• Following consumption of 1.2 litres of cows' milk by normal human adults there was a rapid fall in the proportion of peripheral blood lymphocytes bearing receptors for the reacted Fc of IgG (Fcγ-receptors). (karger.com)
  • In man it was found that Fcγ-receptors could only be re-expressed following incubation of post-milk lymphocytes in normal human serum. (karger.com)
  • It is proposed that rapid in vivo modulation of lymphocyte Fcγ-receptors occurs following oral antigen (cows' milk) challenge probably mediated by soluble food antigen-antibody complexes. (karger.com)
  • Triggering of the T3-Ti receptor complex induces a rapid increase in free cytoplasmic Ca2+ and gives rise to specific antigen-induced proliferation through an autocrine pathway involving endogenous interleukin-2 production, release and subsequent binding to interleukin-2 receptors. (ox.ac.uk)
  • It interacts with SIALIC ACIDS and mediates signaling from B-CELL ANTIGEN RECEPTORS. (bvsalud.org)
  • Lymphocyte antigen 96, also known as "Myeloid Differentiation factor 2 (MD-2)," is a protein that in humans is encoded by the LY96 gene. (wikipedia.org)
  • Differentiation of lymphocytes in mouse bone marrow. (wikidata.org)
  • B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. (cusabio.com)
  • Antigen-initiated b lymphocyte differentiation. (jax.org)
  • Description: Quantitativesandwich ELISA kit for measuring Mouse Lymphocyte antigen 96 (LY96) in samples from serum, plasma, tissue homogenates. (hudsen.org)
  • MHC class I proteins are expressed on the surface of all nucleated host cell membranes and present peptide antigen to cytotoxic T-lymphocytes. (pharmacy180.com)
  • RANTES activates antigen-specific cytotoxic T lymphocytes in a mitogen-like manner through cell surface aggregation. (ox.ac.uk)
  • RANTES (regulated upon activation, normal T cell expressed and secreted) is released by cytotoxic T lymphocytes (CTL), and is a potent chemoattractant factor for monocytes and T cells, also known for its ability to suppress HIV infection. (ox.ac.uk)
  • the TB2 tube contains an additional set of peptides targeted to the induction of CMI responses from CD8+ cytotoxic T lymphocytes. (cdc.gov)
  • antigen-specific-cd4+helper-t-lymphocyte-activation. (immunopaedia.org.za)
  • Mechanism of activation of the bone marrow-derived lymphocyte. (wikidata.org)
  • On the other hand, a P815 tumour rejection antigen appears to arise through the activation of a silent gene, and it may turn out that this is the rule for most tumour rejection antigens. (ox.ac.uk)
  • If, on the other hand, production of tumour rejection antigens results from the activation of a normal gene, then there is a good probability that the same gene may be activated in many different tumours, being perhaps preferentially shared by tumours of the same histological type. (ox.ac.uk)
  • Accumulating data indicate that BM of RA patients participates in the pathogenesis of this disease as a site of proinflammatory cytokines overproduction and lymphocytes activation. (nih.gov)
  • Influence of antigen structure on the activation and induction of unresponsiveness in cloned human T lymphocytes. (ox.ac.uk)
  • Using cloned human helper T lymphocytes reactive with a 24 amino acid peptide (p20) of the carboxyl terminal of the HA-1 molecule of influenza haemagglutinin we have investigated the influence of antigen structure on the activation and in the induction of antigen specific unresponsiveness of T cells. (ox.ac.uk)
  • In order to understand further the mechanism of RANTES-induced activation, the effects of both aggregated and disaggregated RANTES on antigen-specific CD8(+) clones were studied in comparison with the effects of specific antigens and in the presence of specific inhibitors of RANTES-mediated activation. (ox.ac.uk)
  • T cell activation subsequent stimulation with antigen-activated anti-CD3/Compact disc28 or APCs?antibodies, mainly because demonstrated by decreased IL-2 proliferation and secretion. (nsdfu.org)
  • Results EF publicity suppresses activation and proliferation of activated T cells Human being lymphocytes have already been demonstrated previously to migrate towards the cathode upon contact with EFs3,4. (nsdfu.org)
  • CD2 is a T lymphocyte glycoprotein that functions in adhesion of T lymphocytes and also as a putative receptor for activation signals. (ox.ac.uk)
  • The effect of antilymphocyte antibody on lymphocyte transformation. (eurekamag.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Lymphocyte Antigen 96 (LY96) in tissue homogenates, cell lysates and other biological fluids. (hudsen.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Lymphocyte Antigen 96 (LY96) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (hudsen.org)
  • A receptor for antibody on B lymphocytes. (wikidata.org)
  • Relationship between antigen and antibody-induced suppression of immunity. (wikidata.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Lymphocyte Function Associated Antigen 3 (LFA3) in serum, plasma, cell lysatesand other biological fluids. (envite.org)
