera. (bloodantigens.com)
  • Of note, various autoantibodies against ganglioside antigens have been identified and found to have significant associations with the axonal forms of GBS and Fisher syndrome. (afpm.org.my)
  • Graves' Disease results from the production of autoantibodies against receptors for thyroid stimulating hormone (TSH) on thyroid epithelial cells, and represents the prototype for numerous autoimmune diseases caused by autoantibodies that bind to organ-specific cell membrane antigens. (silverchair.com)
  • To study how humoral tolerance is normally maintained to organ-specific membrane antigens, transgenic mice were generated selectively expressing membrane-bound hen egg lysozyme (mHEL) on the thyroid epithelium. (silverchair.com)
  • CD59 blockade enhances antigen-specific CD4+ T cell responses in humans: a new target for cancer immunotherapy? (cardiff.ac.uk)
  • The goal of this research proposal is to study in detail the recently established T-cell costimulatory roles of the adhesion pathways LFA-l/ICAM-1, VLA-4/VCAM-1 and CD2/LFA-3 + CD59. (grantome.com)
  • 2) Analysis of early signal transduction pathways involved in the costimulatory function of the costimulatory adhesion pathways LFA-l/ICAM-1, VLA-4/VCAM-1, and CD2/LFA-3 + CD59. (grantome.com)
  • The unique characteristic of this study will be the utilization of affinity purified natural ligands, namely ICAM-1, VCAM-1, LFA-3 and CD59, to study the contribution of the various pathways in isolation. (grantome.com)
  • The findings were striking and indicated that blockade of CD59 significantly enhanced the CD4+ T cell response to two different tumor Ags. (cardiff.ac.uk)
  • Normal monocytes exhibited significantly dimmer CD59 expression than normal granulocytes. (elsevierpure.com)
  • Our data demonstrate that CD59 is up-regulated on activated CD4+ T cells and serves to down-modulate their activity in response to polyclonal and Ag- specific stimulation. (cardiff.ac.uk)
  • These data highlight the potential for manipulating CD59 expression on T cells for boosting weak immune responses, such as those found in individuals with cancer. (cardiff.ac.uk)
  • Antigen distribution is to be found across many hemopoietic and non-hemopoietic cells. (immunostep.com)
  • Antigen-presenting cells (APCs) produce and release a broad spectrum of EVs involved in the pathogenesis of atherosclerosis. (bmrat.org)
  • They are secreted by a wide array of cells, including cardiac myocytes, mature and progenitor endothelial cells, mesenchymal stem cells, immune cells like antigen-presenting cells (APCs), and malignant cells 5 , 6 . (bmrat.org)
  • The role of an intact endothelial barrier in sequestering organ-specific antigens from circulating preimmune B cells is discussed. (silverchair.com)
  • However, unlike the RBC Blood Groups Systems, the HPA Systems were not named on a per gene or related gene basis with one or more antigens in each system. (bloodantigens.com)
  • Rather, one HPA gene can contain multiple HPA systems so in reality each biallelic antithetical antigen pair is really its own system. (bloodantigens.com)
  • For example, the HPA-1 system contains the antithetical antigens HPA-1a and HPA-1b, but this same gene also contains the HPA-4 system (HPA-4a and HPA-4b). (bloodantigens.com)
  • Interacts with T-cell surface antigen CD2. (lu.se)
  • Conclusion: These results suggest that iPS, immortalized by the introduction of SV40 T, retain their original characteristics, except for the relatively low expression of CD59, and that they may be useful for future in vitro and in vivo studies of immune privilege mechanisms related to SC. (johnshopkins.edu)
  • Red Blood Cell (RBC) and Platelet (PLT) antigen genotype to phenotype correlations. (bloodantigens.com)
  • The CD59 family member Leaky/Coiled is required for the establishment of the blood-brain barrier in Drosophila. (sdbonline.org)