• CD23
  • In contrast to small lymphocytic lymphoma and MCL, staining for CD5 is usually negative, and these lymphomas can be further distinguished with CD23 (positive in small lymphocytic lymphoma) and CyclinD1 (positive in MCL). (wikipedia.org)
  • The MZ B cells within this region typically express high levels of IgM, CD21, CD1, CD9 with low to negligible levels of secreted-IgD, CD23, CD5, and CD11b that help to distinguish them phenotypically from follicular (FO) B cells and B1 B cells. (wikipedia.org)
  • CD10
  • Immunophenotyping helps distinguish B-PLL from similar diseases, one of its key identifiers is the absence in expression of the surface antigens CD10, CD11c, CD25, CD103 and cyclin D1 - an important regulator of cell-cycle progression. (wikipedia.org)
  • expression
  • It has thought that CD5-expression is a marker for unusual and aggressive clinical course. (ispub.com)
  • Fig . 2B ) With exception of CD5 expression, the morphological findings and growth pattern of the neoplastic cells, led us to diagnosis of a malignant small cell B-cell non-Hodgkin lymphoma and sub-typed as extranodal marginal zone B-cell lymphoma of MALT type. (ispub.com)
  • Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells. (exbio.cz)
  • Freedman AS, Freeman G, Whitman J, Segil J, Daley J, Levine H, Nadler LM: Expression and regulation of CD5 on in vitro activated human B cells. (exbio.cz)
  • When the expression of Bcl-2 protein was examined on these cells by immunoluorescene and RT-PCR methods, both CD5+ and CD5- B cells expressed Bcl-2 in almost equal intensity. (nii.ac.jp)
  • Further analysis is necessary to examine whether the role of CD5 antigen functionally link with the expression of Fas. (nii.ac.jp)
  • 0.05) and tumour cell expression for Ki-67 antigen and p53 protein. (bmj.com)
  • In the thymus, there is a correlation with CD5 expression and strength of the interaction of the T cell towards self-peptides. (wikipedia.org)
  • Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. (wikipedia.org)
  • Subtype
  • There are only about 15,000 patients presently in the U.S. MCL is a subtype of B-cell lymphoma, due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles. (wikipedia.org)
  • macular degeneration
  • Radic, M.Z. Circulating autoantibodies in age-related macular degeneration recognize human macular tissue antigens implicated in autophagy, immunomodulation, and protection from oxidative stress and apoptosis. (uthsc.edu)
  • cytoplasmic
  • The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. (exbio.cz)
  • cell
  • Immunohistochemically, the malignant cells expressed markers of B-cell lineage and unusually CD5 positive. (ispub.com)
  • CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. (exbio.cz)
  • Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc. (exbio.cz)
  • Alberola-Ila J, Places L, Cantrell DA, Vives J, Lozano F: Intracellular events involved in CD5-induced human T cell activation and proliferation. (exbio.cz)
  • Polyreactive antigen-binding B cells are the predominant cell type in the newborn B cell repertoire. (healthtap.com)
  • We next examined the functional role of CD5 antigen on CD40-induced B cell activation system. (nii.ac.jp)
  • These data suggest that signals mediated through CD5 on the B cell surface may modify the B cell maturation pathway from naive to memory transition. (nii.ac.jp)
  • The absence of CD5 in T cell acute lymphoblastic leukemia, while relatively rare, is associated with a poor prognosis. (wikipedia.org)
  • This occurs in a similar manner to the association of CD3 with the T-cell receptor, and enables the cell to respond to the presence of antigens on its surface. (wikipedia.org)
  • CD5-CD72 is thought to mediate B cell-B cell interaction. (wikipedia.org)
  • These studies indicate preexisting subset differences in B cell receptor (BCR) specificity and antigen-driven B cell fate that remain important unresolved features of the system. (wikipedia.org)
  • Hence, there appears to be a role for self or foreign antigen in shaping the repertoire of the B-1 B cell compartment. (wikipedia.org)
  • It is believed they are especially reactive to bacterial cell wall components and self-antigens which are the products of aging. (wikipedia.org)
  • The ability of T cells to recognize foreign antigens is mediated by the T cell receptor (TCR), which is a surface protein able to recognize short protein sequences (peptides) that are presented on MHC. (wikipedia.org)
  • McHeyzer-Williams LJ, McHeyzer-Williams MG. Antigen-specific memory B cell development. (wikipedia.org)
  • Thy-1 or CD90 (Cluster of Differentiation 90) is a 25-37 kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen. (wikipedia.org)
  • The antigen Thy-1 was the first T cell marker to be identified. (wikipedia.org)
  • peptide
  • Partnering with distributor, Organon Teknika/Biomerieux, UBI's peptide antigen based HCV blood screening test was a success in Europe in early 1990s. (wikipedia.org)
  • bacterial
  • CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. (wikipedia.org)
  • These polyspecific immunoglobulins often have a preference for other immunoglobulins, self antigens and common bacterial polysaccharides. (wikipedia.org)
  • tissue
  • We report a 35-year-old woman with multicentric CD5-positive mucosa associated lymphoid tissue (MALT) lymphoma of conjunctival region. (ispub.com)
  • Cluster
  • Cluster of Differentiation 5 (CD5), recombinant mouse protein is supplied as a lyophilized powder. (fishersci.co.uk)
  • CD5 is a cluster of differentiation expressed on the surface of T cells (various species) and in a subset of murine B cells known as B-1a. (wikipedia.org)
  • MALT
  • The occurrence of multicentric conjunctival CD5-positive MALT lymphoma in the younger age further support to the notation that CD5+ MALT-lymphomas arising in the ocular adnexa might be characterized by an unusual clinical course. (ispub.com)
  • In recent studies, several cases of conjunctival CD5-positive MALT lymphoma have been reported [ 3 5 6 ]. (ispub.com)
  • thymocytes
  • The processes of beta-selection, positive selection, and negative selection shape the population of thymocytes into a peripheral pool of T cells that are able to respond to foreign pathogens and are immunologically tolerant towards self antigens. (wikipedia.org)
  • Early, double negative thymocytes express (and can be identified by) CD2, CD5 and CD7. (wikipedia.org)
  • It was originally named theta (θ) antigen, then Thy-1 (THYmocyte differentiation antigen 1) due to its prior identification in thymocytes (precursors of T cells in the thymus). (wikipedia.org)
  • findings
  • These findings have led to the view that (auto)antigen drive is a promoting factor in the development and evolution of CLL and have been a pivotal in refining patient prognosis. (wikipedia.org)