• apoptosis
  • The family of Raf protein kinases, which comprises A-Raf, B-Raf, and Raf-1, is at the apex of the 3-tiered Raf-MAP/ERK kinase (MEK) pathway that regulates many fundamental cellular functions, including proliferation, differentiation, transformation, apoptosis, and metabolism ( 1 ). (aacrjournals.org)
  • The p53 tumour suppressor protein is considered the guardian of the genome and has a number of biological functions including cell cycle arrest, DNA repair, and apoptosis in response to various stresses, such as ultraviolet irradiation, serum deprivation, and exposure to anticancer drugs. (ubc.ca)
  • In vitro , the combination induced greater decreases in HER2, a G 2 cell-cycle arrest, and increased apoptosis. (aacrjournals.org)
  • Specifically, under growth-limiting conditions, ( a ) GSTP1 protected HCT116 cells from oxidative stress and associated apoptosis and ( b ) promoted mitogen-activated protein kinase-extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase-mediated G 1 -S cell cycle progression. (aacrjournals.org)
  • The pro-apoptotic proteins in the BCL-2 family, including Bax and Bak, normally act on the mitochondrial membrane to promote permeabilization and release of cytochrome C and ROS, that are important signals in the apoptosis cascade. (wikipedia.org)
  • Due to the fact that dendritic cells are the immune system's most important antigen-presenting cells, their activity must be tightly regulated by mechanisms such as apoptosis. (wikipedia.org)
  • mammalian
  • Beta-catenin was initially discovered in the early 1990s as a component of a mammalian cell adhesion complex: a protein responsible for cytoplasmatic anchoring of cadherins. (wikipedia.org)
  • But very soon, it was realized that the Drosophila protein armadillo - implicated in mediating the morphogenic effects of Wingless/Wnt - is homologous to the mammalian β-catenin, not just in structure but also in function. (wikipedia.org)
  • There are five proteins in the mammalian NF-κB family: Below are the five human NF-κB family members: In addition to mammals, NF-κB is found in a number of simple animals as well. (wikipedia.org)
  • kinase
  • Recently, 2 alternative murine A-Raf splice forms were described, DA-Raf1 and DA-Raf2, which contain the Ras-binding domain (RBD) but lack the kinase domain due to preterminal stop codons ( 20, 21 ). (aacrjournals.org)
  • 3. The method of claim 2 wherein the screening assay is a kinase assay. (freepatentsonline.com)
  • Additional functions of lipoarabinommanan are thought to include the neutralization of cytotoxic oxygen free radicals produced by macrophages, inhibition of protein kinase C, and induction of early response genes. (wikipedia.org)
  • tumor
  • The protein is involved in the activation of several oncogenic pathways as well as in tumor metastasis and angiogenesis. (clontech.com)
  • Colorectal cancer develops through multiple steps, with the sequential acquisition of genetic alterations in key tumor suppressors and oncogenes ( 10 ). (aacrjournals.org)
  • cellular
  • BCL-2 is localized to the outer membrane of mitochondria, where it plays an important role in promoting cellular survival and inhibiting the actions of pro-apoptotic proteins. (wikipedia.org)
  • Thus beta-catenin became one of the very first examples of moonlighting: a protein performing more than one radically different cellular function. (wikipedia.org)
  • NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. (wikipedia.org)
  • cells
  • It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. (githubusercontent.com)
  • In this context of binding to the stress signaling protein JNK, there is emerging evidence that GSTP1 may affect the proliferation of cells. (aacrjournals.org)
  • complex
  • The cyclin D1-CDK4 complex promotes passage through the G1 phase by inhibiting the retinoblastoma protein (pRb). (wikipedia.org)
  • Cyclin D1-CDK4 also enables the activation of cyclin E-CDK2 complex by sequestering Cip/Kip family CDK inhibitory proteins p21 and p27, allowing entry into the S phase. (wikipedia.org)
  • differ
  • All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. (wikipedia.org)
  • domain
  • Termed armadillo repeats, all these elements fold together into a single, rigid protein domain with an elongated shape - called armadillo (ARM) domain. (wikipedia.org)
  • All proteins of the NF-κB family share a Rel homology domain in their N-terminus. (wikipedia.org)
  • A subfamily of NF-κB proteins, including RelA, RelB, and c-Rel, have a transactivation domain in their C-termini. (wikipedia.org)
  • rabbit
  • Do not freeze taw, rather use anti_ PCNA antibody, rabbit serum anti_ PCNA antibody, rabbit serum from the fridge if your use is less than 1 or 2 weeks. (antibody-antibodies.com)
  • Do not freeze taw, rather use Anti_Human, pab IL_4 Source Rabbit from the fridge if your use is less than 1 or 2 weeks. (antibody-antibodies.com)
  • human
  • The c-Met (HGFR) assay can be used to measure soluble human c-Met protein in serum, EDTA plasma, or cell culture supernatants. (clontech.com)
  • Mouse Anti Human TAR DNA-binding protein 43 TARDBP antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Mouse Anti Human TAR DNA-binding protein 43 TARDBP. (antibody-antibodies.com)
  • Mouse Anti Human TAR DNA-binding protein 43 TARDBP Human samples 80 % of the research is conducted on human samples. (antibody-antibodies.com)
  • acts
  • Other models suggest that ManLAM acts to mediate immunosuppressive effects through suppression of LPS-induced IL-12 p40 protein production. (wikipedia.org)
  • fusion
  • The first repeat of β-catenin (near the N-terminus) is slightly different from the others - as it has an elongated helix with a kink, formed by the fusion of helices 1 and 2. (wikipedia.org)