• Scopolamine has been used in beverages as "knockout drops," and several cases of anticholinergic syndrome have been reported following Chinese herbal tea consumption. (medscape.com)
  • Muscarinic antagonists such as atropine and scopolamine. (wikipedia.org)
  • Treatment to reverse anticholinergic effects (e.g., delirium, prolonged somnolence) produced by atropine and/or scopolamine preanesthetic medications. (drugs.com)
  • To reverse anticholinergic effects of atropine or scopolamine preanesthetic medications, administer a dose twice that of the anticholinergic drug, on a weight basis. (drugs.com)
  • belladonna alkaloids (made up of the drugs hyoscyamine , atropine, and scopolamine) and phenobarbital . (webmd.com)
  • The humans may have had out-of-body experiences or thought they were growing fur or feathers as a result of consuming the anticholinergic substances atropine or scopolamine. (discovermagazine.com)
  • Today, psychedelic users often avoid deliriants such as atropine and scopolamine because of the unpredictable, nightmarish experiences they can cause at large doses, not to mention intense anxiety and dysphoria. (discovermagazine.com)
  • At sufficient doses, both atropine and scopolamine can kill the user, but they retain medical uses, nonetheless. (discovermagazine.com)
  • Doctors use atropine to reduce saliva during surgery, and to accelerate the heart rate when needed, and scopolamine protects against post-surgery nausea and vomiting. (discovermagazine.com)
  • Atropa belladonna is a highly poisonous plant which contains variety of active alkaloids such as atropine, scopolamine and many others. (ijpsonline.com)
  • Aclidinium bromide, the active component of TUDORZA PRESSAIR is an anticholinergic with specificity for muscarinic receptors. (rxlist.com)
  • Atropine acts as a competitive, reversible antagonist of muscarinic receptors: an anticholinergic drug. (statpearls.com)
  • Anticholinergic syndrome commonly follows the ingestion of a wide variety of prescription and over-the-counter medications. (medscape.com)
  • Medications: Anticholinergics and medications with anticholinergic properties, alpha-adrenergic agonists, opiates, nonsteroidal anti-inflammatories (NSAIDs), calcium-channel blockers and beta-adrenergic agonists, may increase the risk. (wikipedia.org)
  • Tudorza Pressair may interact with anticholinergic medications. (rxlist.com)
  • Table II lists common medications with significant anticholinergic properties and potential adverse consequences, but is not all-inclusive. (wellnessresources.com)
  • Any of the following signs and symptoms may be caused by any of the medications in the lists below, alone or in combination, as well as by other medications not listed here that have anticholinergic properties. (wellnessresources.com)
  • However, in patients with severe bradycardia or those with the possibility of progression to higher-degree AV block, medications (eg, atropine, isoproterenol) can be used in anticipation of insertion of a cardiac pacemaker. (medscape.com)
  • Patients presenting with anticholinergic toxicity should be transported to the nearest emergency facility with advanced life support (ALS) capabilities. (medscape.com)
  • 1 hour), clinically significant ingestions that are anticipated to result in moderate-to-severe anticholinergic toxicity, single-dose activated charcoal may be administered to minimize absorption of the ingested medication. (medscape.com)
  • The antidote for anticholinergic toxicity is physostigmine salicylate. (medscape.com)
  • Has also been used successfully in the treatment of tricyclic antidepressant-induced anticholinergic toxicity, but currently is rarely used because of potentially serious adverse effects (seizures, bronchospasm, bradycardia, asystole). (drugs.com)
  • Type of cholinesterase inhibitor toxicity that may require extremely high doses of atropine. (cdc.gov)
  • It has been suggested that when these physiological changes do not occur with this dose (sometimes referred to as an atropine challenge ), this is indicative of cholinesterase inhibitor toxicity. (cdc.gov)
  • Parenteral atropine is not generally recommended for those whose sole manifestation of toxicity is miosis (pupillary constriction). (cdc.gov)
