AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
LymphomaLymphoma, B-CellLymphoma, Non-HodgkinCarcinomaLymphoma, Large B-Cell, DiffuseLymphoma, T-CellCarcinoma, Large CellAntigensLymphoma, FollicularCarcinoma, Squamous CellAntigens, NeoplasmCarcinoma, HepatocellularBurkitt LymphomaAntigens, BacterialLymphoma, B-Cell, Marginal ZoneAntigens, CD30Antigens, SurfaceCarcinoma, NeuroendocrineLymphoma, T-Cell, CutaneousImmunohistochemistryLymphoma, T-Cell, PeripheralAntigens, ViralLymphoma, AIDS-RelatedHodgkin DiseaseLymphoma, Mantle-CellCarcinoma in SituAntibodies, MonoclonalLymphoma, Large-Cell, ImmunoblasticTumor Markers, BiologicalLymphoma, Large-Cell, AnaplasticCarcinoma, PapillaryLung NeoplasmsPrognosisLiver NeoplasmsCarcinoma, Small CellAntigens, CDTumor Cells, CulturedCell Line, TumorNeoplasm StagingImmunoenzyme TechniquesVincristineAdenocarcinomaCarcinoma, Ductal, BreastSkin NeoplasmsCarcinoma, Basal CellAntigens, ProtozoanGene Expression Regulation, NeoplasticFatal OutcomeAntigens, Polyomavirus TransformingCarcinoma, BronchogenicTranslocation, GeneticHLA AntigensNeoplasm ProteinsReceptor Protein-Tyrosine KinasesAntigens, CD20Lymph NodesCarcinoembryonic AntigenDNA, NeoplasmPrednisoneB-LymphocytesMolecular Sequence DataAntineoplastic Combined Chemotherapy ProtocolsT-LymphocytesImmunophenotypingAntigens, FungalLymphoma, Primary Cutaneous Anaplastic Large CellHerpesvirus 4, HumanRetrospective StudiesTreatment OutcomeH-2 AntigensAntigens, HelminthCarcinoma, Transitional CellReceptors, Antigen, B-CellSurvival RateCyclophosphamideFlow CytometryAntineoplastic AgentsBase SequenceSurvival AnalysisCell LineCombined Modality TherapyReed-Sternberg CellsNeoplasm InvasivenessProliferating Cell Nuclear AntigenCarcinoma, Intraductal, NoninfiltratingMice, Inbred BALB CNasopharyngeal NeoplasmsAntigens, Viral, TumorAntibodies, Monoclonal, Murine-DerivedCarcinoma, Adenoid CysticChromosomes, Human, Pair 2RNA, MessengerReceptors, Antigen, T-CellBiopsyDoxorubicinCarcinoma, MedullaryHLA-DR AntigensBreast NeoplasmsNeoplasm TransplantationProtein-Tyrosine Kinases
Chimeric antigen receptorKinaseALCLTumorsSquamousMalignant lymphomasHodgkinCutaneous T-Cell LDIFFUSEBurkittCancersLeuk LymphomaLymph nodesAggressive lymphomasLeukemiaTissuesGeneProliferationHepatocellular carcinomaCancerApoptosisGastricMultiple myelomaTumor-associatedBasalEpithelial cellsBone marrowLymphoid cellsOvarianPeripheralMetastaticInhibitionLymphocytesDLBCLMonoclonal antibodiesAntitumorAutoimmuneExpressionClonalUncommonAntibodyDifferentiationIndolentGenesBreastProteinPrimaryAbnormalMalignanciesLesionsClinicalNeoplastic
Chimeric antigen receptor2
  • Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of antigenic epitopes capable of evoking the most potent CAR activation is an important objective in optimizing immune therapy. (nature.com)
  • Adoptive cellular therapy, especially chimeric antigen receptor (CAR) T cell therapy, has gained unprecedented success among hematologic tumors [ 11 ]. (hindawi.com)
Kinase12
  • ALK, i.e. anaplastic lymphoma kinase, is a protein product of the ALK gene located on chromosome 2. (wikipedia.org)
  • ALK is a serine/threonine-specific protein kinase that activities PI3K/AKT/mTOR, Ras-activated ERKs, Janus kinase-activated STAT proteins, and other cell signaling pathways as well as the expression of various genes by epigenetic mechanisms. (wikipedia.org)
  • GzB expression is also a hallmark of the non-Hodgkin lymphoma, anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL). (biomedcentral.com)
  • Anaplastic Lymphoma Kinase. (lab-ally.com)
  • ALK is one of the receptor tyrosine kinase (RTK) family of enzymes, which have significant roles in the proliferation and differentiation of cells. (lab-ally.com)
  • Over 80 cases of anaplastic lymphoma kinase-negative anaplastic large cell lymphoma have been reported in patients with silicone breast implants and have been accepted as a new clinical entity. (biomedcentral.com)
  • The ALK protein have a kinase domain in its intracellular domain, and its function is associated with the promotion of cell growth and inhibition of apoptosis. (nichireibiosciences.com)
  • 1) Shiota M., et al: Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3. (nichireibiosciences.com)
  • et al: Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. (nichireibiosciences.com)
  • 5) Sugawara E., et al: Identification of Anaplastic Lymphoma Kinase Fusions in Renal Cancer. (nichireibiosciences.com)
  • The need for an alternative to physical biopsies is no more apparent than in lung cancer given the high risks associated with lung biopsies, as well as the discovery of actionable driver mutations like the epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) for which targeted therapies now exist ( 3 - 5 ) together with identified resistance mutations to tyrosine kinase inhibitor therapy. (amegroups.org)
