Antigens leukemia myeloid acute. Medical search. Frequent questions

Small-molecule inhibitors, antagonistic monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), bispecific antibodies or biologics (bsAbs) and chimeric antigen receptor-modified T cells (CAR-Ts) targeting Notch signaling components have been developed as investigational anti-cancer drugs ( 10 - 12 ). (spandidos-publications.com)
The male patient was 65 years of age and previously underwent chimeric antigen receptor T-cell therapy for acute myeloid leukemia. (cdc.gov)
Specifically, she will develop chimeric antigen receptor T cells (CAR-T cells) to treat blood cell cancers. (wustl.edu)
This serves as a guidepost for rationally designing new combination checkpoint therapies, downstream T cell receptor (TCR) isolation, cancer antigen identification and molecular characterization of naturally occurring tumor-reactive T cells in human cancer. (upenn.edu)
Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
The most active T cell endogenous inhibitory pathway is the immunoglobulin superfamily such as CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4): B7-1/B7-2 receptor/ligand grouping, which plays a central role in coordinating immune responses [ 7 , 8 ]. (hindawi.com)
This phase I trial studies the best dose and side effects of CD19/CD22 chimeric antigen receptor (CAR) T cells when given together with chemotherapy, and to see how well they work in treating children or young adults with CD19 positive B acute lymphoblastic leukemia that has come back or does not respond to treatment. (stanford.edu)
Under the terms of the MSTA, InfoWorks is to provide clinical services and technologies for the Company's upcoming Phase I study of its anti-FLT3 chimeric antigen receptor-redirected T cells ("CAR-T cells") in subjects with relapsed/refractory acute myeloid leukemia (AML). (wate.com)
Understanding of cellular evolution and molecular programs of chimeric antigen receptor-engineered (CAR)-T cells post-infusion is pivotal for developing better treatment strategies. (bvsalud.org)
This phase I trial tests the safety, side effects, and the best dose of anti-CD33 chimeric antigen receptor (CAR) T-Cell therapy in treating patients with acute myeloid leukemia that has come back (recurrent) or does not respond to treatment (refractory). (survivornet.com)
The special receptor is called a chimeric antigen receptor. (survivornet.com)
Chimeric Antigen Receptor T Cell Therapy During the COVID-19 Pandemic. (cdc.gov)

It can be acute (fast-growing) or chronic (slow growing). (kidshealth.org)
In this review, we aim to summarize the composition of CAR-T cell and its application in the treatment of acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma (HL), multiple myeloma (MM), and acute myeloid leukemia (AML). (hindawi.com)
PI3K inhibitors in chronic lymphocytic leukemia: where do we go from here? (haematologica.org)
Acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) are myeloid blood cell malignancies that show great heterogeneity. (biomedcentral.com)
In early phase clinical trials for both acute and chronic myeloid leukemias, we have observed the induction of anti-tumor immunity and associated clinical responses following K562/GM-CSF vaccination (see preliminary data). (acgtfoundation.org)
Gene therapy is under development for the treatment of acute leukaemia such as relapsed and refractory acute myeloid leukemia (AML), acute lymphoid leukemia (ALL) and chronic myeloid leukemia (CML) after allogeneic hematopoietic stem cell transplantation. (globaldata.com)
I have clinical expertise in the care of children, adolescents, and young adults with hematologic malignancies, particularly those with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and juvenile myelomonocytic leukemia (JMML). (upenn.edu)
KITE-363 is under development for the treatment of relapsed and refractory B-cell lymphoma and diffuse large B-cell lymphoma, mantle cell lymphoma, recurrent chronic lymphocytic leukemia, refractory chronic lymphocytic leukemia, acute lymphocytic leukemia, burkitt lymphoma, primary mediastinal b-cell lymphoma, refractory acute myeloid leukemia. (pharmaceutical-technology.com)
When PR1 elicits an immune response, PR1-specific cytotoxic T lymphocytes are produced that selectively kill three types of leukemia - myelodysplastic syndrome, acute myelogenous leukemia and chronic myelogenous leukemia. (algodonwineestates.com)
Disease-specific Phase II clinical trials of the vaccine for chronic myelogenous leukemia and myelodysplastic syndrome are planned or under way at M. D. Anderson. (algodonwineestates.com)
4) Chronic myeloid leukemia (CML) as a second tumour, definite acute variant. (who.int)
Tyrosine Kinase Inhibitors Play an Antiviral Action in Patients Affected by Chronic Myeloid Leukemia: A Possible Model Supporting Their Use in the Fight Against SARS-CoV-2. (cdc.gov)
B19 has also been associated with fetal death (both spontaneous abortions and stillbirths), acute arthralgias and arthritis, and chronic anemia in immunodeficient patients (5-14). (cdc.gov)
MRLs are derived for acute (1-14 days), intermediate (15-364 days), and chronic (365 days and longer) durations and for the oral and inhalation routes of exposure. (cdc.gov)
Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. (medscape.com)
See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)

