• Receptors
  • Pathogenic antigens can bind to toll-like receptors that stimulate macrophage activation and response. (wikipedia.org)
  • Macrophages are then able to internalize modified lipoproteins like βVLDL (beta very low density lipoprotein), AcLDL (acetylated low density lipoprotein) and OxLDL (oxidized low density lipoprotein), which are rich in cholesterol esters, through their binding to scavenger receptors (SR), CD36 and SR-A located on the macrophage surface. (wikipedia.org)
  • proteins
  • TSP1 and fusion proteins derived from CD36-related TSP1-binding domains were able to compete with radiolabeled soluble CD4 binding to immobilized gp120. (nih.gov)
  • SCARB2
  • Based on the crystal structure of the homologous SCARB2, a model of the extracellullar domain of CD36 has been produced. (wikipedia.org)
  • Like SCARB2, CD36 is proposed to contain an antiparallel β-barrel core with many short α-helices adorning it. (wikipedia.org)
  • peptide
  • Based on peptide blocking experiments, the TSP1-gp120 interaction involves CSVTCG sequences in the type 1 properdin-like repeats of TSP1, the known binding site for CD36. (nih.gov)
  • cells
  • Based on this notion and the observation that CD36 is found on the surface of cells, CD36 is thought to have a 'hairpin-like' structure with α-helices at the C- and N- termini projecting through the membrane and a larger extracellular loop (Fig. 1). (wikipedia.org)
  • This topology is supported by transfection experiments in cultured cells using deletion mutants of CD36. (wikipedia.org)
  • Tagliani, Guermonprez, Sepúlveda, López-Bravo, Ardavín, Amigorena, Benvenuti, Burrone: Selection of an antibody library identifies a pathway to induce immunity by targeting CD36 on steady-state CD8 alpha+ dendritic cells. (antikoerper-online.de)
  • Using the techniques of radioiodination and immunoprecipitation, they found a unique but yet unknown antigen from P. falciparum-infected RBCs that appeared to cause binding with other cells. (wikipedia.org)
  • Both antigens bind to cultured skin cancer (melanoma) cells. (wikipedia.org)
  • mRNA
  • In contrast, HBA2 was up-regulated during ALC formation and resulted in decreased intracellular lipid accumulation and CD36 mRNA expression upon knockdown assay. (nih.gov)
  • LIMPII
  • CSVTCG peptides found in the type 1 repeats of TSP1 are binding sites for CD36 and LIMPII (35, 52-54). (nih.gov)
  • This is further evidence that the TSP1-gp120 interaction is mediated through a CD36/LIMPII-related structural domain. (nih.gov)
  • intracellular
  • Disulfide linkages between 4 of the 6 cysteine residues in the extracellular loop are required for efficient intracellular processing and transport of CD36 to the plasma membrane. (wikipedia.org)
  • CD36 is modified with 4 palmitoyl chains, 2 on each of the two intracellular domains. (wikipedia.org)
  • human
  • Moniuszko, Kowal, Rusak, Pietruczuk, Dabrowska, Bodzenta-Lukaszyk: Monocyte CD163 and CD36 expression in human whole blood and isolated mononuclear cell samples: influence of different anticoagulants. (antikoerper-online.de)
  • The first human RBC antigen was reported in 1986. (wikipedia.org)
  • lipid
  • The function of these lipid modifications is currently unknown but they likely promote the association of CD36 with the membrane and possibly lipid rafts which appear to be important for some CD36 functions. (wikipedia.org)
  • induce
  • It is during this condition that the parasites induce an immune response (antigen-antibody reaction) and evade destruction in the spleen. (wikipedia.org)
  • Fatty
  • Work in genetically modified rodents suggest a role for CD36 in fatty acid metabolism, heart disease, taste, and dietary fat processing in the intestine. (wikipedia.org)
  • molecular
  • In humans, rats and mice, CD36 consists of 472 amino acids with a predicted molecular weight of approximately 53,000 Da. (wikipedia.org)
  • However, CD36 is extensively glycosylated and has an apparent molecular weight of 88,000 Da as determined by SDS polyacrylamide gel electrophoresis. (wikipedia.org)
  • surface
  • Later in the same year, they found out that the unknown antigen was associated only with RBCs having small lumps called knobs on their surface. (wikipedia.org)
  • found
  • Howard's team found that the antigens from Gambian children, who were suffering from falciparum malaria, were similar to those from the RBCs of night monkey. (wikipedia.org)