• Lymphoma
  • Nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is an indolent CD20(+) form of lymphoma. (wikipedia.org)
  • This is because the Reed-Sternberg cell (RSC) variants (popcorn cells) that characterize this form of the disease invariably express B lymphocyte markers such as CD20 (thus making NLPHL an unusual form of B cell lymphoma), and that (unlike classic HL) NLPHL may progress to diffuse large B cell lymphoma. (wikipedia.org)
  • receptor
  • After leaving the bone marrow, the B cell acts as an antigen presenting cell (APC) and internalizes offending antigens, which are taken up by the B cell through receptor-mediated endocytosis and processed. (wikipedia.org)
  • protein
  • The protein has no known natural ligand and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. (wikipedia.org)
  • The treatment consists of removal of antigen-presenting cells from blood by leukapheresis and growing them with the fusion protein PA2024 made from GM-CSF and prostate-specific prostatic acid phosphatase (PAP) and reinfused. (wikipedia.org)
  • cells
  • CD20 is not on hematopoietic stem cells, nor is it expressed in any great extent on other normal body tissues. (knowcancer.com)
  • B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. (wikipedia.org)
  • It is suspected that it acts as a calcium channel in the cell membrane.It has been shown that CD20 plays a role in the microenvironmental interactions of B cells. (wikipedia.org)
  • Immunohistochemistry can be used to determine the presence of CD20 on cells in histological tissue sections. (wikipedia.org)
  • Because CD20 remains present on the cells of most B-cell neoplasms, and is absent on otherwise similar appearing T-cell neoplasms, it can be very useful in diagnosing conditions such as B-cell lymphomas and leukaemias. (wikipedia.org)
  • CD20 positive cells are also sometimes found in cases of Hodgkins disease, myeloma, and thymoma. (wikipedia.org)
  • Once activated by an antigen, B-cells proliferate and further differentiate into plasma cells and memory B-cells. (wikipedia.org)
  • B-cells that have not encountered an antigen are called naive B cells. (wikipedia.org)
  • When naïve B-cells encounter an antigen, one of the pathways that they can follow is through the germinal center environment. (wikipedia.org)
  • A large fraction of germinal center B-cells acquire somatic mutations that prohibit antigen binding and these undergo apoptosis. (wikipedia.org)
  • Pieces of the antigen (which are now known as antigenic peptides) are loaded onto MHC II molecules, and presented on its extracellular surface to CD4+ T cells (sometimes called T helper cells). (wikipedia.org)
  • First, the B cells have to encounter a foreign antigen, and are then required to be activated by T helper cells before they differentiate to specific cells. (wikipedia.org)
  • They divide rapidly and are still capable of internalizing antigens and presenting them to T cells. (wikipedia.org)
  • Unlike classic RSC, the non-classic popcorn-shaped RS cells of NLPHL are CD15 and CD30 negative while positive for the B cell marker CD20. (wikipedia.org)
  • Gene
  • CHO-Anti-Human CD20 F(ab) stable cell line is clonally-derived from a CHO cell line, which has been transfected with an anti-human CD20 F(ab) gene to allow expression of the F(ab). (creativebiomart.net)
  • In humans CD20 is encoded by the MS4A1 gene. (wikipedia.org)
  • bind
  • Once released into the blood and lymph, these antibody molecules bind to the target antigen (foreign substance) and initiate its neutralization or destruction. (wikipedia.org)
  • fragment
  • Libraries of antibody Fab (fragment, antigen binding) regions were generated with codon substituted variations of the antibody complementarity determining regions (CDRs) inserted into human antibody light and heavy chain germline frameworks (data on file at Mentrik Biotec). (wikipedia.org)
  • Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM. (wikipedia.org)
  • immune
  • Aside these inherent difficulties, the potency of the immune responses raised by the antigen-IgE-FcεRI axis is unquestionably among the most immediate and powerful biological reactions to the external environment. (mdpi.com)
  • cell
  • It also has increased direct cell-death related to an elbow hinge amino acid exchange and Type II binding of the CD20 epitope. (knowcancer.com)
  • Immunophenotyping helps distinguish B-PLL from similar diseases, one of its key identifiers is the absence in expression of the surface antigens CD10, CD11c, CD25, CD103 and cyclin D1 - an important regulator of cell-cycle progression. (wikipedia.org)
  • interactions
  • The expression of CD20 is regulated by the chemokine signalling through the CXCR4/SDF1 axis, and this can be impaired by drugs interfering with microenvironmental interactions. (wikipedia.org)
  • absence
  • However, the presence or absence of CD20 in such tumours is not relevant to prognosis, with the progression of the disease being much the same in either case. (wikipedia.org)
  • Activity
  • A variable region with increased binding activity for CD20 was selected and developed as AME-133v (data on file at Mentrik Biotech). (wikipedia.org)