  • The anaplastic lymphoma kinase (ALK) gene encodes a receptor tyrosine kinase, and fusions involving this gene have been reported in a variety of mesenchymal neoplasms. (bvsalud.org)
ALCL17
  • Anaplastic large-cell lymphoma (ALCL) refers to a group of non-Hodgkin lymphomas in which aberrant T cells proliferate uncontrollably. (wikipedia.org)
  • Considered as a single entity, ALCL is the most common type of peripheral lymphoma and represents ~10% of all peripheral lymphomas in children. (wikipedia.org)
  • ALCL is defined based on microscopic histopathological examination of involved tissues which shows the presence of at least some ALCL-defining pleomorphic cells. (wikipedia.org)
  • ALK-positive and ALK-negative ALCL are aggressive systemic lymphomas. (wikipedia.org)
  • pcALCL and BIA-ALCL are far less aggressive lymphomas that tend to be localized to one or a very few sites. (wikipedia.org)
  • Its neoplastic cells may contain some gene translocations including, in very rare cases, ones with the ALK gene that are similar to those in ALK-positive ALCL. (wikipedia.org)
  • These tissues have lymphoma-like infiltrates that have variable numbers of ALCL "hallmark" cells, i.e. cells with kidney- or horseshoe-shaped nuclei that strongly express CD30 as detected by immunohistochemistry and an ALK fusion protein as detected by fluorescence in situ hybridization. (wikipedia.org)
  • Given the fact that ALK+ ALCL exhibits high levels of apoptosis and is typically responsive to conventional chemotherapy, we examined whether GzB expression might play a role in sensitizing ALK+ ALCL tumour cells to apoptosis. (biomedcentral.com)
  • ALK+ ALCL cell lines stably expressing GzB or non-targeting (control) shRNA were generated and apoptosis was examined by anti-PARP western blotting and terminal deoxynucleotidyl transferase dUTP nick end labelling. (biomedcentral.com)
  • In order to assess whether additional granzymes might be important in promoting cell death in ALK+ ALCL, we examined whether other human granzymes were expressed in ALK+ ALCL cell lines using reverse-transcriptase PCR and western blotting. (biomedcentral.com)
  • Expression of several GzB shRNAs in multiple ALK+ ALCL cell lines resulted in a significant decrease in GzB levels and activity. (biomedcentral.com)
  • While spontaneous apoptosis was similar in ALK+ ALCL cell lines expressing either GzB or control shRNA, GzB shRNA-expressing cells were less sensitive to staurosporine or doxorubicin-induced apoptosis as evidenced by reduced PARP cleavage and decreased DNA fragmentation. (biomedcentral.com)
  • Furthermore, we found that GzB is the only granzyme that is expressed at significant levels in ALK+ ALCL cell lines. (biomedcentral.com)
  • Our findings are the first to demonstrate that GzB expression sensitizes ALK+ ALCL cell lines to drug-induced apoptosis. (biomedcentral.com)
  • The ALK gene was identified in 1994 as a gene fused to the nucleophosmin (NPM) gene in anaplastic large-cell lymphoma (ALCL) with t(2;5)(p23;q35) translocation. (nichireibiosciences.com)
  • Ultimately, however, anaplastic large cell lymphoma (ALCL) was diagnosed. (cancernetwork.com)
  • At the time of TCL diagnosis, Anaplastic large-cell lymphoma (ALCL) was the most common TCL subtype within PWH. (cdc.gov)
Tumors15
  • A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
  • B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
  • As with all tumors, whether benign or malignant, identification of the cell or cell layer of origin is of the utmost importance. (medscape.com)
  • 1 The most frequent primary tumor types of anterior mediastinal masses are thymic tumors and lymphoma, with approximate proportions of 35% and 25% among mediastinal lesions, respectively. (allenpress.com)
  • MCPyV in tumor cell genomes, tumor-associated mutations search Ethics Board, Halifax, Nova Scotia, Canada, and in the large T-antigen (T-ag) gene, and large T-ag expres- by the Baylor College of Medicine Institutional Review sion in tumors suggest that MCPyV is not only associated Board, Houston. (cdc.gov)
  • Immunocytochemical analysis of cell lines derived from solid tumors. (mpg.de)
  • Here, we generate dromedary camel nanobodies targeting B7-H3 and demonstrate that CAR-T cells, based on the nanobodies recognizing the IgC but not IgV domain, had potent antitumour activity against large tumors in female mice. (nature.com)
  • However, the successful application of these emerging cell-based therapies in solid tumors remains limited. (nature.com)
  • however, they may cause on-target off-tumor toxicity because of minimal expression of tumor-associated antigens (TAAs) on normal tissues, particularly in the context of treating solid tumors. (biomedcentral.com)
