• CD44
  • catenin, but not E-cadherin, and CD24, but not CD44, were involved in the effect of growth inhibition induced by HSS. (biomedsearch.com)
  • ALDH(high) and ALDH(low) cell populations were further examined for co-expression of CD44 and/or CD24. (nih.gov)
  • ALDH(high)/CD44(+)/CD24(+) or ALDH(low)/CD44(+)/CD24(+) phenotypes do not appear to significantly contribute to tumor formation at low numbers of inoculated tumor cells. (nih.gov)
  • CD24 enhances DNA damage-induced apoptosis by modulating NF-κB signaling in CD44-expressing breast cancer cells. (semanticscholar.org)
  • bCSC), characterized by expression of different markers [CD44 high /CD24 low /epithelial-specific antigen (ESA)+], aldehyde dehydrogenase-1 (ALDH1) activity, and ability to form mammospheres under ultra-low attachment culture conditions, are suspected to evade conventional therapies leading to disease recurrence. (aacrjournals.org)
  • Mammosphere formation frequency and CD44 high /CD24 low /ESA+ and/or ALDH1+ populations in cultured MCF-7 (estrogen receptor-positive) and SUM159 (triple-negative) human breast cancer cells were decreased significantly in the presence of plasma achievable concentrations of BITC. (aacrjournals.org)
  • In breast cancer cells expressing CD44 and CD24, DHRS7B expression was observed to be down regulated. (wikipedia.org)
  • CD44 is an antigen found on the surface of most cell types and functions as a receptor that binds tissue macromolecules. (wikipedia.org)
  • The CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. (wikipedia.org)
  • In humans, the CD44 antigen is encoded by the CD44 gene on Chromosome 11. (wikipedia.org)
  • CD44 has been referred to as HCAM (homing cell adhesion molecule), Pgp-1 (phagocytic glycoprotein-1), Hermes antigen, lymphocyte homing receptor, ECM-III, and HUTCH-1. (wikipedia.org)
  • In addition, variations in CD44 are reported as cell surface markers for some breast and prostate cancer stem cells.In breast cancer research CD44+/CD24- expression is commonly used as a marker for breast CSCs and is used to sort breast cancer cells into a population enriched in cells with stem-like characteristics and has been seen as an indicator of increased survival time in epithelial ovarian cancer patients. (wikipedia.org)
  • Antibody
  • It is the bound IgE antibody that confers a selective response of these cells to environmental substances, for example, pollen proteins or helminth antigens. (wikipedia.org)
  • However, peripheral blood Bregs were mostly CD24 and CD27 positive after cultivation with anti-CD40 antibody and CpG bacterial DNA. (wikipedia.org)
  • tumor
  • Immunohistochemical staining of CD24 protein in tumor cells of high-grade glioma (a) and nonneoplastic brain (b) tissues (original magnification ×400). (nih.gov)
  • Positive staining of CD24 is seen in the cytoplasm and membrane of tumor cells in gliomas, whereas the nonneoplastic brain tissues showed no expression of CD24. (nih.gov)
  • cluster
  • Cluster-4 and CD24 cDNA's have recently been cloned from the small cell lung carcinoma (SCLC) cell line SW2 and from the erythroleukemia cell line K562, respectively. (ox.ac.uk)
  • The only difference in the coding sequence, between cluster-4 and CD24 antigens is the substitution of a single base pair leading to a substitution of Val by Ala near the putative glycosylphosphatidylinositol (GPI) anchorage sites of the mature protein. (ox.ac.uk)
  • Here we demonstrate that the nucleotide substitution which distinguishes the cluster-4 and CD24 antigen genes is due to an allelic polymorphism on chromosome band 6q21. (ox.ac.uk)
  • In addition, we identified by Southern blotting and PCR of DNA from somatic human x hamster hybrid cell lines homologues of cluster-4/CD24 on the Y chromosome and chromosome 15. (ox.ac.uk)
