• proteins
  • TSP1 and fusion proteins derived from CD36-related TSP1-binding domains were able to compete with radiolabeled soluble CD4 binding to immobilized gp120. (nih.gov)
  • The characters studied were parasite surface antigens, proteins detected by two-dimensional polyacrylamide gel electrophoresis, enzymes, and drug response. (ajtmh.org)
  • macrophages
  • Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. (semanticscholar.org)
  • Use a concentration of 2 µg/ml. (or 1/500).Note: ab23680 inhibits CD36 binding of ox-LDL (macrophages) and rod puter segments (retinal pigment epithelial cells) and prevents foam cell formation of macrophages. (abcam.cn)
  • A MAF can also alter the ability of macrophages to present MHC I antigen, participate in Th responses, and/or affect other immune responses. (wikipedia.org)
  • Regulatory macrophages produce Interleukin 10, which can inhibit cytotoxic responses of other lymphocytes to cancer cell antigens. (wikipedia.org)
  • Macrophages are then able to internalize modified lipoproteins like βVLDL (beta very low density lipoprotein), AcLDL (acetylated low density lipoprotein) and OxLDL (oxidized low density lipoprotein), which are rich in cholesterol esters, through their binding to scavenger receptors (SR), CD36 and SR-A located on the macrophage surface. (wikipedia.org)
  • LIMPII
  • CSVTCG peptides found in the type 1 repeats of TSP1 are binding sites for CD36 and LIMPII (35, 52-54). (nih.gov)
  • This is further evidence that the TSP1-gp120 interaction is mediated through a CD36/LIMPII-related structural domain. (nih.gov)
  • Amino Acid Seq
  • Using Kyte-Doolittle analysis, the amino acid sequence of CD36 predicts a hydrophobic region near each end of the protein large enough to span cellular membranes. (wikipedia.org)
  • SCARB2
  • Based on the crystal structure of the homologous SCARB2, a model of the extracellullar domain of CD36 has been produced. (wikipedia.org)
  • Like SCARB2, CD36 is proposed to contain an antiparallel β-barrel core with many short α-helices adorning it. (wikipedia.org)
  • Adhesion
  • The effect of proteolytic digestion of parasite erythrocyte surface antigens on surface IgG binding and adhesion to CSA and hyaluronic acid (HA) was also studied. (biomedcentral.com)
  • Acting as both an antigen and adhesion protein, it is thought to play a key role in the high level of virulence associated with P. falciparum. (wikipedia.org)
  • epitopes
  • Neither the nature of the protective immune response nor the target antigens and epitopes recognized by infection clearing antibodies are fully understood. (biomedcentral.com)
  • To evaluate the ability of antibodies to Plasmodium falciparum ring-infected erythrocyte surface antigen (Pf155/RESA) epitopes to discriminate between individuals well protected or poorly protected against malaria, a receiver operating characteristic analysis was performed in two populations living in Madagascar and Malawi. (ajtmh.org)
  • bind
  • This study investigates whether chondroitin sulphate A (CSA) binding parasites express trypsin-resistant variant surface antigens (VSA) that bind female-specific antibodies induced as a result of pregnancy associated malaria (PAM). (biomedcentral.com)
  • Pathogenic antigens can bind to toll-like receptors that stimulate macrophage activation and response. (wikipedia.org)
  • Both antigens bind to cultured skin cancer (melanoma) cells. (wikipedia.org)
  • peptide
  • Based on peptide blocking experiments, the TSP1-gp120 interaction involves CSVTCG sequences in the type 1 properdin-like repeats of TSP1, the known binding site for CD36. (nih.gov)
  • mRNA
  • In contrast, HBA2 was up-regulated during ALC formation and resulted in decreased intracellular lipid accumulation and CD36 mRNA expression upon knockdown assay. (nih.gov)
  • cells
  • Based on this notion and the observation that CD36 is found on the surface of cells, CD36 is thought to have a 'hairpin-like' structure with α-helices at the C- and N- termini projecting through the membrane and a larger extracellular loop (Fig. 1). (wikipedia.org)
  • This topology is supported by transfection experiments in cultured cells using deletion mutants of CD36. (wikipedia.org)
  • Using the techniques of radioiodination and immunoprecipitation, they found a unique but yet unknown antigen from P. falciparum-infected RBCs that appeared to cause binding with other cells. (wikipedia.org)
  • intracellular
  • Disulfide linkages between 4 of the 6 cysteine residues in the extracellular loop are required for efficient intracellular processing and transport of CD36 to the plasma membrane. (wikipedia.org)
  • CD36 is modified with 4 palmitoyl chains, 2 on each of the two intracellular domains. (wikipedia.org)
  • lipid
  • The function of these lipid modifications is currently unknown but they likely promote the association of CD36 with the membrane and possibly lipid rafts which appear to be important for some CD36 functions. (wikipedia.org)
  • surface
  • It is not clear what role these linkages play on the function of the mature CD36 protein on the cell surface. (wikipedia.org)
  • Later in the same year, they found out that the unknown antigen was associated only with RBCs having small lumps called knobs on their surface. (wikipedia.org)
  • Fatty
  • Work in genetically modified rodents suggest a role for CD36 in fatty acid metabolism, heart disease, taste, and dietary fat processing in the intestine. (wikipedia.org)
  • humans
  • In humans, rats and mice, CD36 consists of 472 amino acids with a predicted molecular weight of approximately 53,000 Da. (wikipedia.org)
  • molecular
  • However, CD36 is extensively glycosylated and has an apparent molecular weight of 88,000 Da as determined by SDS polyacrylamide gel electrophoresis. (wikipedia.org)
  • cell
  • A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. (semanticscholar.org)
  • A role for CD36 in the regulation of dendritic cell function. (semanticscholar.org)
  • CD molecules are leucocyte antigens on cell surfaces. (wikipedia.org)
  • Low calcium response V antigen (IPR005413) The type III secretion system of Gram-negative bacteria is used to transport virulence factors from the pathogen directly into the host cell and is only triggered when the bacteri. (ebi.ac.uk)
  • Active transport Antigen presentation Antigen presenting cell Emperipolesis Endosymbionts in protists Paracytophagy Phagoptosis Residual body Cell wall Ambrose, Charles T. (2006). (wikipedia.org)