  • Notably, vaccination with DREP-GP and DREP-VP40, which produces both GP and VP40 antigens, induced a significantly higher level of anti-GP IgG2a antibody and increased IFN-γ secreting CD8 + T-cell responses relative to vaccination with DREP-GP or DREP-VP40 vector alone. (frontiersin.org)
  • On the other hand, antigen mostly degraded but still capable of precipitating with antibody was separated bound to the non-histone proteins of B-cells. (elsevierpure.com)
  • Alemtuzumab is a recombinant monoclonal antibody against CD52 (lymphocyte antigen). (medscape.com)
  • Description: A sandwich ELISA kit for detection of Lymphocyte Function Associated Antigen 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (envite.org)
  • Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion. (ox.ac.uk)
  • LY6G5C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. (nih.gov)
  • It is our hope that other genes coding for mouse and human tumour rejection antigens will soon be identified, so that it will become clear whether the activational mechanism is the rule or the exception. (ox.ac.uk)
  • B-lymphocytes also serve the function of an APC because they interact with protein antigen through high-affinity surface IgM molecules. (pharmacy180.com)
  • Subsequently, they internalize the protein antigen for processing to generate peptides that will be presented by MHC II molecules expressed on the B-lymphocyte cell surface. (pharmacy180.com)
  • Immunological paralysis induced by brief exposure of cells to protein antigens. (wikidata.org)
  • Glycoprotein (GP) is the major protective antigen of EBOV, and can generate virus-like particles (VLPs) by co-expression with matrix protein (VP40). (frontiersin.org)
  • The TAP1 and TAP2 proteins attach (bind) together to form a protein complex called transporter associated with antigen processing (TAP) complex. (medlineplus.gov)
  • A vaccination strategy designed to enhance the immunogenicity of self-antigens that are overexpressed in tumor cells is to identify and slightly modify immunodominant epitopes that elicit T-cell responses. (aacrjournals.org)
  • Epitopes for T-lymphocytes comprise exclusively linear peptide sequences. (pharmacy180.com)
  • Recent studies using cloned antigen-specific T lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to identification of the human T cell antigen receptor as a surface complex comprised of a clonotypic 90 kDa Ti heterodimer and the invariant 20 and 25 kDa T3 molecules. (ox.ac.uk)
  • These studies suggest that RANTES acted more like a mitogen than an antigen-independent activator. (ox.ac.uk)
  • The QFT Gold Plus system uses specialized blood collection tubes, which are used to collect whole blood via venipuncture, which include a Nil control tube, two TB Antigen tubes and a Mitogen tube (positive control). (cdc.gov)
  • Overexpressed tumor-self antigens represent the largest group of candidate vaccine targets. (nih.gov)
  • This review considers this subset of self antigens by highlighting vaccine efforts for some of the better known members and focusing on TPD52, a new promising vaccine target. (nih.gov)
  • This procedure involved the addition of PELs from immune donors to monolayers of antigen-pulsed adherent peritoneal exudate cells from nonprimed syngeneic donors. (rupress.org)
  • These selected cells were largely T lymphocytes and could be maintained in culture for 2-5 wk in an antigen-responsive state and, in 20-30% of cases, for 8-10 wk in an antigen-independent state. (rupress.org)
  • T-lymphocytes are unable to respond to carbohydrate, lipid or nucleic acid material and they only respond to peptide antigen when it is presented to the T-lymphocyte by surface proteins on the plasma membrane of host cells. (pharmacy180.com)
  • As such, all cells of the body must possess MHC I molecules to afford antigen presentation to cytotoxic T-cells. (pharmacy180.com)
  • hence the use of the terms CD8+ lymphocytes to refer to cytotoxic T-cells and CD4+ lymphocytes to refer to helper T-cells. (pharmacy180.com)
  • on cells, including infection-fighting white blood cells (lymphocytes), which is where the condition got its name. (medlineplus.gov)
  • Antigen-presenting cells (APCs) in screening bioassays for new molecules, including mAbs, interfering with immune checkpoints . (invivogen.com)
  • Purified LFA-3 inhibited rosetting of human and sheep erythrocytes with CD2+ T lymphoma cells and T lymphocytes, and mediated aggregation of a CD2+ T lymphoma cell line. (ox.ac.uk)
  • Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells. (bepress.com)
  • Analyses of CD8+ TIL show increases in tumor-antigen reactive, proliferating CD103+ CD39+ cells in 25% of patients with evaluable tumor tissue (N = 4/16), all of whom remain disease-free. (bepress.com)
  • cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)
