Anticancer drugs microtubules. Medical search. Frequent questions

Eribulin is in a class of anticancer medications called microtubule dynamics inhibitors. (medlineplus.gov)
They further offer fundamental structural insights into the control mechanisms of microtubule dynamics. (uzh.ch)
Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death. (ens-lyon.fr)
Home / Teams / Evolutionary Cell Biology in Nematodes - M. Delattre / Publications / Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death. (ens-lyon.fr)
Small molecules that interfere with microtubule dynamics, such as Taxol and the Vinca alkaloids, are widely used in cell biology research and as clinical anticancer drugs. (ens-lyon.fr)
Here, we introducethe photostatins, inhibitors that can be switched on and off in vivo by visible light, to optically control microtubule dynamics. (ens-lyon.fr)
Photostatins modulate microtubule dynamics with a subsecond response time and control mitosis in living organisms with single-cell spatial precision. (ens-lyon.fr)
In addition, cell expansion does not only rely on cortical microtubule orientation but also plays a regulatory role in microtubule dynamics, as well. (biomedcentral.com)
The mechanism of vincristine is the inhibition of microtubule dynamics that would cause mitotic arrest and eventual cell death. (smpdb.ca)
Binding between vincristine and solubale tubulin decreases the rate of microtubule dynamics (lengthening and shortening) and increases the duration of attenuated state of microtubules. (smpdb.ca)
He is selected for his outstanding contribution to understanding the assembly dynamics of microtubules and the mechanism of action of microtubule-targeted drugs. (wrcb.in)
The drug hyperstabilizes microtubules, disrupts normal microtubule organization and dynamics, blocks cells in mitosis, and induces apoptosis. (yu.edu)
Tubulin isotypes are known to regulate microtubule stability and dynamics, as well as to play a role in the development of resistance to microtubule-targeted cancer drugs. (bvsalud.org)
Griseofulvin is known to disrupt cell microtubule dynamics and cause cell death in cancer cells through binding to tubulin protein at the taxol site. (bvsalud.org)
Notably, he has elucidated the role of microtubule dynamics in the regulation of cell cycle, cell migration, and apoptosis. (sunpharmasciencefoundation.net)

Taxol is an anticancer chemotherapy drug that functions as a microtubule inhibitor, stalling cell division. (europa.eu)
Taxol is traditionally extracted from yew trees which nowadays cannot meet market demands for the drug. (europa.eu)
For example, paclitaxel (Taxol), which is prescribed for breast, ovarian and other cancers, works by binding to the tubulin protein, inhibiting the formation of structures called microtubules that are needed for cell division. (livescience.com)
Taxol is the best anticancer agent ever been isolated from plants, but its major disadvantage is the dose limiting toxicity. (rgcb.res.in)
Chapters one, two and three focus on the marine secondary metabolite peloruside A (1), which has been shown to stabilise microtubules during mitosis and hence cause apoptosis (cell death) in a similar manner to the very successful anticancer drug Taxol. (vuw.ac.nz)
Taxol is an anticancer drug approved by the FDA for the treatment of ovarian, breast and lung carcinomas. (yu.edu)
In an in vitro system, Taxol can polymerize stable microtubules in the absence of GTP that is normally required for tubulin assembly. (yu.edu)
Recently, three new natural products, the epothilones, eleutherobin and discodermolide, whose chemical structures are highly diverse, have been reported to have mechanisms of action similar to that of Taxol, in that they all stabilize microtubules. (yu.edu)
Taxol is an effective drug in breast cancer, but resistance to it is known. (bvsalud.org)
After the discovery of paclitaxel's unique mechanism of action as a microtubule stabilizer, intense research followed, which despite drawbacks such as supply problems and low water solubility, resulted in the successful anti cancer medicine Taxol. (lu.se)

Many drug molecules are enzyme inhibitors that inhibit an aberrant human enzyme or an enzyme critical for the survival of a pathogen such as a virus , bacterium or parasite . (wikipedia.org)
Since anti-pathogen inhibitors generally target only one enzyme, such drugs are highly specific and generally produce few side effects in humans, provided that no analogous enzyme is found in humans. (wikipedia.org)
His research has unveiled several inhibitors of microtubules with a strong-anticancer potential. (wrcb.in)
We here demonstrate that the dolastatin family of microtubule inhibitors, from which the cytotoxic component of brentuximab vedotin is derived, comprises potent inducers of phenotypic and functional DC maturation. (biomedcentral.com)
Combined with in-vitro proliferation assays using CRISPR-Cas9/RNAi and patient survival analysis, MEK inhibitors PD19830 and BRD-K12244279, pilocarpine, and tremorine were discovered as potential new drug options for treating breast cancer. (cdc.gov)

