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  • maturation
  • Although the new system codifies and standardizes the definitions of disease entities based upon histology, genetic abnormalities, and cell surface immunophenotype, its organization is based upon cell of origin (B cell vs. T cell) and maturation stage (precursor vs. mature) of the tumor, features that are of limited value to the clinician. (wordpress.com)
  • driven
  • Anti-dsDNA as 475 476 RIEMEKASTEN ET AL well as anti-Sm antibody responses are polyclonal, antigen-driven, somatically mutated, and high-titered (6), suggesting that both responses are driven by autoreactive T helper cells. (docme.ru)
  • chronic
  • We studied the effect of highly active antiretroviral therapy (HAART) on the frequency of HIV-1-specific CD8+ T cells in patients treated during early (n = 31) or chronic (n = 23) infection. (jove.com)
  • granulomatous
  • Wegener's granulomatosis a multisystem disease chiefly affecting males, characterized by necrotizing granulomatous vasculitis involving the upper and lower respiratory tracts, glomerulonephritis, and variable degrees of systemic, small vessel vasculitis, which is generally considered to represent an aberrant hypersensitivity reaction to an unknown antigen. (thefreedictionary.com)
  • flow cytometry
  • Tissue undergoes three kinds of studies: (1) light microscopy to discern the pattern of growth and the morphologic features of the malignant cells, (2) flow cytometry for assessment of immunophenotype, and (3) genetic studies (cytogenetics, DNA extraction). (wordpress.com)
  • follicular
  • Some genetic alterations are characteristic of particular histologic entities: t(8;14) in Burkitt's lymphoma, t(14;18) in follicular lymphoma, t(11;14) in mantle cell lymphoma, t(2;5) in anaplastic large cell lymphoma, translocations or mutations involving bcl-6 on 3q27 in diffuse large cell lymphoma, and others. (wordpress.com)
  • Tissue
  • However, when scrapings are negative, analysis of conjunctival and scleral specimens by histopathology (stainings and cultures), tissue homogenization (PCR, culture, or cell culture lines), and indirect immunofluorescence (antimicrobe antibodies) techniques may be important for microbe isolation. (springer.com)
  • monoclonal
  • However, also this therapy is very costly and since effective TILs seem to be restricted to melanoma and genetically engineered T cells only possess monoclonal specificity, targeting DCs directly in vivo therefore provides an attractive alternative. (frontiersin.org)
  • Like other cancers, the malignant cells are monoclonal and often contain numerous genetic abnormalities. (wordpress.com)
  • pathogenesis
  • This peptide is an interesting target structure for the modulation of autoreactive T cells, and its characterization may contribute to our understanding of the role of autoantigen-reactive T cells in the pathogenesis of SLE. (docme.ru)
  • autoantibodies
  • autoantibodies directed against own cell components (AUTOANTIGENS) disease is called? (brainscape.com)
  • The SmD183-119 peptide plays an important role in generating T cell help for autoantibodies, including anti-dsDNA, and activates different subsets of T cells as defined by distinct cytokine expression. (docme.ru)
  • lymphoma
  • HTLV-I is associated with adult T cell leukemia/lymphoma. (wordpress.com)
  • Gastric Helicobacter pylori infection is associated with gastric MALT lymphoma and perhaps gastric large cell lymphoma. (wordpress.com)
  • responses
  • For this reason strategies have been developed to instruct DCs for the induction of CD4 + and CD8 + T cell responses. (frontiersin.org)
  • Besides triggering activating immune responses aiming at the clearance of pathogens, DCs are also capable to down-modulate unwanted auto-immune reactions by maintaining immune tolerance via the induction of regulatory T cells ( Maldonado and von Andrian, 2010 ). (frontiersin.org)
  • This strategy involved the generation of DCs from monocytes or CD34 + precursors and the subsequent re-injection into the patient to generate effective T and B cell responses against the tumor. (frontiersin.org)
  • Residual Viral Replication During Antiretroviral Therapy Boosts Human Immunodeficiency Virus Type 1-specific CD8+ T-cell Responses in Subjects Treated Early After Infection Journal of Virology. (jove.com)
  • tumor
  • Additionally, several studies point to improved anti-tumor efficacy when the T cells are activated immediately prior to or directly after adoptive transfer. (frontiersin.org)
  • tissues
  • Since DCs are localized, amongst other locations, in peripheral tissues such as the skin, new vaccines are aiming at targeting antigens to DCs in situ . (frontiersin.org)
  • either
  • All living cells arise from other cells, either by division of one cell to make two, as in mitosis and meiosis, or by fusion of two cells to make one, as in the union of the sperm and ovum to make the zygote in sexual reproduction. (thefreedictionary.com)
  • synthesis
  • Platelets stimulate thromboplastin synthesis in human endothelial cells. (springer.com)
  • Activation of SmD183-119-reactive T cells by immunization of NZB/ NZW mice resulted in elevated anti-dsDNA synthesis and, later, increased antibodies to SmD183-119. (docme.ru)
  • Type
  • Pubmed ID: 11739706 Human immunodeficiency virus type 1 (HIV-1)-infected subjects treated early after infection have preserved HIV-1-specific CD4+ T-cell function. (jove.com)