• Specificity
  • Chimeric antigen receptors (CARs, also known as chimeric immunoreceptors, chimeric T cell receptors, artificial T cell receptors or CAR-T) are engineered receptors which graft an arbitrary specificity onto an immune effector cell (T cell). (wikipedia.org)
  • Antibodies
  • Immunohistochemistry (IHC) involves the process of selectively imaging antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues. (wikipedia.org)
  • Although antibodies show preferential avidity for specific epitopes, they may partially or weakly bind to sites on nonspecific proteins (also called reactive sites) that are similar to the cognate binding sites on the target antigen. (wikipedia.org)
  • FUT9
  • FUT9 synthesizes the LeX oligosaccharide (CD15), which is expressed in organ buds progressing in mesenchyma during human embryogenesis. (wikipedia.org)
  • cells
  • CD15 is present on almost all Reed-Sternberg cells, including their rare mononuclear variants, and, as such, can be used in immunohistochemistry to identify the presence of such cells in biopsies. (wikipedia.org)
  • Reed-Sternberg cells display a characteristic pattern of CD15 positivity, with membranous staining combined with staining of the Golgi apparatus. (wikipedia.org)
  • citation needed] Follicular dendritic cells are localized in germinal centers of lymphoid follicles and have an integral role in regulation of the germinal center reaction and present antigens to B cells. (wikipedia.org)
  • Unlike classic RSC, the non-classic popcorn-shaped RS cells of NLPHL are CD15 and CD30 negative while positive for the B cell marker CD20. (wikipedia.org)
  • Ki-1 (CD30) antigen is released by Ki-1-positive tumor cells in vitro and in vivo. (wikipedia.org)
  • detection
  • A great amount of non-specific binding causes high background staining which will mask the detection of the target antigen. (wikipedia.org)
  • cell
  • An antigen recognition domain from native T-cell receptor (TCR) alpha and beta single chains have been described, as have simple ectodomains (e.g. (wikipedia.org)
  • often
  • For formalin-fixed paraffin-embedded tissues, antigen-retrieval is often necessary, and involves pre-treating the sections with heat or protease. (wikipedia.org)