  • B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)
  • Decreased antigen presentation contributes to the ability of cancer cells to evade the immune system. (lu.se)
  • We used the minimal gene regulatory network of type 1 conventional dendritic cells (cDC1) to reprogram cancer cells into professional antigen-presenting cells (tumor-APCs). (lu.se)
  • Reprogramming restored the expression of antigen presentation complexes and costimulatory molecules on the surfaces of tumor cells, allowing the. (lu.se)
  • Human primary tumor cells could also be reprogrammed to increase their capability to present antigen and to activate patient-specific tumor-infiltrating lymphocytes. (lu.se)
  • Our approach serves as a platform for the development of immunotherapies that endow cancer cells with the capability to process and present endogenous tumor antigens. (lu.se)
  • Reprogramming cancer cells to antigen-presenting cells. (lu.se)
  • Lymphocyte immune globulin inhibits the cell-mediated immune response by altering T-cell function or by eliminating antigen-reactive cells. (medscape.com)
  • Single amino acid substitutions were introduced to the CAP1 peptide (YLSGANLNL), an immunogenic HLA-A2 + -binding peptide derived from human carcinoembryonic antigen (CEA). (aacrjournals.org)
  • Description: A sandwich ELISA kit for detection of Lymphocyte Antigen 96 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (hudsen.org)
  • Human lymphocytes were disrupted by N 2 cavitation, the nuclei isolated by differential centrifugation, the chromatin purified, and the DNA separated from chromatin proteins by chromatography on Bio-Gel A 5M in the presence of 4 M guanidine-HCl. (elsevierpure.com)
  • Rubinstein, A , Gatien, JG & Merler, E 1976, ' Fractionation of the non-histone proteins of antigen-reactive human lymphocytes: Criteria for the specificity of antigen uptake ', Immunochemistry , vol. 13, no. 1, pp. 59-65. (elsevierpure.com)
  • Human being PBMCs lymphocytes were turned on by PPD recall antigen (5?g/ml) and LPS (1?g/ml), with (EF) or without? (nsdfu.org)
  • The ontogeny, structure and function of the human T lymphocyte receptor for antigen and major histocompatibility complex. (ox.ac.uk)
  • Approximately 30,000-40,000 Ti and T3 molecules exist on the surface of human T lymphocytes. (ox.ac.uk)
  • In the presence of active S. equina infection, antigens from the adult and microfilaraemic stages showed the highest degree of cross-reaction with human sera. (who.int)
  • In addition to acquiring improved antigen presentation, tumor-APCs had impaired tumorigenicity in vitro and in vivo. (lu.se)
  • T-lymphocytes are unable to respond to carbohydrate, lipid or nucleic acid material and they only respond to peptide antigen. (pharmacy180.com)
  • This process of MHC presentation of peptide and interaction with T-lymphocyte receptor is shown in Figure 9.8. (pharmacy180.com)
  • A foreign peptide presented by a MHC molecule will be recognized by a TCR expressed on the surface of an appropriate T-lymphocyte. (pharmacy180.com)
  • The QuantiFERON®-TB Gold Plus assay tests for Cell Mediated Immune (CMI) responses to peptide antigens that simulate mycobacterial proteins. (cdc.gov)
  • Both tubes contain peptide antigens from the MTB-complex-associated antigens, ESAT-6 and CFP-10. (cdc.gov)
  • Following the incubation period, plasma is harvested and the amount of IFN-γ that was produced in response to the peptide antigens is measured by ELISA. (cdc.gov)
  • In addition, antigen-driven T cell proliferation was measured to study the effect of the clinical status and / or infection status on the host responsiveness in lymphatic filariasis. (egyptianjournal.xyz)
  • Individuals positive for CAg had significantly lower lymphocyte proliferation responses to parasite antigen than did CAg-negative people. (egyptianjournal.xyz)
  • The term autoimmune inner ear disease (AIED) implies a direct attack of the immune system upon an endogenous inner ear antigen. (medscape.com)
  • and Ly-m10, chromosome 19) and a fourth xenotropic proviral locus mapped near a gene on chromosome 4 that has a major influence on xenotropic virus cell surface antigen levels. (houstonmethodist.org)
  • Therefore T-cell antigen recognition is not determined by side chains alone. (ox.ac.uk)
  • The results presented suggest that structure of extrinsic antigen influences T-cell antigen recognition. (ox.ac.uk)
  • Such a distinct cellular distribution of MHC proteins and restriction in presentation to discrete T-lymphocyte sub-populations may be remembered by considering the different T-lymphocyte functions. (pharmacy180.com)
  • Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K a" by Linlin Luo, Peter McGarvey et al. (gwu.edu)
  • Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome. (gwu.edu)
  • The QFT-Plus has two distinct TB antigen tubes: TB Antigen Tube 1 (TB1) and TB Antigen Tube 2 (TB2). (cdc.gov)