  • A previous study showed that oxygen-sensitive multichain CAR-T cells are responsive to hypoxia [ 7 ], while a simple single-chain hypoxia-inducible CAR-T cells (HiCAR-T cells) could respond to hypoxia within solid tumors is elusive. (biomedcentral.com)
  • My research interests comprise cutaneous tumors with emphasis in lymphomas and melanoma. (mdanderson.org)
  • In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
  • Overview of Lymphoma Lymphomas are a heterogeneous group of tumors arising in the reticuloendothelial and lymphatic systems. (msdmanuals.com)
Squamous5
  • Histologically, the fully formed domelike lesion reveals a mass of proliferating squamous epithelial cells, which created the central core of keratin. (medscape.com)
  • KA lesions can easily be mistaken for squamous cell carcinoma (SCC). (medscape.com)
  • [ 7 ] In KAs, cells that stain positive with proliferating-cell nuclear antigen immunostaining are distributed only in the outer edges of the tumor, corresponding to the proliferating squamous epithelial cells. (medscape.com)
  • The antigen can also be detected in squamous cell carcinomas, even if the epithelium of origin (e.g. epidermis) itself is not reactive. (histoprime.com)
  • Pembrolizumab (Keytruda), a humanized monoclonal anti-PD-1 antibody, is the first anti-PD-1 antibody approved by the FDA for the treatment of patients with unresectable or metastatic melanoma, non-small-cell lung cancer (NSCLC), head and neck squamous cell carcinoma, cervical cancer, colorectal cancer, and gastric/gastroesophageal junction cancer [ 4 - 10 ]. (hindawi.com)
Malignant lymphomas3
  • A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. (lookformedical.com)
  • In this study, we investigated the presence of Merkel cell polyomavirus (MCPyV) was fi rst described MCPyV in benign lymph nodes and malignant lymphomas in 2008 ( 1 ) as a new human virus associated with in patients from Canada. (cdc.gov)
  • The area of research for our group is malignant lymphomas - all possible aspects, aiming for the improvement of the quality of life and survival of these patients. (lu.se)
Hodgkin10
  • A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
  • It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. (lookformedical.com)
  • An abbreviation for a chemotherapy combination used to treat Hodgkin lymphoma. (massivebio.com)
  • Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the spleen, the liver, and the gastrointestinal tract. (msdmanuals.com)
  • The major types are Hodgkin lymphoma Non-Hodgkin lymphoma See table Comparison of Hodgkin. (msdmanuals.com)
  • Hodgkin Lymphoma Hodgkin lymphoma is a localized or disseminated malignant proliferation of cells of the lymphoreticular system, primarily involving lymph node tissue, spleen, liver, and bone marrow. (msdmanuals.com)
  • Non-Hodgkin lymphoma is not one disease but rather a category of lymphocyte cancers with a number of subgroups largely divided into aggressive and indolent types. (msdmanuals.com)
  • Non-Hodgkin lymphoma is the 2nd most common cancer in HIV-infected patients Non-Hodgkin lymphoma AIDS-defining cancers in patients infected with HIV are Kaposi sarcoma Lymphoma, Burkitt (or equivalent term) Lymphoma, immunoblastic (or equivalent term) Lymphoma, primary, of central nervous system read more , and some AIDS patients present with lymphoma. (msdmanuals.com)
  • Indeed, patients with non-Hodgkin lymphoma should generally be screened for HIV and hepatitis viruses. (msdmanuals.com)
  • Also, patients with a first-degree relative with Hodgkin or non-Hodgkin lymphoma have an increased risk of non-Hodgkin lymphoma. (msdmanuals.com)
Cutaneous T-Cell L1
DIFFUSE4
  • The first-in-human testing of scFv-based B7-H3 CAR-T cells has shown antitumor response against anaplastic meningioma and childhood diffuse intrinsic pontine glioma without severe side effects 16 , 17 . (nature.com)
  • Abstract B38: FOXP1 truncated isoforms differentially regulate target genes in diffuse large B cell lymphoma. (growkudos.com)
  • Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) with concurrent BCL2 and IRF4 rearrangements are rare. (qxmd.com)
  • In our study 52, 64, 101, 500 and 246 PWH with histological confirmation of TCL, primary CNS, Burkitt's, diffuse large B-cell lymphoma (DLBCL) and Hodgkin's lymphoma (HL) respectively and 450 TCL without HIV were eligible for analysis. (cdc.gov)
Burkitt2
Cancers3
  • Cancers of both lymphoid and non-lymphoid origin also express GzB, and in some cases this expression has been linked to pathogenesis or sensitizing tumour cells to cell death. (biomedcentral.com)
  • Non-small cell lung cancer (NSCLC) is the most common type of lung cancer in pregnant women, accounting for approximately 85% of all gestational cancers [ 6 ]. (biomedcentral.com)