If successfully developed into a treatment, the compound would be the first of a new class of anticancer drugs. (scripps.edu)

Drugs that work via this mechanism should spare many of the healthy, fast-dividing cells, such as hair follicle cells, that are harmed by standard chemotherapy drugs. (scripps.edu)
The most widely used gout drug is allopurinol, a 75-year-old drug, which operates by an entirely different mechanism - the inhibition of uric acid production. (acsh.org)
Even though the "alignment hypothesis" has been proposed decades ago, a mechanism explaining how cortical microtubules, located inside of the plasma membrane, control the orientation of cellulose microfibrils, outside of the protoplast, remained ambiguous. (biomedcentral.com)

Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. (nature.com)
Traditional anti-mitosis drugs target proteins such as microtubules that are basic features of the cell division apparatus," Bollong said. (scripps.edu)
A drug that blocks mitosis by targeting vimentin should be less toxic than traditional chemotherapeutic drugs that targets cell-division," Lairson said. (scripps.edu)
Microtubules play a crucial role in segregating chromosomes from one cell to another during cell mitosis and division. (databasefootball.com)
At that time scientists were using the term "mitotic figures" to describe microtubules because they were observed during metaphase of mitosis. (databasefootball.com)

This is the first time that UPR markers are reported to change in human blood in response to any drug treatment, supporting their use as pharmacodynamic biomarkers for compounds that activate ER stress in humans. (nih.gov)
Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed. (justia.com)
The invention also relates to methods of using antibodies and antibody-drug conjugate compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. (justia.com)
Furthermore, they were found to have anticancer activity, exemplified by mitoxantrone and pixantrone, and many are well known redox-active compounds. (bvsalud.org)
Most of the compounds exhibit anticancer effects against all cell lines, therefore the compounds were further studied to determine their IC50-values. (bvsalud.org)

Source: "In vitro and in vivo anticancer activities of synthetic (-)-laulimalide, a marine natural product microtubule stabilizing agent. (acsh.org)

It binds to beta-tubulin and disrupts microtubules, causing cell cycle arrest and apoptosis. (prettechengineering.com)

The chemo drugs vincristine and vinblastine, vinca alkaloids, although they come from a different plant, Catharanthus roseus, aka the Madagascan Periwinkle, work in the same manner - inhibiting cell division. (acsh.org)
One way in which cells have developed resistance against the vinca alkaloids is by drug efflux. (smpdb.ca)

According to these findings, it may be concluded that inhibition of cell expansion, irrespective of the cause, results in increased microtubule stability in A. thaliana root. (biomedcentral.com)
The drug moieties may affect cytotoxic and cytostatic mechanisms including tubulin binding, DNA binding, or topoisomerase inhibition. (justia.com)
This inhibition was due to a combination of mechanisms, including disruption of microtubules and activation of p53. (prettechengineering.com)

Antiviral drugs target proteins that are essential for viruses to replicate. (livescience.com)
Antibiotics and antiviral drugs attack proteins that are only found in the targeted bacterium or virus and that are crucial for the pathogen's survival or multiplication. (livescience.com)
Newer anticancer drugs are more discriminating, often targeting important proteins that are abnormally active in certain cancers.One such drug, imatinib mesylate (Gleevec), halts a cell-communication pathway that is always "on" in a cancer of the blood called chronic myelogenous leukemia. (livescience.com)
Some of the most widely prescribed drugs function by blocking proteins called G protein-coupled receptors, which play key roles in transmitting the signals that allow a cell to respond to its environment. (livescience.com)
With a better understanding of the specific relationships between a drug and its target (and off-target) proteins, researchers are using a variety of existing data to identify and test FDA-approved drugs for new uses and to predict potential side effects. (livescience.com)
Results indicate FROST450 resistance is associated with increased mitochondrial respiration and with changes in gene sequence or expression level of proteins associated with microtubules, and that these mechanisms do not confer cross-resistance to other common microtubule targeting agents. (byu.edu)
Dr. Oakley was interested in identifying proteins which associate with microtubules in the cytoplasm, particularly during the breakdown of microtubule filaments. (databasefootball.com)

