• Antibody
  • It has been reported that P-selectin (CD62P) binds to CD24.Applications Reported: The M1/69 antibody has been reported for use in flow cytometric analysis.Applications Tested: The M1/69 antibody has been tested by flow cytometric analysis of mouse splenocytes. (fishersci.co.uk)
  • The ELISA analytical biochemical technique of the MBS2021939 kit is based on CD24 antibody-CD24 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CD24 antigen targets in samples. (mybiosource.com)
  • It is the bound IgE antibody that confers a selective response of these cells to environmental substances, for example, pollen proteins or helminth antigens. (wikipedia.org)
  • However, peripheral blood Bregs were mostly CD24 and CD27 positive after cultivation with anti-CD40 antibody and CpG bacterial DNA. (wikipedia.org)
  • tumor
  • Immunohistochemical staining of CD24 protein in tumor cells of high-grade glioma (a) and nonneoplastic brain (b) tissues (original magnification ×400). (nih.gov)
  • Positive staining of CD24 is seen in the cytoplasm and membrane of tumor cells in gliomas, whereas the nonneoplastic brain tissues showed no expression of CD24. (nih.gov)
  • gene
  • Our data provides convincing evidence for the first time that the overexpression of CD24 at gene and protein levels is correlated with advanced clinicopathological parameters and poor prognosis in patients with glioma. (nih.gov)
  • CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 1p36, 3p26, 15q21.3, 20q11.2 and Yq11.222. (wikipedia.org)
  • 3. CD10 this is the blast state of the immature cells "Neprilysin, also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP),cluster of differentiation 10 (CD10), and common acute lymphoblastic leukemia antigen (CALLA) is an enzyme that in humans is encoded by the MME gene. (ipscell.com)
  • cluster
  • Cell lines derived from human small cell carcinoma of the lung express high levels of a surface polypeptide termed the cluster-w4 antigen, which was previously identified as a potential target for toxin-based immunotherapy of lung cancer. (semanticscholar.org)
  • We have cloned a complementary DNA encoding the cluster-w4 antigen from COS-1 fibroblasts transfected with a SW2 small cell carcinoma library, by panning with a mixture of the cluster-w4-specific monoclonal antibodies SWA11, SWA21, and SWA22. (semanticscholar.org)
  • Furthermore, the cloned cluster-w4 antigen expressed on COS cells was shown to react with a comprehensive panel of CD24-specific monoclonal antibodies, as assessed by indirect immunofluorescence staining. (semanticscholar.org)
  • Northern blot hybridization indicated the presence of several transcript sizes for the cluster-w4 antigen that were greatly overexpressed in small cell carcinoma cell lines, compared with normal hemopoietic cells and CD24-positive cell lines. (semanticscholar.org)
  • ab31622 binds to the non-glycosylated GPI anchor of the protein core of the cluster w4/CD24. (abcam.com)
  • expression
  • and (3) in all diseased muscles studied here, CD24 expression was always associated with a subpopulation of regenerative fibers. (springer.com)
  • In this study, we show that CD24+ cells isolated from human NPC cell lines express stem cell genes (Sox2, Oct4, Nanog, Bmi-1, and Rex-1), and show activation of the Wnt/β-catenin signaling pathway.CD24+ cells further show increased invasion ability in vitro, which correlates with enhanced expression of matrix metalloproteinase 2 and 9.In summary, our results suggest that CD24 represents a novel CSC biomarker in NPC. (nih.gov)
  • A) mRNA expression levels of Sox2, Oct4, Nanog, Bmi-1 and Rex-1 in parental, CD24+ and CD24− cells from the NPC cell lines, TW02 (left) and TW04 (right), was evaluated using quantitative RT-PCR analysis. (nih.gov)
  • CD24 expression can also be observed in the cytoplasm. (abcam.com)
  • Note=Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface. (abcam.com)
  • CD24 expression as a marker for predicting clinical outcome in human gliomas. (nih.gov)
  • Quantitative real-time PCR, immunochemistry assay, and Western blot analysis were carried out to investigate the expression of CD24. (nih.gov)
  • CD24 expression was studied in a total of 151 glioma specimens of which 68 were low grade glioma (grade I and II) and 83 were high grade (grade III and IV). (nih.gov)
  • The expression of CD24 has been used to resolve stages of B lymphopoiesis in mouse bone marrow. (fishersci.co.uk)
  • For example, the relationship of CD24 expression to MGSC isolated under different conditions has remained unclear, as are the identities of possible additional stem cell markers. (aacrjournals.org)
  • These considerations underscore the need to identify additional cell surface markers and to characterize the expression patterns of known markers, such as CD24, by populations of MGSC. (aacrjournals.org)
  • However, in contrast to the nuanced models proposed in the mouse, thus far human studies have, by and large, described a rather homogenous population of transitional B cells (T1/T2) defined by the expression of high levels of CD24, C38 and CD10. (wikipedia.org)
  • protein
  • Three key terms antigen presentation (be it protein or cell-cell interaction) potency (blastomere pluripotent stem cells are the gold standard) and migration (or in cancer know as metastasis) and a possible answer to your question of Cancer Stem cell and what are they? (ipscell.com)
  • novel
  • In summary, our results suggest that CD24 represents a novel CSC biomarker in NPC. (nih.gov)
  • Human
  • CONCLUSION: HSS has a potential cytotoxic effect on human ovarian cancer cells, which was mediated by multiple signal molecules including bcl-2, caspase-3, beta-catenin, and CD24. (biomedsearch.com)
  • Identification of CD24 as a cancer stem cell marker in human nasopharyngeal carcinoma. (nih.gov)
  • Cox multifactor analysis showed that CD24 (P = 0.02) was an independent prognosis factor for human glioma. (nih.gov)
  • cells
  • B) Western blots analysis of phosphorylated-GSK, GSK, phosphorylated-β-catenin, β-catenin and β-actin in whole cell lysates, and of β-catenin and lamin B1 in nuclear fractions of parental, CD24+, and CD24− cells isolated from the TW02 and TW04 cell lines. (nih.gov)
  • As indicated in Figure 2A, CD24+ cells consistently expressed higher levels of the five stem cell genes than parental or CD24− cells. (nih.gov)
  • CD24 is overexpressed in glioma cells in vitro and in vivo. (nih.gov)
  • interaction
  • CD48 and CD2 molecular coupling together with other interaction pairs of CD28 and CD80, TCR and peptide-MHC and LFA-1 and ICAM-1 contribute to the formation of an immunological synapse between a T cell and an antigen presenting cell. (wikipedia.org)
  • high
  • Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level CD24 were tested 20 times on one plate, respectively. (mybiosource.com)
  • Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level CD24 were tested on 3 different plates, 8 replicates in each plate. (mybiosource.com)
  • Product
  • The CD24 cd24 product has the following accession number(s) (GI #619329006) (NCBI Accession #NP_001278666.1) (Uniprot Accession #P25063). (mybiosource.com)