  • More than 95% of thyroid cancers are derived from thyroid follicular epithelial cells and are classified into differentiated thyroid cancer (DTC), including papillary and follicular thyroid cancer (PTC and FTC), poorly differentiated thyroid cancer (PDTC), and anaplastic thyroid cancer (ATC). (oncotarget.com)
Leuk Lymphoma1
Lymph nodes1
Aggressive lymphomas1
  • With few exceptions, stem cell transplantation is usually reserved for patients with aggressive lymphomas after incomplete remission or relapse. (msdmanuals.com)
Leukemia13
  • Involvement of the central nervous system or a leukemia-like circulation of malignant cells in the blood occurs only very rarely. (wikipedia.org)
  • In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
  • Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
  • B-Cell Acute Lymphoblastic Leukemia. (lab-ally.com)
  • Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)
  • Leukemia may affect red blood cells, white blood cells, and platelets. (massivebio.com)
  • Acute lymphocytic leukemia (ALL) is a type of cancer of the blood and bone marrow - the spongy tissue inside bones where blood cells are made. (massivebio.com)
  • The word "acute" in acute lymphocytic leukemia comes from the fact that the disease progresses rapidly and creates immature blood cells, rather than mature ones. (massivebio.com)
  • Leukemia and Lymphoma. (wustl.edu)
  • However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)
  • In this chapter, we will focus on IL-21's biological effects and signaling pathways as well as discuss the potential implications and applications of IL-21 in leukemia cells. (intechopen.com)
  • Moreover, it has been shown that the PD-1 ligand (PD-L1) is highly expressed in leukemia cells. (biomedcentral.com)
  • In addition, PD-1/PD-L1 interactions contribute to functional T-cell impairment, which fails to elicit minimal residual disease and may be related to leukemia relapse. (biomedcentral.com)
Tissues8
  • This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
  • These fi ndings suggest that in human lymphoid tissues, blood cells, and lymphomas the lymphoid system plays a role in MCPyV infection and ( 17 - 20 ). (cdc.gov)
  • This design, founded on the oxygen-dependent degradation domain (ODD), might be particularly useful for targeting common antigens shared between normal and neoplastic tissues. (biomedcentral.com)
  • Developing top down proteomics to maximize proteome and sequence coverage from cells and tissues. (chicagobiomedicalconsortium.org)
  • In normal tissues, very low expression of sialylated HEG1 is observed, but a few positive cases may be found in capillary endothelium or reactive mesothelial cells. (nichireibiosciences.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Ab-3 shows no reaction with a variety of normal tissues .CEA is not found in benign glands, stroma, or malignant prostatic cells. (samatashkhis.com)
  • Cells Tissues Organs. (cancercentrum.se)
Gene4
  • The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
  • Specific RNAi Mediated Gene Knockdown in Zebrafish Cell Lines. (mpg.de)
  • Recently, other ALK fusion genes with EML4 gene, KIF5B gene or KCL1 gene in non-small cell carcinoma of lung, SEC31A gene or SQSTM1 gene in ALK-positive large B-cell lymphoma and VCL gene in renal cell cancer have been also reported. (nichireibiosciences.com)
  • For example, microarray technology has been used to compare gene expression profiles between normal and diseased cells and this has led to dramatic advances in the understanding of cellular processes at the molecular level [ 1 ]. (biomedcentral.com)
Proliferation11
  • Activations of these signaling pathways and genes may stimulate cell growth, proliferation, survival, and/or other behaviors that promote malignancy. (wikipedia.org)
  • We are using this virus to study the initiating immortalizing process and switches between resting and proliferating phenotypes to better understand EBV protein - host cell interactions involved in tumorigenesis controlling the switch from cell arrest to proliferation and reprogramming of metabolism. (ki.se)
  • p21/WAF 1/Cip 1 expression in invasive ductal breast carcinoma: relationship to p53, proliferation rate, vimentin, cathepsin D and survival at 5 years. (mpg.de)
  • Prognostic significance of tumor cell proliferation rate as determined by the MIB-1 antibody in breast carcinoma: Its relationship with vimentin and p53 protein. (mpg.de)
  • Its roles include regulation of proliferation, promotion of immune system and activation of apoptosis in B cells. (intechopen.com)
  • In these cells, IL-21 does not promote proliferation but enhances apoptosis and chemotaxis. (intechopen.com)