  • However, it is noteworthy that homozygosity for cluster-4 was found in only one case whereas heterozygosity and homozygosity for CD24 both contribute up to 50% of the samples examined. (ox.ac.uk)
  • Cell lines derived from human small cell carcinoma of the lung express high levels of a surface polypeptide termed the cluster-w4 antigen, which was previously identified as a potential target for toxin-based immunotherapy of lung cancer. (semanticscholar.org)
  • Northern blot hybridization indicated the presence of several transcript sizes for the cluster-w4 antigen that were greatly overexpressed in small cell carcinoma cell lines, compared with normal hemopoietic cells and CD24-positive cell lines. (semanticscholar.org)
  • ab31622 binds to the non-glycosylated GPI anchor of the protein core of the cluster w4/CD24. (abcam.com)
  • Expression
  • In this study, we show that CD24+ cells isolated from human NPC cell lines express stem cell genes (Sox2, Oct4, Nanog, Bmi-1, and Rex-1), and show activation of the Wnt/β-catenin signaling pathway.CD24+ cells further show increased invasion ability in vitro, which correlates with enhanced expression of matrix metalloproteinase 2 and 9.In summary, our results suggest that CD24 represents a novel CSC biomarker in NPC. (nih.gov)
  • A) mRNA expression levels of Sox2, Oct4, Nanog, Bmi-1 and Rex-1 in parental, CD24+ and CD24− cells from the NPC cell lines, TW02 (left) and TW04 (right), was evaluated using quantitative RT-PCR analysis. (nih.gov)
  • CD24 expression can also be observed in the cytoplasm. (abcam.com)
  • CD24 expression as a marker for predicting clinical outcome in human gliomas. (nih.gov)
  • Quantitative real-time PCR, immunochemistry assay, and Western blot analysis were carried out to investigate the expression of CD24. (nih.gov)
  • CD24 expression was studied in a total of 151 glioma specimens of which 68 were low grade glioma (grade I and II) and 83 were high grade (grade III and IV). (nih.gov)
  • However, in contrast to the nuanced models proposed in the mouse, thus far human studies have, by and large, described a rather homogenous population of transitional B cells (T1/T2) defined by the expression of high levels of CD24, C38 and CD10. (wikipedia.org)
  • genes
  • As indicated in Figure 2A, CD24+ cells consistently expressed higher levels of the five stem cell genes than parental or CD24− cells. (nih.gov)
  • Human
  • CONCLUSION: HSS has a potential cytotoxic effect on human ovarian cancer cells, which was mediated by multiple signal molecules including bcl-2, caspase-3, beta-catenin, and CD24. (biomedsearch.com)
  • Cox multifactor analysis showed that CD24 (P = 0.02) was an independent prognosis factor for human glioma. (nih.gov)
  • The Human CD24 cd24 (Catalog # MBS704170 ) is an ELISA Kit and is intended for research purposes only. (mybiosource.com)
  • cells
  • B) Western blots analysis of phosphorylated-GSK, GSK, phosphorylated-β-catenin, β-catenin and β-actin in whole cell lysates, and of β-catenin and lamin B1 in nuclear fractions of parental, CD24+, and CD24− cells isolated from the TW02 and TW04 cell lines. (nih.gov)
  • CD24 is overexpressed in glioma cells in vitro and in vivo. (nih.gov)
  • interaction
  • CD48 and CD2 molecular coupling together with other interaction pairs of CD28 and CD80, TCR and peptide-MHC and LFA-1 and ICAM-1 contribute to the formation of an immunological synapse between a T cell and an antigen presenting cell. (wikipedia.org)
  • surface
  • Bispecific antibodies that can simultaneously bind to cell surface antigens and payloads are a very ideal delivery system for therapeutic use. (mdpi.com)
  • Product
  • The CD24 cd24 product has the following accession number(s) (GI #619329006) (NCBI Accession #NP_001278666.1) (Uniprot Accession #P25063). (mybiosource.com)