Colchicine is a microtubule inhibitor - a drug that prevents the formation of the mitotic spindle, which is an essential process in dividing cells. (acsh.org)
As a microtubule destabilizing agent, Vincristine stimulates mitotic spindle destruction and microtubule depolymerization at high concentrations. (smpdb.ca)
We aim to obtain a n integrated view of chromosome segregation that considers all the elements of the mitotic machinery , including centrosomes, the different microtubule populations of the mitotic spindle, kinetochores, chromosomes, and the cell cortex. (unige.ch)

Cysteine engineered anti-MUC16 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-MUC16 antibody-drug conjugates having Formula I: Ab-(L-D)p I where p is 1 to 4. (justia.com)
The use of antibody-drug conjugates (ADC), i.e. immunoconjugates, for the local delivery of cytotoxic or cytostatic agents, i.e. drugs to kill or inhibit tumor cells in the treatment of cancer (Lambert, J. (2005) Curr. (justia.com)
Drug moieties used in antibody drug conjugates include bacterial protein toxins such as diphtheria toxin, plant protein toxins such as ricin, small molecules such as auristatins, geldanamycin (Mandler et al (2000) J. of the Nat. (justia.com)
Antibody drug conjugates (ADCs) are emerging as powerful treatment strategies with outstanding target specificity and high therapeutic activity in cancer patients. (biomedcentral.com)
Antibody-drug conjugates (ADCs) are revolutionizing care for patients with certain advanced solid tumors. (medscape.com)

Vincristine works partly by binding to the tubulin protein, stopping the tubulin dimers from polymerizing to form microtubules, causing the cell to be unable to separate its chromosomes during the metaphase. (wikipedia.org)
But even when a drug is designed to target a specific protein, it can sometimes impact others, causing side effects. (livescience.com)
Microtubules also enable many biological processes, such as protein transport within cells and cell to cell communication. (databasefootball.com)
In this work, the persistence of cortical microtubules against anti-microtubule treatment was thoroughly studied in the roots of several cesa mutants, namely thanatos , mre1 , any1 , prc1-1 and rsw1 , and the Cellulose Synthase Interacting 1 protein ( csi1) mutant pom2-4 . (biomedcentral.com)
Some cytotoxic drugs tend to be inactive or less active when conjugated to large antibodies or protein receptor ligands. (justia.com)
Microtubules are a protein scaffold that gives cells their shape and structure. (prettechengineering.com)
The drug works by disrupting the formation of microtubules, a protein scaffold that helps establish the shape and structure of cells. (prettechengineering.com)
While textbook depictions of cells show them to float in amorphous bags of liquid, the fact is that they are established through the cytoskeleton, which comprises protein structures called microtubules. (prettechengineering.com)
The spike (S) protein of SARS-CoV-2, which mediates receptor binding and subsequent membrane fusion to promote viral entry, is a major target for current drug development and vaccine design. (bvsalud.org)
From experimentally validated target genes of these 86 miRNAs, pan-sensitive and pan-resistant genes with concordant mRNA and protein expression associated with in-vitro drug response to 19 NCCN-recommended breast cancer drugs were selected. (cdc.gov)
The mRNA and protein expression of the 26 genes was associated with sensitivity or resistance to 18 NCCN-recommended drugs for treating breast cancer. (cdc.gov)

The overuse of vincristine may also lead to drug resistance by overexpression of the p-glycoprotein pump (Pgp). (wikipedia.org)
The liposome encapsulation of vincristine enhances the efficacy of the vincristine drug while simultaneously decreasing the neurotoxicity associated with it. (wikipedia.org)
Left top) Catharanthus roseus, aka the Madagascan Periwinkle, a member of the Vinca plant family, is the source of the cancer drug vincristine (Right top) Nice structure, huh? (acsh.org)
Vincristine are used as chemotherapy medication such as an antimitotic anticancer agent. (smpdb.ca)
Unlike the taxanes, which bind poorly to soluble tubulin, vincristine can bind both soluble and microtubule-associated tubulin. (smpdb.ca)
Vincristine binds to β-tubulin subunits at the positive end of microtubules at a region called the _Vinca_-binding domain. (smpdb.ca)

Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo . (nature.com)
The evidence for these anticancer effects, in vitro , in vivo , and clinical are summarised, and the putative mechanisms of their action outlined. (ecancer.org)

From the knowledge gained through pioneering studies in both simple and complex model organisms such as these, we now know that microtubules interact with chromosomes during the entire cell cycle, not just during cell division. (databasefootball.com)
This cellular structure is made of microtubules, which are also used to pull and separate the chromosomes during cell division. (prettechengineering.com)

We applied our workflow to quantify cell-cycle effects of three antimitotic cancer drugs over 8 d in HT-1080 fibrosarcoma xenografts in living mice using a data set of 38,000 cells and compared the induced phenotypes. (nature.com)
Microtubule-stabilizing agents (MSAs) are efficacious chemotherapeutic drugs widely used for the treatment of cancer. (uzh.ch)
Whether they originate from EMT-transformed epithelial cells or from mesenchymal tissues, mesenchymal cancer cells are prone to form deadly metastases and are generally difficult to treat with drugs-surgical removal is often the only good option. (scripps.edu)
FiVe1's selectivity for vimentin-containing mesenchymal cancer cells means that it wouldn't have the same side-effects as traditional chemotherapy drugs. (scripps.edu)
The search for new anti-cancer drugs and their development is a field of utmost importance in current drug research. (csic.es)
Sensitization of cancer cells to conventional drugs using multi-target agents that block survival and oncogenic pathways, alone or in combination, is an emerging strategy to overcome drug resistance. (researchsquare.com)
As primary treatment strategies tend to lose potency against cancer, there is a need for treatment options that overcome drug resistance mechanisms. (byu.edu)
Microtubule-targeting agents (MTAs) are a class of clinically successful anti-cancer drugs. (tcd.ie)
First evidence of anti-tumor activity from phase 1 study data was presented in June at the Annual Meeting of the American Society of Clinical Oncology (ASCO) for Basilea's novel microtubule-destabilizing and vascular disrupting anti-cancer drug, BAL101553. (basilea.com)
Additionally, based on the properties summarised previously, it is proposed that itraconazole may synergise with a range of other drugs to enhance the anti-cancer effect, and some of these possible combinations are presented in the supplementary materials accompanying this paper. (ecancer.org)
It is not a coincidence that colchicine is also a potential cancer drug . (acsh.org)
4. Repurposed Drugs Were Studied Against Cancer by Accident as Metformin from the Women's Health Initiative by Dr. Pamela Goodwin of U. of Toronto. (yufoundation.org)
One of the respectable oncologist named Michael P. Lasanti MD PhD just moved from the United States just moved to United Kingdom University of Salford Manchester to focus on cancer micro environment intervention and will be studying many drugs available to bring many old drugs as repurposed drugs to be used in the near future. (yufoundation.org)
Fenbendazole is an antiparasitic drug that has been shown to slow down cancer cell growth in petri dishes and mice. (prettechengineering.com)
Our group investigates the fundamental mechanisms of cell division ensuring faithful chromosome segregation in human cells, how a deregulation of these mechanisms contribute to genetic instability in cancer cells, and how this erroneous process can reveal new targets for anti-cancer treatments or be exploited by novel anti-cancer drugs. (unige.ch)
Chromosomal instability and aneuploidy are not only symptoms of cancer cells, they can directly cause or enhance cancer formation, as they create dosage imbalances between oncogenes and tumour suppressors, and contribute to the development of cancer drug resistances. (unige.ch)
Modern anticancer treatments use a combination of multiple drugs to alleviate the problem of cancer cells resistance to chemotherapy. (bvsalud.org)
Microtubule targeting agents (MTAs) have been exploited mainly as anti-cancer drugs because of their impact on cellular division and angiogenesis. (bvsalud.org)
Multi-omics biomarkers of response to the discovered drugs were identified using human breast cancer cell lines. (cdc.gov)
This study presented an artificial intelligence pipeline of miRNA-based discovery of biomarkers, therapeutic targets, and repositioning drugs that can be applied to many cancer types. (cdc.gov)
Based on this gene expression signature, the VEGFR inhibitor ZM-306416 was discovered as a new drug for treating breast cancer. (cdc.gov)
Given the growing number of patients receiving ADCs and the expanding indications for their use, understanding the toxicity profiles of these drugs, and developing strategies to mitigate and manage these side effects have become paramount, Paolo Tarantino, MD, of the Dana-Farber Cancer Institute in Boston, and colleagues explained in a recent review exploring ADC toxicities and efforts to improve patient safety. (medscape.com)