  • Such immune dysfunction may be due to a disorder in thymic output function (in particular in young patients), which results in a lower level of naive T-cells in the peripheral blood available for an immune response to the proliferation and abnormal expression of the T cell receptor (TCR) repertoire. (biomedcentral.com)
  • Knockdown of KDM1B inhibits cell proliferation and induces apoptosis of pancreatic cancer cells. (cancerindex.org)
  • Knockdown of nuclear PATZ1 by siRNA in an immortalized normal follicular epithelial cell line (Nthy-ori 3-1) altered cellular morphology and significantly increased cell proliferation, migration, and invasion. (oncotarget.com)
  • When PATZ1 was silenced in differentiated thyroid cancer (DTC) cell lines (TPC-1 and FTC-133), proliferation, cellular motility, and expression of uPA and MMPs were significantly increased. (oncotarget.com)
  • Forced expression of exogenous PATZ1 decreased proliferation, cellular motility, and the expression of uPA and MMPs in ATC cell lines (ACT-1 and FRO). (oncotarget.com)
Hepatocellular carcinoma1
Cancer29
  • Merkel cell carcinoma (MCC), an uncommon but aggressive form of skin cancer. (cdc.gov)
  • Other pathologies such as hyperthyroidism refractory to medical treatment, large and / or symptomatic goiter and thyroid cancer are surgical treatment. (teknon.es)
  • The objective of the surgeon who should indicate thyroid surgery should be in cases of non-response to medical treatment, cases that present symptoms, are usually large goiters (dysphagia, airway obstruction, etc.) and thyroid cancer. (teknon.es)
  • We particularly study Epstein-Barr Virus (EBV)-infection, which can also be used as a model to study early steps in in vitro transformation, viral genetic switches, non-genetic variation and cancer cell metabolism. (ki.se)
  • It is associated with ten different forms of cancer in humans out of which some epithelial ones are very common in certain regions, in particular nasopharyngeal carcinoma (NPC) and gastric cancer (5-10 % thereof). (ki.se)
  • Furthermore, it is the 4th largest infectious cause of cancer in humans involved in approximately 200,000 new cases of cancer every year worldwide. (ki.se)
  • Prediction of improved survival in patients with pancreatic cancer via IL-21 enhanced detection of mesothelin epitope-reactive T-cell responses. (ki.se)
  • Cancer cells that proliferate quickly and unlike normal cells. (lab-ally.com)
  • This is a cancer that usually affects the skeletal cells in the trunk, arms, and legs. (lab-ally.com)
  • Anaplastic Thyroid Cancer. (lab-ally.com)
  • BCC is a type of skin cancer that creates lesions and uncontrolled growth in the basal cells of the epidermis. (lab-ally.com)
  • Ongoing research investigates mechanisms invoked by cancer cells to abrogate MHC-I expression and attenuate anti-tumour CD8 + cytotoxic T cell response. (portlandpress.com)
  • Cancer Cell. (chicagobiomedicalconsortium.org)
  • Polydopamine-enabled surface functionalization of gold nanorods for cancer cell-targeted imaging and photothermal therapy. (chicagobiomedicalconsortium.org)
  • a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (massivebio.com)
  • Roche is additionally innovating in fields of unmet need by developing new medicines for diseases in which there has been no major progress for decades, including bladder cancer (Tecentriq), multiple sclerosis (Ocrevus) and giant cell arteritis (Actemra/RoActemra). (pharmalive.com)
  • Techniques for analysis of single cell genomics, as well as protein expression on a single cell basis provide scientists with the capacity to understand cancer cell populations as a collection of individual cells, rather than as an average of all cells. (amegroups.org)
  • Invariably, the development of new mutations, changes in cancer cell populations, and other resistance mechanisms lead to therapeutic resistance. (amegroups.org)
  • The first report of a CTC came in 1869 from Thomas Ashworth, who described the presence of tumor-derived epithelial cells in the blood compartment of a patient with end stage metastatic cancer, and postulated that this circulation of cells may account for the presence of multiple tumor metastases throughout the body of the patient ( 6 ). (amegroups.org)
  • An early approach was to identify the presence of free nucleic acids released from cancer cells into the blood by cancer cell apoptosis and necrosis, as well as by active secretion ( 8 , 9 ). (amegroups.org)
  • She was diagnosed with non-small cell lung cancer (NSCLC) with bone metastasis and pneumocystis pneumonia (PCP). (biomedcentral.com)
  • When targeting cancer cells, both animal and plant proteins may be used in a formulation process to create self-assembled viruses and platforms that can successfully eradicate metastatic cancer cells. (benthamscience.com)