Multidrug resistance parameters, tissue infiltration parameters, receptors for colony-stimulating factors (CSFr) and cell cycle parameters were analyzed using flow cytometry in 145, 109 initial and 36 relapsed or refractory, acute nonlymphoblastic leukemia (ANLL) patients to find out clinically more reliable functional parameters. (karger.com)
Another approach relies upon the use of chimeric antigen receptors (CARs) that directly target cancer cells or immunosuppressive cellular elements in the tumor microenvironment. (upenn.edu)
The therapeutic candidate comprises of NK cells genetically engineered to express chimeric antigen receptors (CAR) targeting cells expressing CD123. (pharmaceutical-technology.com)
The urgent need for novel treatments inspired me to pursue a research project in adoptive immunotherapy, genetically modifying Tcells to express artificial T cell receptors, termed chimeric antigen receptors (CARs), that target AML specific antigens. (stanford.edu)
The drug candidate consists of autologous T-cells are engineered to express dual chimeric antigen receptors (CAR) that targets cells expressing CD19 and CD20. (pharmaceutical-technology.com)
Their response involves antigen capture, enhancing their MHC-II presentation receptors and production of chemokines and/or cytokines at the site of inflammation [9]. (fortunejournals.com)

The therapeutic is under development for the treatment of relapsed and refractory acute myeloid leukemia lymphoma and blastic plasmacytoid dendritic cell neoplasm (BPDCN). (pharmaceutical-technology.com)