The cysteine engineered antibodies may be conjugated with chemotherapeutic drugs, toxins, affinity ligands such as biotin, and detection labels such as fluorophores. (justia.com)

Microtubule filaments composed of tubulins are now known to play an active role in chromosome separation. (databasefootball.com)
But a pertinent question remains: how do tubulins organize themselves into microtubule filaments? (databasefootball.com)
At that time, there were only two known types of tubulins that make up microtubules: alpha and beta tubulin, and alpha and beta tubulins are just the building blocks that create microtubule filaments. (databasefootball.com)
Model organisms were once again critical in answering the question of how tubulins are organized into microtubule filaments in 1989 in the lab of Dr. Berl Oakley. (databasefootball.com)
These microtubules form a network of filaments that allow the cell to change shape and transport organelles and cargo around the body. (prettechengineering.com)

Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. (research.com)

Microtubule binding drugs are of special interest as they have important roles in the modulation of cellular functions and many of them act as anticancer agents. (rgcb.res.in)
No. 4,975,278) allows targeted delivery of the drug moiety to tumors, and intracellular accumulation therein, where systemic administration of these unconjugated drug agents may result in unacceptable levels of toxicity to normal cells as well as the tumor cells sought to be eliminated (Baldwin et al (1986) Lancet pp. (justia.com)
Microtubule destabilising agents: far more than just antimitotic anticancer drugs. (research.com)
Prof. Panda has made immense contributions to the discovery of tubulin targeting anticancer agents and understanding their mechanisms of action. (sunpharmasciencefoundation.net)

It does this by binding to the cytoskeleton and blocking the synthesis of new microtubules. (prettechengineering.com)

Figure 6: Antimitotic drugs induce different mitotic and interphase phenotypes. (nature.com)

Drugs that interfere with the formation of microtubules stop important cellular processes, and this is how fenbendazole and other antiparasitic drugs kill parasites. (prettechengineering.com)

We remain open to explore innovative collaboration and transaction structures and we were very pleased to announce a significant agreement with BARDA allowing for non-dilutive funding of up to USD 89 million for our drug candidate BAL30072, which addresses Gram-negative bacterial resistance. (basilea.com)
Additionally, microtubules (MTs) are key structures for intracellular transport, which is frequently hijacked during viral infection. (bvsalud.org)

Because the M-loop establishes lateral tubulin contacts in microtubules, these findings explain how taxane-site MSAs promote microtubule assembly and stability. (uzh.ch)
While the regulation of cell wall properties by cortical microtubules is well studied, the data on the influence of cell wall to cortical microtubule organization and stability remain scarce. (biomedcentral.com)
Furthermore, to examine if the enhanced stability of cortical microtubules was due to reduced cellulose biosynthesis or to suppression of cell expansion, treatments of wild-type roots with 2,6-dichlorobenzonitrile (DCB) and Congo red were performed. (biomedcentral.com)
Various hypotheses may explain the increased cortical microtubule stability under decreased cell expansion such as the role of cell wall sensors and the presence of less dynamic cortical microtubules. (biomedcentral.com)

Cortical microtubules regulate cell expansion by determining cellulose microfibril orientation in the root apex of Arabidopsis thaliana . (biomedcentral.com)

with chemotherapy drugs 6 - 8 (Figure 1). (lookchem.com)
Vimentin is not expressed at significant levels in the hair follicle cells and mouth- and gut-lining epithelial cells damaged by standard chemotherapy drugs. (scripps.edu)

Apigenin is a flavonoid widely presented in fruits and vegetables, and is known to possess anti-inflammatory, antioxidant, and anticancer properties. (bvsalud.org)

Despite the importance of MSAs for medical applications and basic research, their molecular mechanisms of action on tubulin and microtubules remain elusive. (uzh.ch)
Based on this research, you might understand how important microtubules are for normal biological processes. (databasefootball.com)
The husband, Connor Bowman, a former resident at the Mayo Clinic in Minnesota, did online research on colchicine , one of 19,000 FDA-approved drugs. (acsh.org)
Anticancer Research 27(3B):1509-18, May 2007. (acsh.org)