  • Immune checkpoint inhibitors (ICIs) are antibodies that target crucial signaling pathways, such as programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), to improve the activation of T cells and enhance the immune response to cancer cells. (hindawi.com)
  • In thyroid cancer cell lines, PATZ1 functioned as a tumor suppressor regardless of p53 status. (oncotarget.com)
  • Our study demonstrates that PATZ1 knockdown enhances malignant phenotype both in thyroid follicular epithelial cells and thyroid cancer cells, suggesting that PATZ1 functions as a tumor suppressor in thyroid follicular epithelial cells and is involved in the dedifferentiation of thyroid cancer. (oncotarget.com)
  • However, for cancer prevention, the elimination or inactivation of mutated cells is debated on whether this is a prime function of the immune system. (studylib.net)
  • However, tumor cells can evade host's immune surveillance using a number of protective mechanisms, including downregulation of MHC-I molecules, secretion of anti-inflammatory cytokines, in other words, TGF-β and IL-10, secretion of immunosuppressive factors, VEGF, upregulation of PD-L1 and downregulation of co-stimulatory molecules thereby preventing activation of T cells, resulting in cancer invasion. (studylib.net)
  • In fact, cancer cells, in particular renal and breast cells express high levels of PD-L1 leading to poor patient survival [15,16]. (studylib.net)
  • Furthermore, upregulation of PD-L1 by cancer cells results in cancer invasion and correlates with poor prognostic outcomes in breast, gastric, meningioma, non-small-cell lung carcinoma (NSCLC) and soft-tissue sarcoma patients [9,26-29]. (studylib.net)
Apoptosis8
  • Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
  • The serine protease Granzyme B (GzB) is primarily expressed by cytotoxic T lymphocytes and natural killer cells, and functions in allowing these cells to induce apoptosis in virally-infected or transformed cells. (biomedcentral.com)
  • For example, GzB expression in urothelial carcinoma was implicated in promoting tumour cell invasion, whereas its expression in nasal-type NK/T lymphomas was found to correlate with increased apoptosis. (biomedcentral.com)
  • Bennett J, Baumgarten SC, Stocco C. GATA4 and GATA6 Silencing in Ovarian Granulosa Cells Affects Levels of mRNAs Involved in Steroidogenesis, Extracellular Structure Organization, IGF-I Activity, and Apoptosis. (chicagobiomedicalconsortium.org)
  • Murine PD-1 mRNA expression has been shown to be correlated with activation-induced apoptosis in a mouse T-cell hybridoma cell line and murine thymocytes [ 13 ]. (biomedcentral.com)
  • The antibody is useful for studying the phenomenon of cell death by apoptosis as a pathogenic mechanism of numerous pathologies: nerve damage, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, AIDS and malignancies. (samatashkhis.com)
  • In contrary, tumor cells have evolved immune escape mechanisms whereby overexpression of PD-L1 induces anergy and/or apoptosis of PD-1 positive T cells by interfering with T cell receptor signal transduction. (studylib.net)
  • The binding of T cells expressing PD-1 and tumor cells expressing PD-L1 initiates an array of inhibitory signals resulting in reduced function and/or apoptosis of T cells [8,11] providing a mechanism for tumor cell evasion of host's immune surveillance [12-14]. (studylib.net)
Gastric1
  • Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). (samatashkhis.com)
Multiple myeloma1
  • Carfilzomib, lenalidomide, and dexamethasone or lenalidomide alone as maintenance therapy after autologous stem-cell transplantation in patients with multiple myeloma (ATLAS): interim analysis of a randomised, open-label, phase 3 trial. (cuanschutz.edu)
Tumor-associated1
  • Consequently, it was shown by others that tumor cells also expressed MHC-I and presented short tumor-associated peptides to immune cells [6]. (studylib.net)
Basal4
  • In the oral mucosa, melanocytes are observed in a ratio of about 1 melanocyte to 10 basal cells. (medscape.com)
  • Microscopically, this melanin deposit is mainly in the basal cell layers. (medscape.com)
  • Melanin may also be seen in the connective tissue near the basal cell layer, as shown below. (medscape.com)
  • Basal Cell Carcinoma. (lab-ally.com)
Epithelial cells1
  • The E049 antibody reacts with a variety of human epithelial cells. (histoprime.com)
Bone marrow7
  • Tumor cells are found in the bone marrow in up to 40% of the cases when immunohistochemical analysis is performed. (wikipedia.org)
  • Anaplastic Anemia is an uncommon disease resulting in deficiencies of blood cell production by bone marrow. (lab-ally.com)
