• Prognosis
  • While localized disease has an excellent prognosis, involvement of high risk organs often ends fatal in spite of research regarding new therapies such as stem cell therapy or immunotherapy. (lecturio.com)
  • adjuvant
  • Finally, we discuss the potential mechanisms underlying the immunomodulating effects of nanomaterials by describing the involvement of the protein corona in the interaction of nanomaterials with biological components and by presenting recent data about the adjuvant effects of well-characterized particle adjuvant, aluminum salt, as an example of immunomodulatory particulate. (frontiersin.org)
  • diffuse
  • Some genetic alterations are characteristic of particular histologic entities: t(8;14) in Burkitt's lymphoma, t(14;18) in follicular lymphoma, t(11;14) in mantle cell lymphoma, t(2;5) in anaplastic large cell lymphoma, translocations or mutations involving bcl-6 on 3q27 in diffuse large cell lymphoma, and others. (wordpress.com)
  • lesions
  • given that many of these lesions evolve to lymphoma, the WHO has flagged them as B-cell proliferations of uncertain malignant potential. (thefreedictionary.com)
  • The term extranodal natural killer/T-cell lymphoma (NKTCL) refers to a group of clonal proliferations of cytotoxic lymphocytes of natural killer (NK) or, more rarely, T-cell types, with peculiar clinicopathologic features, arising mainly as tumors or destructive lesions in the nasal cavity, maxillary sinuses, or palate [ 1 ]. (hindawi.com)
  • granulomatosis
  • lymphomatoid granulomatosis a multisystem disease involving predominantly the lungs, skin, central nervous system, and kidneys, caused by invasion and destruction of vessels by atypical lymphoreticular cells. (thefreedictionary.com)
  • Wegener's granulomatosis a multisystem disease chiefly affecting males, characterized by necrotizing granulomatous vasculitis involving the upper and lower respiratory tracts, glomerulonephritis, and variable degrees of systemic, small vessel vasculitis, which is generally considered to represent an aberrant hypersensitivity reaction to an unknown antigen. (thefreedictionary.com)
  • genes
  • In most cases, translocations involve insertion of a distant chromosome segment into the antigen receptor genes (either immunoglobulin or T cell receptor) during the rearrangement of the gene segments that form the receptors. (wordpress.com)
  • granular
  • basal granular cells APUD cells located at the base of the epithelium at many places in the gastrointestinal tract. (thefreedictionary.com)
  • Extranodal NKTCL represents the major group of mature NK cell neoplasms in the recently revised WHO classification of hematolymphoid tumors, which also include the aggressive NK cell leukemia (ANKL) and a provisional group of chronic NK-cell lymphoproliferative disorder of uncertain malignant potential, most likely related to T-cell large granular lymphomas [ 1 ]. (hindawi.com)
  • about two weeks are needed for a cell to migrate from the basal cell layer to the top of the granular cell layer, and an additional two weeks to cross the stratum corneum. (wikipedia.org)
  • flow cytometry
  • Tissue undergoes three kinds of studies: (1) light microscopy to discern the pattern of growth and the morphologic features of the malignant cells, (2) flow cytometry for assessment of immunophenotype, and (3) genetic studies (cytogenetics, DNA extraction). (wordpress.com)
  • stratum basale
  • basal cell an early keratinocyte, present in the stratum basale of the epidermis. (thefreedictionary.com)
  • This stratified squamous epithelium is maintained by cell division within the stratum basale, in which differentiating cells slowly displace outwards through the stratum spinosum to the stratum corneum, where cells are continually shed from the surface. (wikipedia.org)
  • thereby
  • In other words, vaccine adjuvants are capable of enhancing, sustaining and directing the immunogenicity of antigens, thereby effectively modulating appropriate immune responses, reducing the amount of antigen and/or number of required immunizations, and improving the efficacy of vaccines, which is of increased relevance for vaccination strategies aimed at newborns, elderly, or immune-compromised individuals (5). (scielo.br)
  • lymphoma
  • HTLV-I is associated with adult T cell leukemia/lymphoma. (wordpress.com)
  • Gastric Helicobacter pylori infection is associated with gastric MALT lymphoma and perhaps gastric large cell lymphoma. (wordpress.com)
  • Tissue
  • Arias-Stella cells columnar cells in the endometrial epithelium which have a hyperchromatic enlarged nucleus and which appear to be associated with chorionic tissue in an intrauterine or extrauterine site. (thefreedictionary.com)
  • cytotoxic
  • NK cells and CD8+ cytotoxic T cells also produce IFNγ. (wikipedia.org)
  • If the majority of NKTCL are likely to originate from mature NK cells, a small proportion of cases, with expression of γδ or αβ TCR appear to derive from cytotoxic T lymphocytes, reflected in the "NK/T" cell terminology. (hindawi.com)
  • anaplastic
  • BACKGROUND: Multinucleated giant cells of osteoclastlike appearance are seen in some anaplastic carcinomas, but only three cases in which the diagnosis was made by aspiration cytology are reported in the international medical literature. (biomedsearch.com)
  • maturation
  • Although the new system codifies and standardizes the definitions of disease entities based upon histology, genetic abnormalities, and cell surface immunophenotype, its organization is based upon cell of origin (B cell vs. T cell) and maturation stage (precursor vs. mature) of the tumor, features that are of limited value to the clinician. (wordpress.com)
  • eradication
  • A distinctive form of mononuclear inflammation usually evoked by infectious agents that resist eradication, but are capable of stimulating strong T cell mediated immunity. (brainscape.com)
  • tumor
  • PROBLEM CONSIDERED: Giant cell fibroblastoma (GCF) is a rare mesenchymal neoplasm, which is classified as a fibrohistiocytic tumor of intermediate malignancy owing to its propensity for local recurrence, although metastasis has not been documented. (biomedsearch.com)