  • Cross-reaction was found between S. equina antigens and antibodies in the sera of Wuchereria bancrofti -infected patients, with the highest levels observed between sera of chronic infected patients and Setaria spp. (who.int)
  • Antigens are any substances that the immune system can recognize and that can thus stimulate an immune response. (msdmanuals.com)
  • Polymorphism of lymphocyte antigens-encoding loci in wild mice. (psu.edu)
  • Dive into the research topics of 'Polymorphism of lymphocyte antigens-encoding loci in wild mice. (psu.edu)
  • These studies indicate that xenotropic proviral loci are located on many different mouse chromosomes and may be useful markers for molecularly cloning and characterizing regions of the mouse genome important in lymphocyte development. (houstonmethodist.org)
  • Non-histone proteins were separated from the nuclei of lymphocytes for the purpose of testing if antigen, following antigen uptake, could be localized within this fraction. (elsevierpure.com)
  • The T-lymphocyte undertakes this MHC surveillance through the possession of accessory molecules. (pharmacy180.com)
  • This would probably not result in the expression of the same antigen in all these tumours, because the patients would differ in their presenting molecules, which are determined by their HLA haplotype. (ox.ac.uk)
  • Antigens may also exist on their own-for example, as food molecules or pollen. (msdmanuals.com)
  • Kinetics and t lymphocyte dependence of the primary and secondary in vitro immune responses to the hapten 4-hydroxy-3-iodo-5-nitrophenylacetic acid presented on the carrier polymerised bacterial flagellin. (jax.org)
  • Cytotoxic T-lymphocyte-associated antigen (CTLA-4) is normally a naturally occurring inhibitor of T-cell costimulation. (sciencepop.org)
  • Beyond antigen presentation, the interaction between MHC molecule and T-lymphocyte also serves to identify that the T-lymphocyte and host cell membrane arise from the same embryonic tissue. (pharmacy180.com)
  • Definition of a new t lymphocyte cell surface antigen ly 10.2. (core.ac.uk)
  • Using our EF-cell migration experimental process and EF advantages of 50 and 150?mV/mm, just like those within wounded pores and skin9,14 or airway epithelia8, we confirmed the responsiveness of T lymphocytes for an applied EF and therefore their striking preferential cathodal migration (Fig.?1a and Supplementary Video?1). (nsdfu.org)
  • Stem cell antigen-1 (Sca-1) is used to isolate and characterize tumor initiating cell populations from tumors of various murine models [1]. (gwu.edu)
  • A lectin and cell adhesion molecule found in B-LYMPHOCYTES. (bvsalud.org)
  • ELISA et transfert Western afin d'étudier la réaction croisée avec des sérums humains en provenance de zones endémiques pour la filariose de Bancroft. (who.int)
  • Plausible candidates for the mutational mechanism are the "tumour specific transplantation antigens" observed on methylcholanthrene induced tumours and tumours induced by ultraviolet light. (ox.ac.uk)
  • In vitro selection and extended culture of antigen-specific T lymphocytes. (rupress.org)
  • Our study indicates that co-expression of GP and VP40 antigens based on the SFV replicon vector generates EBOV VLPs in vitro , and vaccination with recombinant DREP vectors containing GP and VP40 antigens induces Ebola antigen-specific humoral and cellular immune responses in mice. (frontiersin.org)
  • The CD4+ T-lymphocyte is the primary target for HIV infection because of the affinity of the virus for the CD4 surface marker (3). (cdc.gov)
  • crude female worm surface antigen (CFSWA). (who.int)
  • During the initial or prepatent period of tions critical to the success of lymphatic infection, large amount of soluble filariae occurs shortly after 3rdstage filarial antigens are excreted and infective larvae are deposited on the secreted by developing parasites, skin during blood feeding by the especially during the molting process. (egyptianjournal.xyz)
  • Eggensperger S, Tampe R. The transporter associated with antigen processing: a key player in adaptive immunity. (medlineplus.gov)
  • Comparison of tumor biopsies before and after treatment reveals an increase of activated, conventional CD4+ tumor-infiltrating lymphocytes (TIL) in most patients and higher clonality by TCRβ sequencing. (bepress.com)
  • A population from a W. bancrofti - endemic area was evaluated by use of microfilaria(Mf) and adult worm circulating antigen(CAg) enzyme linked immunosorbent assay to demonstrate the relation of these two parameters to age , gender and the clinical status (symptomatic or asymptomatic) of the examined individuals. (egyptianjournal.xyz)
  • The CD4+ T-lymphocyte coordinates a number of important immunologic functions, and a loss of these functions results in progressive impairment of the immune response. (cdc.gov)
  • If antigens are perceived as dangerous (for example, if they can cause disease), they can stimulate an immune response in the body. (msdmanuals.com)