• Immunology
  • Radial immunodiffusion (RID) or Mancini method, Mancini immunodiffusion or single radial immunodiffusion assay, is an immunodiffusion technique used in immunology to determine the quantity or concentration of an antigen in a sample. (wikipedia.org)
  • exposure
  • In experimentally-infected animals, anti-25 kDa complex IgG(T) levels correlated positively with field exposure and with early third stage larval (r(s)=0.74, P=0.015) and total mucosal parasite (r(s)=0.78, P=0.010) burdens. (surrey.ac.uk)
  • These antigen-antibody complexes are thought to be caused by excessive exposure to bacterial antigens (especially peptidoglycans). (wikipedia.org)
  • molecules
  • The intestinal mucosa absorbs and digests nutrients, turning large complex molecules into small simple ones. (bookpubco.com)
  • Normally, only the small molecules are allowed to pass through the intestinal wall, while the large ones that can act as antigens, causing immune reactions, have a limited ability to pass through. (bookpubco.com)
  • inclusion complex one in which molecules of one type are enclosed within cavities in the crystalline lattice of another substance. (thefreedictionary.com)
  • The C1 complex is composed of 1 molecule of C1q, 2 molecules of C1r and 2 molecules of C1s, or C1qr2s2. (wikipedia.org)
  • titres
  • Higher titres of anti-dsDNA antibodies are more suggestive of SLE and lower titres can be found in people without the disease. (wikipedia.org)
  • Increases in titres of the antibodies can coincide with, or even precede an increase of disease activity. (wikipedia.org)
  • Researchers at Indiana University found that titres of anti-beta-amyloid antibodies in cerebral spinal fluid was lower in AD patients compared to normal patients. (wikipedia.org)
  • specific
  • In naturally exposed horses whose parasite burdens were quantified upon post-mortem examination, antigen-specific IgG(T) responses were significantly higher in infected than in uninfected horses (P=0.0001 and 0.002, for anti-25 and anti-20 kDa responses, respectively). (surrey.ac.uk)
  • In cases of larval cyathostominosis, antigen-specific IgG(T) levels were significantly higher than in uninfected ponies (P=0.002 and 0.0035, for anti-25 and anti-20 kDa responses, respectively). (surrey.ac.uk)
  • 5. The enzyme immunoassay of claim 1, wherein the analyte is a therapeutic drug and the binding material is an antibody specific for said therapeutic drug. (google.com)
  • Anti-dsDNA antibodies are incredibly specific for SLE, with studies quoting nearly 100%, and are therefore used in the diagnosis of SLE. (wikipedia.org)
  • Ehrlich believed that each antigen-specific amboceptor has its own specific complement, whereas Bordet believed that there is only one type of complement. (wikipedia.org)
  • In the early 20th century, this controversy was resolved when it became understood that complement can act in combination with specific antibodies, or on its own in a non-specific way. (wikipedia.org)
  • The mannose-binding lectin pathway can be activated by C3 hydrolysis or antigens without the presence of antibodies (non-specific immune response). (wikipedia.org)
  • Complement activity is not antigen sensitive, but can be triggered by specific antigens. (wikipedia.org)
  • immunity
  • Antibodies passing from the mother to the fetus via the placenta or breat milk to the infant is an example of what type of immunity? (sporcle.com)
  • amino
  • 5) The amino acid sequence determination of antibody started in 1990 at the Institut Pasteur in Paris according to G. Winter's procedure. (nii.ac.jp)
  • We completely determined the amino acid sequence of the heavy chain in Ab-Fab in 1991, and found two consensus cysteine residues in comparison with the other antibody sequences. (nii.ac.jp)
  • For vaccine development and disease surveillance, it is often vital to assess the impact of amino acid substitutions on antibody binding. (frontiersin.org)
  • An important area of focus is the impact on antibody binding of amino acid substitutions in the epitope-could mutation lead to escape? (frontiersin.org)
  • therefore
  • Therefore, presence of anti-dsDNA antibodies are suggestive of SLE, however an absence of the antibodies does not rule out the disease. (wikipedia.org)
  • Therefore, a graph that compares the quantities or concentrations of antigen in the original samples with the areas or the squares of the diameters of the precipitin circles on linear scales will usually be a straight line when all circles have reached their end points (equivalence method). (wikipedia.org)
  • Therefore, if areas or diameters of circles are measured while some, but not all, circles have stopped expanding, such a graph will be straight in the portion that contains the smaller quantities or concentrations of antigen and will be curved in the portion that contains the larger quantities or concentrations. (wikipedia.org)
  • It is therefore often desirable to adjust the concentration of antibody and the quantity of antigen to assure that precipitin rings will be large. (wikipedia.org)
  • Formation
  • When injected into target tissue encourages recruitment of C1q and activates downstream events, eventually leading to the formation of the C5b-9 complex which damages tumor cells, killing them. (wikipedia.org)
  • Cap formation can be visualised by attaching a fluorophore, such as fluorescein, to the antibody. (wikipedia.org)
  • interactions
  • We find that in some cases the impact of a substitution is local, while in others it causes a reorientation of the antibody with wide-ranging impact on residue-residue interactions: this explains, in part, why the change in chemical properties of a residue can be, on its own, a poor predictor of overall change in binding energy. (frontiersin.org)
  • genes
  • Modular variations of the human major histocompatibility complex class III genes for serine/threonine kinase RP, complement component C4, steroid 21-hydroxylase CYP21, and tenascin TNX (the RCCX module). (wikipedia.org)
  • Plasma
  • anti-inhibitor coagulant complex (AICC) a concentrated fraction from pooled human plasma, which includes various coagulation factors. (thefreedictionary.com)
  • factor IX complex a sterile, freeze-dried powder consisting of partially purified coagulation factor IX fraction, as well as concentrated factor II, VII, and X fractions, of venous plasma from healthy human donors. (thefreedictionary.com)
  • inflammation
  • This process, called antibody-dependent cellular cytotoxicity, can cause inflammation of surrounding tissues and damage to healthy cells. (wikipedia.org)
  • cells
  • True or false: Cytotoxic cells circulate the body in search of body cells that display antigens to which they have been sensitized. (sporcle.com)
  • Do Helper T cells attack and eliminate antigens? (sporcle.com)
  • Helper T cells must be primed by a presented antigen in order for it to start doing its job. (sporcle.com)
  • This could be due to the preferential survival of long-lived memory B cells producing homotypic antibodies. (wikipedia.org)
  • It is thought that by binding to but not neutralizing the virus, these antibodies cause it to behave as a "trojan horse", where it is delivered into the wrong compartment of dendritic cells that have ingested the virus for destruction. (wikipedia.org)
  • Mice that have T cells directed towards the nucleosome can elicit a response to other antigens such as dsDNA and histone via a mechanism known as antigen spreading. (wikipedia.org)