  • Too many immature white blood cells are present in the blood and bone marrow. (lab-ally.com)
  • This is a form of AML in which excess amounts of promyelocytes (immature white blood cells) are found in bone marrow. (lab-ally.com)
  • Similarly, only a trephine biopsy shows the architecture of the bone marrow and permits the detection of an abnormal distribution of cells, bone marrow granulomas, and focal lymphoid infiltrates. (bmj.com)
  • Most lymphomas are nodal with variable involvement of the bone marrow and peripheral blood. (msdmanuals.com)
  • CONCLUSIONS: This study represents the largest analysis of RMS metastatic to bone marrow, defining the poor prognostic outcome for these patients. (bvsalud.org)
Lymphoid cells3
  • Lymphoid cells concerned with humoral immunity. (lookformedical.com)
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
Ovarian2
  • Ovarian High-grade Serous Carcinoma with Transitional-like (SET) Morphology: A Homologous Recombination-deficient Tumor. (qxmd.com)
  • Thirteen years ago, we pointed out that ovarian transitional cell carcinomas (TCCs) and conventional high-grade serous carcinomas (HGSC) had similar genetic alterations and clinical behavior. (qxmd.com)
Peripheral2
  • Moreover, increasing data have shown that peripheral T-cell tolerance is an essential property of the specific immune response to tumor cells. (biomedcentral.com)
  • [email protected] ‡ Authors contributed equally Aim: Expression of PD-1 on T/B cells regulates peripheral tolerance and autoimmunity. (studylib.net)
Metastatic1
  • Sozzi G, Bertoglio MG, Pilotti S, Rilke F, buy betagan eye drops online usa Pierotti MA, Della G, Porta Cytogenetic studies in main and metastatic neuroboundaryocrine Merkel chamber carcinoma. (upb.ro)
Inhibition2
  • RNAi of FACE1 protease results in growth inhibition of human cells expressing lamin A: implications for Hutchinson-Gilford progeria syndrome. (mpg.de)
  • The most potent nanobody-based CAR-T cells show inhibition of large tumor xenografts in mice with rigorous T-cell signaling and significant T-cell infiltration into the tumor. (nature.com)
Lymphocytes8
  • They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
  • Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (lookformedical.com)
  • A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. (lookformedical.com)
  • A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
  • Granzyme B (GzB) is a serine protease found in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. (biomedcentral.com)
  • MHC-I and MHC-II proteins are key components of the antigen presentation machinery responsible for neoantigen presentation to CD8 + and CD4 + T lymphocytes, respectively. (portlandpress.com)
  • the remainder arise from T lymphocytes or natural killer cells. (msdmanuals.com)
  • BOB.1 from "B cell binding Octamer protein 1 "is a specific coactivator of transcription factors Oct-1 and Oct-2 of B lymphocytes. (samatashkhis.com)
DLBCL1
  • It is unclear whether such cases should be classified as large B- cell lymphoma with IRF4 rearrangement or FL/DLBCL-not otherwise specified. (qxmd.com)
Monoclonal antibodies1
  • New monoclonal antibodies recognizing phosphorylated proteins in mitotic cells. (mpg.de)
Antitumor2
  • HiCAR-T cells showed enhanced cytotoxicity against tumor cells under hypoxia compared to normoxia in vitro and antitumor efficacy comparable to that of conventional CAR-T cells in vivo. (biomedcentral.com)
  • Adoptive cellular therapy transmits the sensitized T cells to patients with low cellular immune function, which helps patients obtain antitumor immunity. (hindawi.com)
Autoimmune2
  • A histological examination of the capsule tissue showed an extensive lymphohistiocytic/giant cell foreign body reaction suggestive of autoimmune/inflammatory syndrome induced by adjuvants. (biomedcentral.com)
  • The genetic background of our patient with silicone breast implants might have predisposed her to three rare and difficult to diagnose syndromes/diseases: macrophage activation syndrome/hemophagocytic lymphohistiocytosis, autoimmune/inflammatory syndrome induced by adjuvants, and intravascular large B-cell lymphoma. (biomedcentral.com)
Expression10
  • This suggests that GzB expression may be a factor contributing to the favourable response of this lymphoma to treatment. (biomedcentral.com)
  • Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
  • This review provides a comprehensive overview of physiologically conserved or novel mechanisms utilised by tumour cells to reduce MHC-I or MHC-II expression. (portlandpress.com)
  • In melanoma, i have focused in acral lentiginous melanoma for which we described KIT mutation and protein expression status in a large series of cases and described TERT amplification in progression to metastasis. (mdanderson.org)