  • One author suggest avoiding large doses of pre-mixed atropine containing alcohol preservatives in children out of concern that alcohol toxicity could complicate the situation. (cdc.gov)
  • Answer: Anticholinergic toxicity--this brew can be eye-opening. (acepnow.com)
  • Use of NSAIDs, or drugs with anticholinergic properties. (wikipedia.org)
  • The manufacturers state that physostigmine is used to reverse CNS effects resulting from clinical or toxic dosages of drugs (e.g., some antihistamines, antimuscarinics, antiparkinsonian agents, phenothiazines) capable of producing anticholinergic syndrome and from intoxication with certain plants (e.g. (drugs.com)
  • Belladonna alkaloids belong to a class of drugs known as anticholinergics/antispasmodics. (webmd.com)
  • The anticholinergic effect of drugs such as tri- and tetracyclic antidepressants, antihistamines, quinidine, amantadine, antipsychotics (e.g. butyrophenones, phenothiazines), disopyramide and other anticholinergics (e.g. tiotropium, ipratropium, atropine-like compounds) may be intensified by Buscopan. (janusinfo.se)
  • Anticholinergic drugs, atropine and glycopyrrolate, are frequently used with the intention to improve sedation safety by virtue of their antisialagogue effects. (bvsalud.org)
  • Combivent Inhalation Aerosol is a combination of the anticholinergic bronchodilator, ipratropium bromide, and the beta 2 -adrenergic bronchodilator, albuterol sulfate. (theodora.com)
  • Ipratropium bromide is an anticholinergic (parasympatholytic) agent which, based on animal studies, appears to inhibit vagally mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released from the vagus nerve. (theodora.com)
  • Anticholinergic substances minimally compete with acetylcholine at other sites (eg, autonomic ganglia). (medscape.com)
  • Atropine works by competitively occupying muscarinic receptor sites, thus reducing the effects of excessive acetylcholine on these sites brought about by cholinesterase inhibition. (cdc.gov)
  • Anticholinergics prevent the increases in intracellular concentration of cyclic guanosine monophosphate (cyclic GMP) which are caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle. (theodora.com)
  • Atropine is an antimuscarinic that works through competitive inhibition of postganglionic acetylcholine receptors and direct vagolytic action, which leads to parasympathetic inhibition of the acetylcholine receptors in smooth muscle. (statpearls.com)
  • Anticholinergic syndrome (ACS) is produced by the inhibition of cholinergic neurotransmission at muscarinic receptor sites. (medscape.com)
  • Mechanism by which atropine counters the effects of the cholinergic toxidrome. (cdc.gov)
  • The initial presentation in the emergency department was a classic cholinergic toxidrome, and clinical resolution was achieved after provision of atropine. (scielo.org.za)
  • most clinicians advise against the routine use of physostigmine in tricyclic intoxication, and some clinicians recommend to reserve use only for life-threatening anticholinergic symptoms refractory to other treatment. (drugs.com)
  • 2002) Thus, even when given sufficient doses of atropine, patients may need artificial ventilation, sometimes for weeks. (cdc.gov)
  • Some cases of mild to moderate poisonings may improve with these doses of atropine. (cdc.gov)
  • If there is no improvement in the clinical state after repeat doses of atropine, additional treatments with atropine are unlikely to be effective. (statpearls.com)
  • Atropine sulfate injection should always be readily available. (drugs.com)
  • These atropine autoinjectors are packaged with a 2-PAM autoinjector, called Mark I kits. (cdc.gov)
  • Pretreatment with anticholinergic agents (e.g., atropine) may reduce the occurrence of bradyarrhythmias. (nih.gov)
  • Atropine/diphenoxylate is an antimotility agent that can be useful in the treatment of diarrhea as second-line therapy by allowing the central-acting opioid effect of diphenoxylate and capitalization on its anticholinergic side effect of constipation to slow motility. (statpearls.com)