Similarly, trastuzumab emtansine (Kadcyla), enfortumab vedotin (Padcev), mirvetuximab soravtansine (Elahere), and tisotumab vedotin (Tivdak), which have a microtubule inhibitor as the payload, come with similar toxicities to the microtubule-inhibiting drugs. (medscape.com)

Itraconazole, a common triazole anti-fungal drug in widespread clinical use, has evidence of clinical activity that is of interest in oncology. (ecancer.org)
The drug has not been tested in clinical trials, and there is no guarantee that it will be safe for use as a treatment. (prettechengineering.com)
Many of the drugs currently in clinical use originate from natural products. (lu.se)

Drug resistance remains problematic for chemotherapy treatments. (byu.edu)
In addition, various treatments with drugs affecting cell expansion were performed on wild-type roots. (biomedcentral.com)
After these treatments, cortical microtubules appeared more resistant to oryzalin, than in the control. (biomedcentral.com)

The regulatory role of cortical microtubules on cellulose microfibrils was initially postulated, and remains widely accepted, by the "alignment hypothesis" [ 4 ]. (biomedcentral.com)

FROST450, a novel microtubule destabilizing agent, has proven anticancer effects that overcome taxane and multidrug resistance. (byu.edu)

Apart from the role of cortical microtubules on cellulose microfibril orientation, several authors supported that CESA activity and cellulose synthesis also exert an effect on cortical microtubule orientation, suggesting thus that cortical microtubule-cellulose microfibril relationship is bi-directional. (biomedcentral.com)

[10] If given together with other medications, the dosing interval depends on the drug combination. (mdwiki.org)

He has also studied FtsZ in bacterial cell division and established it as an antibacterial drug target. (wrcb.in)
His work has greatly aided in establishing FtsZ as a new antibacterial drug target. (sunpharmasciencefoundation.net)

Figure 4: Quantitative analysis of drug response to paclitaxel treatment at a single-cell level. (nature.com)
Numerous phytochemicals and their determined analogs have been recognized as possible contender for anticancer treatment and the present review article sheds light on few of these phytocompounds. (researchsquare.com)
Several drug therapies are valuable in the treatment of symptomatic MM. Clinicians treat many patients with high-dose therapy and peripheral blood or bone marrow stem cell transplantation. (medscape.com)

Drug efflux is mediated by a number of multidrug resistant transporters as depicted in this pathway. (smpdb.ca)

Scientists are also learning more about how a person's genes may influence the effectiveness and safety of certain drugs. (livescience.com)
He has established himself as one of the world's leading scientists in the field of C-H activation by designing innovative catalytic methods for transforming organic molecules into several bio-active natural products as well as drug molecules and materials in step and atom-economic fashion. (sunpharmasciencefoundation.net)

Figure 5: Pharmacodynamics of antimitotic drugs in the HT-1080 xenograft system. (nature.com)
How do antimitotic drugs work? (csic.es)

Throughout history, chemicals (or their synthetic derivatives) from plant extracts have led to the discovery of many important drugs. (acsh.org)

In addition, our findings suggest a differentiation between short- and long-term drug resistance mechanisms. (byu.edu)

The absolute stereochemistry at these carbons is responsible for vincristine's anticancer activity. (wikipedia.org)

Anatomy41

Organisms17

Diseases6

Chemicals and Drugs105

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes56

Disciplines and Occupations4

Technology, Industry, Agriculture8

Information Science4

Health Care1

Dynamics15

Taxol10

Inhibitors5

Class of anticancer1

Mechanism3

Mitosis5

Compounds5

Vitro and in vivo1

Disrupts1

Vinca alkaloids2

Inhibition3

Proteins7

Mitotic spindle3

Antibody drug conjugates5

Protein11

Vincristine6

Vivo2

Chromosomes2

Cancer22

Chemotherapeutic drugs1

Filaments5

Apoptosis1

Agents4

Cytoskeleton1

Induce1

Cellular1

Structures2

Stability4

Regulate1

Chemotherapy drugs2

Anti-inflammatory1

Research4

Vedotin1

Clinical3

Treatments3

Widely1

Agent1

Synthesis1

Medications1

Antibacterial drug target2

Treatment3

Multidrug1

Scientists2

Antimitotic drugs2

Synthetic1

Resistance1

Activity1