  • Thereby, mammary carcinomas show the strongest expression. (histoprime.com)
  • In addition, the low cytotoxicity of T-cells may be related to the high expression level of inhibitory molecules including programmed death-1 (PD-1), LAG-3 and NKG2A in CD8+T cells [ 11 ]. (biomedcentral.com)
  • Various statistical algorithms are available for probe-cell level normalization and expression-value summary. (biomedcentral.com)
  • Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. (cancerindex.org)
  • In addition, the expression of urokinase-type plasminogen activator (uPA), matrix metalloproteinase (MMP) 2, MMP9, and MMP11 was increased by PATZ1 knockdown in Nthy-ori 3-1 cells. (oncotarget.com)
  • Conclusion: For immunotherapy/vaccines to be successful, the expression of PD-L1/PD-1 on immune cells should be considered, and the combination of checkpoint inhibitors and vaccines may pave the way for successful outcomes to disease. (studylib.net)
Clonal1
  • A type of clonal malignancy characterized by excess accumulation of lymphoblasts that phenotypically resemble the early stages of normal B-cell differentiation. (lab-ally.com)
Uncommon1
  • In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)
Antibody4
  • The monoclonal antibody was obtained by immunizing mice with human milk fat globulin and fusing the spleen cells with mouse myeloma cells. (histoprime.com)
  • The antibody also detects some lymphoid neoplasms, especially CD30-positive large cell lymphomas. (histoprime.com)
  • A new monoclonal antibody to epithelial membrane antigen (EMA) - E29. (histoprime.com)
  • This antibody has a high affinity for CEA and shows no detectable reactivity to nonspecific cross-reacting antigen (NCA), biliary glycoprotein (BGP) and human polymorphonuclear leucocytes. (samatashkhis.com)
Differentiation1
  • Based on their functional outcome, co-signaling molecules can be divided as co-stimulators and co-inhibitors, which positively and negatively control the priming, growth, differentiation and functional maturation of a T-cell response. (biomedcentral.com)
Indolent1
  • Two courses of four weekly infusions of rituximab with or without interferon-2a: final results from a randomized phase III study in symptomatic indolent B-cell lymphomas. (cancercentrum.se)
Genes1
  • Single-cell transcriptome RNA sequencing coupled with functional T-cell proteomics analysis uncovers the top-upregulated genes that might be critical for the persistence of polyfunctional CAR-T cells in mice. (nature.com)
Breast2
  • To the best of our knowledge, an intravascular large B-cell lymphoma associated with a silicone breast implant has not been reported previously. (biomedcentral.com)
  • Human leukocyte antigen testing in all women who undergo silicon breast implantation could in the future enable us to better evaluate the risk of potential side effects. (biomedcentral.com)
Protein3
  • These "hallmark" cells have abnormal kidney-shaped or horseshoe-shaped nuclei, prominent Golgi, and express the CD30 tumor marker protein on their surface membranes. (wikipedia.org)
  • Most patients, including up to 90% of young children and adolescents, have circulating autoantibodies directed against the ALK fusion protein expressed by their tumor cells. (wikipedia.org)
  • Effects of expressing lamin A mutant protein causing Emery-Dreifuss muscular dystrophy and familial partial lipodystrophy in HeLa cells. (mpg.de)
Primary2
  • Primary cutaneous CD30+ anaplastic large cell lymphomas mimicking KAs have been reported. (medscape.com)
  • These data encouraged us to test whether HiCAR could function in primary T cells. (biomedcentral.com)
Abnormal1
  • Interleukin-21 (IL-21) is produced by activated T cells and it plays many diverse roles by regulating the functions of normal and abnormal cells. (intechopen.com)
Malignancies2
  • The role of PD-1 and PD-L1 in T-cell immune suppression and the potential for immunotherapy via blocking PD-1 and PD-L1 in hematological malignancies are also reviewed. (biomedcentral.com)
  • Related studies have reported that the complete response rate of CD19-CAR-T cells in hematological malignancies is approximately 88-90% [ 13 , 14 ]. (hindawi.com)
Lesions2
  • Lesions with larger particles might be visible on dental radiographs. (medscape.com)
  • Many carcinomas are solid, while several cystic or mixed lesions are benign. (teknon.es)
Clinical2
  • Overall, our study demonstrates the potential of the HiCAR for improving the safety of CAR-T cells to promote the clinical application of CAR-T immunotherapy. (biomedcentral.com)
  • 2. Clinical epidemiology - using data from the Swedish Lymphoma Registry to provide clinically useful real world data on treatment and prognosis, in many cases in collaboration with Nordic colleagues. (lu.se)
Neoplastic1