• hypersensitivity
  • Presentation on theme: "Types II and III Immediate Hypersensitivity: Antibody-Mediated and Antigen-Antibody Complex-Mediated Folder Title: AgAbHypeNoTP Updated: November 02, 2012. (slideplayer.com)
  • 17 Antigen-generation and Persistence in Type III Immediate Hypersensitivity Persistent Infection Leprosy Malaria Viral hepatitis Dengue hemorrhagic fever Staphylococcal Endocarditis Streptococcal glomerulonephritis Mononucleosis Autoimmunity Rheumatoid arthritis Systemic Lupus Erythrematosis Persistent Exogenous Acquisition (Inhalation of Ag) Extrinsic Allergic Alveolitis (e.g. (slideplayer.com)
  • Such hypersensitivity progressing to disease states produces the immune complex diseases. (wikipedia.org)
  • cross-reactive
  • Neutralizing heterotypic (cross-reactive) IgG antibodies are responsible for this cross-protective immunity, which typically persists for a period of several months to a few years. (wikipedia.org)
  • The production of such cross-reactive but non-neutralizing antibodies could be the reason for more severe secondary infections. (wikipedia.org)
  • Immunology
  • Radial immunodiffusion (RID) or Mancini method, Mancini immunodiffusion or single radial immunodiffusion assay, is an immunodiffusion technique used in immunology to determine the quantity or concentration of an antigen in a sample. (wikipedia.org)
  • Tumor
  • Tumor antigen 90 (TA-90), a 90-kd glycoprotein, appears on the surface of melanoma cells and can be identified using an enzyme-linked immunoassay for the TA90 antigen-antibody complex in blood, said Dr. (thefreedictionary.com)
  • When injected into target tissue encourages recruitment of C1q and activates downstream events, eventually leading to the formation of the C5b-9 complex which damages tumor cells, killing them. (wikipedia.org)
  • Cytotoxicity
  • This process, called antibody-dependent cellular cytotoxicity, can cause inflammation of surrounding tissues and damage to healthy cells. (wikipedia.org)
  • equivalence
  • Expansion of the circle reaches an end point and stops when free antigen is depleted and when antigen and antibody reach equivalence. (wikipedia.org)
  • Therefore, a graph that compares the quantities or concentrations of antigen in the original samples with the areas or the squares of the diameters of the precipitin circles on linear scales will usually be a straight line when all circles have reached their end points (equivalence method). (wikipedia.org)
  • membrane
  • In addition, the C5 convertase initiates the terminal phase of the complement system, leading to the assembly of the membrane attack complex (MAC). (wikipedia.org)
  • The membrane attack complex creates a pore on the target cell's membrane, inducing cell lysis and death. (wikipedia.org)
  • Subsequent interactions between C5b and other terminal components C6, C7, C8, and C9 form the membrane attack complex or the C5b-9 complex which forms pores on the target cell membranes to lysing. (wikipedia.org)
  • interaction
  • These assays can be expensive and time consuming to conduct, particularly if the required antibody is not to hand, and can only provide a limited understanding of the contribution that individual residues make to the interaction. (frontiersin.org)
  • Ions and some metal complexes are excluded, as well as cases where no interaction profile could be generated. (rcsb.org)
  • specific
  • In naturally exposed horses whose parasite burdens were quantified upon post-mortem examination, antigen-specific IgG(T) responses were significantly higher in infected than in uninfected horses (P=0.0001 and 0.002, for anti-25 and anti-20 kDa responses, respectively). (surrey.ac.uk)
  • In cases of larval cyathostominosis, antigen-specific IgG(T) levels were significantly higher than in uninfected ponies (P=0.002 and 0.0035, for anti-25 and anti-20 kDa responses, respectively). (surrey.ac.uk)
  • Anti-dsDNA antibodies are incredibly specific for SLE, with studies quoting nearly 100%, and are therefore used in the diagnosis of SLE. (wikipedia.org)
  • In the early 20th century, this controversy was resolved when it became understood that complement can act in combination with specific antibodies, or on its own in a non-specific way. (wikipedia.org)
  • The mannose-binding lectin pathway can be activated by C3 hydrolysis or antigens without the presence of antibodies (non-specific immune response). (wikipedia.org)
  • Complement activity is not antigen sensitive, but can be triggered by specific antigens. (wikipedia.org)
  • amino
  • 5) The amino acid sequence determination of antibody started in 1990 at the Institut Pasteur in Paris according to G. Winter's procedure. (nii.ac.jp)
  • We completely determined the amino acid sequence of the heavy chain in Ab-Fab in 1991, and found two consensus cysteine residues in comparison with the other antibody sequences. (nii.ac.jp)
  • For vaccine development and disease surveillance, it is often vital to assess the impact of amino acid substitutions on antibody binding. (frontiersin.org)
  • An important area of focus is the impact on antibody binding of amino acid substitutions in the epitope-could mutation lead to escape? (frontiersin.org)
  • therefore
  • Therefore, presence of anti-dsDNA antibodies are suggestive of SLE, however an absence of the antibodies does not rule out the disease. (wikipedia.org)
  • Therefore, if areas or diameters of circles are measured while some, but not all, circles have stopped expanding, such a graph will be straight in the portion that contains the smaller quantities or concentrations of antigen and will be curved in the portion that contains the larger quantities or concentrations. (wikipedia.org)
  • interactions
  • We find that in some cases the impact of a substitution is local, while in others it causes a reorientation of the antibody with wide-ranging impact on residue-residue interactions: this explains, in part, why the change in chemical properties of a residue can be, on its own, a poor predictor of overall change in binding energy. (frontiersin.org)
  • mechanism
  • Although the exact mechanism of the generation of dsDNA antibodies is still unknown, it is likely that extracellular DNA is one cause of an immune response against dsDNA. (wikipedia.org)
  • Mice that have T cells directed towards the nucleosome can elicit a response to other antigens such as dsDNA and histone via a mechanism known as antigen spreading. (wikipedia.org)