Leukemia is a cancer that mostly affects white blood cells. (kidshealth.org)
With leukemia (loo-KEE-mee-uh), the bone marrow makes white blood cells that don't work. (kidshealth.org)
Acute myeloid leukemia (AML) happens when the body makes too many immature blood cells. (kidshealth.org)
These cells, called myeloid (MYE-uh-loyd) blasts, can't mature into normal white blood cells. (kidshealth.org)
Because their white blood cells can't fight infections, kids with leukemia are more likely to get viral or bacterial infections. (kidshealth.org)
Doctors use these to rule out other causes of symptoms, or look for a mass of leukemia cells in the chest that can affect breathing or blood circulation. (kidshealth.org)
Doctors carefully look at the cancer cells and figure out the type and subtype of the leukemia. (kidshealth.org)
A key mechanism of immune evasion deployed by tumour cells is to reduce neoantigen presentation through down-regulation of the antigen presentation machinery. (portlandpress.com)
Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
CD33 is intended for in vitro diagnostic use in the identification of cells expressing CD33 antigen, using a BD FACS™ brand flow cytometer. (bdbiosciences.com)
The L4F3 antigen is expressed by unipotent and multipotent colony-forming cells but not by their precursors. (bdbiosciences.com)
Myeloid-associated differentiation antigens on stem cells and their progeny identified by monoclonal antibodies. (bdbiosciences.com)
Treatment of acute myeloid leukemia cells in vitro with a monoclonal antibody recognizing a myeloid differentiation antigen allows normal progenitor cells to be expressed. (bdbiosciences.com)
Expression of normal myeloid-associated antigens by acute leukemia cells. (bdbiosciences.com)
The CMV-induced generation of highly differentiated adaptive-like NK cells has been proposed to affect favorably on the maintenance of remission in patients with acute myeloid leukemia (AML) after allogeneic stem cell transplantation (allo-SCT). (aacrjournals.org)
Leukemia stem cells (LSCs) in acute myeloid leukemia (AML) played important roles in development of leukemia, chemotherapeutic drug resistance, and disease relapse and progression. (researchsquare.com)
Therefore, our results suggest that CD45 dim CD34 + CD38 - CD133 + cells in AML might have the potential of leukemia stem cells. (researchsquare.com)
Giving CD19/CD22-CAR T cells and chemotherapy may work better in treating children or young adults with B acute lymphoblastic leukemia. (stanford.edu)
Everyone at our fund is confident in the growth and success of Hemogenyx Pharmaceuticals as they develop CAR-T cells to target acute myeloid leukemia. (wate.com)
Herein, we report a potential leukocyte differentiation antigen gene VSTM1 ( V-set and transmembrane domain-containing 1 ) that was downregulated in bone marrow cells from leukemia patients and exhibited a higher degree of promoter methylation. (biomedcentral.com)
Restoration of VSTM1-v1 expression inhibited myeloid leukemia cells' growth. (biomedcentral.com)
VSTM1 ( V-set and transmembrane domain-containing 1 ) encodes a potential leukocyte differentiation antigen that is highly expressed in myeloid cells, but silenced in multiple leukemia cell lines [ 1 ]. (biomedcentral.com)
To determine whether it plays a role in leukemogenesis, we characterized its expression pattern and function in bone marrow cells from AML/CML patients and myeloid leukemia cell lines. (biomedcentral.com)
Therefore, we speculated that VSTM1-v1 expression might be associated with the maturity of myeloid cells. (biomedcentral.com)
A combination of CD34/CD117/CD13/CD16 staining showed that VSTM1-v1 expression in myeloid cells was positively correlated with cell maturation state. (biomedcentral.com)
The myelodysplastic syndromes (MDS) are a group of clonal neoplastic hematologic disorders characterized by varying degrees of bone marrow failure, abnormal hematopoiesis, and proliferation of myeloid blast cells. (acgtfoundation.org)
K562 cells express many of the antigens shown to be overexpressed in myeloid leukemias and MDS. (acgtfoundation.org)
However, in more than half of them, the disease returns within one to two years because the chemotherapy has not destroyed all leukemia cells. (idw-online.de)
The therapy comprises of T-cells genetically modified by lentiviral transduction to express TCR targeting the leukemia-associated minor H antigen, HA-1 and is administered as an intravenous infusion. (globaldata.com)
The PR1 vaccine is derived from two myeloid leukemia-associated antigens, proteins that are either overexpressed or aberrantly expressed in cancer cells. (algodonwineestates.com)
Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
Here, we construct a longitudinal high-precision single-cell transcriptomic landscape of 7,578 CAR-T cells from 26 patients with B cell acute lymphoblastic leukemia (B-ALL) post-infusion. (bvsalud.org)
We further validate in vitro that the generation of B-featured CAR-T cells is induced by excessive tumor antigen stimulation or suppressed TCR signaling, while it is relieved by exogenous IL-12. (bvsalud.org)
I. Examine the anti-tumor activity and safety of administering patient-specific donor-derived (allogeneic) CD33-CAR T cells following lymphodepletion in research participants with CD33+ recurrent/refractory (r/r) acute myeloid leukemia ( AML ). (survivornet.com)
I. Change from baseline in numbers of CD33+ blood cells, CD33 expression on leukemia cells and hematopoietic cells. (survivornet.com)
Overview of Leukemia Leukemias are cancers of white blood cells or of cells that develop into white blood cells. (msdmanuals.com)
The leukemia cells also are released into the bloodstream and are transported to other organs, where they continue to grow and divide. (msdmanuals.com)
There are several subtypes of AML, which are identified based on characteristics of the leukemia cells. (msdmanuals.com)
Symptoms Acute lymphoblastic leukemia is a life-threatening disease in which the cells that normally develop into lymphocytes (a type of white blood cell) become cancerous and rapidly replace normal. (msdmanuals.com)
The proliferation and differentiation of pluripotent stem cells give rise to progeny that can populate the entire immunologic and hematopoietic systems through committed progenitors of both the lymphoid and myeloid lineages. (medscape.com)
We hope to provide the blueprints for a new generation of smart circuit immune cells that can be tailored to perform precise actions upon combinatorial antigen signatures to enable safe and effective targeting of tumor cells. (lu.se)

Notch signaling is aberrantly activated in breast cancer, non‑small‑cell lung cancer and hematological malignancies, such as T‑cell acute lymphoblastic leukemia and diffuse large B‑cell lymphoma. (spandidos-publications.com)
Immunologic classification of leukemia and lymphoma. (bdbiosciences.com)
I am Chief of the Hematologic Malignancies Program at the Children's Hospital of Philadelphia and attend on the inpatient leukemia/lymphoma service and outpatient clinic. (upenn.edu)
More than 85% of the products in the development pipeline are presently being developed to treat various types of cancers, including (in decreasing order of number of pipeline products) acute lymphoblastic leukemia, non-Hodgkin's lymphoma, multiple myeloma and melanoma. (rootsanalysis.com)
Clinical lymphoma, myeloma & leukemia 2022 0 0. (cdc.gov)