  • Subtherapeutic amounts of atropine are included in the dosage form to discourage diphenoxylate abuse. (statpearls.com)
  • To stop the excessive saliva, you may need to take a prescription medication called an anticholinergic drug. (askdocweb.com)
  • and 3) Anticholinergic side effects are particularly common and problematic, especially in the older individual61, 62. (wellnessresources.com)
  • See Reversal of Anticholinergic Effects under Uses and also see Rapid IV Administration under Cautions. (drugs.com)
  • Whether PMs are also more prone to experience anticholinergic side effects needs to be further studied in larger patient populations. (nih.gov)
  • Describe the potential adverse effects of atropine. (statpearls.com)
  • While atropine can be used independently for anti-salivation effects, it is not formally recommended for routine use in controlled airways, though it can be used off-label for minimizing secretions in the intubated patient. (statpearls.com)
  • The TGA recently reviewed this issue following a coronial hearing of a fatal case involving a 74-day old infant being given over-the-counter (OTC) promethazine oral liquid, a phenothiazine derivative that is a long-acting antihistamine with mild atropine-like anticholinergic effects and some anti-serotonin effects. (tga.gov.au)
  • Atropine increases heart rate through vagolytic effects, causing increase in cardiac output. (medscape.com)
  • Many of the listed undesirable effects can be assigned to the anticholinergic properties of BUSCOPAN. (janusinfo.se)
  • To compare measures of anticholinergic activity between metabolic phenotypes of the polymorphic enzymes cytochrome P450 2D6 (CYP2D6) and CYP2C19 in the elderly patients exposed to anticholinergic agents. (nih.gov)
  • Long-term nursing home patients (n = 80) with an anticholinergic drug scale (ADS) score ≥3 were recruited from 22 nursing homes in Norway. (nih.gov)
  • Intravenous (IV) atropine indications include patients with hypersalivation, bronchial secretions, or bradycardia. (statpearls.com)
  • Due to the risk of anticholinergic complications, caution should be used in patients susceptible to intestinal or urinary outlet obstructions. (janusinfo.se)
  • Because of the possibility that anticholinergics may reduce sweating, Buscopan should be administered with caution to patients with pyrexia. (janusinfo.se)
  • Elevation of intraocular pressure may be produced by the administration of anticholinergic agents such as Buscopan in patients with undiagnosed and therefore untreated narrow angle glaucoma. (janusinfo.se)
  • Anticholinergic medicines help the muscles around the airways in your lungs stay relaxed to prevent symptoms such as wheezing , cough , chest tightness , and shortness of breath . (hdkino.org)
  • If there are local symptoms in the eyes or respiratory tract, atropine is not indicated. (statpearls.com)
  • Bronze Age ancestors used what they had at hand for shamanic purposes, and according to a new hair analysis, that meant powerful anticholinergic substances. (discovermagazine.com)
  • Anticholinergic syndrome may be caused by intentional overdose, inadvertent ingestion, medical noncompliance, or geriatric polypharmacy. (medscape.com)
  • Review interprofessional team strategies for improving care coordination and communication to enhance patient outcomes and minimize adverse events with atropine. (statpearls.com)
  • Tudorza Pressair (aclidinium bromide) inhalation powder is an anticholinergic indicated for the long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease ( COPD ), including chronic bronchitis and emphysema . (rxlist.com)
  • However, transient improvements with repeat dosing are an indication to continue treatment with atropine (which may exceed standard cumulative dosing maximums). (statpearls.com)
  • These preliminary findings suggest that elderly CYP2D6/CYP2C19 PMs with a high anticholinergic drug burden are at increased risk of elevated SAA. (nih.gov)
  • More than 80% used more than 1 anticholinergic agent, and their median ADS score was 4. (nih.gov)
  • A number of authors have recommended the "atropine challenge" as an aid to diagnosis. (cdc.gov)
  • Yupelri is an anticholinergic medicine. (hdkino.org)