We measured VSTM1 expression in leukemia cell lines and bone marrow biopsies from leukemia patients using qRT-PCR. (biomedcentral.com)
Use of peripheral blood instead of bone marrow to monitor residual disease in children with acute lymphoblastic leukemia. (smw.ch)
2) Diagnosis of acute lymphoblastic leukaemia (T-ALL or B-ALL) confirmed by bone marrow cytomorphology and immunophenotyping, etc. (who.int)
Bone marrow failure syndrome (BMFS) is a group of disorders that may manifest as single cytopenia (eg, erythroid, myeloid, or megakaryocytic) or as pancytopenia. (medscape.com)

Mylotarg is a chemotherapy agent approved for the treatment of CD33 positive acute myeloid leukemia (AML) in first relapse. (centerwatch.com)
Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)

The honorees will receive up to $150,000 in funding to study ways to improve care and help find cures for people with breast, colorectal, pancreatic, and small cell lung cancer, as well as pediatric acute myeloid leukemia. (biospace.com)

The Vaccine Company, which makes the PR1 vaccine, is conducting a national Phase III clinical trial for acute myelogenous leukemia. (algodonwineestates.com)

Minimal residual disease assessment in childhood acute lymphoblastic leukaemia: a Swedish multi-centre study comparing real-time polymerase chain reaction and multicolour flow cytometry. (smw.ch)
Exclusion criteria: (1) Acute mixed phenotype leukaemia (excluding ALL with myeloid antigen expression). (who.int)
3) Acute lymphoblastic leukaemia of mature B-cell lineage (B-cell ALL). (who.int)

Prospective minimal residual disease monitoring to predict relapse of acute promyelocytic leukemia and to direct pre-emptive arsenic trioxide therapy. (smw.ch)
Acute promyelocytic leukemia is an important subtype of AML. (msdmanuals.com)
Acute promyelocytic leukemia affects a younger age group (median age 31 years) and particular ethnicity (Hispanic people). (msdmanuals.com)
Acute promyelocytic leukemia (APL) is a distinct variant of acute myeloid leukemia (AML). (medscape.com)

The new drug approval is for the treatment of adults with newly diagnosed acute myeloid leukemia whose tumors express the CD33 antigen (CD33-positive AML). (centerwatch.com)

Therefore, VSTM1-v1 might represent an important myeloid leukocyte differentiation antigen and provide a potential target for the diagnosis and treatment of leukemia. (biomedcentral.com)

The expression level of its predominant encoded product, VSTM1-v1, was positively correlated with myeloid cell maturation state. (biomedcentral.com)

We have developed a genetically modified tumor cell vaccine for the treatment of myeloid malignancies. (acgtfoundation.org)
I am an experienced early-phase clinical trialist and current serve as a steering member of the COG ALL committee, the COG Myeloid Diseases Vice-Chair of Relapse, the LLS PedAL Clinical Trials Leader, and the COG Developmental Therapeutics committee Vice-Chair of Biology for Hematologic Malignancies. (upenn.edu)

Recent progress in understanding the biology of acute myeloid leukemia (AML) and the identification of targetable driver mutations, leukemia specific antigens and signal transduction pathways has ushered in a new era of therapy. (elsevierpure.com)

Acute myeloid leukemia (AML) is a common, heterogeneous, and aggressive hematopoietic malignancy, characterized by apparent genetic abnormalities ( 1 ). (frontiersin.org)

Remarkably, long-term remission is coincident with the dominance of cytotoxic subtypes, while leukemia progression is correlated with the emergence of subtypes with B cell transcriptional profiles, which have dysfunctional features and might predict relapse. (bvsalud.org)

My overarching career goal as an academic pediatric oncologist and translational physician-scientist is to develop successful precision medicine therapies for children with high-risk leukemias aimed at decreasing relapse risk, minimizing toxicity, and improving long-term survival. (upenn.edu)

Join us on November 30th for a virtual meeting bringing together experts across disciplines to discuss developments in antigen discovery, preclinical vaccine development and clinical advances in cancer vaccine therapy, and reflect on the ongoing challenges and necessities in the field. (nature.com)

My clinical training as a pediatric hematology oncology fellow at Memorial Sloan Kettering Cancer Center highlighted the desperate need for novel therapeutic options for a subtype of aggressive pediatric leukemia, Acute Myeloid Leukemia (AML). (stanford.edu)

De Palma and colleagues develop a dendritic cell therapy based on dendritic cell progenitors engineered to produce IL-12 and FLT3L and show antigen-agnostic reduction of tumor burden that can be exploited for combination therapy in glioma. (nature.com)

Furthermore, it was developed using the basic platform of the CD34 + CD38 - markers, but applying more advanced antigens such as CD45 dim and CD133. (researchsquare.com)

Dr. Sallman's research focuses on the development of novel, targeted therapeutic strategies for patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). (moffitt.org)
Phase I and II clinical trials) for patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) based on the underlying mutational drivers of each disease. (moffitt.org)

Her research will focus on new immunotherapy approaches to treating acute myeloid leukemia using gene- and cell-based therapy techniques. (wustl.edu)
Unlike other forms of blood cancer, acute myeloid leukemia (AML) cannot currently be treated with CAR-T cell immunotherapy. (idw-online.de)

Induction therapy should not be modified based on the presence of leukemia cell characteristics that have variably been considered to predict a poorer prognosis (eg, secondary chromosomal abnormalities, FLT3 mutations, CD56 expression, BCR3 PML-RARA isoform). (medscape.com)

The origin and evolution of mutations in acute myeloid leukemia. (smw.ch)
De novo activating mutations drive clonal evolution and enhances clonal fitness in KMT2A-rearranged leukemia. (lu.se)

Immune-checkpoint blockade has revolutionized cancer treatment, but some cancers, such as acute myeloid leukemia (AML), do not respond or develop resistance. (stanford.edu)
Together with the SUSD6/TMEM127/WWP2 gene signature, which negatively correlates with cancer survival, our findings define a membrane-associated MHC-I inhibitory axis as a potential therapeutic target for both leukemia and solid cancers. (stanford.edu)

DNA (cytosine-5)-methyltransferase 3A (DNMT3A)-mutated acute myeloid leukemia (AML) has a poor prognosis, but the exact mechanism is still unclear. (frontiersin.org)
Leukocyte differentiation antigens often represent important markers for the diagnosis, classification, prognosis, and therapeutic targeting of myeloid leukemia. (biomedcentral.com)

CD133 antigen, also known as prominin-1, is a glycoprotein that in humans is encoded by the PROM1 gene. (wikipedia.org)

He has published significantly on this topic including recently in highly regarded journals including Leukemia and Haematologica and these work form the foundation of the clinical trials that he is bringing to patients in order to improve their quality of life and survival. (moffitt.org)

Dr. Sallman studies the genetic drivers of myeloid diseases in order to improve prognostication for patients and also to allow for more personalized treatment. (moffitt.org)

Acute myeloid leukemia (AML) is generally regarded as a stem cell disease, and it originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity [ 1 , 2 ]. (researchsquare.com)

Leukemia is the most common type of cancer in children. (kidshealth.org)
By contrast, somatic alterations in the genes encoding Notch signaling components drive various types of human cancer, such as breast cancer, small-cell lung cancer (SCLC) and T-cell acute lymphoblastic leukemia (T-ALL) ( 6 - 9 ). (spandidos-publications.com)
AML - one of several forms of leukemia ("blood cancer") - is a treacherous disease. (idw-online.de)

Anatomy22

Organisms18

Diseases40

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes34

Disciplines and Occupations2

Information Science3

Health Care5

Receptor12

Chronic16

Receptors6

Refractory acute1

Cells41

Lymphoma5

Bone marrow4

Chemotherapy2

Pediatric acute1

Myelogenous Leukemia1

Leukaemia3

Promyelocytic leukemia4

CD331

Differentiation antigen1

Maturation1

Malignancies2

Specific antigens1

Hematopoietic1

Cytotoxic1

Relapse1

Preclinical1

Hematology1

Tumor1

CD381

Myelodysplastic syndromes2

Immunotherapy2

Expression1

Mutations2

Cancers2

Prognosis2

Gene1

Clinical trials1

Diseases1

Stem1

Cancer3